Elisenda Bueichekú
she/her/hers
Associate Research ScientistCards
About
Research
Publications
2025
Sex and APOE status moderate locus coeruleus network related resilience in preclinical Alzheimer's disease
Lawn T, Diez I, Bueichekú2 E, Van Egroo M, Coughlan G, Buckley R, Rentz D, Johnson K, Sperling R, Sepulcre J, Jacobs H. Sex and APOE status moderate locus coeruleus network related resilience in preclinical Alzheimer's disease. Alzheimer's & Dementia 2025, 21: e107257. PMCID: PMC12791154, DOI: 10.1002/alz70856_107257.Peer-Reviewed Original ResearchAlzheimer's diseasePreclinical Alzheimer Cognitive CompositeLC-FCLocus coeruleusCognitive resilienceCognitive declineAPOE-e4 carriersTask-positiveTau pathologyFrontoparietal control networkResting-state fMRIBrain network architectureAssociated with resiliencePreclinical Alzheimer's diseaseFalse-discovery rate correctionGenetic riskNoradrenergic functionLimbic regionsEffects of sexCognitive compositeFunctional connectivityAPOE-e4Higher Ab levelsControl networkFramewise displacementSpatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueicheku E, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3783.Peer-Reviewed Original ResearchTau accumulationCognitive changesPositron emission tomographyEarly cognitive changesLongitudinal positron emission tomographyAmyloid-betaCortical patternsAlzheimer's diseaseTauAging BrainCognitive scoresPreclinical ADOlder adultsSpatiotemporal levelsEmission tomographyBrainComplex roleAccumulationImaging markersAmyloid
2024
AD Pathology Spreading Detection Using Directional Motifs in Brain Connectomes
Bueichekú E, Diez I, Úbeda A, Kim C, Jacobs H, Sepulcre J. AD Pathology Spreading Detection Using Directional Motifs in Brain Connectomes. Alzheimer's & Dementia 2024, 20: e088834. PMCID: PMC11710655, DOI: 10.1002/alz.088834.Peer-Reviewed Original ResearchTau progressionAlzheimer's diseaseNetwork motifsProgression of tau pathologyContext of ADFeed-forward loopToxic tauTau propagationTau proteinTau pathologyTau accumulationProtein spreadingMotifMotif networkEmergence of cognitive declineMedial prefrontal regionsAmyloid accumulationTauCharacteristics of pathologyMild cognitive impairmentAlzheimer's Disease Neuroimaging InitiativePrefrontal regionsTau PET dataBrain systemsClinical ADSubject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer's Disease
Sánchez C, Diez I, Bueichekú E, Kim C, Grothe M, Sanchez‐Juan P, Sepulcre J. Subject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer's Disease. Alzheimer's & Dementia 2024, 20: e093803. PMCID: PMC11713922, DOI: 10.1002/alz.093803.Peer-Reviewed Original ResearchAlzheimer's diseaseNeurodegenerative diseasesGraph-theory-based frameworkHealthy agingBrain atrophyVoxel-based morphometryGray matter measuresAtrophy phenotypeSingle-subject levelPreclinical Alzheimer's diseaseCognitively normal participantsT1 MRI scansDisease phenotypePhenotypic heterogeneityBrain mechanismsGraph theory approachLongitudinal MRI dataFocal neurodegenerationNormal participantsAtrophy patternsFollow-up timepointsGroups of subjectsPhenotypePreclinical ADStructural similaritySubject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer’s Disease
Sánchez C, Diez I, Bueichekú E, Kim C, Grothe M, Sanchez‐Juan P, Sepulcre J. Subject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer’s Disease. Alzheimer's & Dementia 2024, 20: e089064. PMCID: PMC11715297, DOI: 10.1002/alz.089064.Peer-Reviewed Original ResearchAlzheimer's diseaseNeurodegenerative diseasesGraph-theory-based frameworkHealthy agingBrain atrophyVoxel-based morphometryGray matter measuresAtrophy phenotypeSingle-subject levelPreclinical Alzheimer's diseaseCognitively normal participantsT1 MRI scansDisease phenotypePhenotypic heterogeneityBrain mechanismsGraph theory approachLongitudinal MRI dataFocal neurodegenerationNormal participantsAtrophy patternsFollow-up timepointsGroups of subjectsPhenotypePreclinical ADStructural similarityCortical hubs of highly superior autobiographical memory
Orwig W, Diez I, Bueichekú E, Pedale T, Parente F, Campolongo P, Schacter D, Sepulcre J, Santangelo V. Cortical hubs of highly superior autobiographical memory. Cortex 2024, 179: 14-24. PMID: 39094240, DOI: 10.1016/j.cortex.2024.06.018.Peer-Reviewed Original ResearchConceptsSuperior autobiographical memoryAutobiographical memoryCortical hubsWhole-brain connectivity analysisPattern of increased connectivityResting-state fMRI dataWhole-brain analysisAutobiographical memory networkPosterior cingulate cortexMidline areaSeed-based analysisFunctional brain connectivityGraph theory analysisCingulate cortexNeural underpinningsNeuroimaging studiesEnhance memoryRemembering eventsBrain regionsControl participantsConnectivity analysisFMRI dataBrain connectivityCortical regionsWhole-brainLower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals
Engels‐Domínguez N, Riphagen J, Van Egroo M, Koops E, Smegal L, Becker J, Prokopiou P, Bueichekú E, Kwong K, Rentz D, Salat D, Sperling R, Johnson K, Jacobs H. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Annals Of Neurology 2024, 96: 650-661. PMID: 39007398, PMCID: PMC11534559, DOI: 10.1002/ana.27022.Peer-Reviewed Original ResearchConceptsLocus coeruleus integrityClinical Dementia RatingBeta-amyloidHippocampal volumePositron emission tomographyClinical progressionAsymptomatic individualsReceiver operating characteristic analysisCortical tau depositionCox proportional hazards modelsLociAccumulation of pathologyBeta-amyloid burdenAsymptomatic older individualsMild cognitive impairmentTau depositionProportional hazards modelTau signalEC tauLocus coeruleusPET-negativeEntorhinal tauCognitive impairmentScreening instrumentCognitive declineTau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Diez I, Ortiz-Terán L, Ng T, Albers M, Marshall G, Orwig W, Kim C, Bueichekú E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs H, Sepulcre J. Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging. Nature Communications 2024, 15: 4809. PMID: 38844444, PMCID: PMC11156945, DOI: 10.1038/s41467-024-48462-3.Peer-Reviewed Original ResearchConceptsOlfactory systemMedial temporal lobe structuresCognitively normal older adultsOlfactory pathwayOdor identification deficitsNormal older adultsTemporal lobe structuresTau accumulationAlzheimer's diseaseIdentification deficitsGenetic vulnerabilityLobe structuresCortical systemsOlfactory circuitsAssociated with tau accumulationIdentification measuresCortical neurodegenerationOlder adultsPiB-PETTau propagationTau progressionPathological aggregationGenetic backgroundDiffusion MRIPredictive powerLocus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease
Pahl J, Prokopiou P, Bueichekú E, Schultz A, Papp K, Farrell M, Rentz D, Sperling R, Johnson K, Jacobs H. Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease. Alzheimer's Research & Therapy 2024, 16: 119. PMID: 38822365, PMCID: PMC11140954, DOI: 10.1186/s13195-024-01485-w.Peer-Reviewed Original ResearchConceptsDigit Symbol Substitution TestLC integrityLocus coeruleusAttentional declineCognitive declineDigit-symbol substitution test performanceHarvard Aging Brain StudyResting-state functional MRILocus coeruleus integrityNetwork functional connectivityAlzheimer's diseaseAging Brain StudyPreclinical Alzheimer's diseaseCognitive follow-upYears of educationNeural reserveNeural correlatesAttentional performanceAttention deficitMixed effects analysisCortical target regionsSubstitution TestCognitive changesFrontoparietal connectivityFunctional MRISpatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú E, Diez I, Kim C, Becker J, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature Aging 2024, 4: 625-637. PMID: 38664576, PMCID: PMC11108787, DOI: 10.1038/s43587-024-00626-y.Peer-Reviewed Original ResearchConceptsTau spreadingDisease pathologyGene expression profilesTau positron emission tomography imagingTranscriptomic informationLocus coeruleusHyperphosphorylated tauAlzheimer's disease pathologyTau accumulationBiological functionsExpression profilesTau depositionGenetic featuresCortical tauAlzheimer's diseaseLocus coeruleus integrityTauAssociated with lower cognitive performanceLower cognitive performanceTransport regulationLC integrityCognitive performanceAlzheimerAllocortical regionsSpatiotemporal patterns