Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsArgyrios Tzouvelekis, MD, PhD
Associate Professor Adjunct of Medicine (Pulmonary, Critical Care and Sleep Medicine)About
Research
Publications
2026
When cancer treatment affects the lungs: a clinical overview on pulmonary toxicity induced by new cancer drugs
Komninos D, Psarros E, Theochari E, Tsirikos G, Sampsonas F, Tzouvelekis A. When cancer treatment affects the lungs: a clinical overview on pulmonary toxicity induced by new cancer drugs. Expert Review Of Respiratory Medicine 2026, ahead-of-print: 1-14. PMID: 41717783, DOI: 10.1080/17476348.2026.2631816.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsCheckpoint inhibitorsPulmonary toxicityAdverse eventsLung cancerTherapeutic landscape of lung cancerHigh indexHigh index of suspicionTherapeutic landscapePulmonary adverse eventsSpectrum of adverse eventsTyrosine kinase inhibitorsIndex of suspicionClinical trial dataClinically significant concernsComprehensive literature searchPulmonary complicationsPulmonary eventsSurvival outcomesTargeted therapySpecialized centersKinase inhibitorsCancer therapyTreatment continuationPneumonitisThe Fibrotic–Cancer Continuum in IPF: Shared Mechanisms, Clinical Implications and Therapeutic Challenges
Tsiri P, Kouvela M, Papaioannou O, Sotiropoulou V, Katsaras M, Syrigos N, Sampsonas F, Tzouvelekis A. The Fibrotic–Cancer Continuum in IPF: Shared Mechanisms, Clinical Implications and Therapeutic Challenges. Life 2026, 16: 295. PMID: 41752931, PMCID: PMC12941835, DOI: 10.3390/life16020295.Peer-Reviewed Original ResearchPatient survivalPulmonary fibrosisLung cancerIdiopathic pulmonary fibrosisLethal lung diseaseMolecular pathogenetic mechanismsAnti-fibrotic agentsLung cancer developmentPotential risk factorsAnti-cancer drugsLung tumorsTherapeutic algorithmTherapeutic challengeIPF treatmentLung scarringLung diseasePathogenetic mechanismsDisease entityMesenchymal phenotypeEarly diagnosisCancer developmentTherapeutic approachesRisk factorsQuality of lifeLungPost-stroke sleep disordered breathing and the effect of positive airway pressure treatment. A systematic review and meta-analysis of randomized control trials
Papalexatos D, Sampsonas F, Lykouras D, Karamouzos V, Doulberis M, Karkoulias K, Steiropoulos P, Katsaras M, Tzouvelekis A. Post-stroke sleep disordered breathing and the effect of positive airway pressure treatment. A systematic review and meta-analysis of randomized control trials. Sleep Medicine 2026, 138: 107605. DOI: 10.1016/j.sleep.2025.107605.Peer-Reviewed Original ResearchLipidemic Profile of Patients with Non-Small Cell Lung Cancer and Its Association with Driver Mutations: A Tertiary Center Retrospective Study
Lagadinou M, Efthymiou D, Sampsonas F, Karidis P, Marlafeka I, Adamopoulou E, Michailides C, Bosgana P, Papaioannou O, Psarros E, Tsiri P, Sotiropoulou V, Katsaras M, Tzelepi V, Tzouvelekis A, Marangos M. Lipidemic Profile of Patients with Non-Small Cell Lung Cancer and Its Association with Driver Mutations: A Tertiary Center Retrospective Study. Cancers 2026, 18: 374. PMID: 41681847, PMCID: PMC12896490, DOI: 10.3390/cancers18030374.Peer-Reviewed Original ResearchNon-small cell lung cancerNon-small cell lung cancer patientsSquamous cell carcinomaCell lung cancerCell carcinomaHDL levelsLipidemic profileLung cancerDriver mutationsSquamous cell carcinoma patientsCell carcinoma patientsReal-world cohortBenjamini-Hochberg false discovery rateLow-density lipoprotein (LDL)Associated with driver mutationsProfile of patientsSerum lipid parametersStatistically significant differenceCarcinoma patientsHistological subtypesPrognostic roleRetrospective studyNon-smallPredominant subtypeLipid parameters
2025
Diagnosis and treatment of sarcoidosis with nephrocalcinosis: A case report
Tryfona F, Psarros E, Komninos D, Tzelepi V, Sampsonas F, Tzouvelekis A. Diagnosis and treatment of sarcoidosis with nephrocalcinosis: A case report. Pneumon 2025, 38: 1-4. DOI: 10.18332/pne/216113.Peer-Reviewed Original ResearchEfficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial
Massonnaud C, Peiffer-Smadja N, Poignard P, Jamard S, Goehringer F, Danion F, Reignier J, de Castro N, Garot D, Lapique E, Lacombe K, Tolsma V, Faure E, Malvy D, Staub T, Courjon J, Cazenave-Roblot F, Riise A, Leturnier P, Martin-Blondel G, Roger C, Akinosoglou K, Le Moing V, Piroth L, Sellier P, Lescure X, Trøseid M, Clevenbergh P, Dalgard O, Gallien S, Gousseff M, Loubet P, Vardon-Bounes F, Visée C, Belkhir L, Botelho-Nevers É, Cabié A, Kotanidou A, Lanternier F, Rouveix-Nordon E, Silva S, Thiery G, Carcelain G, Diallo A, Mercier N, Terzić V, Bouscambert-Duchamp M, Gaymard A, Destras G, Josset L, Belhadi D, Billard N, Guedj J, Han T, Couffin-Cadiergues S, Dechanet A, Delmas C, Esperou H, Fougerou-Leurent C, Le Mestre S, Métois A, Noret M, Bally I, Dergan-Dylon S, Tubiana S, Kalif O, Bergaud N, Leveau B, Eustace J, Greil R, Hajdu E, Halanova M, Paiva J, Piekarska A, Baño J, Tonby K, Trojánek M, Tsiodras S, Unal S, Burdet C, Costagliola D, Yazdanpanah Y, Mentré F, Ader F, Hites M, Couffin-Cadièrgues S, Espérou H, Investigators, Egle A, Egle A, Greil R, Grundbichler M, Hauck V, Ratzinger L, De Bièvre F, Hites M, Jacobs F, Larranaga E, Pierre E, Verschelden G, Clevenbergh P, Leemans S, Maillart E, Belkhir L, De Greef J, Yombi J, Colin I, Visée C, Leys M, Samaey P, Cox J, Messiaen P, Van der Hilst J, Van Halem K, Badaev Z, Grebenyuk V, Trojanek M, Bednarova V, Chaloupka A, Dolezalova K, Nagy A, Rezek M, Soucek F, Trckova A, Bauvois A, Charron C, Coutte L, Geri G, Godement M, Greffe S, Jouffroy R, Jullien E, Kahn J, Pepin M, Petit M, Rouveix-Nordon E, Andrejak C, Basille D, Joseph C, Lanoix J, Lion S, Schmit J, Soriot-Thomas S, Belzunce C, Bougon D, Charretier P, Chouquer R, Dorez D, Escudier E, Gay S, Hautefeuille S, Janssen C, Levrat A, Macheda G, Maillet M, Manuel A, Merlet A, Muller M, Panh S, Piet E, Rougon M, Sirodot M, Tolsma V, Varache C, Vitrat V, Bouiller K, Chirouze C, Ilic D, Navellou J, Tissot N, Bessi S, Chantalat C, Jaureguiberry S, Bachelard A, Bertin C, Collias L, Fleurot O, Peiffer-Smadja N, Isernia V, Lescure X, Mallo B, Proux C, Yazdanpanah Y, Cazanave C, Boyer P, Boyer A, Bui H, Carrier C, Clouzeau B, Desclaux A, Ducours M, Gil-Jardine C, Gros A, Gruson D, Leitao J, Lescure M, Malvy D, Neau D, Poteau M, Sazio C, Bourrachot C, Corbin V, Grapin K, Jacomet C, Laurichesse H, Lesens O, Mrozek N, Sauvat L, Simon A, Theis C, Vidal M, Gravier S, Ion C, Kayser D, Martinot M, Mohseni-Zadeh M, Guerpillon B, Khatchatourian L, Saidani N, Talarmin J, Dollat M, Gambier N, Khuong M, Tandjaouilambiotte Y, Buisson M, Catherine F, Chavanet P, Duong M, Esteve C, Mahy S, Piroth L, Andreu P, Aptel F, Charles P, Labruyere M, Prin S, Quenot J, Roudaut J, Aswad N, Beltramo G, Berrier A, Bonniaud P, Dignoire C, Favrolt N, Georges M, Rabec C, Spanjaard M, Guillaud C, Dubos G, Lelievre J, Mahevas M, Gallien S, Mehawej H, Melica G, Michel M, Runyo F, Saada N, Vindrios W, Delcey V, Devatine S, Kopp A, Manda V, Munier A, Sellier P, Salmon-Rousseau A, Faure E, Ader F, Alfaiate D, Allaouchiche B, Becker A, Benech N, Bert A, Berton E, Bitker L, Bohe J, Braun E, Cannesson O, Chabert P, Chauvelot P, Chidiac C, Flores R, Conrad A, Devouassoux G, Ferry T, Gormand F, Granger A, Grumet P, Jay L, Joffredo E, Jullien T, Kiakouama L, Levrad M, Lucena e Silva I, Mezidi M, Miailhes P, Pelton O, Perpoint T, Petitjean T, Philit F, Pouderoux C, Richard J, Richard-Colmant G, Roux S, Seve P, Thiolliere F, Fillit C, Valour F, Vassal O, Wallet F, Yonis H, Abel S, Bigeard B, Cabié A, Cabras O, Guitteaud K, Lehoux M, Marquise A, Pierre-François S, Turmel J, Abdelmagid H, Hanisch A, Lacassin-Beller F, Mirabel M, Cerezo I, Sement A, Boulle C, Lejeune J, Le Moing V, Morquin D, Pansu N, Perez L, Baldacini M, Degoul S, Dureau A, Ionescu C, Kuteifan K, Labro G, Mootien J, Oudeville P, Pinto L, Poidevin A, Rabouel Y, Stiel L, Baronnet G, Baux E, Bevilacqua S, Corbel A, Goehringer F, Jeanmaire E, Kimmoun A, Lefevre B, Boutoille D, Canet E, Deschamvres C, Gaborit B, Garret C, Wilquin P, Lascarrou J, Le Turnier P, Lecompte A, Lecomte R, Lemarie J, Martin M, Miailhe A, Ottavy G, Querne G, Raffi F, Reignier J, Seguin A, Sruvay S, Zambon O, Lanternier F, Melenotte C, Rouzaud C, Serris A, Beatini J, Buscot M, Chirio D, Courjon J, cua E, Degoutte A, Demonchy E, Durant J, Leroy S, Marquette C, Michelangeli C, Mondain V, Prouvost-Keller B, Pugliese P, Risso K, Bulyez S, Buzancais A, Daurat A, Larcher R, Loubet P, Louart G, Muller L, Perin N, Roger C, Beraud G, Catroux M, Cazenave-Roblot F, Giraud V, Le Moal G, Martellosio J, Bani-Sadr F, Bermejo M, Cousson J, Goury A, Hentzien M, Julien G, Mourvillier B, Nguyen Y, Tromeur T, Allain J, Baldeyrou M, Benezit F, Dewitte M, Laine F, Laviolle B, Patrat-Delon S, Revest M, Tattevin P, Ait-Oufella H, Bollens D, Chiarabini T, Ingiliz P, Lacombe K, Lefebvre B, Meynard J, Valin N, Botelho-Nevers E, Accassat S, Cazorla C, De Magalhaes E, Fresard A, Gagneux-Brunon A, Lutz M, Morel J, Schein F, Thiery G, De Castro N, Denis B, Liegeon G, Molina J, Rubenstein E, Tateo M, Cattelan J, Clere-Jehl R, Danion F, Hansmann Y, Helms J, Kummerlen C, Lefebvre N, Loewert S, Merdji H, Meziani F, Monnier A, Oulehri W, Rahmani H, Ruch Y, Studer A, Tacquard C, Ursenbach A, Bachir M, Calin R, Chas J, Lassel L, Nadal M, Palacios C, Pialoux G, Siguier M, Alvarez M, Calvas F, Catala H, Debard A, Delobel P, Galitzky M, Garnier C, Grouteau G, Guibert N, Lansalot-Matras P, Lauret S, Lelievre L, Blondel G, Mazieres J, Noelsavina E, Pellerin S, Pontier-Marchandise S, Porte L, Prevot G, Rousset S, Sedkaoui K, Thalamas C, Bastides F, Contentin L, Carvalho-Schneider C, Coustilleres F, Dequin P, Ehrmann S, Flament T, Garot D, Gourraud M, Guillon A, Jacquier S, Larrat C, Legras A, Lemaignen A, Lacasse M, Mankikian J, Mercier E, Rouault L, Gandonniere C, Guy T, Gousseff M, D'Anglejan E, Fragkou P, Grigoropoulos I, Moschopoulos C, Tsiodras S, Tsioulos G, Tziolos N, Kotanidou A, Theodorakopoulou M, Yajai E, Akinosoglou C, Dimakopoulou V, Maragkos M, Polyzou E, Tzouvelekis A, Bakos I, Sandor E, Varkonyi I, Armos R, Balazs S, Istvan T, Bergin C, Kent B, Kerr C, Townsend L, Alexandre M, Aouali N, Arendt V, Bintener T, Braquet P, de la Vega E, Colling J, Damilot G, Henin T, Michaux C, Reuter J, Staub T, Skhiri L, Werer C, Znati A, Berdal J, Dalgard O, Fossum O, Schive H, Fin A, Holten A, Jenum S, Macpherson M, Riise A, Tonby K, Braz S, Ribeiro J, Paiva J, Roncon-Albuquerque R, de la Rosa Riestra S, Baena Z, Palacios P, Bano J. Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial. Clinical Microbiology And Infection 2025, 32: 618-628. PMID: 41429349, DOI: 10.1016/j.cmi.2025.12.014.Peer-Reviewed Original ResearchConceptsModified intention-to-treatSerum drug concentrationsSARS-CoV-2 reinfectionMITT populationPlacebo groupAntidrug antibodiesNo significant differenceAdverse eventsNeutralizing activityTreatment-emergent antidrug antibodiesLong-term clinical efficacyDrug concentrationsPCR-confirmed SARS-CoV-2 infectionSignificant differenceSARS-CoV-2Serum neutralizing activityLong-term resultsIntention-to-treatSARS-CoV-2 infectionNeutralizing antibody titresDouble-blindPrimary endpointClinical benefitTixagevimab-cilgavimabClinical efficacyThe Prognostic Role of Different Blood Cell Count-to-Lymphocyte Ratios in Patients with Lung Cancer at Diagnosis
Papaioannou O, Fiste O, Theohari E, Sampsonas F, Dimitrakopoulos F, Koutras A, Gkiozos I, Vathiotis I, Kotteas E, Tzouvelekis A. The Prognostic Role of Different Blood Cell Count-to-Lymphocyte Ratios in Patients with Lung Cancer at Diagnosis. Cancers 2025, 17: 3879. PMID: 41375080, PMCID: PMC12691473, DOI: 10.3390/cancers17233879.Peer-Reviewed Original ResearchPlatelet-to-lymphocyte ratioMonocyte to lymphocyte ratioNeutrophil-to-lymphocyte ratioNon-small-cell lung cancerMedian neutrophil-to-lymphocyte ratioSmall-cell lung cancerDiagnosis of LCLung cancerLymphocyte ratioPrognostic roleSquamous non-small-cell lung cancerMLR valuesSecondary outcomesUniversity HospitalPrognostic of clinical outcomeDepartment of Respiratory MedicinePD-L1 expressionUniversity Hospital of PatrasKaplan-Meier curvesTime of diagnosisAssociation of tumorsMortality riskCancer-related mortalityAssociated with significantly higher mortality riskPD-L1Post-stroke sleep disordered breathing and the effect of positive airway pressure treatment: An updated systematic review and meta-analysis of randomized control trials
Sampsonas F, Karamouzos V, Doulberis M, Karkoulias K, Lykouras D, Steiropoulos P, Tzouvelekis A. Post-stroke sleep disordered breathing and the effect of positive airway pressure treatment: An updated systematic review and meta-analysis of randomized control trials. Sleep Medicine Reviews 2025, 85: 102207. PMID: 41297370, DOI: 10.1016/j.smrv.2025.102207.Peer-Reviewed Original ResearchPositive airway pressure treatmentMeta-analysis of randomized controlled trialsRandomized Controlled TrialsRecurrent vascular eventsEffect of positive airway pressure treatmentVascular eventsControlled TrialsPositive airway treatmentObstructive sleep apneaMeta-analysisSleep apneaAirway treatmentPAP treatmentNeurological deficitsCognitive functionUnder-treatedUnder-diagnosedPatientsIndependent ORConventional armSystematic reviewElsevier databasesTreatmentPAPStrokeS148 Citrullination of fibrin by PAD4 is an important contributor to fibrinolytic deficiency in pleural infection
Hollins S, Chu J, Manoharan N, Feng Y, Elsheikh A, Tzouvelekis A, Koulousousa E, Sampsonas F, Dong T, Knight J, Rahman N, Kanellakis N. S148 Citrullination of fibrin by PAD4 is an important contributor to fibrinolytic deficiency in pleural infection. 2025, a103.2-a103. DOI: 10.1136/thorax-2025-btsabstracts.154.Peer-Reviewed Original ResearchIntravenous immunoglobulin in acute exacerbations of fibrotic interstitial lung diseases: A retrospective, real-world study
Sotiropoulou V, Theochari E, Katsaras M, Tsiri P, Komninos D, Christopoulos I, Tsirikos G, Sampsonas F, Kalogeropoulou C, Daoussis D, Karkoulias K, Tzouvelekis A. Intravenous immunoglobulin in acute exacerbations of fibrotic interstitial lung diseases: A retrospective, real-world study. 2025, pa1824. DOI: 10.1183/13993003.congress-2025.pa1824.Peer-Reviewed Original Research