Jeremy B. Jacox, MD, PhD
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About
Titles
Instructor of Medicine (Medical Oncology)
Biography
Dr. Jeremy B. Jacox, MD, PhD, is an Instructor in the Department of Medicine (Medical Oncology) at Yale School of Medicine and a Medical Oncologist at Smilow Cancer Hospital. He earned his bachelor’s degree from MIT before pursuing his MD and PhD at Yale University School of Medicine. Under the mentorship of Dr. Ruslan Medzhitov, Dr. Jacox completed his doctoral studies in immunobiology, focusing on how intracellular circuits based on growth factors regulate macrophage and fibroblast interactions in both homeostasis and melanoma. His work was supported by a Ruth Kirchstein F30 NRSA Fellowship from the National Cancer Institute, and his PhD dissertation work awarded with Distinction and the MD/PhD Prize from Yale.
Dr. Jacox completed his residency in Internal Medicine at Yale New Haven Hospital through the Physician-Scientist Training Program and continued his specialized training with a fellowship in Hematology/Oncology at Yale Cancer Center. His clinical practice primarily focuses on the treatment of patients with gastrointestinal cancers.
During his post-doctoral fellowship, mentored by Dr. Mandar D. Muzumdar, Dr. Jacox investigated the impact of obesity and extreme dietary conditions on the development of pancreatic cancer. He also explored how targeting the tumor microenvironment can enhance anti-tumor immunity in pancreatic cancer. His research efforts have been supported by the ASCO Conquer Cancer Foundation Young Investigator Award, the Yale Cancer Center Advanced Training Program for Physician Scientists (T32), and the Yale Center for Clinical Investigation (KL2).
Dr. Jacox's interests include community service and his faith, DIY (home and auto), and being with his family. Since meeting his spouse on the Yale shuttle bus, they have raised a family of five precious children together, his greatest accomplishment.
Appointments
Medical Oncology and Hematology
InstructorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow (T32)
- Yale Cancer Biology Institute (2024)
- Clinical Fellow
- Yale School of Medicine (2023)
- Internal Medicine Resident
- Yale New Haven Hospital (2019)
- MD
- Yale School of Medicine, Medicine (2017)
- PhD
- Yale University, Immunobiology (2016)
- BA
- MIT, Physics (2008)
Research
Publications
Featured Publications
Circuit Design Features of a Stable Two-Cell System
Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R. Circuit Design Features of a Stable Two-Cell System. Cell 2018, 172: 744-757.e17. PMID: 29398113, PMCID: PMC7377352, DOI: 10.1016/j.cell.2018.01.015.Peer-Reviewed Original ResearchConceptsMost mammalian tissuesCell-cell contactGrowth factorNegative feedback regulationCell communicationMammalian tissuesCell survivalParacrine signalsFactor exchangeCell typesCell interactionsEnvironmental constraintsExperimental approachTwo-cell systemHomeostasisTissueRegulationCircuit design featuresCell circuitFibroblastsProliferationCellsAnalytical screeningDecoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma
Ruiz C, Garcia C, Jacox J, Lawres L, Muzumdar M. Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma. Life Science Alliance 2023, 6: e202302228. PMID: 37648285, PMCID: PMC10474221, DOI: 10.26508/lsa.202302228.Peer-Reviewed Original ResearchConceptsPancreatic adenocarcinomaPreclinical modelsObesity-cancer connectionObesity-associated cancersMicrobial dysbiosisHormone dysregulationEarly progressionRisk factorsWorldwide prevalencePancreatic tumorigenesisObesityPreclinical modelingCancer typesCancer developmentTumor cellsAdenocarcinomaTumor initiationCancerMetabolic stateCellular metabolismNovel strategyDysbiosisInflammationTherapyPrevalenceEndocytosis as a stabilizing mechanism for tissue homeostasis
Adler M, Mayo A, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U. Endocytosis as a stabilizing mechanism for tissue homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e1926-e1935. PMID: 29429964, PMCID: PMC5828590, DOI: 10.1073/pnas.1714377115.Peer-Reviewed Original Research
2025
Pancreatic Cancer (Chapter 175), Netter's Integrated Review of Medicine, second edition
Jacox, J. Pancreatic Cancer (Chapter 175), Netter's Integrated Review of Medicine: Pathogenesis to Treatment, Second Edition, Ed. B. Leppert, L. Seligman, J. Gribben; Elsevier Press (Philadelphia, PA), release 09-08-2026, ISBN: 9780443378614Chapters
2020
Cryptic Cachexia
Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI. Cryptic Cachexia. New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985, DOI: 10.1056/nejmcps1817531.Peer-Reviewed Original ResearchPancreatic Cancer (Chapter 161), Netter's Integrated Review of Medicine
Jacox, J. Pancreatic Cancer (Chapter 161). In: Netter's Integrated Review of Medicine: Pathogenesis to Treatment; Ed. B. Leppert, C. Kelly; Elsevier Press (Philadelphia, PA), 2020.Chapters
2016
The Heartaches of Cancer Therapy: Acute and Late Cardiotoxicity in Cancer Survivors.
Chokshi S, Jacox J, Hull SC, Sanft T. The Heartaches of Cancer Therapy: Acute and Late Cardiotoxicity in Cancer Survivors. Oncology (Williston Park, N.Y.) 2016, 30: 1095-8. PMID: 27987202.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Teaching & Mentoring
Teaching
Didactic Hematology/Oncology Fellow Lecture Series
LecturerLecture Setting1/1/2025 - PresentForHouse Staff4 Average Instructional Hours Per YearClinical Medical Oncology Teaching & Consult Service
Clinical Faculty MemberInpatient Clinical Setting8/1/2024 - PresentForHouse Staff25 Average Instructional Hours Per YearInpatient didactics and clinical teaching for medical oncology fellows, housestaff (residents), and medical students/trainees
Mentoring
Shravani Shashikant Daptardar
Postgrad associate2025 - PresentSri Sai Ram Chaitanya Vattem
Postgrad associate2023 - 2025Dhruvi Shah
Postgrad associate2021 - 2023Akin Sogunro
Graduate student2021 - Present
Clinical Care
Overview
Jeremy B. Jacox, MD, PhD, is a medical oncologist who specializes in caring for people with gastrointestinal cancers, such as stomach, liver, colorectal, and pancreatic cancers.
As an instructor of medicine (medical oncology) at Yale School of Medicine, Dr. Jacox focuses on strategies to boost the body’s immune defenses against tumors.
He earned his medical and doctoral degrees from Yale School of Medicine, completed his residency in internal medicine at Yale New Haven Hospital, and then pursued a fellowship in oncology-hematology at Yale Cancer Center.
Clinical Specialties
Fact Sheets
Gastrointestinal Cancers
Learn More on Yale MedicineSmall Intestine Adenocarcinoma
Learn More on Yale MedicinePediatric Chemotherapy
Learn More on Yale Medicine
Board Certifications
Medical Oncology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2023
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2021
Yale Medicine News
News & Links
AACR Cancer Immunology Working Group
Interview 11/2024
Media
Interview 11/2024