Hyojin Park
Associate Research ScientistCards
About
Research
Publications
2022
Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling
Edgar LT, Park H, Crawshaw JR, Osborne JM, Eichmann A, Bernabeu MO. Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling. Frontiers In Cell And Developmental Biology 2022, 10: 840066. PMID: 35663401, PMCID: PMC9160721, DOI: 10.3389/fcell.2022.840066.Peer-Reviewed Original ResearchCell polarityCell-cell adherens junctionsAngiogenic remodellingEndothelial cellsAggregation of cellsMixed populationRearrangement of cellsVascular patterningAdherens junctionsForce transmissionALK1 receptorCell migrationAbnormal remodellingNew targetsEC dynamicsCellsMouse retinaRemodellingMigrationPolarityPopulationMutations
2021
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation
Zarkada G, Howard JP, Xiao X, Park H, Bizou M, Leclerc S, Künzel SE, Boisseau B, Li J, Cagnone G, Joyal JS, Andelfinger G, Eichmann A, Dubrac A. Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation. Developmental Cell 2021, 56: 2237-2251.e6. PMID: 34273276, PMCID: PMC9951594, DOI: 10.1016/j.devcel.2021.06.021.Peer-Reviewed Original ResearchConceptsSuperficial retinal vascular plexusRetinal vascular plexusTGF-β receptor IRetinal vascular developmentEndothelial tip cellsMouse neuroretinaIschemic retinopathyRetinal revascularizationVascular malformationsAngiogenic therapyReceptor IUnique transcriptional signatureVascular plexusNeural functionPericyte differentiationTranscriptional signatureComplex branching patternsRevascularizationEndothelial deletionPlexus formationSmad effectorsTissue vascularizationPrimary targetVascular developmentBranching pattern