Xingguang Luo, MD
Associate Research Scientist in PsychiatryCards
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
About
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Titles
Associate Research Scientist in Psychiatry
Assistant Professor, Psychiatry
Appointments
Psychiatry
Associate Research ScientistPrimary
Other Departments & Organizations
- Division of Human Genetics
- Psychiatry
- Yale Global Mental Health Program
Education & Training
- Assistant Professor
- Yale University School of Medicine (2012)
- Post-doc (2000-2003)
- Yale University (2003)
- MD
- Shanghai Medical University (2000)
Research
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Overview
NIH R01: Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
NIH R21: Deep sequencing of glutamatergic pathway genes in alcohol and nicotine co-dependence
NIH R21: Post-GWAS transcriptome-wide LncRNA profiling in alcoholism
Medical Research Interests
Behavior and Behavior Mechanisms; Mental Disorders; Psychiatry and Psychology
Public Health Interests
Genetics, Genomics, Epigenetics; Substance Use, Addiction; Mental Health
ORCID
0000-0003-3585-042X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xingguang Luo's published research.
Publications Timeline
A big-picture view of Xingguang Luo's research output by year.
Research Interests
Research topics Xingguang Luo is interested in exploring.
Chiang-Shan Ray Li, MD, PhD
Joel Gelernter, MD
John Krystal, MD
Heping Zhang, PhD
Lingeng Lu, MD, PhD
Jaime Ide, PhD
208Publications
4,778Citations
Mental Disorders
Publications
2025
The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers
Chen Y, Luo X, Li H, Li G, Ide J, Li C. The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers. Translational Psychiatry 2025, 15: 495. PMID: 41271663, PMCID: PMC12638819, DOI: 10.1038/s41398-025-03719-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNegative emotion processingPolygenic risk scoresEmotional processingBinge drinkersAlcohol misuseNon-bingersNeurobiological processesSymptom severityGenetic riskNegative emotionsProcessing of negative emotionsSeverity of somatic complaintsResponse to negative emotionsEffect of polygenic riskNegative emotional facesAlcohol use severityYoung adult binge drinkersDefault mode networkFemale binge drinkersAdult binge drinkersEmotional facesHuman Connectome ProjectPublished routinesEmotional tasksAlcohol dependenceSocial cognition and interactive training for first-episode, drug-naïve MDD patients
Li J, Li R, Li D, Ji S, Luo X, Zhang Y. Social cognition and interactive training for first-episode, drug-naïve MDD patients. Frontiers In Psychiatry 2025, 16: 1566811. PMID: 41169487, PMCID: PMC12568539, DOI: 10.3389/fpsyt.2025.1566811.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyFunctioning Assessment Short TestBrain-derived neurotrophic factorMDD patientsSocial cognitionFirst-episodeImpact of social cognitionSCIT groupSerum brain-derived neurotrophic factorHamilton Rating ScaleNeurotrophic factorFunctional impairment severitySerum GDNF levelsGlial cell line-derived neurotrophic factor levelsInterpersonal relationship domainGlial cell line-derived neurotrophic factorInteractive trainingHDRS-17Depressive disorderBehavioral therapyDepressive symptomsPsychosocial functioningRandomized Controlled TrialsMDDRating ScaleCortical surface area as a stronger mediator of the waist-to-height ratio and cognitive impairment link in patients with first-episode schizophrenia compared to body mass index and waist-hip ratio
Lin C, Yin Y, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Li Y, Cui Y, Wang Z, Luo X, Zhang P, Huang J, Chen S, Tan Y. Cortical surface area as a stronger mediator of the waist-to-height ratio and cognitive impairment link in patients with first-episode schizophrenia compared to body mass index and waist-hip ratio. BMC Psychiatry 2025, 25: 962. PMID: 41068743, PMCID: PMC12512609, DOI: 10.1186/s12888-025-07458-z.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsFirst-episode schizophreniaCortical surface areaPositive and Negative Syndrome ScaleMCCB composite scoreCortical thicknessCognitive functionSchizophrenia Consensus Cognitive BatteryMechanisms of cognitive deficitsCognitive impairmentRight inferior parietal gyrusNegative Syndrome ScaleConsensus Cognitive BatteryComposite scoreWaist-to-hip ratioInferior parietal gyrusAssociated with cognitive impairmentBrain structural changesBody mass indexHealthy controlsWaist-to-height ratioMCCB scoresSyndrome ScaleVerbal learningCognitive batterySocial cognitionAssociation of cerebrospinal fluid FGF21 with sleep quality in Chinese adults
Chen L, Li S, Chen X, Chen Y, Luo X, Hu W, Kang Y, Chen L, Wang F, Li X, Liu Y, Tong C. Association of cerebrospinal fluid FGF21 with sleep quality in Chinese adults. Sleep And Breathing 2025, 29: 279. PMID: 40906257, DOI: 10.1007/s11325-025-03443-8.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsProlonged sleep latencyCerebrospinal fluidFGF21 levelsSleep latencyResultsSpearman correlation analysisSleep disorder severitySleep disturbanceAnterior cruciate ligament reconstruction surgeryCruciate ligament reconstruction surgerySleep qualityCerebrospinal fluid samplesDaytime dysfunctionPlasma FGF21 levelsLigament reconstruction surgeryPSQI scoreClinical characteristicsHigher PSQI scoresApoA1 levelsPlasma FGF21Reconstructive surgeryBiochemical markersSevere sleep disturbanceAssociated with higher PSQI scoresSleep disordersSleep parametersModerating effect of insulin resistance on the relationship between cortical surface area and cognitive function in patients with first-episode schizophrenia
Lin C, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Li Y, Cui Y, Tian B, Tan S, Wang Z, Luo X, Zhang P, Huang J, Chen S, Yin Y, Tan Y. Moderating effect of insulin resistance on the relationship between cortical surface area and cognitive function in patients with first-episode schizophrenia. Psychiatry Research Neuroimaging 2025, 352: 112048. PMID: 40829289, DOI: 10.1016/j.pscychresns.2025.112048.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCortical surface areaMCCB composite scoreFirst-episode schizophreniaCognitive functionCognitive deficitsPositive and Negative Symptom ScaleSchizophrenia Consensus Cognitive BatteryCognitive impairmentLeft middle temporal gyrusCaudal anterior cingulate gyrusConsensus Cognitive BatteryNegative Symptom ScaleComposite scoreMiddle temporal gyrusAnterior cingulate gyrusMechanism of cognitive impairmentModerating effectMCCB domainsCognitive batteryVerbal learningTemporal gyrusTreatment researchCingulate gyrusSchizophreniaBrain structuresAssociation Between Soy Product Intake and Insomnia in Chinese Middle-Aged and Older Adults: A Cross-Sectional Study
Sun L, Lao J, Guo H, Xu J, Chen Y, Luo X, He S, Hu W, Wang F, Chen L, Liu Y, Wang Q, Lin W. Association Between Soy Product Intake and Insomnia in Chinese Middle-Aged and Older Adults: A Cross-Sectional Study. Nature And Science Of Sleep 2025, 17: 1837-1849. PMID: 40827234, PMCID: PMC12358130, DOI: 10.2147/nss.s506431.Peer-Reviewed Original ResearchAltmetricConceptsSoy product intakeC-reactive proteinFood frequency questionnaireProduct intakeWhite blood cellsPlatelet countChinese middle-agedRed blood cellsInterleukin-2Lipoprotein cholesterolTNF-aOlder adultsInterleukin-6Blood C-reactive proteinMiddle-agedTumor necrosis factor-alphaLow-density lipoprotein cholesterolAbsolute neutrophil countHigh-density lipoprotein cholesterolInsomnia Severity IndexBlood cellsAssociated with higher ratesNecrosis factor-alphaCross-sectional studyFrequency questionnaireAssociation between fibroblast growth factor 19 and depressive symptoms: the moderating role of smoking
Li S, Chen L, Ma M, Hu Y, Wang F, Luo X, Chen Y, Gao H, Ren Y, Hu W, Kang Y, Wang W, Chen L, Li X, Liu Y, Wu J. Association between fibroblast growth factor 19 and depressive symptoms: the moderating role of smoking. Acta Neuropsychiatrica 2025, 37: e74. PMID: 40653598, DOI: 10.1017/neu.2025.10028.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsBeck Depression Inventory scoresBeck Depression InventoryAssociated with BDI scoresDepressive symptomsBDI scoresModerating RoleFGF19 levelsSeverity of depressive symptomsDevelopment of depressive symptomsCerebrospinal fluidSimple slope analysesModerating effectNon-smokersDepression InventoryFibroblast growth factor 19Effects of smokingSpearman rank correlation analysisSmoking statusFibroblast growth factorRank correlation analysisSymptomsGrowth factorSmokingChinese adult malesFGF19The Mediating Effect of Cerebrospinal Fluid Relaxin on Cigarette Smoking and Depressive Symptoms
Ma M, Hu Y, Wu Y, Chen Y, Luo X, Kang Y, Hu W, Chen L, Liu Y, Wang F, Wu F. The Mediating Effect of Cerebrospinal Fluid Relaxin on Cigarette Smoking and Depressive Symptoms. International Journal Of Mental Health And Addiction 2025, 1-14. DOI: 10.1007/s11469-025-01526-x.Peer-Reviewed Original ResearchAltmetricConceptsDepressive symptomsBDI scoresSeverity of depressive symptomsMediation effectRelaxin levelsBeck Depression InventoryCerebrospinal fluidCigarette smokingDepression InventoryMediation modelMediation analysisPsychiatric diseasesAssociated with smokingCase-control studyPublic health concernBDIMarital statusSymptomsSmokingHealth concernPositive associationChinese adult malesRelaxinOverall populationScoresCortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia
Jiang X, Gou M, Yin Y, Chen W, Li Y, Chen S, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Wang J, Li H, Yu T, Wang Z, Zhang P, Huang J, Tian L, Kochunov P, Li C, Hong L, Tan Y. Cortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia. Psychoneuroendocrinology 2025, 179: 107501. PMID: 40479922, DOI: 10.1016/j.psyneuen.2025.107501.Peer-Reviewed Original ResearchConceptsCortisol response patternsDuration of illnessDiffusion tensor imagingCortisol levelsWM integrityPositive and Negative Syndrome ScaleResponse to acute stress exposureHC groupPaced Auditory Serial Addition TaskResponse patternsNegative Syndrome ScaleFirst-episode schizophreniaBiomarkers of schizophreniaAcute stress exposureWhite matter integrityWM microstructural integrityWM tract integritySalivary cortisol levelsSyndrome ScaleChronic schizophreniaClinical psychopathologyCortisol reactivitySchizophrenia pathogenesisWhite matterBrain regionsPolygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025, 10: 1155-1165. PMID: 40412620, PMCID: PMC12354074, DOI: 10.1016/j.bpsc.2025.05.008.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPolygenic risk scoresPunishment processingNeural responsesAchenbach Adult Self-ReportInfluence of genetic riskCortical activityAdult Self-ReportYoung adultsGenetic riskRisk of depressionGambling TaskAberrant rewardDrinking severityHuman Connectome ProjectDepression severityPublished routinesBrain responsesPolygenic riskDepression scoresSelf-ReportDepressionConnectome ProjectRewardBrain imagingPunishment
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