Nihar Desai, MD, MPH
Associate Professor of Medicine (Cardiovascular Medicine)Cards
About
Titles
Associate Professor of Medicine (Cardiovascular Medicine)
Biography
Nihar R. Desai, MD, MPH is an Associate Professor of Medicine and Vice Chief of the Section of Cardiovascular Medicine at Yale University School of Medicine, an Investigator at the Center for Outcomes Research and Evaluation, and Executive Director for Bundled Payments and Clinical Service Line Operations at the Yale New Haven Health System. His interests focus on cardiovascular health services and comparative effectiveness research, examining patterns of care, identifying opportunities to improve clinical outcomes, and evaluating the impact of novel care delivery systems on cost and quality. In addition, he serves as a clinical consultant on the CMS acute myocardial infarction, heart failure, and coronary artery bypass graft surgery readmission and mortality measures. He graduated with highest honors from Lehigh University before completing an internship in the Clinton White House. He then attended the University of Connecticut School of Medicine where he received his Doctorate in Medicine and the Harvard School of Public Health where he received his Master’s in Public Health. Dr. Desai completed his residency training in Internal Medicine as well as his clinical fellowship in Cardiovascular Medicine at Brigham and Women’s Hospital and Harvard Medical School. He then completed a research fellowship at the TIMI Study Group with Dr. Eugene Braunwald. His scholarly work has been published in New England Journal of Medicine, Journal of the American Medical Association, Circulation, and the Journal of the American College of Cardiology.
Appointments
Cardiovascular Medicine
Associate Professor on TermPrimary
Other Departments & Organizations
- All Institutions
- Cardiovascular Medicine
- Center for Outcomes Research & Evaluation (CORE)
- Clinical and Translational Research Accelerator (CTRA)
- Internal Medicine
- Yale Medicine
- Yale New Haven Health System
- Yale Ventures
- Yale-BI Biomedical Data Science Fellowship
Education & Training
- Fellowship
- Brigham & Women's Hospital (2013)
- Residency
- Brigham & Women's Hospital (2009)
- MD
- University of Connecticut School of Medicine (2006)
- MPH
- Harvard School of Public Health (2005)
Research
Publications
2026
Emergency Department Visits in the United States for Paroxysmal Supraventricular Tachycardia Are Increasing Among Adults: An Analysis from the Nationwide Emergency Department Sample
Desai N, Pollack C, Venkatesh A, Jiang X, Sacks N, Holz A, Bharucha D, Pokorney S. Emergency Department Visits in the United States for Paroxysmal Supraventricular Tachycardia Are Increasing Among Adults: An Analysis from the Nationwide Emergency Department Sample. Journal Of The American College Of Emergency Physicians Open 2026, 7: 100343. DOI: 10.1016/j.acepjo.2026.100343.Peer-Reviewed Original ResearchED visitsEmergency departmentPrimary diagnosisNationwide Emergency Department Sample dataSecondary diagnosisNationwide Emergency Department SampleAcute care utilizationHealth-care resource useDiagnosis of paroxysmal supraventricular tachycardiaUS emergency departmentsEconomic burdenEmergency department visitsED visit ratesParoxysmal supraventricular tachycardiaEmergency Department SampleUS ED visitsIndividuals aged <Annual visit rateUnited StatesED visit countsCare utilizationDepartment visitsPoisson regressionHealthcare ResearchUS populationRecurrent Hospital Admissions in Acute Pancreatitis and Persistent Chylomicronemia
Desai N, Kertesz N, Kleinman N, Loomba R, S.Rosenson R, Watts G. Recurrent Hospital Admissions in Acute Pancreatitis and Persistent Chylomicronemia. Metabolism 2026, 177: 156526. DOI: 10.1016/j.metabol.2026.156526.Peer-Reviewed Original ResearchA Monte Carlo simulation Comparing TG Lowering with Plozasiran Versus Olezarsan in Patients with FCS
Desai N, Bognar K, Speller A, Das A. A Monte Carlo simulation Comparing TG Lowering with Plozasiran Versus Olezarsan in Patients with FCS. Metabolism 2026, 177: 156521. DOI: 10.1016/j.metabol.2026.156521.Peer-Reviewed Original ResearchWCN26-7734 DOSING, TREATMENT PATTERNS, UACR CHANGES, AND SAFETY WITH FINERENONE TREATMENT: AN INTERIM ANALYSIS OF THE ASIA-PACIFIC COHORT OF FINE-REAL
Kim N, Guo L, Pantalone K, Wanner C, Wheeler D, Desai N, Correa-Rotter R, Nicholas S, Gómez S, Horvat-Broecker A, Schulze M, Merz M, Navaneethan S. WCN26-7734 DOSING, TREATMENT PATTERNS, UACR CHANGES, AND SAFETY WITH FINERENONE TREATMENT: AN INTERIM ANALYSIS OF THE ASIA-PACIFIC COHORT OF FINE-REAL. Kidney International Reports 2026, 11: 104643. DOI: 10.1016/j.ekir.2026.104643.Peer-Reviewed Original ResearchModeling In-Hospital Mortality Among Patients Undergoing Percutaneous Coronary Intervention with Acute Myocardial Infarction Complicated by Cardiogenic Shock Receiving Mechanical Circulatory Support
Hurley N, Mortazavi B, Dhruva S, Ross J, Ngufor C, Curtis J, Krumholz H, Desai N. Modeling In-Hospital Mortality Among Patients Undergoing Percutaneous Coronary Intervention with Acute Myocardial Infarction Complicated by Cardiogenic Shock Receiving Mechanical Circulatory Support. Medical Devices Evidence And Research 2026, 19: 585943. PMID: 41804390, PMCID: PMC12967445, DOI: 10.2147/mder.s585943.Peer-Reviewed Original ResearchMortality riskAssociated with higher mortality riskNational Cardiovascular Data RegistryAssociated with lower riskIntra-aortic balloon pumpHigher systolic blood pressureHigher mortality riskHeterogeneity of treatment effectsRisk of mortalityPercutaneous coronary interventionAssociated with usePatient visitsHigher RatesIn-Hospital MortalitySystolic blood pressureAcute myocardial infarctionData registryAMI-CSCoronary interventionMortality effectsMyocardial infarction complicationsIn-HospitalImpella deviceLow riskAcute myocardial infarction complicationsLow-Density Lipoprotein Cholesterol Lowering and Out-of-Pocket Cost of Inclisiran Therapy in the United States
Desai N, Van Hise N, Niu X, Brown A. Low-Density Lipoprotein Cholesterol Lowering and Out-of-Pocket Cost of Inclisiran Therapy in the United States. Journal Of Clinical Lipidology 2026 PMID: 41794574, DOI: 10.1016/j.jacl.2026.02.010.Peer-Reviewed Original ResearchBaseline LDL-CLDL-C levelsLDL-CAdverse eventsOptimization of lipid-lowering therapyMedical records of patientsLow-density lipoprotein cholesterol loweringHistory of atherosclerotic cardiovascular diseaseLow-density lipoprotein cholesterolElectronic medical recordsLDL-C reductionPatients initiate treatmentLipid-Lowering TherapyHeterozygous familial hypercholesterolemiaElectronic medical records of patientsRecords of patientsLDL-C measurementAtherosclerotic cardiovascular diseaseOut-of-pocket costsMedicare-insured patientsOOP costsPrimary hyperlipidemiaInitial doseFamilial hypercholesterolemiaAverage percent reductionAssociations between practice-level compliance with cardiac performance measures and clinical outcomes in US cardiovascular ambulatory care
Hess P, Fu Z, Desai N, Alam M, Khalid M, Jones P, Virani S. Associations between practice-level compliance with cardiac performance measures and clinical outcomes in US cardiovascular ambulatory care. American Heart Journal 2026, 296: 107364. PMID: 41638384, DOI: 10.1016/j.ahj.2026.107364.Peer-Reviewed Original ResearchSteroidal vs. non-steroidal mineralocorticoid receptor antagonists in heart failure with preserved ejection fraction: a propensity-matched multi-network nationwide cohort study
Almas T, Shelig M, Al-Hindawi A, Bansal K, Akbar A, Qureshi A, Ismayl M, Reed J, Burahmah J, AlHamlan A, AlMojil K, Almukhaizeem A, Rana M, Alansari A, Zacharias M, Ramani R, Sullivan C, Simon D, Desai N, O’Neill T. Steroidal vs. non-steroidal mineralocorticoid receptor antagonists in heart failure with preserved ejection fraction: a propensity-matched multi-network nationwide cohort study. European Heart Journal - Quality Of Care And Clinical Outcomes 2026, qcag014. PMID: 41616082, DOI: 10.1093/ehjqcco/qcag014.Peer-Reviewed Original ResearchMineralocorticoid receptor antagonistsRisk of heart failure exacerbationNon-steroidal mineralocorticoid receptor antagonistHeart failure exacerbationAll-Cause MortalityHeart failureReceptor antagonistEfficacy of mineralocorticoid receptor antagonistsCohort studyRetrospective observational cohort studyPreserved Ejection FractionAssociated with lower riskAcute kidney injuryNationwide cohort studyObservational cohort studyStratified subgroup analysisTriNetX Research NetworkPortend significant morbidityPropensity score matchingEjection fractionHFpEF cohortSignificant morbidityKidney injuryElectrolyte derangementsAKI riskEpidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023
Butzner M, ElHabr A, Farajkhah K, Chhatwal J, Ayer T, Gebrehiwet P, Shreay S, Riello R, Desai N, Owens A, Abraham T, Masri A. Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023. JACC Advances 2026, 5: 102552. PMID: 41570793, PMCID: PMC12859511, DOI: 10.1016/j.jacadv.2025.102552.Peer-Reviewed Original ResearchDiagnosis codesContemporary prevalenceUnited StatesClaims-based studyPrevalence of hypertrophic cardiomyopathyHypertrophic cardiomyopathyIncidence of hypertrophic cardiomyopathySymptomatic hypertrophic cardiomyopathyNonobstructive HCMObstructive HCMHypertrophic cardiomyopathy casesAdministrative claimsSymphony Integrated DataVerseIntegrated DataversePrevalence ratesObservational studyDisease characteristicsPatient demographicsPrevalenceStudy periodTotal populationObstructive hypertrophic cardiomyopathyNonobstructive hypertrophic cardiomyopathyPatient subgroupsEpidemiology
2025
Accelerating evidence generation to implementation: Establishment of the Leading Awareness to Action through Implementation of Cardiometabolic Efforts (LATTICE) consortium
Jones L, Gluckman T, Bhatt A, Boer L, Bonaca M, Campbell-Salome G, Davis E, Desai N, George J, Head L, Marvel F, Penn M, Peterson E, Scirica B, Shah N, Wilemon K, Kalich B, Martin S. Accelerating evidence generation to implementation: Establishment of the Leading Awareness to Action through Implementation of Cardiometabolic Efforts (LATTICE) consortium. American Journal Of Preventive Cardiology 2025, 24: 101358. PMID: 41431600, PMCID: PMC12718180, DOI: 10.1016/j.ajpc.2025.101358.Peer-Reviewed Original ResearchEvidence-based toolsHealth care strategiesEvidence-based advancesPatient advocacy groupsClinical practice settingPopulation-level benefitsImplementation scienceCardiometabolic healthHealthcare settingsCare strategiesAvailability of innovative therapyPractice settingsHealthcare systemCardiometabolic eventsWorld's leading causeAdvocacy groupsLeading causeConsortium's missionCareHealthcareLength of timeUnique collaborationAwarenessMortalityConsortium
Clinical Trials
Current Trials
Pragmatic Trial Of Alerts for Use of Mineralocorticoid Receptor Antagonists (PROMPT-MRA)
IRB ID2000030513RoleSub InvestigatorPrimary Completion Date12/01/2023Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
Clinical Care
Overview
Nihar Desai, MD, MPH, is a cardiovascular medicine specialist, treating patients with complex cardiovascular conditions, including acute coronary syndromes, heart failure, valvular heart disease, and arrhythmias.
Dr. Desai’s research explores opportunities to improve the quality of care, the impact of decision support tools on care patterns, and how different models of care affect quality, outcomes, and cost of care. He leads clinical trials and real world studies using administrative and clinical datasets to conduct hypothesis driven research of importance to patients, providers, payers, and policymakers.
Dr. Desai is an associate professor of medicine at Yale School of Medicine.
Clinical Specialties
News
News
- October 24, 2024
New Analytics Center for Cardiovascular Medicine
- July 24, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (July 2024)
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- March 29, 2024Source: The New York Times
Heart Pump Is Linked to 49 Deaths, the F.D.A. Warns
Get In Touch
Contacts
Cardiovascular Medicine
15 York Street, PO Box 208017
New Haven, CT 06520-8017
United States
Administrative Support
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.