John Elefteriades, MD
William W.L. Glenn Professor of Surgery (Cardiac)Cards
Contact Info
Cardiac Surgery
P.O. Box 208039
New Haven, CT 06520-8039
United States
About
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Titles
William W.L. Glenn Professor of Surgery (Cardiac)
Biography
Dr. John Elefteriades is the William W.L. Glenn Professor of Cardiothoracic Surgery and former Chief of Cardiothoracic Surgery at Yale University and Yale New-Haven Hospital. He has been among the most clinically active academic surgeons in the country.
Dr. Elefteriades graduated magna cum laude with a triple concentration in Physics, French and Psychology from Yale University. He received his MD degree from the Yale University School of Medicine. He trained at Yale in both general surgery and cardiothoracic surgery. After completing his training, he joined the faculty at the Yale University School of Medicine.
He has performed all aspects of adult cardiac and thoracic surgery. He is a recognized authority in interventions for the failing left ventricle, including coronary artery bypass grafting, left ventricular aneurysmectomy, and artificial heart implantation. Dr. Elefteriades directs the Aortic Institute at Yale, one of the nation's largest facilities for treatment of the dilated thoracic aorta. He conducts laboratory research in new techniques of heart transplantation. Among his research projects, he is working to identify the genetic mutations responsible for thoracic aortic aneurysms.
Dr. Elefteriades serves on multiple scientific advisory and editorial boards. He is a past President of the Connecticut Chapter of the American College of Cardiology and member of the national Board of Governors of the College. Dr. Elefteriades is also past President of the International College of Angiology. He serves on the editorial board of the American Journal of Cardiology, the Journal of Cardiac Surgery, Cardiology, and the Journal of Thoracic and Cardiovascular Surgery as well as being Editor-in-Chief of the journal AORTA. He has been a member of the Thoracic Surgery Director's Association and has been named consistently in The Best Doctors in America. He is a frequently requested international lecturer, visiting professor and guest surgeon. He is the author of over 400 scientific publications on a wide range of cardiac and thoracic topics. He was selected as one of the ten best doctors in America by Men’s Health magazine. He has been featured in many dozens of print, radio, and television presentations. He has received the Walter Bleifeld Memorial Award for Distinguished Contribution in Clinical Research in Cardiology and the John B. Chang Research Achievement Award. In 2005 he was selected to lecture at the Leadership in Biomedicine Series at the Yale University School of Medicine. In 2006, he received the Socrates Award from the Thoracic Residents Association, Thoracic Surgery Directors' Association, and the Society of Thoracic Surgeons, recognizing exceptional achievement in teaching and mentorship of residents.
Dr. Elefteriades was named the William W.L. Glenn Professor of Cardiothoracic Surgery in 2006. This endowed chair honors the memory of Dr. Elefteriades’ mentor, Dr. Glenn. Dr. Elefteriades is the author of the books House Officer Guide to ICU Care (1st, 2nd, and 3rd Editions), Advanced Treatment Options for the Failling Left Ventricle, Your Heart: The Owner's Guide, Acute Aortic Disease, Extraordinary Hearts: A Journey of Cardiac Medicine and the Human Spirit, The Woman's Heart: An Owner's Guide, and the medical ethics thriller Transplant.
In 2017, Dr. Elefteriades was awarded an Honorary Phd degree from the University of Liege (Belgium) in recognition of his work in diagnosis and treatment of aortic diseases.
In 2020, Dr. Elefteriades was recognized by expertscape as the top aortic specialist in the world.
Appointments
Cardiac Surgery
ProfessorPrimary
Other Departments & Organizations
- All Institutions
- Cardiac Surgery
- Surgery
- Yale Center for Thoracic Aortic Disease
- Yale Medicine
- Yale Ventures
Education & Training
- Chief Resident
- Yale-New Haven Hospital (1983)
- Resident
- Yale-New Haven Hospital (1982)
- Chief Resident
- Yale-New Haven Hospital (1981)
- Resident
- Yale-New Haven Hospital (1980)
- MD
- Yale University (1976)
- BA
- Yale University, Psychology (1972)
- Fellow
- Yale-New Haven Hospital, New Haven, CT
- Residency
- Yale New Haven Hospital, New Haven, CT
- Fellowship
- Yale New Haven Hospital, New Haven, CT
Board Certifications
Thoracic & Cardiac Surgery
- Certification Organization
- AB of Thoracic Surgery
- Latest Certification Date
- 2014
- Original Certification Date
- 1985
Research
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Overview
Dr. Elefteriades and his team at the Aortic Institute have contributed to our understanding of when (at what size) aneurysms are likely to rupture and when surgery is necessary. They have elucidated the family patterns of aneurysm disease, as well as determined the exact changes in "letters" of the genetic alphabet that allow aneurysms to develop. They have developed and advanced the techniques for safe, effective surgery on the thoracic aorta.
Medical Research Interests
ORCID
0000-0001-6255-8139
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Mohammad Abdullah Zafar, MBBS
George Tellides, MD, PhD
Sandip Mukherjee, MD, FACC
Hamid Mojibian, MD
Wanda Popescu, MD
Cassius Iyad Ochoa Chaar, MD, MPH, MS, RPVI
Aortic Aneurysm, Thoracic
Coronary Artery Bypass
Heart Aneurysm
Publications
2026
Association Between JAK2 V617F Somatic Mutation and Thoracic Aortic Aneurysms
Collins S, Zafar M, Elefteriades J. Association Between JAK2 V617F Somatic Mutation and Thoracic Aortic Aneurysms. Genes 2026, 17: 364. DOI: 10.3390/genes17040364.Peer-Reviewed Original ResearchConceptsJAK2 V617F somatic mutationV617F somatic mutationThoracic aortic aneurysmThoracic aortic aneurysm formationAortic aneurysm formationAortic aneurysmJAK2 V617FSomatic mutationsFormation of thoracic aortic aneurysmAneurysm formationThoracic aortic aneurysm developmentAssociated with germline mutationsAortic aneurysm developmentPopulation-based cohort studyPro-inflammatory leukocytesAneurysm growth rateEhlers-Danlos syndromeVariant allele frequencyLoeys-DietzGermline mutationsCytokine productionCohort studyAneurysm developmentEhlers-DanlosAneurysmMendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases
Grewal N, Elefteriades J. Mendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases. JACC Basic To Translational Science 2026, 11: 101517. PMCID: PMC13031055, DOI: 10.1016/j.jacbts.2026.101517.Peer-Reviewed Original ResearchMILITARY-SPECIFIC MANAGEMENT OF ACTIVE DUTY PATIENTS WITH ANEURYSM OR DILATION OF THE ASCENDING AORTA
Antevil J, Wozniak C, Kucera J, Prescher L, Kelly F, Blaker M, Farmer D, Gore R, Grona A, Gustafson J, Kaufman A, Kuckelman J, Mace J, Rojas R, Trachiotis G, Tseng E, Veronneau D, Veronneau M, Elefteriades J. MILITARY-SPECIFIC MANAGEMENT OF ACTIVE DUTY PATIENTS WITH ANEURYSM OR DILATION OF THE ASCENDING AORTA. The Annals Of Thoracic Surgery 2026 PMID: 41819247, DOI: 10.1016/j.athoracsur.2026.02.031.Peer-Reviewed Original ResearchConceptsAscending Aortic DilatationAortic dilatationActive duty military serviceMilitary treatment facilitiesResponse to exerciseHypertensive response to exerciseEvidence-based criteriaPatient-specific limitationsPhysical activityAscending Aortic AneurysmMilitary-specificActive duty patientsMilitary medical practiceMilitary servicemembersActive dutyGenetic associationMedical practiceAortic complicationsCivilian counterpartsAortic pathologyDuty patientsSurgical interventionAortic aneurysmCardiothoracic surgeryConsensus recommendationsThromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era
Strachan S, Zafar M, Ziganshin B, Elefteriades J. Thromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era. Annals Of Thoracic Surgery Short Reports 2026, 4: 22-24. DOI: 10.1016/j.atssr.2025.07.015.Peer-Reviewed Original ResearchAltmetricIliac Artery Involvement Determines Optimal Therapy in Acute Uncomplicated Type B Aortic Dissection
Huckaby L, Dong H, Liu M, Aslam M, Cebull H, Gleason R, Oshinski J, Elefteriades J, Leshnower B. Iliac Artery Involvement Determines Optimal Therapy in Acute Uncomplicated Type B Aortic Dissection. JTCVS Structural And Endovascular 2026, 100110. DOI: 10.1016/j.xjse.2026.100110.Peer-Reviewed Original ResearchConceptsAcute uncomplicated type B aortic dissectionAortic-related deathUncomplicated type B aortic dissectionAortic event-free survivalType B aortic dissectionEvent-free survivalB aortic dissectionAortic interventionIliac involvementIliac arteryAortic-related survivalEfficacy of OMTAnatomic risk factorsAortic centersAortic eventsAortic databaseRetrospective reviewAssociated with freedomOptimal therapyOptimal treatmentPatientsRisk factorsIliacInclusion criteriaDissectionChanges in Aortic Centerline Length and Curvature Predict Aortic Diameter Growth in Chronic Type B Aortic Dissection
Liang X, Dong H, Schmid M, Liu M, Cebull H, Zhang M, Xu S, Naeem M, Oshinski J, Elefteriades J, Gleason R, Leshnower B. Changes in Aortic Centerline Length and Curvature Predict Aortic Diameter Growth in Chronic Type B Aortic Dissection. JTCVS Open 2026, 101680. DOI: 10.1016/j.xjon.2026.101680.Peer-Reviewed Original ResearchConceptsChronic type B aortic dissectionType B aortic dissectionB aortic dissectionComputed tomographyInverse correlationCT-2TBAD patientsAortic diameterAortic volumeSurgical interventionLeft subclavianCT imagesCeliac branchLinear regression analysisAortic centerlineCT-1Diameter growth rateCT-3PatientsCenterline lengthDissectionRegression analysisDiameter growthInverse relationshipPredictorsFrozen elephant trunk for acute type A aortic dissection: long-term outcomes over two decades
Ma W, Chen Y, Chen S, Zhang W, Zheng J, Li Q, Lu L, Zhu J, Piffaretti G, Elefteriades J, Sun L. Frozen elephant trunk for acute type A aortic dissection: long-term outcomes over two decades. European Heart Journal 2026, ehaf1117. PMID: 41614598, DOI: 10.1093/eurheartj/ehaf1117.Peer-Reviewed Original ResearchAltmetricConceptsAcute Type A Aortic DissectionLong-term outcomesLate adverse eventsType A Aortic DissectionDistal aortic dilatationA Aortic DissectionFrozen elephant trunkHemiarch repairLate deathsOperative mortalityAortic dilatationManagement of acute type A aortic dissectionAcute Type A Aortic Dissection RepairRisk factors of late deathSatisfactory long-term survivalIncidence of late adverse eventsElephant trunkRisk factorsReoperation-free survivalTotal arch replacementAcute kidney injuryPropensity-matched pairsLong-term survivalArch repairArch replacementEthnic variation in thoracic aortic dimensions in the general population: a comparison between Indian and Dutch populations
Bacour N, Idhrees M, Samraj J, Grewal S, Velayudhan B, Celik N, Zafar M, Elefteriades J, Grewal N. Ethnic variation in thoracic aortic dimensions in the general population: a comparison between Indian and Dutch populations. Open Heart 2026, 13: e003808. PMID: 41577370, PMCID: PMC12853485, DOI: 10.1136/openhrt-2025-003808.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAortic dimensionsIndian patientsAortic diameterAortic archAortic rootAscending aortaDescending AortaAbdominal aortaDutch patientsRetrospective cohort studySurgical decision-makingIndividualised risk assessmentAortic complicationsConsecutive patientsSurgical thresholdMultivariate linear regression modelCurrent guidelinesSurgical guidelinesSurgical interventionWestern cohortsTreatment strategiesCohort studyAnatomical locationPatientsAorta
2025
Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection
Liu M, Du Y, Cebull H, Wu Y, Mazlout A, Kalyanasundaram A, Agarwal R, Dong H, Piccinelli M, Oshinski J, Elefteriades J, Gleason R, Leshnower B. Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection. Biomechanics And Modeling In Mechanobiology 2025, 25: 11. PMID: 41456249, PMCID: PMC12745335, DOI: 10.1007/s10237-025-02031-9.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsComputational fluid dynamicsWall stress distributionStress distributionStructural stressComputational fluid dynamics simulationsInlet flow conditionsUncomplicated type B aortic dissectionWall shear stressAcute uncomplicated type B aortic dissectionType B aortic dissectionPatient-specific computed tomography angiographyAortic growth rateComputed tomography angiographyPressure distributionShear stressFluid dynamicsB aortic dissectionTransthoracic echocardiographyWall stressLong-term survivalFlow conditionsBrachial blood pressureAcute type B aortic dissectionBaseline computed tomography angiographyThree-dimensionalAcute effects of aerobic exercise on aortic wall stress in thoracic aortic disease
Skow R, Foulkes S, Thompson R, Grenier J, Moulson N, Niederseer D, McKinny J, Elefteriades J, McMurtry M, Haykowsky M. Acute effects of aerobic exercise on aortic wall stress in thoracic aortic disease. AJP Heart And Circulatory Physiology 2025, 330: h338-h347. PMID: 41442224, DOI: 10.1152/ajpheart.00829.2025.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAerobic exerciseAcute effects of aerobic exerciseLight-to-moderate intensity exerciseModerate-intensity aerobic exerciseLight-to-moderate intensityEffects of aerobic exercisePhysical activity guidelinesThoracic aortic diseaseActivity guidelinesAortic wall stressStepping exerciseIntensity exerciseAortic diseaseIndividual risk profileEffective exerciseAcute effectsMechanical efficiencyBiomechanical dataAge-matched controlsExerciseBiomechanical impactDescending AortaRisk profileWell-controlled blood pressureWall stress
Academic Achievements & Community Involvement
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Activities
activity Neither extreme LV dilation nor lack of ischemia on stress testing should contradict CABG for advanced ischemic cardiomyopathy
01/01/2000 - PresentLectureInvited Lecture, “Neither extreme LV dilation nor lack of ischemia on stress testing should contradict CABG for advanced ischemic cardiomyopathy,” 3rd International Congress on Coronary Artery Disease- From Prevention to InterventionDetailsLyon, Auvergne-Rhône-Alpes, FranceAbstract/SynopsisInvited Lecture, “Neither extreme LV dilation nor lack of ischemia on stress testing should contradict CABG for advanced ischemic cardiomyopathy,” 3rd International Congress on Coronary Artery Disease- From Prevention to Intervention
activity Scientific Executive Committee
01/01/1999 - PresentResearchDetailsWashington, Georgia, United StatesAbstract/Synopsis1st International Congress on Heart Disease, International Academy of Cardiology
Honors
honor "top expert in Aortic Aneurysm in the world"
10/15/2020National AwardexpertscapeDetailsUnited Stateshonor Connecticut Magazine Top Docs 2015
04/01/2016Regional AwardConnecticut MagazineDetailsUnited Stateshonor Connecticut Magazine Top Docs 2016
04/03/2015Regional AwardConnecticut MagazineDetailsUnited Stateshonor Socrates Award
01/22/2006National AwardThoracic Residents Association, Thoracic Surgery Directors' Association, and Society of Thoracic Surgeons (Chicago, IL), recognizing exceptional achievement in teaching and mentorship of residents.DetailsUnited Stateshonor Most Outstanding Invited Faculty Presentation- "The Aneurysmatic Patient: From Large to Multifocal."
10/01/2005International Award6th International Advances in Understanding Aortic Diseases MeetingDetailsUnited States
News & Links
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Media
- This image from our Scientific American article conveys vividly the threat represented by aneurysms of the ascending aorta, which are silent until they tear or rupture. If you have a family history of such aneurysms, you should be investigated.
- If you can cross your thumb all the way over the edge of your flat palm, it is possible that you have aneurysm disease. This Thumb-Palm Sign is evidence that the long bones are excessive and the joints are lax.. This should be called to the attention of your doctor. An ECHO or CT scan of your thoracic aorta will probably be needed.
News
- February 28, 2025Source: Yale Ventures
YSM Faculty Win Awards From the Blavatnik Fund for Innovation at Yale
- August 12, 2024
AI Accurately Diagnoses a Genetic Condition From Facial Photographs
- January 02, 2024Source: Medscape
Ascending Thoracic Aortic Aneurysms: A 'Silver Lining'?
- August 17, 2022
AHA Scientific Sessions 2022: Latest updates from Yale Cardiovascular Medicine
Get In Touch
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Contacts
Cardiac Surgery
P.O. Box 208039
New Haven, CT 06520-8039
United States