Xingguang Luo, MD
Associate Research Scientist in PsychiatryCards
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
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Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
About
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Titles
Associate Research Scientist in Psychiatry
Assistant Professor, Psychiatry
Appointments
Psychiatry
Associate Research ScientistPrimary
Other Departments & Organizations
- All Institutions
- Division of Human Genetics
- Psychiatry
- Yale Global Mental Health Program
Education & Training
- Assistant Professor
- Yale University School of Medicine (2012)
- Post-doc (2000-2003)
- Yale University (2003)
- MD
- Shanghai Medical University (2000)
Research
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Overview
NIH R01: Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
NIH R21: Deep sequencing of glutamatergic pathway genes in alcohol and nicotine co-dependence
NIH R21: Post-GWAS transcriptome-wide LncRNA profiling in alcoholism
Medical Research Interests
Behavior and Behavior Mechanisms; Mental Disorders; Psychiatry and Psychology
Public Health Interests
Genetics, Genomics, Epigenetics; Substance Use, Addiction; Mental Health
ORCID
0000-0003-3585-042X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xingguang Luo's published research.
Publications Timeline
A big-picture view of Xingguang Luo's research output by year.
Research Interests
Research topics Xingguang Luo is interested in exploring.
Chiang-Shan Ray Li, MD, PhD
Joel Gelernter, MD
John Krystal, MD
Heping Zhang, PhD
Lingeng Lu, MD, PhD
Jaime Ide, PhD
231Publications
5,063Citations
Mental Disorders
Publications
2026
Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma
Chen Y, Li X, Luo C, Lin G, Zhou X, Wen Z, Su H, Meng W, Chen C, Lu J, Luo X, Jiang D, Liu H, Ning Z, Chen Y, Tam P, Pan X. Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma. Journal Of Advanced Research 2026 PMID: 41864611, DOI: 10.1016/j.jare.2026.03.039.Peer-Reviewed Original ResearchConceptsCancer stem-like cellsHepatocellular carcinoma mouse modelHepatocellular carcinomaStem-like cellsFerroptosis resistanceScRNA-seq analysisMouse modelDevelopment of effective targeted therapiesPro-tumorigenic nicheRNA sequencingStemness propertiesHepatocellular carcinoma patientsEffective targeted therapiesScRNA-seqCancer stem cellsSnRNA-seqAssociated with tumor metastasisTumor-promoting effectsHepatic stellate cellsProgression of hepatocellular carcinomaRisk score modelTumor microenvironmentPotential therapeutic targetPoor prognosisTumor progressionEarly Clinical Symptom Patterns Predict the Subsequent Treatment Response of Patients with Acute Schizophrenia
Liu Z, Chen W, Wang X, Huang J, Gou M, Han H, Wang J, Wang D, Chen S, Xie T, Tian L, Luo X, Li C, Li Y, Tan Y. Early Clinical Symptom Patterns Predict the Subsequent Treatment Response of Patients with Acute Schizophrenia. Schizophrenia Bulletin 2026, 52: sbag009. PMID: 41863369, PMCID: PMC13005118, DOI: 10.1093/schbul/sbag009.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPositive and Negative Syndrome ScalePoor treatment respondersClinical symptom patternsSymptom patternsAcute schizophreniaSymptom changeSymptom trajectoriesTreatment respondersPositive and Negative Syndrome Scale changeTreatment responseTreatment outcomesEarly treatment responsePredictors of treatment outcomeEarly symptom changeNegative Syndrome ScaleClinical symptom severityClinical symptom profilesAntipsychotic treatmentLong-term treatment outcomesSyndrome ScalePrediction of treatment responseSymptom severitySymptom profilesWeek 2SchizophreniaPhenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes
Zhu L, Mao Q, Luo Z, Chen B, Zhang Y, Lu X, Liu P, Ji J, Wang X, Wang K, Pan X, Cao Y, Liu N, Zheng J, Wang F, Yang K, Yang F, Yu Z, Hu J, Luo J, Zuo L, Wang Z, Luo X, Guo X. Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes. Journal Of Affective Disorders 2026, 402: 121327. PMID: 41672153, DOI: 10.1016/j.jad.2026.121327.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsGray matter volumeDisease-associated SNPsPhenome-wide association studyBipolar disorderEuropean AmericansFalse discovery rateNeuropsychiatric disordersBrain regionsP2RX7 mRNATrans-ancestry meta-analysisSubcortical gray matter volumesAssociated with bipolar disorderSNP-disease associationsDisease-risk variantsMultiple neuropsychiatric disordersCortical surface areaMeta-analysisRegulatory effectsAnxiety disordersTrans-ancestryDepressive disorderMajor depressionMood disordersMatter volumeProtein expressionDecreased N-acetylaspartate plus N-acetyl-aspartyl-glutamate levels in the caudate of schizophrenia patients with tardive dyskinesia
Yu T, Li Y, Li N, Gou M, Chen W, Wang Z, Tan S, Yang F, Tian B, Luo X, Tan Y. Decreased N-acetylaspartate plus N-acetyl-aspartyl-glutamate levels in the caudate of schizophrenia patients with tardive dyskinesia. Scientific Reports 2026, 16: 6773. PMID: 41617886, PMCID: PMC12913869, DOI: 10.1038/s41598-026-37396-z.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleAbnormal Involuntary Movement ScaleTardive dyskinesiaTD groupPositive and Negative Syndrome Scale scoresCaudate nucleusAntipsychotic medication dosageNegative Syndrome ScaleAbsolute metabolite concentrationsHealthy controlsProton magnetic resonance spectroscopySyndrome ScaleYears of educationSchizophrenia patientsTD symptomsMovement ScaleNT groupAnalysis of covarianceBrain regionsN-acetyl-aspartyl-glutamateNo significant differenceCaudateDisease durationMedication dosageN-acetyl-aspartyl-glutamate levelsThe moderation effect of remnant cholesterol for linking cerebrospinal fluid interleukin 10 to blood pressure
Yang X, Su L, Fan J, Chen Y, Yang Z, Kang Y, Luo X, Han X, Liu Y, Wang F. The moderation effect of remnant cholesterol for linking cerebrospinal fluid interleukin 10 to blood pressure. Science Progress 2026, 109: 00368504251410792. PMID: 41481098, PMCID: PMC12759153, DOI: 10.1177/00368504251410792.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsIndependent risk factorRemnant cholesterolBlood pressureCerebrospinal fluidPotential protective effectAnti-inflammatory cytokines IL4Elevated total cholesterol levelsPathophysiology of hypertensionTotal cholesterol levelsMethodsThis cross-sectional studyElevated remnant cholesterolCross-sectional studyCerebrospinal fluid collectionIL10 levelsSystemic inflammationCytokines IL4Arterial wallRisk factorsCholesterol levelsHypertensionIncident hypertensionConventional lipidsIL10IL levelsIL4
2025
Profiling Cell-state Fingerprints Based on Deep Learning Model with Meta-programs of Pan-cancer
Wen Z, Zhang Y, Lin G, Li X, Xiao C, Xu S, Wang J, Cao S, Chen Y, Liu H, Luo X, Chen Y, Tam P, Pan X. Profiling Cell-state Fingerprints Based on Deep Learning Model with Meta-programs of Pan-cancer. Genomics Proteomics & Bioinformatics 2025, qzaf123. PMID: 41329499, DOI: 10.1093/gpbjnl/qzaf123.Peer-Reviewed Original ResearchConceptsMultiplexed single-cell RNA sequencingCell linesCell statesScRNA-seq dataSingle-cell RNA sequencingLipid metabolic pathwaysEpithelial-mesenchymal transition programPan-cancer landscapeScRNA-seqRNA sequencingMetabolic pathwaysBiological processesPerturbation experimentsCancer samplesPan-CancerTissue typesCell clustersCancer typesCellsMalignant cellsGenesIDEDNIK syndrome: a newly recognized rare genetic disorder caused by AP1S1 and AP1B1 mutations
Wu R, Luo X, Wang X. IDEDNIK syndrome: a newly recognized rare genetic disorder caused by AP1S1 and AP1B1 mutations. Frontiers In Neurology 2025, 16: 1695128. PMID: 41404470, PMCID: PMC12702699, DOI: 10.3389/fneur.2025.1695128.Peer-Reviewed Original ResearchAltmetricConceptsAdaptor protein complex AP-1Intracellular vesicle traffickingComplex AP-1Primary causative geneCopper-transporting ATPases ATP7AVesicle traffickingRare genetic disordersRare autosomal recessive neurocutaneous disorderMultiple proteinsCausative genesAutosomal recessive neurocutaneous disorderPathogenic mutationsCopper homeostasisAP-1Oral zinc acetateMutationsGenetic disordersCurative therapyB1 subunitCranial MRIClinical spectrumClinical featuresLaboratory findingsMultisystem involvementPeripheral neuropathyThe effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers
Chen Y, Luo X, Li H, Li G, Ide J, Li C. The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers. Translational Psychiatry 2025, 15: 495. PMID: 41271663, PMCID: PMC12638819, DOI: 10.1038/s41398-025-03719-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNegative emotion processingPolygenic risk scoresEmotional processingBinge drinkersAlcohol misuseNon-bingersNeurobiological processesSymptom severityGenetic riskNegative emotionsProcessing of negative emotionsSeverity of somatic complaintsResponse to negative emotionsEffect of polygenic riskNegative emotional facesAlcohol use severityYoung adult binge drinkersDefault mode networkFemale binge drinkersAdult binge drinkersEmotional facesHuman Connectome ProjectPublished routinesEmotional tasksAlcohol dependenceSocial cognition and interactive training for first-episode, drug-naïve MDD patients
Li J, Li R, Li D, Ji S, Luo X, Zhang Y. Social cognition and interactive training for first-episode, drug-naïve MDD patients. Frontiers In Psychiatry 2025, 16: 1566811. PMID: 41169487, PMCID: PMC12568539, DOI: 10.3389/fpsyt.2025.1566811.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyFunctioning Assessment Short TestBrain-derived neurotrophic factorMDD patientsSocial cognitionFirst-episodeImpact of social cognitionSCIT groupSerum brain-derived neurotrophic factorHamilton Rating ScaleNeurotrophic factorFunctional impairment severitySerum GDNF levelsGlial cell line-derived neurotrophic factor levelsInterpersonal relationship domainGlial cell line-derived neurotrophic factorInteractive trainingHDRS-17Depressive disorderBehavioral therapyDepressive symptomsPsychosocial functioningRandomized Controlled TrialsMDDRating ScaleCortical surface area as a stronger mediator of the waist-to-height ratio and cognitive impairment link in patients with first-episode schizophrenia compared to body mass index and waist-hip ratio
Lin C, Yin Y, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Li Y, Cui Y, Wang Z, Luo X, Zhang P, Huang J, Chen S, Tan Y. Cortical surface area as a stronger mediator of the waist-to-height ratio and cognitive impairment link in patients with first-episode schizophrenia compared to body mass index and waist-hip ratio. BMC Psychiatry 2025, 25: 962. PMID: 41068743, PMCID: PMC12512609, DOI: 10.1186/s12888-025-07458-z.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsFirst-episode schizophreniaCortical surface areaPositive and Negative Syndrome ScaleMCCB composite scoreCortical thicknessCognitive functionSchizophrenia Consensus Cognitive BatteryMechanisms of cognitive deficitsCognitive impairmentRight inferior parietal gyrusNegative Syndrome ScaleConsensus Cognitive BatteryComposite scoreWaist-to-hip ratioInferior parietal gyrusAssociated with cognitive impairmentBrain structural changesBody mass indexHealthy controlsWaist-to-height ratioMCCB scoresSyndrome ScaleVerbal learningCognitive batterySocial cognition
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