Mridu Gulati, MD
Associate Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine)Cards
About
Research
Publications
2025
Higher Acute Exposure to Air Pollution Is Associated With Respiratory Hospitalizations in Idiopathic Pulmonary Fibrosis: Data From the IPF-PRO Registry
Sack C, Wojdyla D, Macmurdo M, Gassett A, Redlich C, Raghu G, Kaufman J, Olson A, Neely M, Snyder L, Gulati M, on behalf of the IPF-PRO Registry investigators. Higher Acute Exposure to Air Pollution Is Associated With Respiratory Hospitalizations in Idiopathic Pulmonary Fibrosis: Data From the IPF-PRO Registry. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3245-a3245. DOI: 10.1164/ajrccm.2025.211.abstracts.a3245.Peer-Reviewed Original ResearchLong-Term Air Pollution Exposure and Severity of Idiopathic Pulmonary Fibrosis: Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry.
Sack C, Wojdyla D, MacMurdo M, Gassett A, Kaufman J, Raghu G, Redlich C, Li P, Olson A, Leonard T, Todd J, Neely M, Snyder L, Gulati M, Baker A, Beegle S, Belperio J, Condos R, Cordova F, Southern B, Dilling D, Fitzgerald J, Flaherty K, Gibson K, Gulati M, Guntupalli K, Gupta N, Case A, Hotchkin D, Huie T, Kaner R, Kim H, Lancaster L, Lasky J, Lee D, Liesching T, Lipchik R, Lobo J, Luckhardt T, Mageto Y, Kokoszynska M, Morrison L, Namen A, Oldham J, Paul T, Zhang D, Porteous M, Raj R, Ramaswamy M, Russell T, Sachs P, Safdar Z, Shafazand S, Siddiqi A, Fowler R, Strek M, Rivas-Perez H, Tabak J, Walia R, Whelan T. Long-Term Air Pollution Exposure and Severity of Idiopathic Pulmonary Fibrosis: Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry. Annals Of The American Thoracic Society 2025, 22: 378-386. PMID: 39531618, DOI: 10.1513/annalsats.202404-382oc.Peer-Reviewed Original ResearchAssociated with worse qualityExposure to air pollutionGene-environment interactionsQuality of lifePollution exposureEffects of long-term exposure to air pollutionLong-term exposure to PM<sub>2.5</sub> anLong-term exposure to air pollutionWorse qualityParticipant's residential addressQuality of life measuresNon-Hispanic whitesExposure to PM<sub>2.5</sub>Multi-pollutant modelsYears of follow-upCox proportional hazards modelsLower FVC %Residential addressesProportional hazards modelIPF-PRO RegistryMultivariate regression modelEffect modificationEuroQol scoresLife measuresEnrollment dateChanges in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis
Oldham J, Neely M, Wojdyla D, Gulati M, Li P, Patel D, Palmer S, Todd J, Investigators I. Changes in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis. CHEST Journal 2025 PMID: 40020995, DOI: 10.1016/j.chest.2025.02.018.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisLung transplantationLung function declinePulmonary fibrosisAssociated with 1.8-foldProgressive fibrosing interstitial lung diseaseMedian follow-up timeFibrosing interstitial lung diseaseFollow-up timeInterstitial lung diseaseCox proportional hazards modelsRisk of deathFunctional declineRisk of mortalityProportional hazards modelAntifibrotic treatmentThreshold of declineAssociated with lung function declineOutcomes RegistryLung diseaseEnrolling centersDLCOSmoking statusDiffusing capacityLung function
2024
Changes in lung function and mortality risk in patients with idiopathic pulmonary fibrosis (IPF)
Oldham J, Neely M, Wojdyla D, Gulati M, Li P, Patel D, Palmer S, Todd J, Patel D. Changes in lung function and mortality risk in patients with idiopathic pulmonary fibrosis (IPF). 2024, pa674. DOI: 10.1183/13993003.congress-2024.pa674.Peer-Reviewed Original ResearchPlasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts
Sand J, Jessen H, Leeming D, Yu S, Lee C, Hu B, Sun Y, Adams T, Pivarnik T, Liu A, Woo S, McGovern J, Fiorini V, Saber T, Higuero-Sevilla J, Gulati M, Kaminski N, Damsky W, Shaw A, Mohanty S, Goobie G, Zhang Y, Herzog E, Ryu C. Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts. Thorax 2024, 79: 1136-1144. PMID: 39117421, PMCID: PMC12147189, DOI: 10.1136/thorax-2023-221095.Peer-Reviewed Original ResearchSarcoidosis cohortMultiorgan diseasePRO-C3Interleukin-4Case Control Etiologic Study of SarcoidosisPlasma levels of interleukin-4Alpha-1 antitrypsin deficiencyLevels of interleukin-4Pathogenesis of sarcoidosisC6MC3MHealthy control patientsStudy of sarcoidosisGenomic researchAbnormal extracellular matrixAssociated with dermatological diseaseCollagen degradationScadding stageCorticosteroid useComplex diseasesPRO-C6Control patientsIL-13IL-5IL-9Innate Immune Effects of Α1-adrenoreceptor Antagonism in Sarcoidosis
Saber T, Yu S, Lee C, Fiorini V, Mcgovern J, Woo S, Gulati M, Ryu C, Herzog E. Innate Immune Effects of Α1-adrenoreceptor Antagonism in Sarcoidosis. 2024, a2531-a2531. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2531.Peer-Reviewed Original ResearchTelomere Attrition Is Associated With Sarcoidosis
Gandhi S, Lee C, Yu S, Saber T, Woo S, Mcgovern J, Fiorini V, Gulati M, Herzog E, Ryu C. Telomere Attrition Is Associated With Sarcoidosis. 2024, a2530-a2530. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2530.Peer-Reviewed Original ResearchLong-term Air Pollution Exposure Is Associated With Increased Severity of Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry
Sack C, Wojdyla D, Macmurdo M, Gassett A, Kaufman J, Raghu G, Redlich C, Li P, Olson A, Leonard T, Todd J, Neely M, Snyder L, Gulati M, on behalf of the IPF-PRO Registry investigators. Long-term Air Pollution Exposure Is Associated With Increased Severity of Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry. 2024, a1798-a1798. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1798.Peer-Reviewed Original ResearchDevelopment and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease
Swaminathan A, McFatrich M, Mkumba L, Wright L, Redlich C, Snyder L, Reeve B, Patel D, Gulati M. Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease. Respiratory Research 2024, 25: 372. PMID: 39407223, PMCID: PMC11481565, DOI: 10.1186/s12931-024-03000-z.Peer-Reviewed Original ResearchConceptsCognitive interviewsContent validityExposure questionnaireMultidisciplinary teamSemi-structured interview guideEvidence of content validityFibrosing ILDsInterstitial lung diseaseRelevant exposuresFibrotic interstitial lung diseaseClinically relevant exposuresTrained interviewersInterview guideAssessment QuestionnaireQuestionnaireInterviewsLung diseaseAdultsTeamClinicPatientsSource of misunderstandingOccupational inhalation exposureValidityDisease
2023
Circulating Mitochondrial DNA Is Associated With High Levels of Fatigue in Two Independent Sarcoidosis Cohorts
Fiorini V, Hu B, Sun Y, Yu S, McGovern J, Gandhi S, Woo S, Turcotte-Foster S, Pivarnik T, Khan Z, Adams T, Herzog E, Kaminski N, Gulati M, Ryu C. Circulating Mitochondrial DNA Is Associated With High Levels of Fatigue in Two Independent Sarcoidosis Cohorts. CHEST Journal 2023, 165: 1174-1185. PMID: 37977267, PMCID: PMC11110677, DOI: 10.1016/j.chest.2023.11.020.Peer-Reviewed Original ResearchPatient-related outcome measuresToll-like receptor 9Fatigue Assessment ScalePlasma mtDNA concentrationsTLR9 activationSarcoidosis patientsMtDNA concentrationsMulti-organ sarcoidosisCommon chief complaintInnate immune activationNovel therapeutic strategiesDomains of fatigueSevere clinical phenotypePsychobiologic mechanismsSarcoidosis cohortScadding stageCorticosteroid useCytokine levelsExtrapulmonary diseaseProspective cohortFAS scoresPulmonary fibrosisChief complaintImmune activationPatient population
Clinical Trials
Current Trials
Genetic Determinants of Aneurysms in Autosomal Dominant Polycystic Kidney Disease
HIC ID2000029350RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18+ yearsPathogenic Wnt-beta catenin target genes in macrophages and fibrosis
HIC ID2000024862RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting Participants
Clinical Care
Overview
Mridu Gulati, MD, is a pulmonologist and critical care specialist who also focuses on occupational and environmental lung diseases. She cares for people with interstitial lung disease (a group of conditions that cause scarring in the lungs) and sarcoidosis (an inflammatory disease that can affect multiple organs, especially the lungs).
An associate professor of medicine (pulmonary, critical care and sleep medicine) at Yale School of Medicine, Dr. Gulati earned her medical degree from New York University. After completing a residency in internal medicine at the University of Michigan Medical Center, she pursued fellowships in pulmonary and critical care at Yale School of Medicine the University of California, San Francisco and New York University School of Medicine.
Clinical Specialties
Occupational Health & Environmental Medicine; Pulmonology & Sleep Medicine; Pulmonary Critical Care
Fact Sheets
Interstitial Lung Disease (ILD)
Learn More on Yale MedicineSarcoidosis
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Pulmonary, Critical Care & Sleep Medicine
PO Box 208057, 300 Cedar Street
New Haven, CT 06520-8057
United States
Locations
Lippard Laboratory of Clinical Investigation (LLCI)
Academic Office
15 York Street, Ste 101D
New Haven, CT 06510
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