Zsuzsanna Tobias
Research ScientistCards
About
Research
Publications
2024
IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation.
Mullan C, Summer L, Lopez-Giraldez F, Tobiasova Z, Manes T, Yasothan S, Song G, Jane-Wit D, Saltzman W, Pober J. IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation. The Journal Of Immunology 2024, 213: 1338-1348. PMID: 39302113, PMCID: PMC11493510, DOI: 10.4049/jimmunol.2400331.Peer-Reviewed Original ResearchIL-15Surface expressionIL-1BIL-15 transcriptsEndothelial cellsCD8 T cell activationExpression of IL-15EC surface expressionIL-15 transpresentationComplement activationGraft endothelial cellsActivity of CTLT cell activationIL-15 mRNAEndothelial surface expressionAbsence of complement activationCultured human endothelial cellsIL-1-mediated activationIL-15RAProtein translationAllograft rejectionRNA polymerase II-mediated transcriptionHuman endothelial cellsSuppression of protein translation
2023
Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells
Wang S, Song G, Barkestani M, Tobiasova Z, Wang Q, Jiang Q, Lopez R, Adelekan-Kamara Y, Fan M, Pober J, Tellides G, Jane-wit D. Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells. Frontiers In Immunology 2023, 14: 1248027. PMID: 37915586, PMCID: PMC10616247, DOI: 10.3389/fimmu.2023.1248027.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryHuman skin xenograftsSkin xenograftsT cellsPolyfunctional cytokine responsesSolid organ transplantationT cell subsetsResponse of CD4Expression of ICOST cell populationsHumanized mouse modelPeripheral helper cellsAllograft lossIL-21PD-1Reperfusion injuryCytokine responsesVascular inflammationPolyclonal expansionHelper cellsOrgan transplantationMouse modelClinical problemCostimulatory signalsDistinct subsets
2013
The nuclear receptor PPARγ regulates T cell tolerance and germinal center formation via generation of follicular helper T cells (P4545)
Choi J, Park H, Choi J, Senejani A, Tobiasova Z, Kim D, Bothwell A. The nuclear receptor PPARγ regulates T cell tolerance and germinal center formation via generation of follicular helper T cells (P4545). The Journal Of Immunology 2013, 190: 197.7-197.7. DOI: 10.4049/jimmunol.190.supp.197.7.Peer-Reviewed Original ResearchT cell toleranceFollicular helper T cellsHelper T cellsT cellsGerminal center formationDeficient T cellsCell toleranceHelper T cell subsetsExpression of IkBαPeroxisome proliferator-activated receptor gammaT cell subsetsProliferator-activated receptor gammaWild-type T cellsType T cellsRole of PPARγNuclear receptor PPARγFunction of PPARγPhosphorylation of ERKTfh generationTh9 cellsIL-17Kidney inflammationAutoantibody productionCell subsetsCenter formation
2009
Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells
Sochorová K, Budinský V, Rožková D, Tobiasová Z, Dusilová-Sulková S, Špíšek R, Bartůňková J. Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells. Clinical Immunology 2009, 133: 69-77. PMID: 19660988, DOI: 10.1016/j.clim.2009.06.011.Peer-Reviewed Original ResearchConceptsAntigen-specific T cellsDendritic cellsT cellsVDR agonistsImmunomodulatory effectsChronic immune-mediated inflammatory diseaseEnd-stage renal disease patientsImmune-mediated inflammatory diseasesImmunomodulatory activityVitamin D receptor activatorsRenal disease patientsImmature dendritic cellsRisk of atherosclerosisPathogenesis of atherosclerosisPotent immunomodulatory effectsToll-like receptorsBioactive IL-12Functional TregsIL-12DC differentiationCalcium resorptionDisease patientsHypercalcemic effectInflammatory diseasesImmunomodulatory potency
2007
Phenotype and Function Analysis of Dendritic Cells From Patients with Prostate Carcinoma After Radical Prostatectomy
Minarik I, Tobiasova Z, Bartunkova J, Kawaciuk I. Phenotype and Function Analysis of Dendritic Cells From Patients with Prostate Carcinoma After Radical Prostatectomy. Clinical Immunology 2007, 123: s114-s115. DOI: 10.1016/j.clim.2007.03.505.Peer-Reviewed Original ResearchVitamin D Receptor Activators Calcitriol and Paricalcitol Modulate Dendritic Cell Phenotype and Function In Vitro Study
Sochorova K, Budinsky V, Tobiasova Z, Bartunkova J, Sulkova S. Vitamin D Receptor Activators Calcitriol and Paricalcitol Modulate Dendritic Cell Phenotype and Function In Vitro Study. Clinical Immunology 2007, 123: s51. DOI: 10.1016/j.clim.2007.03.322.Peer-Reviewed Original Research
2006
In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients
Tobiásová Z, Pospíšilová D, Miller A, Minárik I, Sochorová K, Špíšek R, Rob L, Bartůňková J. In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients. Clinical Immunology 2006, 122: 18-27. PMID: 17059893, DOI: 10.1016/j.clim.2006.09.003.Peer-Reviewed Original ResearchConceptsOvarian cancer patientsCancer patientsDendritic cellsAutologous irradiated tumor cellsLymphocyte IFN-gamma productionTumor cellsAntigen-pulsed DCsIFN-gamma ELISPOTMonocyte-derived DCsMaturation of DCsIrradiated tumor cellsIFN-gamma productionNew treatment optionsAbility of DCsResidual tumour diseaseProliferation of lymphocytesApoptotic tumor cellsTumor cell apoptosisDC vaccinesAutologous lymphocytesLymphocyte responsesStandard treatmentTreatment optionsOvarian cancerPatients
2005
Effects of human plasma proteins on maturation of monocyte-derived dendritic cells.
Tobiásová-Czetoová Z, Palmborg A, Lundqvist A, Karlsson G, Adamson L, Bartůnková J, Masucci G, Pisa P. Effects of human plasma proteins on maturation of monocyte-derived dendritic cells. Immunol Lett 2005, 100: 113-9. PMID: 16154491, DOI: 10.1016/j.imlet.2005.03.009.Peer-Reviewed Original ResearchMethods of dendritic cell preparation for acute lymphoblastic leukemia immunotherapy in children
Pospíšilová D, Borovičková J, Rožková D, Stary J, Seifertová D, Tobiásová Z, Špišek R, Bartůnková J. Methods of dendritic cell preparation for acute lymphoblastic leukemia immunotherapy in children. Medical Oncology 2005, 22: 79-88. PMID: 15750200, DOI: 10.1385/mo:22:1:079.Peer-Reviewed Original ResearchConceptsDendritic cellsPeripheral mononuclear cellsAcute lymphoblastic leukemiaMononuclear cellsCostimulatory moleculesBone marrow leukemic blastsPreparation of DCsPeripheral blood mononuclear cellsDendritic cell preparationsSpecific cytotoxic lymphocytesTime of remissionTime of diagnosisMature dendritic cellsBlood mononuclear cellsEfficiency of immunotherapyAutologous lymphocyte proliferationHematopoietic malignant cellsEvidence of inductionInduction chemotherapyBM blastsPediatric patientsCell immunotherapyB-ALLLymphoblastic leukemiaLeukemic blasts
2004
Immunotherapy--perspectives in therapy of ovarian carcinomas.
Zapletalová K, Tobiasová Z, Spísek R, Rob L, Bartůnková J. Immunotherapy--perspectives in therapy of ovarian carcinomas. Česká Gynekologie 2004, 69: 372-5. PMID: 15587893.Peer-Reviewed Original ResearchConceptsUniversity Hospital MotolMonoclonal antibody therapyCytokine therapyAntibody therapyMalignant ovarian epithelial tumorsCombination of surgeryDepartment of GynecologyOvarian cancer patientsOvarian epithelial tumorsDendritic cellsVaccine therapyMedical FacultyCancer patientsIL-2Clinical studiesTherapeutic protocolsEpithelial tumorsTherapyGM-CSFImmunotherapyTumor cellsMotolChemotherapySurgeryUsual standard