Salil Garg, MD, PhD
Assistant Professor of Laboratory MedicineCards
About
Research
Publications
2024
The dynamics of hematopoiesis over the human lifespan
Li H, Côté P, Kuoch M, Ezike J, Frenis K, Afanassiev A, Greenstreet L, Tanaka-Yano M, Tarantino G, Zhang S, Whangbo J, Butty V, Moiso E, Falchetti M, Lu K, Connelly G, Morris V, Wang D, Chen A, Bianchi G, Daley G, Garg S, Liu D, Chou S, Regev A, Lummertz da Rocha E, Schiebinger G, Rowe R. The dynamics of hematopoiesis over the human lifespan. Nature Methods 2024, 22: 422-434. PMID: 39639169, PMCID: PMC11908799, DOI: 10.1038/s41592-024-02495-0.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsHematopoietic stemProgenitor cellsClassification of acute myeloid leukemiaDifferentiation of hematopoietic stem cellsAssociated with poor prognosisAcute myeloid leukemiaHuman hematopoietic stemWave of hematopoiesisGene expression networksMyeloid leukemiaPoor prognosisLineage outputMultilineage capacityDynamics of hematopoiesisCell ontogenyStem cellsLineage primingFate decisionsModel organismsTranscriptomic statesExpression networksHuman lifespanTranscriptional programsHematopoiesis
2022
Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
Hu S, Metcalf E, Mahat D, Chan L, Sohal N, Chakraborty M, Hamilton M, Singh A, Singh A, Lees J, Sharp P, Garg S. Transcription factor antagonism regulates heterogeneity in embryonic stem cell states. Molecular Cell 2022, 82: 4410-4427.e12. PMID: 36356583, PMCID: PMC9722640, DOI: 10.1016/j.molcel.2022.10.022.Peer-Reviewed Original ResearchConceptsGene expression heterogeneityMurine embryonic stem cellsCell statesGeneration of diverse cell typesExpression heterogeneityCell-type identityDiverse cell typesEmbryonic stem cell stateChromatin programmingStem cell stateTranscribed enhancersDevelopmental robustnessTranscription factor KLF4Expressed genesTranscription processDampened variationsGene expressionEmbryonic stem cellsGenesRegulatory programsPositive feedback networkCell typesZfp281CO bindingKinetics of switchingDevelopmental Deconvolution for Classification of Cancer Origin.
Moiso E, Farahani A, Marble HD, Hendricks A, Mildrum S, Levine S, Lennerz JK, Garg S. Developmental Deconvolution for Classification of Cancer Origin. Cancer Discovery 2022 PMID: 36041084, DOI: 10.1158/2159-8290.CD-21-1443.Peer-Reviewed Original ResearchDevelopmental Deconvolution for Classification of Cancer Origin
Moiso E, Farahani A, Marble H, Hendricks A, Mildrum S, Levine S, Lennerz J, Garg S. Developmental Deconvolution for Classification of Cancer Origin. Cancer Discovery 2022, 12: 2566-2585. PMID: 36041084, PMCID: PMC9627133, DOI: 10.1158/2159-8290.cd-21-1443.Peer-Reviewed Original Research2017 – HUMAN HEMATOPOIETIC STEM CELL ONTOGENY ACROSS DEVELOPMENT AND MATURATION
Rowe G, Li H, Cote P, Kuoch M, Ezike J, Afanassiev A, Greenstreet L, Tarantino G, Zhang S, Whangbo J, Butty V, Moiso E, Falchetti M, Connelly G, Morris V, Wang D, Chen A, Bianchi G, Daley G, Garg S, Liu D, Chou S, Regev A, da Rocha E, Schiebinger G. 2017 – HUMAN HEMATOPOIETIC STEM CELL ONTOGENY ACROSS DEVELOPMENT AND MATURATION. Experimental Hematology 2022, 111: s39-s40. DOI: 10.1016/j.exphem.2022.07.049.Peer-Reviewed Original ResearchHematopoietic stem cellsAcute myeloid leukemiaHuman HSPCsAssociated with poor survivalHematopoietic stem cell stateHuman hematopoietic developmentUmbilical cord bloodAdult bone marrowMature effector cellsLineage-restricted progenitorsBlood diseasesTranscriptional programsCirculating blood cellsCord bloodEngraftment potentialFetal liverEffector cellsHematopoietic stemLymphoid lineagesMyeloid leukemiaHuman hematopoiesisHSPC populationsBone marrowHematopoietic systemPoor survival
2021
Single Cell Analysis Elucidates the Maturation of Human Stem and Progenitor Cell Function from Fetal through Adult Hematopoiesis
Li H, Ezike J, Afanassiev A, Greenstreet L, Zhang S, Whangbo J, Butty V, Moiso E, Connelly G, Morris V, Wang D, Daley G, Garg S, Chou S, Regev A, da Rocha E, Schiebinger G, Rowe R. Single Cell Analysis Elucidates the Maturation of Human Stem and Progenitor Cell Function from Fetal through Adult Hematopoiesis. Blood 2021, 138: 1079. DOI: 10.1182/blood-2021-151090.Peer-Reviewed Original ResearchHSC subtypesHematopoietic stem cellsEntity's Board of DirectorsCurrent equity holderHematopoietic lineage commitmentHSPC subtypesHSPC compartmentAdult hematopoiesisHematopoietic lineagesProgenitor cellsLineage commitmentClonal hematopoiesis of indeterminate potentialBone marrow failure disordersMultipotent hematopoietic stem cellsBlood disordersHuman adult bone marrowMulti-lineage reconstitutionCommitted progenitor cellsMarrow failure disordersHematopoietic cell transplantationAdult bone marrowFetal liver hematopoiesisNormal physiologic changesBone marrow hematopoiesisTranscription factor networksLineages of embryonic stem cells show non-Markovian state transitions.
Udomlumleart T, Hu S, Garg S. Lineages of embryonic stem cells show non-Markovian state transitions. IScience 2021, 24: 102879. PMID: 34401663, PMCID: PMC8353490, DOI: 10.1016/j.isci.2021.102879.Peer-Reviewed Original ResearchAcquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel
Mueller H, Fowler C, Dalin S, Moiso E, Udomlumleart T, Garg S, Hemann M, Lees J. Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2024055118. PMID: 34408017, PMCID: PMC8403834, DOI: 10.1073/pnas.2024055118.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationDrug Resistance, NeoplasmDrug SynergismEpigenesis, GeneticGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansLung NeoplasmsMiceMutationPaclitaxelProtein-Arginine N-MethyltransferasesStathminConceptsProtein arginine methyltransferase 5Stathmin-2Sensitivity to paclitaxelPRMT5 inhibitorsLung adenocarcinomaPRMT5 inhibitionResponse to taxane treatmentCell linesArginine methyltransferase 5Resistance to inhibitorsRegression of tumorsMicrotubule regulationLung adenocarcinoma lineAcquisition of resistanceCancer cell linesPotential clinical relevanceEpigenetic regulationHuman cancer cell linesBarcoding experimentsMechanisms of resistanceTaxane treatmentPreexisting populationTaxanes paclitaxelCollateral sensitivityLung adenocarcinoma cellsLineages of embryonic stem cells show non-Markovian state transitions
Udomlumleart T, Hu S, Garg S. Lineages of embryonic stem cells show non-Markovian state transitions. IScience 2021, 24: 102879. PMID: 34401663, PMCID: PMC8353490, DOI: 10.1016/j.isci.2021.102879.Peer-Reviewed Original ResearchEnhancers drive heterogeneity in embryonic stem cells
Hu S, Mahat DB, Chakraborty M, Hamilton M, Waterton S, Singh A, Lees J, Sharp P, Garg S. Enhancers drive heterogeneity in embryonic stem cells. Preprint. http://dx.doi.org/10.2139/ssrn.3836130.Peer-Reviewed Original Research
News
News
- October 10, 2024Source: Yale News
Salil Garg, MD, Receives NIH 'High-Risk, High-Reward' Award
- October 09, 2024Source: Yale News
Six Yale Researchers Receive NIH ‘High-Risk, High-Reward’ Awards
- February 28, 2024
Grants Awarded at YCC • 2024
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