2023
Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans
Khazma T, Grossman A, Guez-Haddad J, Feng C, Dabas H, Sain R, Weitman M, Zalk R, Isupov M, Hammarlund M, Hons M, Opatowsky Y. Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Reports 2023, 42: 113026. PMID: 37635352, PMCID: PMC10675840, DOI: 10.1016/j.celrep.2023.113026.Peer-Reviewed Original ResearchConceptsC. elegansCryoelectron microscopy structureNematode C. elegansC. elegans neuronsStructure-function analysisMicroscopy structureNADase activityMolecular mechanismsElegansCellular NADModel animalsSpeciesAxon degenerationWallerian axonal degenerationOrthologsOctamerProteinSARM1DivergenceNADSARMExpressionActivityAxonal degeneration
2014
Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration
Byrne AB, Walradt T, Gardner KE, Hubbert A, Reinke V, Hammarlund M. Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration. Neuron 2014, 81: 561-573. PMID: 24440228, PMCID: PMC3924874, DOI: 10.1016/j.neuron.2013.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsDisease Models, AnimalForkhead Transcription FactorsGene Expression RegulationGreen Fluorescent ProteinsHumansImmunosuppressive AgentsInsulinInsulin-Like Growth Factor INerve DegenerationNerve RegenerationPhosphotransferases (Alcohol Group Acceptor)PTEN PhosphohydrolaseSignal TransductionSirolimusTime FactorsTranscription Factors