Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsDavid Glahn, PhD
Professor Adjunct of PsychiatryDownloadHi-Res Photo
About
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Titles
Professor Adjunct of Psychiatry
Professor of Psychology
Biography
Dr. David Glahn joined Yale’s Department of Psychiatry and the Olin Neuropsychiatry Research Center in 2008. He received his doctorate in clinical psychology from the University of Pennsylvania in 2000 and completed a post-doctoral fellowship at the University of California at Los Angeles. From 2002 to 2008, Glahn was faculty at the University of Texas Health Science Center San Antonio, where he created a psychiatric genetics and imaging research program.
The primary aim of Glahn’s laboratory is to discover genes that predispose affective and psychotic disorders like major depression, bipolar disorder and schizophrenia. To achieve this aim, he develops and applies neuroanatomic, functional neuroimaging, and neurocognitive endophenotypes in large-scale family-based studies. Glahn co-direct the Neurocognition, Neurocomputation and Neurogenetics (n3) Division of the Department of Psychiatry at Yale University Medical School, and the Affective Disorders and Psychosis (ADAPTING) laboratory at the Olin Neuropsychiatric Research Center. In this capacity, he supervises an 11-strong research team comprised of junior faculty, postdoctoral fellows and research assistants. Glahn collaborates with investigators locally at Yale/Olin, nationally and internationally in connection to neuroimaging, neurocognition and genomic research.
Last Updated on April 07, 2025.
Departments & Organizations
- Glahn Lab
- Olin Neuropsychiatry Research Center
- Yale Global Mental Health Program
- Yale Ventures
Education & Training
- MA
- Yale University, Privatim (2015)
- Post-Doctoral Fellow
- University of California Los Angeles (2002)
- PhD
- University of Pennsylvania, Psychology (2000)
- MA
- University of Pennsylvania, Psychology (1997)
- BS
- Drexel University, Psychology (1993)
Research
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Overview
Medical Research Interests
Aging; Bipolar Disorder; Child Development; Depressive Disorder, Major; Genetics; Genetics, Behavioral; Neuroimaging; Neuropsychology; Psychiatry and Psychology; Schizophrenia
ORCID
0000-0002-4749-6977
Research at a Glance
Yale Co-Authors
Frequent collaborators of David Glahn's published research.
Publications Timeline
A big-picture view of David Glahn's research output by year.
Research Interests
Research topics David Glahn is interested in exploring.
Godfrey Pearlson, MA, MBBS
John Krystal, MD
John D Murray, PhD
Kevin Sheth, MD
Alecia Dager, PhD
Janitza Montalvo-Ortiz, PhD
42Publications
251Citations
Schizophrenia
Neuroimaging
Child Development
Aging
Publications
2025
Structural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis
Gray J, Price L, Franklin C, Leonardo C, Chiang F, Choi K, Blangero J, Glahn D, Mayberg H, Fox P. Structural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis. Brain Organoid And Systems Neuroscience Journal 2025, 3: 96-106. DOI: 10.1016/j.bosn.2025.04.008.Peer-Reviewed Original ResearchCitationsAltmetricConceptsVoxel-based morphometrySubgroup of MDD patientsSubgroups of MDDStructural equation modelingMDD patientsDepressive disorderResting-state functional magnetic resonance imagingAbnormalities of brain structureVoxel-based morphometry analysisFunctional magnetic resonance imagingMagnetic resonance imagingMDD patient groupGray matter densityBiomarkers of MDDNeuroimaging-based biomarkersClinical subgroupsMass-univariate analysesMass-univariate methodsMeta-analytic datasetNeuroimaging effectsNeuroimaging studiesMDDBrain areasBrain structuresMeta-analyticallyCharacterizing the Social Epigenome in Mexican Patients with Early-Onset Psychosis
Ruiz-Ramos D, Martínez-Magaña J, Juárez-Rojop I, Nolasco-Rosales G, Sosa-Hernández F, Cruz-Castillo J, Cavazos J, Callejas A, Zavaleta-Ramírez P, Zorrilla-Dosal J, Lanzagorta N, Nicolini H, Montalvo-Ortiz J, Glahn D, Genis-Mendoza A. Characterizing the Social Epigenome in Mexican Patients with Early-Onset Psychosis. Genes 2025, 16: 591. PMID: 40428414, PMCID: PMC12111507, DOI: 10.3390/genes16050591.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsEarly-onset psychosisRisk scoreEpigenetic ageEpigenome-wide association studiesAssociation studiesYears of educationShort life expectancyMexican patientsPsychiatric admissionsAssociation of DNA methylationSocial epigenomicsYears of schoolingAccelerated Epigenetic AgingLife expectancyAssociated with panic disorderEnvironmental exposuresEarly-onsetGlobal functioningClinical characteristicsClinical manifestationsDNA methylationAgeEpigenetic mechanismsPsychosisManifestation of psychosisThalamo-cortical structural co-variation networks are related to familial risk for schizophrenia in the context of lower nuclei volume estimates in patients: an ENIGMA study
Lella A, Antonucci L, Passiatore R, Bellantuono L, Selvaggi P, Popolizio T, Di Sciascio G, Saponaro A, Ricci P, Altamura M, Blasi G, Rampino A, Vriend C, Calhoun V, Rootes-Murdy K, Goldman A, Baeza I, Castro-Fornieles J, Sugranyes G, De la Serna E, Pomarol-Clotet E, Fatjó-Vilas M, Salvador R, Karuk A, Fuentes-Claramonte P, Glahn D, Rodrigue A, Blangero J, Wang L, Lee T, Einenkel K, Hamers S, Gruber O, Preda A, Chung Y, Odkhuu S, Vallée C, Dazzan P, Marcelis M, Michielse S, Brosch K, Stein F, Nenadić I, Straube B, Thomas-Odenthal F, Kircher T, Carruthers S, Rossell S, Sumner P, Van Rheenen T, Demro C, Ramsay I, Sponheim S, Lencer R, Meinert S, Hahn T, Dannlowski U, Grotegerd D, Ciccarelli M, Iasevoli F, Pontillo G, Pearlson G, Cobia D, Piras F, Banaj N, Vecchio D, Barendse M, van Haren N, Jo H, Sim K, Quidé Y, Green M, Slate R, Cecere G, Omlor W, Homan S, Homan P, Thomopoulos S, Manzari A, Bellomo A, Turner J, van Erp T, Thompson P, Bertolino A, Pergola G. Thalamo-cortical structural co-variation networks are related to familial risk for schizophrenia in the context of lower nuclei volume estimates in patients: an ENIGMA study. Biological Psychiatry 2025 PMID: 40345610, DOI: 10.1016/j.biopsych.2025.03.027.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNeurotypical controlsThalamic alterationsFamilial riskAssociated with familial riskRandom-effects meta-analysesFamilial high riskStructural brain differencesStructural MRI scansENIGMA studyStructural co-variance networkThalamo-corticalHigh riskMRI scansNeurobiological correlatesBrain differencesENIGMA consortiumSchizophreniaFHRThalamusCross-sectional sampleTrait-dependentGenetic riskThalamic subdivisionsMeta-analysesRisk traitsLifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
Zhu A, Nir T, Javid S, Villalón-Reina J, Rodrigue A, Strike L, de Zubicaray G, McMahon K, Wright M, Medland S, Blangero J, Glahn D, Kochunov P, Williamson D, Håberg A, Thompson P, Jahanshad N. Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI. Scientific Data 2025, 12: 748. PMID: 40328780, PMCID: PMC12056076, DOI: 10.1038/s41597-025-05028-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts5. Discordant Cortical Patterns Between Psychiatric Disorders and Corresponding Common and Rare Genetic Risks
Kumar K, Liao Z, Kopal J, Moreau C, Ching C, Snyder W, Jean-Louis M, Martin C, Huguet G, Kushan-Wells L, Dos Santos Silva A, Van Den Bree M, Owen M, Hall J, Sønderby I, Andreassen O, Glahn D, Raznahan A, Bearden C, Paus T, Thompson P, Jacquemont S. 5. Discordant Cortical Patterns Between Psychiatric Disorders and Corresponding Common and Rare Genetic Risks. Biological Psychiatry 2025, 97: s75-s76. DOI: 10.1016/j.biopsych.2025.02.195.Peer-Reviewed Original Research32. Cognitive Impairment in Patients With Early Onset Psychosis and Their Siblings: Age and Sex Differences
Mollon J, Lanzagorta N, Mathias S, Rodrigue A, Knowles E, Deaso E, Saavedra J, Cadavid L, Polat N, Nieto M, Brownstein C, D’Angelo E, Deo A, Gonzalez-Heydrich J, Sarmiento E, Walsh C, Almasy L, Nicolini H, Glahn D. 32. Cognitive Impairment in Patients With Early Onset Psychosis and Their Siblings: Age and Sex Differences. Biological Psychiatry 2025, 97: s87-s88. DOI: 10.1016/j.biopsych.2025.02.222.Peer-Reviewed Original Research529. Thalamo-Cortical Structural Co-Variation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An Enigma Study
Lella A, Antonucci L, Sugranyes G, Pomarol-Clotet E, Glahn D, Lee T, Gruber O, Chung Y, Kircher T, Van Rheenen T, Dannlowski U, Iasevoli F, Pearlson G, Piras F, Sim K, Sponheim S, Marcelis M, Green M, Turner J, van Erp T, Thompson P, Bertolino A, Pergola G. 529. Thalamo-Cortical Structural Co-Variation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An Enigma Study. Biological Psychiatry 2025, 97: s315-s316. DOI: 10.1016/j.biopsych.2025.02.768.Peer-Reviewed Original Research42. Whole Genome Sequence Study of Multiplex Psychosis Pedigrees
Knowles E, Peralta J, Thomson P, Nimgaonkar V, McMahon F, McIntosh A, Almasy L, Mathias S, Gur R, Curran J, Henriette R, Contreras J, McCarthy N, Badcock J, Blangero J, Gur R, Glahn D. 42. Whole Genome Sequence Study of Multiplex Psychosis Pedigrees. Biological Psychiatry 2025, 97: s92. DOI: 10.1016/j.biopsych.2025.02.232.Peer-Reviewed Original Research496. Psychosis-Specific Effects of Trauma in Early Onset and Adult Onset Psychosis
Saavedra J, Mathias S, Lanzagorta N, Mollon J, Knowles E, Deaso E, Cadavid L, Brownstein C, D'Angelo E, Gonzalez-Heydrich J, Sarmiento E, Bustamante C, Walsh C, Almasy L, Nicolini H, Pearlson G, Glahn D, Rodrigue A. 496. Psychosis-Specific Effects of Trauma in Early Onset and Adult Onset Psychosis. Biological Psychiatry 2025, 97: s302. DOI: 10.1016/j.biopsych.2025.02.734.Peer-Reviewed Original ResearchDifferential gene expression study in whole blood identifies candidate genes for psychosis in African American individuals
Knowles E, Peralta J, Rodrigue A, Mathias S, Mollon J, Leandro A, Curran J, Blangero J, Glahn D. Differential gene expression study in whole blood identifies candidate genes for psychosis in African American individuals. Schizophrenia Research 2025, 280: 85-94. PMID: 40267851, PMCID: PMC12107465, DOI: 10.1016/j.schres.2025.04.018.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsGene expressionGenome-wide associationDifferential gene expression studiesGene co-expression network analysisWeighted gene co-expression network analysisCo-expression network analysisGene expression phenotypesIndividuals of European descentOverrepresentation of biological processesGene expression studiesGene expression analysisAfrican American ancestryGenomic regionsPsychosis-spectrum disordersRNA-seqAfrican American individualsPopulation stratificationAssociated with psychosisEtiology of psychosisSignificant genesCellular functionsExpression phenotypesExpression studiesAmerican ancestryExpression analysis
Academic Achievements & Community Involvement
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Activities
activity Yale Scholar Awards Committee
05/03/2015 - PresentCommitteesMemberDetailsMemberactivity Yale Center for Clinical Investigation
04/30/2015 - PresentCommitteesMemberDetailsRevieweractivity Burlingame Award Selection Committee
04/30/2000 - PresentCommitteesMemberDetailsMemberactivity Monash Biomedical Imaging Center, Monash University
04/30/2012 - PresentCommitteesMemberDetailsMember, External Advisory Boardactivity Human Brain Mapping (Journal)
04/30/2015 - PresentPublic ServiceMemberDetailsEditorial Board
Honors
honor Joel Elkes Research Award
12/12/2016International AwardAmerican College of Neuropsychopharmacology (ACNP)DetailsUnited Stateshonor Independent Investigator Award
01/01/2013International AwardNational Alliance for Research on Schizophrenia and Depression (NARSAD)DetailsUnited Stateshonor Theodore Reich Research Award
05/01/2011International AwardInternational Society for Psychiatric GeneticsDetailsUnited Stateshonor A.E. Bennett Neuropsychiatric Research Award
05/01/2010International AwardSociety for Biological PsychiatryDetailsUnited Stateshonor Young Investigator Award
05/02/2005International AwardNational Alliance for Research on Schizophrenia and Depression (NARSAD)DetailsUnited States
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