Hee-Hoon Kim, PhD
Postdoctoral Associate in PathologyAbout
Research
Publications
2026
Glutamate excreted by LepR⁺ BM-MSCs mitigates alcohol-associated liver disease by promoting IL-1R2⁺ monocyte migration
Shim Y, Kim H, Kim M, Lee J, Kim K, Choi S, Chung K, Lee E, Lee K, Byun J, Oh J, Han J, Byun J, Park J, Kim W, Lee Y, Jeong W. Glutamate excreted by LepR⁺ BM-MSCs mitigates alcohol-associated liver disease by promoting IL-1R2⁺ monocyte migration. Clinical And Molecular Hepatology 2026 PMID: 42315151, DOI: 10.3350/cmh.2026.0425.Peer-Reviewed Original ResearchExoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging
Mishra M, Kim H, Youm Y, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw A, Scherer P, Artyomov M, Dixit V. Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. Nature Aging 2026, 6: 1064-1078. PMID: 41974968, PMCID: PMC13190345, DOI: 10.1038/s43587-026-01107-0.Peer-Reviewed Original ResearchImmunometabolic resistors of aging in long-lived golden spiny mice
Kim H, Sagiv-Zangi T, Youm Y, Vardi-Naim H, Dlugos T, Strino F, Kazavchinsky-Bar M, Egulsky L, Bodogai M, Biragyn A, Kluger Y, Kronfeld-Schor N, Dixit V. Immunometabolic resistors of aging in long-lived golden spiny mice. Science Advances 2026, 12: eaec9991. PMID: 41739938, PMCID: PMC12935055, DOI: 10.1126/sciadv.aec9991.Peer-Reviewed Original Research
2025
Metabolic regulation of immunological aging
Kim H, Dixit V. Metabolic regulation of immunological aging. Nature Aging 2025, 5: 1425-1440. PMID: 40813811, DOI: 10.1038/s43587-025-00921-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBinge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Yang K, Kim K, Ryu T, Shim Y, Kim H, Choi S, Kim M, Chung K, Lee E, Lee K, Jeon J, Kim P, Kim Y, Ku T, Jeong H, Nam K, Lim G, Choi D, Kim S, Eun H, Kim W, Jeong W. Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells. Nature Communications 2025, 16: 5546. PMID: 40595616, PMCID: PMC12216207, DOI: 10.1038/s41467-025-60820-3.Peer-Reviewed Original ResearchHormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.
Guan C, Ryu S, Dong M, Youm YH, Mohanty S, Maeda R, Orliaguet L, Kim HH, Dlugos T, Smith SR, Ravussin E, Onyuru J, Wang A, Shaw AC, Hoffman HM, Kluger Y, Sugiura Y, Dixit VD. Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome. BioRxiv 2025 PMID: 40501605, DOI: 10.1101/2025.05.27.656381.Publications for non-academic audiences
2024
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity
Kim H, Dixit V. Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity. Cell Metabolism 2024, 36: 1911-1913. PMID: 39232279, DOI: 10.1016/j.cmet.2024.08.003.Peer-Reviewed Original ResearchCX3CR1+ macrophages interact with hepatic stellate cells to promote hepatocellular carcinoma through CD8+ T cell suppression.
Jeong JM, Choi SE, Shim YR, Kim HH, Lee YS, Yang K, Kim K, Kim MJ, Chung KPS, Kim SH, Byun JS, Eun HS, Jeong WI. CX3CR1+ macrophages interact with hepatic stellate cells to promote hepatocellular carcinoma through CD8+ T cell suppression. Hepatology 2024 PMID: 39028913, DOI: 10.1097/HEP.0000000000001021.Peer-Reviewed Original ResearchCX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression
Jeong J, Choi S, Shim Y, Kim H, Lee Y, Yang K, Kim K, Kim M, Chung K, Kim S, Byun J, Eun H, Jeong W. CX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression. Hepatology 2024, 82: 655-668. PMID: 40833997, PMCID: PMC12356560, DOI: 10.1097/hep.0000000000001021.Peer-Reviewed Original Research
2023
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
Kim H, Shim Y, Kim H, Yang K, Ryu T, Kim K, Choi S, Kim M, Woo C, Chung K, Hong S, Shin H, Suh J, Jung Y, Hwang G, Kim W, Kim S, Eun H, Seong J, Jeong W. xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity. Cell Reports 2023, 42: 112636. PMID: 37310859, DOI: 10.1016/j.celrep.2023.112636.Peer-Reviewed Original Research
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Pathology
310 Cedar Street, LH 212
New Haven, Connecticut 06510
United States
Locations
Brady Memorial Laboratory
Lab
310 Cedar St, Fl 3rd, Rm 316A
New Haven, CT 06510