Andrew Prendergast, BA, PhD
Scientific DirectorDownloadHi-Res Photo
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Comparative Medicine
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Comparative Medicine
300 George St., Room 0752
New Haven, CT 06511
United States
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Titles
Scientific Director
Appointments
Comparative Medicine
Research ScientistPrimary
Other Departments & Organizations
- All Institutions
- Comparative Medicine
Education & Training
- PhD
- University of Washington, Neurobiology and Behavior (2013)
- BA
- Knox College, Neuroscience (2007)
Research
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Overview
Medical Research Interests
Cardiovascular System; Embryonic and Fetal Development; Gene Editing; Neurosciences; Zebrafish
Research at a Glance
Yale Co-Authors
Frequent collaborators of Andrew Prendergast's published research.
Publications Timeline
A big-picture view of Andrew Prendergast's research output by year.
Research Interests
Research topics Andrew Prendergast is interested in exploring.
Adife Gulhan Ercan-Sencicek, MSc, MS, PhD
Danielle Miyagishima, MD, PhD
Emma Ristori, PhD
Engin Deniz, MD
Jared Hintzen
Katsuhito Yasuno, PhD
26Publications
1,448Citations
Publications
2023
Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections
Wyart C, Jim K, Prendergast A. Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections. Neuroscience 2023, 525: 47-50. PMID: 37419406, DOI: 10.1016/j.neuroscience.2023.07.008.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSensory cellsNervous systemInternal physiologyPresence of pathogensExternal cuesRelease of compoundsPathogenic bacteriaCentral nervous systemHomeostatic regulationInternal cuesHost defenseNeuronal activationCellsClassical functionsHost responseReceptor propertiesSensory systemsCuesInfectionBacteriaRegulationPhysiologyField of neurosciencePathogensInvasionCSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection
Prendergast A, Jim K, Marnas H, Desban L, Quan F, Djenoune L, Laghi V, Hocquemiller A, Lunsford E, Roussel J, Keiser L, Lejeune F, Dhanasekar M, Bardet P, Levraud J, van de Beek D, Vandenbroucke-Grauls C, Wyart C. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current Biology 2023, 33: 940-956.e10. PMID: 36791723, DOI: 10.1016/j.cub.2023.01.039.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCentral nervous systemCerebrospinal fluidSensory neuronsNervous systemStreptococcus pneumoniaeCentral nervous system infectionBlockade of neurotransmissionCentral sensory neuronsNervous system infectionHost survivalPeripheral nervous systemCell-specific ablationEpileptic-like seizuresCSF-contacting neuronsSupernatants of cellsPneumococcal meningitisSystem infectionBitter taste receptorsCSF infectionPneumoniae infectionNeurotropic virusesSpinal cordPathogenic bacteriaPostural controlMeningitis
2022
Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm
Prendergast A, Ziganshin BA, Papanikolaou D, Zafar MA, Nicoli S, Mukherjee S, Elefteriades JA. Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm. Genes 2022, 13: 123. PMID: 35052463, PMCID: PMC8775119, DOI: 10.3390/genes13010123.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAortic aneurysmSkeletal abnormalitiesThoracic aortic aneurysmWhole-exome sequencingDirect microscopic assessmentSilico genetic analysisVisualized abnormalitiesTAA patientsClinical managementGeneral populationClinical practiceRoutine assessmentClinical testingCell countEvidence-based decisionsUnknown significanceUncertain significanceExperimental modelPilot studyExome sequencingAbnormalitiesMicroscopic assessmentPatientsPositive controlAneurysms
2021
PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans
Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Khokha MK, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nature Medicine 2021, 27: 2165-2175. PMID: 34887573, PMCID: PMC8768030, DOI: 10.1038/s41591-021-01572-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGenome-wide association studiesPeptidyl-prolyl cis-transPathogenesis of IAContribution of variantsCommon genetic variantsVertebrate modelDeleterious mutationsWnt activatorAssociation studiesWhole-exome sequencingSignificant enrichmentGenetic variantsWntAngiogenesis regulatorsMutationsGene mutationsBrain angiogenesisIntracranial aneurysm ruptureJMJD6AngiogenesisCerebrovascular morphologyCerebrovascular integrityIntracerebral hemorrhageAneurysm ruptureVariants
2020
Experience, circuit dynamics and forebrain recruitment in larval zebrafish prey capture
Oldfield C, Grossrubatscher I, Chávez M, Hoagland A, Huth A, Carroll E, Prendergast A, Qu T, Gallant J, Wyart C, Isacoff E. Experience, circuit dynamics and forebrain recruitment in larval zebrafish prey capture. ELife 2020, 9: e56619. PMID: 32985972, PMCID: PMC7561350, DOI: 10.7554/elife.56619.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2019
Glia: A Gate Controlling Animal Behavior?
Wyart C, Prendergast A. Glia: A Gate Controlling Animal Behavior? Current Biology 2019, 29: r847-r850. PMID: 31505186, DOI: 10.1016/j.cub.2019.07.058.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsRegulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons
Desban L, Prendergast A, Roussel J, Rosello M, Geny D, Wyart C, Bardet PL. Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLOS Biology 2019, 17: e3000235. PMID: 31002663, PMCID: PMC6493769, DOI: 10.1371/journal.pbio.3000235.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRing of actinApical junctional complexApical extensionSensory cellsApical actin ringSensory cell typesInner ear sensory cellsTime-lapse imagingVivo time-lapse imagingZebrafish embryosMorphogenesisActin ringsCell typesHair bundlesMechanosensory responsesProtrusion elongationJunctional complexesActinTail bendingMolecular factorsCerebrospinal fluid-contacting neuronsApical attachmentCritical roleOsmolarity changesApical processes
2018
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Sternberg JR, Prendergast AE, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-Del’Immagine A, Castillo L, Djenoune L, Kurisu S, McDearmid JR, Bardet PL, Boccara C, Okamoto H, Delmas P, Wyart C. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9: 3804. PMID: 30228263, PMCID: PMC6143598, DOI: 10.1038/s41467-018-06225-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCentral canalCSF-cNsSpontaneous activityCSF flowCerebrospinal fluid-contacting neuronsSpine curvatureCSF-contacting neuronsCerebrospinal fluid flowSpinal cordIdiopathic scoliosisSingle-channel openingsCalcium activityPKD2L1 channelPKD2L1Mechanosensory cellsNeuronsCanalChannel openingMechanoceptionKyphosisCilia motilityCord
2017
Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion
Knafo S, Fidelin K, Prendergast A, Tseng PB, Parrin A, Dickey C, Böhm UL, Figueiredo SN, Thouvenin O, Pascal-Moussellard H, Wyart C. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. ELife 2017, 6: e25260. PMID: 28623664, PMCID: PMC5499942, DOI: 10.7554/elife.25260.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSpinal cordMechanosensory neuronsRohon-Beard neuronsMonosynaptic inputSpinal circuitsMotor poolsCordNeuronsV2a interneuronsVertebrate spinal cordMechanosensory feedbackNumerous physiological studiesSimple locomotionPhysiological studiesActive locomotionLocomotor speedEscape responseInterneuronsZebrafish larvaeThe dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
Djenoune L, Desban L, Gomez J, Sternberg JR, Prendergast A, Langui D, Quan FB, Marnas H, Auer TO, Rio JP, Del Bene F, Bardet PL, Wyart C. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Scientific Reports 2017, 7: 719. PMID: 28389647, PMCID: PMC5428266, DOI: 10.1038/s41598-017-00350-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsBiomarkersCarrier ProteinsCell DifferentiationCerebrospinal FluidFluorescent Antibody TechniqueGanglia, SpinalHomozygoteMutationNeuronsSensory Receptor CellsSignal TransductionSpinal CordSpinal Nerve RootsTRPP Cation ChannelsZebrafishZebrafish ProteinsConceptsDual developmental originDevelopmental originsDistinct progenitor domainsApical extensionDistinct functional subtypesDifferent developmental originsCerebrospinal fluid-contacting neuronsTranscription factorsMechanical cuesZebrafish larvaeDistinct functionsProgenitor domainsCentral nervous systemCell typesDistinct cascadesFunctional populationsDifferent functional propertiesCSF-cNsNovel avenuesPKD2L1 channelFunctional subtypesSensory neuronsNeuronal targetsDistinct functional populationsSpecific markers
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Comparative Medicine
300 George St., Room 0752
New Haven, CT 06511
United States
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