2023
Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency.
Jindal A, Suri D, Gupta K, Kumar A, Pandiarajan V, Pilania R, Guleria S, Rawat A, Vyas S, Bhatia A, Singh S, Radotra B. Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency. Clinical Neuropathology 2023, 42: 15-25. PMID: 36278299, DOI: 10.5414/np301476.Peer-Reviewed Original ResearchConceptsMeasles inclusion body encephalitisSevere combined immunodeficiencyInclusion body encephalitisPrimary immunodeficiencyCombined immunodeficiencyViral encephalitisCase 2Primary immunodeficiency diseasesFeatures of viral encephalitisWhole-exome sequencingRare giant cellsFatal viral encephalitisCytomegalovirus encephalitisImmunodeficiency diseaseMicroglial nodulesCystic encephalomalaciaHistopathological featuresBacterial pneumoniaHistological featuresAlveolar damageExtracranial organsPathogenic variantsImmunodeficiencyGenetic testingExome sequencing
2021
La Crosse Virus Shows Strain-Specific Differences in Pathogenesis
Wilson S, López K, Coutermash-Ott S, Auguste D, Porier D, Armstrong P, Andreadis T, Eastwood G, Auguste A. La Crosse Virus Shows Strain-Specific Differences in Pathogenesis. Pathogens 2021, 10: 400. PMID: 33805389, PMCID: PMC8066585, DOI: 10.3390/pathogens10040400.Peer-Reviewed Original ResearchLa Crosse virusPediatric viral encephalitisNeuroinvasive capacityPublic health pathogenViral encephalitisImportant public health pathogenMurine modelEndemic regionsStrain-specific differencesTherapeutic efficacyExcessive mortalityPathogenesisViral strainsMouse studiesVirusNeurovirulenceMortalityContemporaneous strainsLineage IEntomological riskEncephalitisVaccineDisease
2016
Age-related alterations in immune responses to West Nile virus infection
Montgomery R. Age-related alterations in immune responses to West Nile virus infection. Clinical & Experimental Immunology 2016, 187: 26-34. PMID: 27612657, PMCID: PMC5167051, DOI: 10.1111/cei.12863.Peer-Reviewed Original ResearchConceptsWest Nile virusToll-like receptorsDendritic cellsSevere diseaseBlood-brain barrier permeabilityImportant public health concernWest Nile virus infectionHuman dendritic cellsNatural killer cellsAnti-viral responseMonocytes/macrophagesPathogen recognition receptorsAge-related alterationsSpecific immune parametersPublic health concernImportant causative agentAge-related impairmentIndividual host factorsAge-related changesKiller cellsViral encephalitisImmune cellsRisk factorsBarrier permeabilityHigh prevalence
2013
Predictors of outcome in acute encephalitis
Thakur K, Motta M, Asemota A, Kirsch H, Benavides D, Schneider E, McArthur J, Geocadin R, Venkatesan A. Predictors of outcome in acute encephalitis. Neurology 2013, 81: 793-800. PMID: 23892708, PMCID: PMC3908458, DOI: 10.1212/wnl.0b013e3182a2cc6d.Peer-Reviewed Original ResearchConceptsMultivariate logistic regression analysisPredictors of outcomeStatus epilepticusLogistic regression analysisCerebral edemaHospital dischargePoor outcomeJohns Hopkins Bayview Medical CenterPredictors of deathFurther prospective studiesIntensive care unitJohns Hopkins HospitalRegression analysisIntubation requirementAutoimmune etiologyAcute encephalitisAggressive managementVentilator supportMedian ageCare unitViral encephalitisProspective studyEncephalitis casesUnknown causeRetrospective analysis
2008
ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System
Dai J, Wang P, Bai F, Town T, Fikrig E. ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System. Journal Of Virology 2008, 82: 4164-4168. PMID: 18256150, PMCID: PMC2292986, DOI: 10.1128/jvi.02621-07.Peer-Reviewed Original ResearchConceptsWest Nile virusICAM-1Control animalsWest Nile virus neuroinvasionBlood-brain barrier leakagePathogenesis of encephalitisNile virusBlood-brain barrierLow viral loadWest Nile encephalitisCentral nervous systemICAM-1 participatesVirus neuroinvasionNeuronal damageLeukocyte infiltrationViral encephalitisViral loadBarrier leakageViral infectionNervous systemEncephalitisMiceICAMVirusAnimals
2007
Transvascular delivery of small interfering RNA to the central nervous system
Kumar P, Wu H, McBride JL, Jung KE, Hee Kim M, Davidson BL, Kyung Lee S, Shankar P, Manjunath N. Transvascular delivery of small interfering RNA to the central nervous system. Nature 2007, 448: 39-43. PMID: 17572664, DOI: 10.1038/nature05901.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBlood-Brain BarrierBrainCell LineDrug Delivery SystemsEncephalitis Virus, JapaneseEncephalitis, JapaneseGene SilencingGenetic VectorsGlycoproteinsGreen Fluorescent ProteinsHeLa CellsHumansLentivirusLiposomesMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, SCIDMolecular Sequence DataNeuronsOligopeptidesRabies virusReceptors, NicotinicRecombinant ProteinsRNA, Small InterferingSuperoxide DismutaseSuperoxide Dismutase-1Viral ProteinsConceptsRVG-9RBlood-brain barrierRabies virus glycoproteinNeuronal cellsTransvascular deliveryFatal viral encephalitisCentral nervous systemTherapeutic moleculesIntravenous treatmentViral encephalitisInflammatory cytokinesAntiviral siRNAIntravenous injectionNervous systemAcetylcholine receptorsNeurological diseasesAnti-peptide antibodiesChimaeric peptidesNoninvasive approachDelivery of siRNABrainSiRNAMiceVirus glycoproteinRobust protection
2004
Detection of Human Anti-Flavivirus Antibodies with a West Nile Virus Recombinant Antigen Microsphere Immunoassay
Wong SJ, Demarest VL, Boyle RH, Wang T, Ledizet M, Kar K, Kramer LD, Fikrig E, Koski RA. Detection of Human Anti-Flavivirus Antibodies with a West Nile Virus Recombinant Antigen Microsphere Immunoassay. Journal Of Clinical Microbiology 2004, 42: 65-72. PMID: 14715733, PMCID: PMC321652, DOI: 10.1128/jcm.42.1.65-72.2004.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidWN virusRelated flavivirusesProtein antigensMicrosphere immunoassayAnti-flavivirus antibodiesAnti-human immunoglobulin antibodiesNew York patientsImmunoglobulin G antibodiesPublic health workersWN virus infectionEnzyme-linked immunosorbent assayEnzyme-linked immunosorbentE proteinSt. Louis encephalitisWest Nile virusViral encephalitisIgM antibodiesAnti-IgG antibodiesManagement of outbreaksG antibodiesVirus infectionHealth workersJapanese encephalitisImmunoglobulin antibodies
1988
The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.
Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL. The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. The Journal Of Immunology 1988, 140: 2210-4. PMID: 2965183, DOI: 10.4049/jimmunol.140.7.2210.Peer-Reviewed Original ResearchConceptsMultiple sclerosisViral encephalitisImmune responseCentral nervous system immune responseSuppressor-inducer functionCentral nervous system tissuePlaque edgeAdjacent white matterIL-2R mAbNervous system tissueMultiple sclerosis lesionsAnti-2H4Anti-CD4Inflammatory cellsMS plaquesImmunohistochemical stainingWhite matterSclerosis lesionsEncephalitisPatientsCellsRare cellsCD8CD4Sclerosis
1985
Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases
Hafler DA, Hemler ME, Christenson L, Williams JM, Shapiro HM, Strom TB, Strominger JL, Weiner HL. Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clinical Immunology 1985, 37: 163-171. PMID: 3930113, DOI: 10.1016/0090-1229(85)90147-3.Peer-Reviewed Original ResearchConceptsT cellsActivated T cellsActivation antigensMultiple sclerosisInflammatory central nervous system diseasesPeripheral blood T cellsCentral nervous system diseaseActive multiple sclerosisSystemic immune activationGroup of patientsMultiple sclerosis patientsBlood T cellsEarly activation antigenNervous system diseasesAbnormal immunologic activityMultiple differentiation stagesMS patientsSclerosis patientsViral encephalitisImmune activationPeripheral bloodNeurologic diseaseImmunologic activitySystem diseasesNormal controls
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