Dong-il Kwon
Postdoctoral FellowAbout
Research
Publications
2025
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Kwon D, Mao T, Israelow B, Santos Guedes de Sá K, Dong H, Iwasaki A. Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice. Nature Immunology 2025, 26: 908-919. PMID: 40360777, PMCID: PMC12133566, DOI: 10.1038/s41590-025-02156-0.Peer-Reviewed Original ResearchMucosal immunityIgA responsesMemory CD4+ T cellsInduce robust mucosal immunitySARS-CoV-2 spike proteinCD4+ T cellsLocal protective immune responseRobust mucosal immunityRespiratory tractMRNA-LNP vaccinesIgA-secreting plasma cellsB cell recruitmentInduce mucosal immunityPre-existing immunityProtective immune responsesLower respiratory tractRecombinant SARS-CoV-2 spike proteinLocal IgA responseIntranasal boosterMucosal boostingIntranasal boostSpike proteinMRNA-LNPChemokines CXCL9T cells
2024
Fc-fused IL-7 provides broad antiviral effects against respiratory virus infections through IL-17A-producing pulmonary innate-like T cells.
Kwon DI, Park S, Jeong YL, Kim YM, Min J, Lee C, Choi JA, Choi YH, Kong HJ, Choi Y, Baek S, Lee KJ, Kang YW, Jeong C, You G, Oh Y, Im SK, Song M, Kim JK, Chang J, Choi D, Lee SW. Fc-fused IL-7 provides broad antiviral effects against respiratory virus infections through IL-17A-producing pulmonary innate-like T cells. Cell Rep Med 2024, 5: 101362. PMID: 38232693, DOI: 10.1016/j.xcrm.2023.101362.Peer-Reviewed Original Research
2022
Dietary antigens suppress the proliferation of type 2 innate lymphoid cells by restraining homeostatic IL-25 production.
Lee M, Ko HJ, Hong SW, Park J, Ham S, Kim M, Kwon DI, Lee MS, Roh TY, Soon Kim K, Lee YJ. Dietary antigens suppress the proliferation of type 2 innate lymphoid cells by restraining homeostatic IL-25 production. Sci Rep 2022, 12: 7443. PMID: 35523930, DOI: 10.1038/s41598-022-11466-4.Peer-Reviewed Original ResearchHomeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival.
Kwon DI, Park ES, Kim M, Choi YH, Lee MS, Joo SH, Kang YW, Lee M, Jo SB, Lee SW, Kim JK, Lee YJ. Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival. Nat Commun 2022, 13: 1418. PMID: 35301301, DOI: 10.1038/s41467-022-29032-x.Peer-Reviewed Original Research
2021
Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia.
Yang C, Kwon DI, Kim M, Im SH, Lee YJ. Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia. Front Immunol 2021, 12: 645741. PMID: 33854510, DOI: 10.3389/fimmu.2021.645741.Peer-Reviewed Original Research
2020
Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells.
Lee M, Lee E, Han SK, Choi YH, Kwon DI, Choi H, Lee K, Park ES, Rha MS, Joo DJ, Shin EC, Kim S, Kim JK, Lee YJ. Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells. Nat Commun 2020, 11: 4367. PMID: 32868763, DOI: 10.1038/s41467-020-18155-8.Peer-Reviewed Original ResearchDysbiotic oral microbiota and infected salivary glands in Sjögren's syndrome.
Alam J, Lee A, Lee J, Kwon DI, Park HK, Park JH, Jeon S, Baek K, Lee J, Park SH, Choi Y. Dysbiotic oral microbiota and infected salivary glands in Sjögren's syndrome. PLoS One 2020, 15: e0230667. PMID: 32208441, DOI: 10.1371/journal.pone.0230667.Peer-Reviewed Original Research
2017
Lineage Differentiation Program of Invariant Natural Killer T Cells.
Kwon DI, Lee YJ. Lineage Differentiation Program of Invariant Natural Killer T Cells. Immune Netw 2017, 17: 365-377. PMID: 29302250, DOI: 10.4110/in.2017.17.6.365.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
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