Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsRobert Aaron Levine, MD
Clinical ProfessorAbout
Research
Publications
2025
Left Atrial Plication for Left Ventricular Posterior Wall Bending With Atrial Functional Mitral Regurgitation
Iwataki M, Oishi Y, Miki H, Onoue T, Nagata Y, Levine R, Otsuji Y, Nishimura Y, Kataoka M. Left Atrial Plication for Left Ventricular Posterior Wall Bending With Atrial Functional Mitral Regurgitation. JACC Case Reports 2025, 106394. PMID: 41342815, DOI: 10.1016/j.jaccas.2025.106394.Peer-Reviewed Original ResearchAtrial functional mitral regurgitationFunctional mitral regurgitationGiant LAMitral regurgitationMV repairMitral valve (MV) surgeryLeft atriumLeft atrial plicationRheumatic mitral regurgitationLow cardiac outputGiant left atriumMV replacementChordal preservationPatient 2Patient 1Basal posterior wallPosterior wallCardiac outputPatientsPlicationRegurgitationRepairSurgeryThe value of a novel three-dimensional mitral valve index in the assessment of the haemodynamic severity of rheumatic mitral stenosis
Giffoni R, Hung J, Neto J, de Sousa Pinto A, Gomes N, Pantaleão A, de Magalhães Esteves W, Dal-Bianco J, Tan T, Levine R, Nunes M. The value of a novel three-dimensional mitral valve index in the assessment of the haemodynamic severity of rheumatic mitral stenosis. Echo Research & Practice 2025, 12: 33. PMID: 41219791, PMCID: PMC12606853, DOI: 10.1186/s44156-025-00094-z.Peer-Reviewed Original ResearchMitral stenosisHaemodynamic severityRheumatic MSHaemodynamic burdenClinical presentationSeverity of rheumatic mitral stenosisPulmonary artery systolic pressureNet atrioventricular complianceArtery systolic pressureLeft atrial volumeRheumatic mitral stenosisClinical presentation of MSPresentation of MSTransmitral pressure gradientMitral valve geometryMean pressure gradientTenting heightTenting volumeAtrial volumeEchocardiographic assessmentValve anatomyAtrioventricular complianceMitral annulusMitral valveHaemodynamic consequencesAtrial Functional Mitral Regurgitation Small Volumes, Big Consequences
Levine R, Dal-Bianco J, Otsuji Y. Atrial Functional Mitral Regurgitation Small Volumes, Big Consequences. JACC Cardiovascular Imaging 2025, 18: 1297-1299. PMID: 41026077, DOI: 10.1016/j.jcmg.2025.08.018.Peer-Reviewed Original ResearchCollagen Fiber Maturity and Architecture in MVP-Associated Fibrosis Quantified by Digital Pathology
Phookan R, Morningstar J, Loizzi B, Van Kampen A, Gensemer C, Dieterlen M, Spampinato R, Petitjean L, Petitjean M, Petrucci T, Fenner R, Griner J, Byerly K, Levine R, Borger M, Norris R. Collagen Fiber Maturity and Architecture in MVP-Associated Fibrosis Quantified by Digital Pathology. Cells 2025, 14: 1536. PMID: 41090764, PMCID: PMC12523760, DOI: 10.3390/cells14191536.Peer-Reviewed Original ResearchConceptsMitral valve prolapseRegional myocardial fibrosisMyocardial fibrosisArrhythmogenic mitral valve prolapseHistopathological analysisAnalysis of endomyocardial biopsiesLife-threatening ventricular arrhythmiasPersistent fibrotic phenotypeMitral valve repairTime of surgeryRisk of arrhythmiaQuantitative image analysisLeaflet involvementEndomyocardial biopsyValve repairValve prolapseVentricular functionSurgical guidelinesVentricular arrhythmiasSubvalvular apparatusSurgical interventionMyocardial scarCollagen fiber maturationFibrotic phenotypeFibrosisShort- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture
Clift C, Goudot G, Bogut G, Kasai T, van Kampen A, Negrao Pantaleao A, Messas E, Aikawa M, Singh S, Levine R, Pernot M, Aikawa E. Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture. Ultrasound In Medicine & Biology 2025, 51: 1936-1944. PMID: 40796501, DOI: 10.1016/j.ultrasmedbio.2025.06.026.Peer-Reviewed Original ResearchConceptsHuman valvular interstitial cellsAortic stenosisUltrasound therapyInterstitial cellsFirst-in-human studyAcute effectsTranscatheter aortic valve replacementLong-term effectsAortic valve replacementSevere aortic stenosisLeft ventricular hypertrophyValvular interstitial cellsCalcified aortic stenosisAortic valve diseaseEffects of ultrasound therapyProteomic profilingCalcific aortic valve diseaseOutflow tractSurgical repairValve replacementCardiac failureCalcification in vitroInvasive alternativeVentricular hypertrophySurgical interventionIs mitral annular disjunction the cause of arrhythmogenic mitral valve prolapse?
van Kampen A, Levine R, Borger M. Is mitral annular disjunction the cause of arrhythmogenic mitral valve prolapse? European Heart Journal 2025, 46: 2806-2808. PMID: 40272106, PMCID: PMC12277878, DOI: 10.1093/eurheartj/ehaf264.Peer-Reviewed Original ResearchArrhythmic Mitral Valve Prolapse: Pathophysiology, Diagnostics, and Management Strategies
Kang J, van Kampen A, Dieterlen M, Spampinato R, Sundt T, Melnitchouk S, Levine R, Borger M. Arrhythmic Mitral Valve Prolapse: Pathophysiology, Diagnostics, and Management Strategies. Seminars In Thoracic And Cardiovascular Surgery 2025, 37: 252-256. PMID: 40189179, PMCID: PMC12212166, DOI: 10.1053/j.semtcvs.2025.03.005.Peer-Reviewed Original ResearchClinical Outcomes After Valve Intervention in Rheumatic Mitral Valve Disease
da Silva Neves M, Fraga L, de Andrade M, Nascimento B, Gelape C, Bráulio R, Costa P, Teixeira M, Melo P, Athayde G, Lodi-Junqueira L, Levine R, Nunes M. Clinical Outcomes After Valve Intervention in Rheumatic Mitral Valve Disease. Global Heart 2025, 20: 38. PMID: 40223816, PMCID: PMC11987853, DOI: 10.5334/gh.1420.Peer-Reviewed Original ResearchConceptsPercutaneous mitral valvuloplastyRheumatic MV diseaseLong-term outcomesPredictor of composite outcomeMV replacementRheumatic heart diseaseMV diseaseSurgical interventionComposite outcomeIndependent predictorsMitral valve (MV) diseaseLower left ventricular ejection fractionHigher NYHA functional classIntention-to-treat studyLeft ventricular systolic dysfunctionOlder agePredictor of all-cause mortalityRheumatic mitral valve diseaseNYHA class III/IVNYHA functional classVentricular systolic dysfunctionVentricular ejection fractionComposite of deathAll-Cause MortalityMitral valve diseasePO-07-016 MAPPING THE RHYTHMIC LANDSCAPE: ELECTROPHYSIOLOGICAL PROFILE REVEALS MYOCARDIAL CHANGES IN AN OVINE SURGICAL MODEL OF MITRAL VALVE PROLAPSE
Steiger N, van Kampen A, Agboola K, John L, Foley L, Nagata Y, Morningstar J, Goudot G, Garcia D, Caravan P, Guerrero L, Yaghoubian K, Woodcock R, Borger M, Melnitchouk S, Norris R, Levine R, Tedrow U. PO-07-016 MAPPING THE RHYTHMIC LANDSCAPE: ELECTROPHYSIOLOGICAL PROFILE REVEALS MYOCARDIAL CHANGES IN AN OVINE SURGICAL MODEL OF MITRAL VALVE PROLAPSE. Heart Rhythm 2025, 22: s737-s738. DOI: 10.1016/j.hrthm.2025.03.1776.Peer-Reviewed Original ResearchMitral Valve Remodeling in Response to Atrial and Ventricular Changes: Mechanisms and Clinical Implications for Functional Mitral Regurgitation
Houle S, Rakotoarivelo V, Levine R, Beaudoin J. Mitral Valve Remodeling in Response to Atrial and Ventricular Changes: Mechanisms and Clinical Implications for Functional Mitral Regurgitation. Journal Of The Heart Valve Society 2025, 2: 171-181. DOI: 10.1177/30494826251344846.Peer-Reviewed Original ResearchFunctional mitral regurgitationMitral regurgitationHeterogeneous disease associated with significant morbidityDisease associated with significant morbidityPresence of transforming growth factor-betaHeart failure therapyClinical observational studyGrowth factor-betaMitral valve closureIschemic heart diseaseLeaflet enlargementLeft ventricular shapeValve enlargementFailure therapySignificant morbidityValve dysfunctionMitral leafletPapillary musclesMitral annulusVentricular sizeAdverse evolutionLeft atriumFibrotic remodelingVentricular changesMyocardial disease
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