Mark Iscoe, MD, MHS
Assistant Professor of Emergency Medicine and Biomedical Informatics and Data ScienceCards
About
Research
Publications
2025
Beyond Right and Wrong: The Diagnostic Calibration Matrix and Decision Latitude as a Tiered Framework for Evaluating Diagnostic Reasoning
Pavuluri S, Sangal R, Taylor R, Iscoe M, Venkatesh A, Sather J. Beyond Right and Wrong: The Diagnostic Calibration Matrix and Decision Latitude as a Tiered Framework for Evaluating Diagnostic Reasoning. Academic Emergency Medicine 2025 PMID: 41225307, DOI: 10.1111/acem.70193.Peer-Reviewed Original ResearchReal-World Evidence Synthesis of Digital Scribes Using Ambient Listening and Generative Artificial Intelligence for Clinician Documentation Workflows: Rapid Review
Kanaparthy N, Villuendas-Rey Y, Bakare T, Diao Z, Iscoe M, Loza A, Wright D, Safranek C, Faustino I, Brackett A, Melnick E, Taylor R. Real-World Evidence Synthesis of Digital Scribes Using Ambient Listening and Generative Artificial Intelligence for Clinician Documentation Workflows: Rapid Review. JMIR AI 2025, 4: e76743. PMID: 41071988, PMCID: PMC12513689, DOI: 10.2196/76743.Peer-Reviewed Original ResearchStranded in the emergency department: an analysis of boarding trends in older adults in the United States
Sifnugel N, Jeffery M, Grogan E, Sangal R, Carr B, Cruz D, Dresden S, Gettel C, Iscoe M, Skains R, Venkatesh A, Hwang U. Stranded in the emergency department: an analysis of boarding trends in older adults in the United States. Health Affairs Scholar 2025, 3: qxaf187. PMID: 41143086, PMCID: PMC12548728, DOI: 10.1093/haschl/qxaf187.Peer-Reviewed Original ResearchOlder adultsHealth systemDiverse hospital typesQuality improvement initiativesHigher risk of hospitalizationClinical administrative dataCross-sectional analysisHigh riskRisk of hospitalizationAdmission pathwayHospital typeImprovement initiativesHospital boardsAdministrative dataHospital bedsEmergency departmentGreater riskAging populationCognitive declineNHAMCSOlder patientsAdultsHealthNegative outcomesHospitalA Measurement Science Framework to Optimize CDS for Opioid Use Disorder Treatment in the ED
Iscoe M, Hooper C, Levy D, Lutz J, Paek H, Rose C, Kannampallil T, Meeker D, Dziura J, Melnick E. A Measurement Science Framework to Optimize CDS for Opioid Use Disorder Treatment in the ED. Applied Clinical Informatics 2025, 16: 1067-1076. PMID: 40834872, PMCID: PMC12431813, DOI: 10.1055/a-2595-0317.Peer-Reviewed Original ResearchConceptsClinical decision supportEmergency departmentED initiationOpioid use disorderScience FrameworkClinical decision support applicationsEmergency department-initiated buprenorphineUse disorderSingle health systemInitiation of buprenorphineOpioid use disorder treatmentWorking group sessionsHealth systemGroup sessionsEligible encountersCo-design processMultidisciplinary partnersCo-designPostmeeting surveysCDS performancePriority categoriesAHRQConsensus methodologyFinal measurementBuprenorphine initiationEmergency Department Implementation of a Multimodal Electronic Health Record–Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency
Sangal R, Iscoe M, Rothenberg C, Possick S, Taylor R, Safdar B, Desai N, Rhodes D, Venkatesh A. Emergency Department Implementation of a Multimodal Electronic Health Record–Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency. Journal Of The American College Of Emergency Physicians Open 2025, 6: 100202. PMID: 40606317, PMCID: PMC12214263, DOI: 10.1016/j.acepjo.2025.100202.Peer-Reviewed Original ResearchEmergency departmentAcute myocardial infarction diagnosisTroponin testingED dischargeMyocardial infarction diagnosisAssociated with lower oddsAccelerated diagnostic protocolPhysician practice variationAcute coronary syndromeInfarction diagnosisChest pain evaluationMultivariate logistic regressionSuspected acute coronary syndromePostintervention periodDownstream testingPhysician practicesPreintervention periodED dispositionLower oddsCoronary syndromeDecreased oddsIncreased oddsPractice variationED patientsHs-cTnTCase Report: A health system’s experience using clinical decision support to promote note sharing after the 21st Century Cures Act
Iscoe M, Venkatesh A, Powers E, Kashyap N, Hsiao A, Millard H, Sangal R. Case Report: A health system’s experience using clinical decision support to promote note sharing after the 21st Century Cures Act. JAMIA Open 2025, 8: ooaf051. PMID: 40510806, PMCID: PMC12161449, DOI: 10.1093/jamiaopen/ooaf051.Peer-Reviewed Original ResearchClinical decision supportHealth system's experienceRegional health systemDecision supportPatient engagementCentury Cures ActHealth systemPortal accessClinical notesConsistent with prior research showingCures ActPromote complianceSensitive informationStudy periodLinear regressionPediatricObservational analysisPsychiatryPatients/proxiesNotesPatientsSupportHealthCliniciansResearch showIdentifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study
Socrates V, Wright D, Huang T, Fereydooni S, Dien C, Chi L, Albano J, Patterson B, Kanaparthy N, Wright C, Loza A, Chartash D, Iscoe M, Taylor R. Identifying Deprescribing Opportunities With Large Language Models in Older Adults: Retrospective Cohort Study. JMIR Aging 2025, 8: e69504. PMID: 40215480, PMCID: PMC12032504, DOI: 10.2196/69504.Peer-Reviewed Original ResearchAdaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial
Iscoe M, Hooper C, Levy D, Buchanan L, Dziura J, Meeker D, Taylor R, D’Onofrio G, Oladele C, Sarpong D, Paek H, Wilson F, Heagerty P, Delgado M, Hoppe J, Melnick E. Adaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial. BMJ Open 2025, 15: e098072. PMID: 39979056, PMCID: PMC11842997, DOI: 10.1136/bmjopen-2024-098072.Peer-Reviewed Original ResearchConceptsClinical decision supportMultiphase optimization strategyOpioid use disorderEmergency departmentInitiation of buprenorphineClinical decision support usePlan-Do-Study-Act cyclesLearning health system approachPlan-Do-Study-ActClinical decision support toolHealth system approachAdaptive decision supportUse disorderDecision supportAddiction treatmentPeer-reviewed journalsBuprenorphine initiationOpioid use disorder treatment initiationOpioid-related mortalityIntervention componentsED settingClinician feedbackInstitute Institutional Review BoardTreatment of opioid use disorderParticipating sites
2024
Leveraging artificial intelligence to reduce diagnostic errors in emergency medicine: Challenges, opportunities, and future directions
Taylor R, Sangal R, Smith M, Haimovich A, Rodman A, Iscoe M, Pavuluri S, Rose C, Janke A, Wright D, Socrates V, Declan A. Leveraging artificial intelligence to reduce diagnostic errors in emergency medicine: Challenges, opportunities, and future directions. Academic Emergency Medicine 2024, 32: 327-339. PMID: 39676165, PMCID: PMC11921089, DOI: 10.1111/acem.15066.Peer-Reviewed Original ResearchClinical decision supportEmergency departmentArtificial intelligencePatient safetyDiagnostic errorsImplementing AIImprove patient safetyClinical decision support systemsEnhance patient outcomesReducing diagnostic errorsLeverage artificial intelligenceEmergency medicineHealth careTargeted educationReduce cognitive loadQuality improvementEmergency cliniciansData retrievalReal-time insightsDecision supportPatient outcomesCognitive overloadInformation-gathering processPatient detailsCliniciansBenchmarking Emergency Physician EHR Time per Encounter Based on Patient and Clinical Factors
Iscoe M, Venkatesh A, Holland M, Krumholz H, Sheares K, Melnick E. Benchmarking Emergency Physician EHR Time per Encounter Based on Patient and Clinical Factors. JAMA Network Open 2024, 7: e2427389. PMID: 39136949, PMCID: PMC11322841, DOI: 10.1001/jamanetworkopen.2024.27389.Peer-Reviewed Original Research
News
News
Get In Touch
Contacts
Email