Nia Fogelman, PhD
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2025
Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder
Barreto S, McGowan C, Fogelman N, Sinha R, Wemm S. Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder. Behavioral Sciences 2025, 15: 1732. PMCID: PMC12729474, DOI: 10.3390/bs15121732.Peer-Reviewed Original ResearchAlcohol use disorderUse disorderSocial drinkingSocial drinking controlsHeart rate variability recoveryPredictor of chronic illnessPre-stress baselineCold pressor testDSM-5 criteriaHeart rate variabilitySubstance use disordersEffects of stressAcute stress responseDSM-5New Haven areaAutonomic reactivityDrinking controlsAutonomic flexibilityStress exposureLevels of stressStress-related chronic diseasesChronic illnessTime-period effectsClinical careRepeated trialsDevelopment of the Yale pain stress test to elicit a multi-level stress response and assess stress adaptability
Fogelman N, Barreto S, McGowan C, Wemm S, Sinha R. Development of the Yale pain stress test to elicit a multi-level stress response and assess stress adaptability. Psychopharmacology 2025, 1-14. PMID: 41361589, DOI: 10.1007/s00213-025-06972-y.Peer-Reviewed Original ResearchCold pressor taskPredictor of chronic illnessPain tolerancePre-stress baselineAcute physiological stress responseStress-related illnessesAcute stress responseLevels of stressPain stressStress responseResilient copingWithin-subject experimentPhysiological stress responseHealthy copingBasal anxietyChronic illnessSubjective distressHigher DBPHigher SBPSubjective stressGreater reactivityLower painStress testPain ratingsComponents of resilience1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity
DOYLE E, FOGELMAN N, JOSEPH K, HU P, JASTREBOFF A, SINHA R. 1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1771-p.Peer-Reviewed Original ResearchTraumatic life eventsCumulative Adversity InterviewLife eventsChronic stressSweet food intakeCue contextLife traumaAcute stressCumulative stressful life eventsScript-driven imageryFood ad libitumRecent life eventsStressful life eventsTotal life eventsSnack foods ad libitumSweet food consumptionFood intakeEffects of stressChronic stress scoresStress scoresFood cuesCommunity adultsNeutral contextsCue conditionTraumatic eventsPregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial
Sakmar E, Wemm S, Fogelman N, Hermes G, Sinha R, Milivojevic V. Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial. Drug And Alcohol Dependence 2025, 274: 112765. PMID: 40570771, PMCID: PMC12264926, DOI: 10.1016/j.drugalcdep.2025.112765.Peer-Reviewed Original ResearchCocaine use disorderCocaine useNeuroactive steroidsUse disorderTreatment of cocaine use disorderCocaine use outcomePregnenolone levelsTreatment-seeking individualsDays of cocaineChronic cocaine useExposure to stressPreg groupCocaine cuesCocaine cravingCraving responsesNeutral cuesInduce cravingCravingWeek 2CocaineChronic treatmentPilot findingsCocaine amountPrecursor pregnenoloneLinear mixed effects modelsNeuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking
Wemm S, Holzhauer C, Harrison L, Milivojevic V, Fogelman N, Cao Z, Wulfert E. Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking. Psychoneuroendocrinology 2025, 177: 107469. PMID: 40250213, PMCID: PMC12131328, DOI: 10.1016/j.psyneuen.2025.107469.Peer-Reviewed Original ResearchConceptsTrier Social Stress TestHypothalamic-pituitary-adrenal axisAxis responseProblem gamblingPathophysiology of addictive disordersHPA axis responseSocial Stress TestHypothalamic-pituitary-gonadal axisHealthy control participantsLaboratory-induced stressStress-related changesStress hormone cortisolHypothalamic-pituitary-gonadal axis hormonesAddictive disordersAddiction mechanismsLaboratory stressorSubstance addictionControl participantsNeuroactive steroidsNeuroendocrine responsesAttenuated cortisolPsychological featuresProblem gamblersHormone cortisolGamblingW139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study
Wemm S, Fogelman N, Sullivan L, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study. Drug And Alcohol Dependence 2025, 267: 112081. DOI: 10.1016/j.drugalcdep.2024.112081.Peer-Reviewed Original ResearchM125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder
Fogelman N, McGowan C, Wemm S, Tate M, Hermes G, Sinha R, Wemm S. M125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder. Drug And Alcohol Dependence 2025, 267: 111719. DOI: 10.1016/j.drugalcdep.2024.111719.Peer-Reviewed Original ResearchPregnenolone Effects on Cocaine Use in Individuals with Cocaine Use Disorder
Milivojevic V, Sakmar E, Fogelman N, Hermes G, Sinha R. Pregnenolone Effects on Cocaine Use in Individuals with Cocaine Use Disorder. Drug And Alcohol Dependence 2025, 267: 112227. DOI: 10.1016/j.drugalcdep.2024.112227.Peer-Reviewed Original Research
2024
Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biologySex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake
McGowan C, Krah M, Fogelman N, Seo D, Sinha R. Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake. Alcohol And Alcoholism 2024, 59: agae047. PMID: 39053499, DOI: 10.1093/alcalc/agae047.Peer-Reviewed Original ResearchConceptsMorning cortisol levelsCortisol levelsHigher morning cortisol levelsHypothalamic-pituitary-adrenal (HPA) axisSex differencesReports of alcohol consumptionProblematic drinking behaviorAlcohol consumptionAverage cortisol levelsBasal cortisol levelsAlcohol intakeHeavy alcohol useChronic alcohol consumptionHPA axisDrinking behaviorNeuroimaging scansPeripheral cortisolAlcohol useStress systemBinge drinkingMorning cortisolStress hormonesMorning plasma cortisolBingeNon-significant relationship