Stuart Campbell
ProfessorCards
About
Research
Publications
2026
BPS2026 – Progressive chronic stretch provokes hypo-contractility in desmoplakin-deficient engineered heart tissue
Li X, Gokhan I, Li X, Akar F, Campbell S. BPS2026 – Progressive chronic stretch provokes hypo-contractility in desmoplakin-deficient engineered heart tissue. Biophysical Journal 2026, 125: 88a. DOI: 10.1016/j.bpj.2025.11.730.Peer-Reviewed Original ResearchBPS2026 – Y261 tropomyosin variants alter calcium sensitivity and relaxation kinetics via disrupted troponin T interactions
Nistala S, Bongiorno A, Rynkiewicz M, Lehman W, Moore J, Campbell S. BPS2026 – Y261 tropomyosin variants alter calcium sensitivity and relaxation kinetics via disrupted troponin T interactions. Biophysical Journal 2026, 125: 88a-89a. DOI: 10.1016/j.bpj.2025.11.732.Peer-Reviewed Original Research
2025
Evaluating pathogenicity of TPM1 variants of unknown significance using in-silico and in-vitro models
Halder S, Bellitto J, Rynkiewicz M, Cheung F, Liu D, Firlar I, Bongiorno A, Barry M, Sewanan L, Moore J, Lehman W, Campbell S. Evaluating pathogenicity of TPM1 variants of unknown significance using in-silico and in-vitro models. The Journal Of Precision Medicine Health And Disease 2025, 2: 100008. DOI: 10.1016/j.premed.2025.100008.Peer-Reviewed Original ResearchIn vitro motilityFilament motilityContext of cardiomyopathyVariant classificationGenetic screeningTwitch contraction forceComputational pipelineMyosin activityEvaluate pathogenicityDiversity changesFunctional studiesIn silicoTropomyosinTPM1VUSMotilityInherited cardiomyopathyCa2+ sensitivityVariantsIn vitro modelIn vitro dataReduced abilityIPSC-derived cardiomyocytesLow Ca2+Ca2+Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes
Luo H, Anderson C, Li X, Lu Y, Hoareau M, Xing Q, Fooladi S, Liu Y, Xu Z, Park J, Fallon M, Thomas J, Gruber P, Elder R, Mak M, Riaz M, Campbell S, Qyang Y. Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Acta Biomaterialia 2025, 211: 92-103. PMID: 40582540, PMCID: PMC12338880, DOI: 10.1016/j.actbio.2025.06.055.Peer-Reviewed Original ResearchSingle ventricle congenital heart defectsHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesCongenital heart defectsHuman umbilical arteryUmbilical arteryHeart defectsPulmonary circulationDecellularized human umbilical arteriesHeart tissueLife-threatening defectsLife-threatening disorderLong-term complicationsEngineered Heart TissueFontan surgeryFunctioning ventriclePrompt treatmentHeart failureSpontaneous beatingPump functionImprove outcomesPressure generationConventional treatmentApplication of instant assembly of collagen to bioprint cardiac tissues
Xiao H, Liang Z, Gong X, Jordan S, Rossello-Martinez A, Gokhan I, Li X, Wen Z, Lee S, Campbell S, Qyang Y, Mak M. Application of instant assembly of collagen to bioprint cardiac tissues. APL Bioengineering 2025, 9: 026124. PMID: 40520649, PMCID: PMC12165719, DOI: 10.1063/5.0252746.Peer-Reviewed Original ResearchTissue engineeringFabrication of biomimetic tissuesCardiac tissue engineeringSupport bathCollagen bioinkBioprinting techniquesBiomimetic tissuesBioprinting methodsEngineered tissuesFabrication techniquesImmediate gelationBioprintingComplex tissue geometriesPolydimethylsiloxaneStructural fidelityNutrient diffusionFabricationTissue geometryEngineeringDamaged heart tissueBioinkStructural supportCardiac modelsCardiac tissueTissue maturationScreening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants
Wen J, Campbell S, Moore J, Lehman W, Rynkiewicz M. Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. Journal Of Molecular And Cellular Cardiology 2025, 203: 82-90. PMID: 40268117, PMCID: PMC12135046, DOI: 10.1016/j.yjmcc.2025.04.009.Peer-Reviewed Original ResearchConceptsDeleterious effects of mutationsTropomyosin-actin interactionsSingle nucleotide mutationsEffects of mutationsThin filament regulationDilated CardiomyopathyTropomyosin sequencesActin interactionNucleotide mutationsFilament regulationMutation-sensitiveSubcellular unitsMutantsPathological cardiac remodelingTropomyosinActinThin filamentsEarly therapeutic interventionFunctional analysisMutationsInherited cardiomyopathyCardiac remodelingCardiac functionRegulatory BCardiomyopathyINHIBITION OF THE PI3K-AKT SIGNALING PATHWAY REVERSES HYPERTROPHY OF HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES MODELING HYPERTROPHIC CARDIOMYOPATHY
Zanetti M, Agashe R, Sewanan L, Li X, Campbell S, Shimada Y. INHIBITION OF THE PI3K-AKT SIGNALING PATHWAY REVERSES HYPERTROPHY OF HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES MODELING HYPERTROPHIC CARDIOMYOPATHY. Journal Of The American College Of Cardiology 2025, 85: 1360. DOI: 10.1016/s0735-1097(25)01844-3.Peer-Reviewed Original ResearchPO-05-029 CHRONIC ATRIAL STRETCH CAUSES ADVANCED PRO-AF REMODELING OF ATRIAL REPOLARIZATION AND CHANNEL EXPRESSION
Gokhan I, Campbell S, Akar F. PO-05-029 CHRONIC ATRIAL STRETCH CAUSES ADVANCED PRO-AF REMODELING OF ATRIAL REPOLARIZATION AND CHANNEL EXPRESSION. Heart Rhythm 2025, 22: s574-s575. DOI: 10.1016/j.hrthm.2025.03.1427.Peer-Reviewed Original ResearchBPS2025 - R451G desmoplakin induces contractile deficits in engineered heart tissue
Gokhan I, Pagan A, Campbell S. BPS2025 - R451G desmoplakin induces contractile deficits in engineered heart tissue. Biophysical Journal 2025, 124: 616a. DOI: 10.1016/j.bpj.2024.11.3180.Peer-Reviewed Original ResearchBPS2025 - Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants
Wen J, Campbell S, Moore J, Lehman W, Rynkiewicz M. BPS2025 - Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. Biophysical Journal 2025, 124: 614a. DOI: 10.1016/j.bpj.2024.11.3172.Peer-Reviewed Original Research