Collin Heer, PhD
Associate Research Scientist in Therapeutic RadiologyAbout
Research
Publications
2025
Auranofin Synergistically Sensitizes KEAP1 Mutant and WT NSCLCs to P-AscH--induced Cell Killing by a Thiol and H2O2 Dependent Mechanism
Sho S, Heer C, Pulliam C, Tomanek-Chalkley A, Marren D, Wasimi S, Lengel A, Gentles M, Dupuy A, Spitz D. Auranofin Synergistically Sensitizes KEAP1 Mutant and WT NSCLCs to P-AscH--induced Cell Killing by a Thiol and H2O2 Dependent Mechanism. Free Radical Biology And Medicine 2025, 240: s42. DOI: 10.1016/j.freeradbiomed.2025.10.122.Peer-Reviewed Original ResearchSomatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs
McGivney G, Brockman Q, Borcherding N, Scherer A, Rauckhorst A, Gutierrez W, Solst S, Heer C, Warrier A, Floyd W, Kirsch D, Knepper-Adrian V, Laverty E, Roughton G, Spitz D, Taylor E, Dodd R. Somatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs. Science Advances 2025, 11: eadu2906. PMID: 40802750, PMCID: PMC12346278, DOI: 10.1126/sciadv.adu2906.Peer-Reviewed Original ResearchMitoregulin Promotes Cell Cycle Progression in Non-Small Cell Lung Cancer Cells
. Mitoregulin Promotes Cell Cycle Progression in Non-Small Cell Lung Cancer Cells. International Journal Of Molecular Sciences 2025, 26: 1939. PMID: 40076565, PMCID: PMC11899852, DOI: 10.3390/ijms26051939.Peer-Reviewed Original Research
2021
HGG-33. EXPLOITING METABOLIC DEFECTS WITH NAMPT INHIBITORS IN DIPG
Muraleedharan R, Heer C, Sundam R, Brenner C. HGG-33. EXPLOITING METABOLIC DEFECTS WITH NAMPT INHIBITORS IN DIPG. Neuro-Oncology 2021, 23: i24-i24. PMCID: PMC8168214, DOI: 10.1093/neuonc/noab090.097.Peer-Reviewed Original ResearchAvasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide
. Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide. Science Translational Medicine 2021, 13 PMID: 33980575, PMCID: PMC8314936, DOI: 10.1126/scitranslmed.abb3768.Peer-Reviewed Original ResearchInhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide‐induced microglial and astrocytic neuroinflammation by increasing NAD+
. Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide‐induced microglial and astrocytic neuroinflammation by increasing NAD+. Journal Of Neurochemistry 2021, 158: 311-327. PMID: 33871064, PMCID: PMC8282715, DOI: 10.1111/jnc.15367.Peer-Reviewed Original Research
2020
Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate.
. Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate. Journal Of Experimental Pathology 2020, 1: 60-70. PMID: 33585836, PMCID: PMC7876477.Peer-Reviewed Original ResearchCoronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity
Heer C, Sanderson D, Voth L, Alhammad Y, Schmidt M, Trammell S, Perlman S, Cohen M, Fehr A, Brenner C. Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. Journal Of Biological Chemistry 2020, 295: 17986-17996. PMID: 33051211, PMCID: PMC7834058, DOI: 10.1074/jbc.ra120.015138.Peer-Reviewed Original ResearchLetting off electrons to cope with metabolic stress
. Letting off electrons to cope with metabolic stress. Nature Metabolism 2020, 2: 485-486. PMID: 32694728, DOI: 10.1038/s42255-020-0207-8.Peer-Reviewed Original Research
2018
The Radioprotector GC4419 Ameliorates Radiation Induced Lung Fibrosis While Enhancing the Response of Non-Small Cell Lung Cancer Tumors to High Dose per Fraction Radiation Exposures
Story M, Sishc B, Polsdofer E, Bloom D, Heer C, Spitz D, Saha D. The Radioprotector GC4419 Ameliorates Radiation Induced Lung Fibrosis While Enhancing the Response of Non-Small Cell Lung Cancer Tumors to High Dose per Fraction Radiation Exposures. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: s187. DOI: 10.1016/j.ijrobp.2018.07.071.Peer-Reviewed Original Research
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