Shufan Huo, MD/PhD
Postdoctoral FellowAbout
Research
Publications
2024
Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessmentIntraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage
Willms J, Boss J, Huo S, Wolf S, Westphal L, Bögli S, Inauen C, Baumann D, Fröhlich J, Keller E. Intraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage. Journal Of Neuroscience Methods 2024, 406: 110113. PMID: 38537749, DOI: 10.1016/j.jneumeth.2024.110113.Peer-Reviewed Original ResearchDetection of delayed cerebral ischemiaAneurysmal subarachnoid hemorrhagePoor-grade aneurysmal subarachnoid hemorrhagePerfusion deficitsSubarachnoid hemorrhageIntracranial pressureCerebral ischemiaMedian valuePerfusion CT scansCerebral perfusion deficitsDetect perfusion deficitsBrain tissue oxygen pressureMeasurement of intracranial pressureCT scanTissue oxygen pressureComatose patientsCerebral infarctionPatientsNear-infrared spectroscopyMultimodal neuromonitoringPatient collectivesHbtotalPerfusionInfarctionPbtO2A supervised, externally validated machine learning model for artifact and drainage detection in high-resolution intracranial pressure monitoring data.
Huo S, Nelde A, Meisel C, Scheibe F, Meisel A, Endres M, Vajkoczy P, Wolf S, Willms J, Boss J, Keller E. A supervised, externally validated machine learning model for artifact and drainage detection in high-resolution intracranial pressure monitoring data. Journal Of Neurosurgery 2024, 141: 509-517. PMID: 38489814, DOI: 10.3171/2023.12.jns231670.Peer-Reviewed Original ResearchMachine learningReal-time artifact removalML-based solutionsSequential feature selectionML-based algorithmsHistogram-based gradientMachine learning modelsCross-validationFeature selectionHyperparameter optimizationArtifact removalML applicationsMultiple biosensorsRandom treeLearning modelsSupervised modelsGrid searchNormal signalMulticlass areaMonitoring signalsValidation cycleDatasetNested 5-fold cross-validationMonitoring dataMachine
2023
Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke
Sperber P, Gebert P, Broersen L, Kufner A, Huo S, Piper S, Teegen B, Heuschmann P, Prüss H, Endres M, Liman T, Siegerink B. Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke. Brain Behavior & Immunity - Health 2023, 34: 100705. PMID: 38033615, PMCID: PMC10684375, DOI: 10.1016/j.bbih.2023.100705.Peer-Reviewed Original ResearchNMDAR1-ABDepressive symptomsHigh titersIschemic strokeProspective cohortEpidemiological Studies Depression ScaleSevere neuropsychiatric symptomsSevere depressive symptomsAutoimmune encephalitisSeronegative patientsAntibody seropositivityIncident strokeSeropositive patientsNeuropsychiatric symptomsSymptoms yearsPatientsLow titersSymptomsTitersCell-based assaysSeropositivityCohortStrokeCESEncephalitisVideo Object Detection for Privacy-Preserving Patient Monitoring in Intensive Care
Emberger R, Boss J, Baumann D, Seric M, Huo S, Tuggener L, Keller E, Stadelmann T. Video Object Detection for Privacy-Preserving Patient Monitoring in Intensive Care. 2023, 00: 85-88. DOI: 10.1109/sds57534.2023.00019.Peer-Reviewed Original ResearchVideo object detectionClinical decision support systemObject detection methodShelf object detectorDecision support systemPatient monitoringImage color channelsPrivacy restrictionsVideo framesIT infrastructureObject detectionObject detectorObject classesHardware constraintsTemporal consistencySupport systemColor channelsBaseline modelImproved detection rateDetection methodReliable classificationProprietary datasetUnwanted artifactsInfrastructureInformation contentMachine learning-based prediction of clinical outcomes after first-ever ischemic stroke
Fast L, Temuulen U, Villringer K, Kufner A, Ali H, Siebert E, Huo S, Piper S, Sperber P, Liman T, Endres M, Ritter K. Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke. Frontiers In Neurology 2023, 14: 1114360. PMID: 36895902, PMCID: PMC9990416, DOI: 10.3389/fneur.2023.1114360.Peer-Reviewed Original ResearchMini-Mental State ExaminationClinical outcomesBarthel IndexIschemic strokePrognostic factorsPatient dischargeCognitive functionFunctional recovery outcomesFurther patient careHealth Stroke ScaleEpidemiologic Studies Depression ScaleIschemic stroke patientsStroke ScaleAcute strokeProspective cohortRankin ScaleFunctional recoveryPrognostic featuresStroke patientsModified Telephone InterviewTreatment strategiesDepression ScaleIndividual patientsState ExaminationHealthcare providersAssociations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke
Arends C, Liman T, Strzelecka P, Kufner A, Löwe P, Huo S, Stein C, Piper S, Tilgner M, Sperber P, Dimitriou S, Heuschmann P, Hablesreiter R, Harms C, Bullinger L, Weber J, Endres M, Damm F. Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke. Blood 2023, 141: 787-799. PMID: 36441964, DOI: 10.1182/blood.2022017661.Peer-Reviewed Original ResearchConceptsComposite end pointPrimary composite end pointRecurrent vascular eventsVascular eventsIschemic strokeClonal hematopoiesisInterleukin-6Risk factorsHigh-sensitivity C-reactive proteinLarge artery atherosclerosis strokeVascular cell adhesion molecule-1Cell adhesion molecule-1Secondary vascular eventsIncident ischemic strokeMultivariable Cox regressionIndependent risk factorC-reactive proteinRisk of atherosclerosisShorter overall survivalMajor risk factorWhite matter lesionsAdhesion molecule-1Peripheral blood DNAPrecision medicine approachIL-6 receptor
2022
Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B)
Stillfried M, Sperber P, Broersen L, Huo S, Piper S, Heuschmann P, Endres M, Siegerink B, Liman T. Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B). Frontiers In Neurology 2022, 13: 963262. PMID: 36247749, PMCID: PMC9554657, DOI: 10.3389/fneur.2022.963262.Peer-Reviewed Original ResearchLow ankle-brachial indexAnkle-brachial indexCognitive functionIschemic strokeRelative riskCognitive impairmentMontreal Cognitive AssessmentGeneralized atherosclerosisProspective cohortRisk factorsGeneral populationState ExaminationCognitive declinePatientsCognitive statusTelephone interviewsMini-MentalCognitive AssessmentStrokeBaselineImpairmentRiskMixed modelsTICSAtherosclerosisSerum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B)
Sperber P, Gebert P, Broersen L, Huo S, Piper S, Teegen B, Heuschmann P, Prüss H, Endres M, Liman T, Siegerink B. Serum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B). Journal Of Neurology 2022, 269: 5521-5530. PMID: 35718820, PMCID: PMC9468072, DOI: 10.1007/s00415-022-11203-x.Peer-Reviewed Original ResearchConceptsSeronegative patientsIschemic strokeCognitive functionNMDAR1-ABLow titersHigh titersFavorable cognitive outcomeModerate ischemic strokeAntibody seropositivityProspective cohortReceptor antibodiesSerum titersPatientsSeropositivityCognitive statusStrokeTelephone interviewsInverse probabilityTitersCognitive outcomesCell-based assaysTICSLong termSerostatusResultsDataIntravenous immunoglobulins for treatment of severe COVID-19-related acute encephalopathy
Huo S, Ferse C, Bösl F, Reincke S, Enghard P, Hinrichs C, Treskatsch S, Angermair S, Eckardt K, Audebert H, Ploner C, Endres M, Prüss H, Franke C, Scheibe F. Intravenous immunoglobulins for treatment of severe COVID-19-related acute encephalopathy. Journal Of Neurology 2022, 269: 4013-4020. PMID: 35538168, PMCID: PMC9089297, DOI: 10.1007/s00415-022-11152-5.Peer-Reviewed Original Research