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Joseph N. Contessa, MD, PhD

Professor Adjunct of Therapeutic Radiology
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Professor Adjunct of Therapeutic Radiology

Biography

Joseph N. Contessa, MD, PhD, a radiation oncologist, is the director of Yale Medicine’s Central Nervous System Radiotherapy Program. He specializes in treating patients with primary tumors of the brain, head and neck, and at the base of the skull.

“Due to Yale's large referral base, I frequently see relatively rare tumors,” he says, including low-grade and malignant gliomas, ependymomas, high-grade meningiomas, hemangiopericytomas, paragangliomas, and schwannomas. His expertise in treating uncommon cancers benefits patients diagnosed with these tumor types. “I look forward to helping patients have the best possible outcome when they are faced with a challenging diagnosis,” he says.

Dr. Contessa is a Professor of therapeutic radiology and of pharmacology at Yale School of Medicine where he is part of a team of physicians and scientists who are actively researching the cellular mechanisms that tumors use to evade or “outsmart” standard cancer therapies in hopes of identifying new approaches that improve treatment.

“We are all working together to increase our knowledge, improve our care and beat cancer,” Dr. Contessa says.

Last Updated on April 07, 2025.

Appointments

Education & Training

Resident
The University of Michigan (2009)
Intern
The University of Michigan (2005)
PhD
Medical College of Virginia Commonwealth Universit (2004)
MD
Medical College of Virginia Commonwealth Universit (2004)

Research

Overview

Therapeutic approaches for the treatment of EGFR and FGFR addicted lung cancer

Radiosensitization of malignant gliomas

Novel small molecule inhibitors of N-linked glycosylation

Molecular Imaging of the Epidermal Growth Factor Receptor

Drug Discovery and High Throughput Screening

Targeted therapy for head and neck squamous cell carcinoma

Medical Research Interests

Chemicals and Drugs; Neoplasms; Radiobiology

Research at a Glance

Yale Co-Authors

Frequent collaborators of Joseph N. Contessa's published research.

Publications

2025

2024

2023

2021

2019

Clinical Trials

Current Trials

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