2014
Endothelin-1 and its role in the pathogenesis of infectious diseases
Freeman BD, Machado FS, Tanowitz HB, Desruisseaux MS. Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences 2014, 118: 110-119. PMID: 24780317, PMCID: PMC4538933, DOI: 10.1016/j.lfs.2014.04.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelin-1Isoforms of endothelinRole of endothelinRickettsia conorii infectionPathogenesis of sepsisPro-inflammatory cytokinesVascular smooth muscle cellsLeukocyte adhesion moleculesSmooth muscle cellsSevere malariaVascular dysfunctionBacterial pneumoniaInflammatory mediatorsVascular tonePotent vasoconstrictorImmunomodulatory propertiesInfectious processAlveolar macrophagesPlatelet aggregationInfectious diseasesMuscle cellsEndothelinAdhesion moleculesPathogenesisChagas disease
2002
The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis.
Laghmani K, Preisig PA, Alpern RJ. The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis. Journal Of Nephrology 2002, 15 Suppl 5: s75-87. PMID: 12027224.Peer-Reviewed Original ResearchConceptsProximal tubulesMetabolic acidosisEndothelin-1NHE3 activityRole of endothelinImmediate early gene c-fosEndothelin B receptorEarly gene c-fosChronic metabolic acidosisGene c-fosKidney functionActivation of Pyk2Endothelin effectsApical membrane NHE3NHE3 abundanceB receptorEndothelinApical membraneAcidosisSecretionEffector agentsC-fosTubulesProton secretionC-Jun
1993
Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction
Cantley L, Spokes K, Clark B, McMahon E, Carter J, Epstein F. Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. Kidney International 1993, 44: 1217-1223. PMID: 8301922, DOI: 10.1038/ki.1993.371.Peer-Reviewed Original ResearchConceptsRenal blood flowRole of endothelinRenal artery constrictionEndothelin receptor antagonistsBlood flowRenal vasoconstrictionArtery constrictionReceptor antagonistSystemic blood pressureUrinary prostaglandin E2Absence of indomethacinRenal hypoperfusionBlood pressureRenal perfusionAortic ringsIntact ratsProstaglandin E2Sustained decreaseNormal ratsRadiocontrast agentsBaseline valuesProstaglandin synthesisProstaglandin formationRatsIndomethacin
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