Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsRobert Aaron Levine, MD
Clinical ProfessorAbout
Research
Publications
2025
Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture
Clift C, Goudot G, Bogut G, Kasai T, van Kampen A, Negrao Pantaleao A, Messas E, Aikawa M, Singh S, Levine R, Pernot M, Aikawa E. Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture. Ultrasound In Medicine & Biology 2025, 51: 1936-1944. PMID: 40796501, DOI: 10.1016/j.ultrasmedbio.2025.06.026.Peer-Reviewed Original ResearchConceptsHuman valvular interstitial cellsAortic stenosisUltrasound therapyInterstitial cellsFirst-in-human studyAcute effectsTranscatheter aortic valve replacementLong-term effectsAortic valve replacementSevere aortic stenosisLeft ventricular hypertrophyValvular interstitial cellsCalcified aortic stenosisAortic valve diseaseEffects of ultrasound therapyProteomic profilingCalcific aortic valve diseaseOutflow tractSurgical repairValve replacementCardiac failureCalcification in vitroInvasive alternativeVentricular hypertrophySurgical interventionMitral valve remodeling in response to atrial and ventricular changes: Mechanisms and clinical implications for functional mitral regurgitation
Houle S, Rakotoarivelo V, Levine R, Beaudoin J. Mitral valve remodeling in response to atrial and ventricular changes: Mechanisms and clinical implications for functional mitral regurgitation. Journal Of The Heart Valve Society 2025 DOI: 10.1177/30494826251344846.Peer-Reviewed Original ResearchFunctional mitral regurgitationMitral regurgitationHeterogeneous disease associated with significant morbidityDisease associated with significant morbidityPresence of transforming growth factor-betaHeart failure therapyClinical observational studyGrowth factor-betaMitral valve closureIschemic heart diseaseLeaflet enlargementLeft ventricular shapeValve enlargementFailure therapySignificant morbidityValve dysfunctionMitral leafletPapillary musclesMitral annulusVentricular sizeAdverse evolutionLeft atriumFibrotic remodelingVentricular changesMyocardial diseaseIs mitral annular disjunction the cause of arrhythmogenic mitral valve prolapse?
van Kampen A, Levine R, Borger M. Is mitral annular disjunction the cause of arrhythmogenic mitral valve prolapse? European Heart Journal 2025, 46: 2806-2808. PMID: 40272106, PMCID: PMC12277878, DOI: 10.1093/eurheartj/ehaf264.Peer-Reviewed Original ResearchArrhythmic Mitral Valve Prolapse: Pathophysiology, Diagnostics, and Management Strategies
Kang J, van Kampen A, Dieterlen M, Spampinato R, Sundt T, Melnitchouk S, Levine R, Borger M. Arrhythmic Mitral Valve Prolapse: Pathophysiology, Diagnostics, and Management Strategies. Seminars In Thoracic And Cardiovascular Surgery 2025, 37: 252-256. PMID: 40189179, PMCID: PMC12212166, DOI: 10.1053/j.semtcvs.2025.03.005.Peer-Reviewed Original ResearchPO-07-016 MAPPING THE RHYTHMIC LANDSCAPE: ELECTROPHYSIOLOGICAL PROFILE REVEALS MYOCARDIAL CHANGES IN AN OVINE SURGICAL MODEL OF MITRAL VALVE PROLAPSE
Steiger N, van Kampen A, Agboola K, John L, Foley L, Nagata Y, Morningstar J, Goudot G, Garcia D, Caravan P, Guerrero L, Yaghoubian K, Woodcock R, Borger M, Melnitchouk S, Norris R, Levine R, Tedrow U. PO-07-016 MAPPING THE RHYTHMIC LANDSCAPE: ELECTROPHYSIOLOGICAL PROFILE REVEALS MYOCARDIAL CHANGES IN AN OVINE SURGICAL MODEL OF MITRAL VALVE PROLAPSE. Heart Rhythm 2025, 22: s737-s738. DOI: 10.1016/j.hrthm.2025.03.1776.Peer-Reviewed Original ResearchSevere Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis
Dahan S, Dal-Bianco J, Plakht Y, Namasivayam M, Capoulade R, Zeng X, Passeri J, Yucel E, Picard M, Levine R, Hung J. Severe Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis. Circulation Cardiovascular Imaging 2025, 18: e017598. PMID: 40116009, PMCID: PMC12245404, DOI: 10.1161/circimaging.124.017598.Peer-Reviewed Original ResearchConceptsLow-gradient severe aortic stenosisParadoxical low-flowSevere aortic stenosisAortic valve replacementPRESERVED LEFT VENTRICULAR EJECTION FRACTIONSevere mitral regurgitationSevere MRVentricular ejection fractionAortic stenosisMitral regurgitationAll-Cause MortalityValve replacementMR degreeEjection fractionComposite outcomeAortic valve replacement ratesAssociated with adverse outcomesComplexity to diagnosisIncreased left ventricular dimensionsLow transaortic gradientNon-severe MRSevere MR groupHeart failure hospitalizationPropensity-adjusted modelLeft ventricular remodelingRheumatic heart valve disease: navigating the challenges of an overlooked autoimmune disorder
Lupieri A, Jha P, Nizet V, Dutra W, Nunes M, Levine R, Aikawa E. Rheumatic heart valve disease: navigating the challenges of an overlooked autoimmune disorder. Frontiers In Cardiovascular Medicine 2025, 12: 1537104. PMID: 40182432, PMCID: PMC11966398, DOI: 10.3389/fcvm.2025.1537104.Peer-Reviewed Original ResearchRheumatic heart diseaseGroup A StreptococcalAcute rheumatic feverGlobal health collaborationsMiddle-income countriesHigh-income countriesDifficulty of diagnosisHealth collaborationHealthcare professionalsMitral valveAutoimmune conditionsAutoimmune disordersHealth issuesRheumatic feverLymphangiogenesis processHeart diseaseAdvocacy groupsFostering optimismPreventive measuresYoung peopleDiseaseInheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study
Cristin L, Dixit S, Bibby D, Tang J, Fang Q, Tastet L, Rich A, Jhawar R, Nagata Y, Higuchi S, Levine R, Hsia H, Tseng Z, Schiller N, Delling F. Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study. Circulation Cardiovascular Imaging 2025, 18: e017051. PMID: 39764632, PMCID: PMC11753933, DOI: 10.1161/circimaging.124.017051.Peer-Reviewed Original ResearchConceptsMitral valve prolapseMitral annular disjunctionSudden cardiac arrestPostsystolic shortening indexAnnular disjunctionNormal mitral valveSudden cardiac deathValve prolapseMitral valveLongitudinal strainShortening indexArrhythmic mitral valve prolapseGlobal longitudinal strainExperience sudden cardiac arrestSpeckle-tracking echocardiographyFamilial mitral valve prolapsePeak longitudinal strainGlobal strain parametersBileaflet involvementGenetic myopathiesArrhythmic riskVentricular ectopyCardiac deathCardiac arrestHealthy controls
2024
Characterization of LTBP2 mutation causing mitral valve prolapse
Shpitzen S, Rosen H, Ben-Zvi A, Meir K, Levin G, Gudgold A, Dor S, Haffner R, Zwas D, Leibowitz D, Slaugenhaupt S, Banin E, Mizrachi R, Obolensky A, Levine R, Gilon D, Leitersdorf E, Tessler I, Reshef N, Durst R. Characterization of LTBP2 mutation causing mitral valve prolapse. European Heart Journal Open 2024, 5: oeae106. PMID: 39882270, PMCID: PMC11775471, DOI: 10.1093/ehjopen/oeae106.Peer-Reviewed Original ResearchMitral valve prolapseValve prolapseKO miceValve phenotypeMouse strainsTGF-bDisorder associated with significant morbidityReduced visual acuityHuman mutationsOptical coherence tomographyKO mouse strainsLTBP2 mutationsAnterior chamberVisual acuityPolymerase chain reaction analysisSignificant morbidityM mutationMyxomatous changesKnockout miceCoherence tomographyHistological phenotypeKI miceExome sequencingEchocardiographyQuantitative polymerase chain reaction analysisMitral Annular Calcification and Valve Dysfunction: Insights and Future Directions
Dal-Bianco J, Levine R, Hung J. Mitral Annular Calcification and Valve Dysfunction: Insights and Future Directions. Journal Of The American Society Of Echocardiography 2024, 37: 756-758. PMID: 38871339, PMCID: PMC12302620, DOI: 10.1016/j.echo.2024.06.002.Peer-Reviewed Original Research
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