Sujin Kim
Associate Research ScientistCards
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Research
Publications
2025
NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease
Lee J, Sim S, Jin Y, Park H, Byeon E, Kim S, Yun S, Lee H, Jeong D, Suh J, Lee I, Lee H, Choi Y, Bae Y. NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease. Advanced Science 2025, 12: e05495. PMID: 40823879, PMCID: PMC12622451, DOI: 10.1002/advs.202505495.Peer-Reviewed Original ResearchConceptsMorris water-maze testNovel object recognitionReactive oxygen species productionWater-maze testAlzheimer's diseaseResilient brainY-mazeMature neuronsImpaired cognitionNeuronal regenerationBrain resilienceBrain oxidationNADPH oxidase inhibitionImmature neuronsTau phosphorylationActivation of NADPH oxidaseCognitionOxygen species productionHippocampalOxidase inhibitionBrainOral administrationMicroglial activationSuperoxide levelsNeuroinflammationEC50 images reveal reproducible spatial variation in drug affinity across single- and repeat-dose occupancy studies
Ibrahimy A, Kim S, Schmidt M, Slifstein M, Mannaert E, Andrews R, Matthews D, Constantinescu C, Searle G, Gunn R, Rabiner E, Morris E. EC50 images reveal reproducible spatial variation in drug affinity across single- and repeat-dose occupancy studies. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2025, 45: 2233-2244. PMID: 40562708, PMCID: PMC12202393, DOI: 10.1177/0271678x251353140.Peer-Reviewed Original ResearchBinding potential mapsRepeat-doseSingle-doseDrug affinityJNJ-37822681Striatal subregionsVentral striatumDopamine receptorsChronic dosing studiesOccupational studiesHealthy male volunteersReceptor upregulationApparent affinityStriatumDrug trialsAntagonist drugsDose optimizationDose studyMale volunteersAnalysis of SDSpatial variationDrugDopamineCaudateOccupational image
2024
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease
Park S, Park C, Eom J, Jo M, Hur H, Choi S, Lee J, Nam S, Jo K, Oh Y, Lee J, Kim S, Kim D, Park C, Kim S, Lee H, Cho M, Kim D, Kim D. Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease. Cell Stem Cell 2024, 31: 278-279. PMID: 38306996, DOI: 10.1016/j.stem.2024.01.006.Peer-Reviewed Original Research
2023
SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images
Ibrahimy A, Hoye J, Wu H, de Laat B, Kim S, Wilson D, Morris E. SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images. EJNMMI Physics 2023, 10: 80. PMID: 38079001, PMCID: PMC10713928, DOI: 10.1186/s40658-023-00600-4.Peer-Reviewed Original ResearchPreclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease
Park S, Park C, Eom J, Jo M, Hur H, Choi S, Lee J, Nam S, Jo K, Oh Y, Lee J, Kim S, Kim D, Park C, Kim S, Lee H, Cho M, Kim D, Kim D. Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease. Cell Stem Cell 2023, 31: 25-38.e8. PMID: 38086390, DOI: 10.1016/j.stem.2023.11.009.Peer-Reviewed Original ResearchConceptsClinical trialsMidbrain dopaminergicPhase 1/2a clinical trialHemi-parkinsonian ratsPD cell therapyParkinson's diseaseEffective dose rangeHuman clinical trialsCell transplantationImmunodeficient ratsCell therapyDopaminergic progenitorsProgenitor cellsCell dosageDose rangeTherapeutic strategiesMinistry of Food and Drug SafetyDrug safetyTrialsProgenitorsRatsBehavioral improvementDiseaseCellsDopaminergicChelidonic acid ameliorates atopic dermatitis symptoms through suppression the inflammatory mediators in in vivo and in vitro
Kim S, Kim D, Lee S, Ahn E, Kee J, Hong S. Chelidonic acid ameliorates atopic dermatitis symptoms through suppression the inflammatory mediators in in vivo and in vitro. Applied Biological Chemistry 2023, 66: 12. DOI: 10.1186/s13765-022-00763-1.Peer-Reviewed Original ResearchAD-like skin lesionsAnti-atopic effectsAtopic dermatitisNF-kB activationSerum levelsSkin lesionsIn vivoIn vitroHistamine-induced scratching behaviorSerum level of IgEExpression of tumor necrosis factorNF-kBPharmacological effectsActivation of nuclear factor kappa BMaximal inhibition rateLevels of IgENuclear factor kappa BAtopic dermatitis symptomsTumor necrosis factorSkin inflammatory conditionsInducible nitric oxide synthaseNitric oxide synthaseMouse peritoneal macrophagesFactor kappa BEffect of CA
2022
In vivo molecular imaging in preclinical research
Kim S, Lee H. In vivo molecular imaging in preclinical research. Laboratory Animal Research 2022, 38: 31. PMID: 36266669, PMCID: PMC9585739, DOI: 10.1186/s42826-022-00142-3.Peer-Reviewed Original ResearchSingle-photon Emission Computed TomographyMagnetic resonance imagingPositron emission tomographyComputed tomographyIn vivo molecular imagingImaging techniquesEmission Computed TomographyAdvanced imaging techniquesMolecular imagingDevelopment of treatmentsPreclinical researchPhenomenon in vivoEmission tomographyLiving bodyResonance imagingMolecular biologyTomographyBiological phenomenaPhysiological changesMagnetic resonance spectroscopyKnowledge of molecular biologyPharmacokinetic evaluation of radiolabeled intraocular anti‐CLEC14a antibody in preclinical animal species and application in humans
Park S, Lee Y, Oh J, Kim S, Lee S, Lee H. Pharmacokinetic evaluation of radiolabeled intraocular anti‐CLEC14a antibody in preclinical animal species and application in humans. Clinical And Translational Science 2022, 15: 2938-2946. PMID: 36129122, PMCID: PMC9747121, DOI: 10.1111/cts.13412.Peer-Reviewed Original ResearchConceptsOne-compartment modelPK parametersHuman half-lifeVitreal volumeMacular degenerationTreatment of neovascular macular degenerationI-125PK characteristicsPharmacokinetic evaluationNeovascular macular degenerationAnti-angiogenic antibodyAntiangiogenic antibodiesIntraocular pharmacokineticsPreclinical animal speciesI-125-labeledHalf-life valuesAfliberceptAntiangiogenic activityHuman antibodiesTomography imagesTherapeutic agentsAnimal dataRatsAntibodiesMiceOne-pot bifunctionalization of silica nanoparticles conjugated with bioorthogonal linkers: application in dual-modal imaging
Lee J, Kim J, Heo I, Kim S, Jang S, Lee H, Jang K, Yang C, Lee Y, Yoo W, Min S. One-pot bifunctionalization of silica nanoparticles conjugated with bioorthogonal linkers: application in dual-modal imaging. Biomaterials Science 2022, 10: 3540-3546. PMID: 35611753, DOI: 10.1039/d2bm00258b.Peer-Reviewed Original ResearchConceptsSurface modification of silica nanoparticlesCovalent surface modificationThiol conjugate additionsFluorescence imaging studiesSilica nanoparticlesModification of silica nanoparticlesTetrazine cycloadditionsBifunctional linkerSiloxane formationSystemic deliveryPositron Emission Tomography/Computed TomographySystemic delivery of therapeuticsEmission Tomography/Computed TomographyNIR dyesMultimodal nanomaterialsDelivery of therapeuticsLinkerTomography/Computed TomographyNanoparticlesProlonged circulationCycloadditionMultimodal imagingCyclopropeneTetrazineDual-modal imaging
2021
Ameliorative Effect of Pu-erh Tea on DSS-induced Colitis through Regulation of NF-κB Activation in Mice
Jeon Y, Kim S. Ameliorative Effect of Pu-erh Tea on DSS-induced Colitis through Regulation of NF-κB Activation in Mice. Biomedical Science Letters 2021, 27: 248-254. DOI: 10.15616/bsl.2021.27.4.248.Peer-Reviewed Original Research
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