Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsAnderson M. Winkler, MD, DPhil
Assistant Clinical ProfessorAbout
Research
Publications
2026
Structural brain analysis in focal upper limb dystonia
de Faria D, Paulo A, de Paiva J, Winkler A, Borges V, Silva S, Ferraz H, de Carvalho Aguiar P. Structural brain analysis in focal upper limb dystonia. Scientific Reports 2026, 16: 9112. PMID: 41691019, PMCID: PMC12996275, DOI: 10.1038/s41598-026-39542-z.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingWhole-brain vertex-wise analysesStructural magnetic resonance imagingWhite matter microstructural integrityVertex-wise analysisTract-based spatial statisticsRight-handed individualsMagnetic resonance imagingDiffusion tensor imaging dataStructural brain analysisROI-based analysisDiffusion tensor imaging metricsPermutation-based statisticsBrain analysisBetween-group differencesWhole-brainWhite matter changesProbabilistic tractographyBasal gangliaMicrostructural integrityCortical morphologyCortical thicknessMulti-modal studyInconsistent findingsLimb dystoniaA comprehensive framework for statistical testing of brain dynamics
Larsen N, Paulsen L, Ahrends C, Winkler A, Vidaurre D. A comprehensive framework for statistical testing of brain dynamics. Nature Protocols 2026, 1-32. PMID: 41555071, DOI: 10.1038/s41596-025-01300-2.Peer-Reviewed Original ResearchHidden Markov ModelNeural activity dataStep-by-step tutorialsPython libraryGraphical interfaceOpen-source Python packageNeural dataTemporal domainPython packageMarkov modelProgramming experienceNon-imaging variablesAnalysis of brain dynamicsBrain dynamicsMonte Carlo resamplingHierarchical relationshipsMultiple testing correctionTask-basedComprehensive frameworkProtocolActivity dataPermutation-based methodsFrameworkStatistical testsComprehensive documentationStructural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide
Han L, Bruin W, Bas-Hoogendam J, Groenewold N, Hilbert K, Winkler A, Zugman A, Asami T, Barber J, Benedetti F, Blair R, Böhnlein J, Brambilla P, Breuer F, Buckner R, Bülow R, Calkins M, Chechko N, Dannlowski U, Dohm K, Domschke K, Dresler T, Erhardt-Lehmann A, Fonzo G, Forstner A, Grabe H, Grotegerd D, Gur R, Gur R, Harmer C, Hofmann D, van den Heuvel O, Jahanshad N, Kircher T, Koch K, Laansma M, Langhammer T, Lee S, Leehr E, Maggioni E, Marino C, Meinert S, Meinert H, Milrod B, Mwangi B, Nielsen J, Ohrmann P, Pantazatos S, Paulus M, Penninx B, Poletti S, Reinecke A, Ridderbusch I, Rjabtsenkov P, Sämann P, Satterthwaite T, Schmaal L, Schrammen E, Soares J, Solomonov N, Stein M, Straube B, Straube T, Suarez-Jimenez B, Smoller J, Talati A, Thomopoulos S, Vazquez C, Völzke H, Wittfeld K, Wu M, Yang Y, Zunta Soares G, Lueken U, Thompson P, Pine D, Stein D, van der Wee N, Veltman D, Aghajani M. Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide. Molecular Psychiatry 2026, 1-16. PMID: 41530384, DOI: 10.1038/s41380-025-03376-4.Peer-Reviewed Original ResearchPanic disorderNeurocircuitry modelsAssociated with panic disorderStructural brain correlatesFronto-temporo-parietal regionsStructural brain differencesTemporo-parietal regionsLarger lateral ventriclesCortical surface areaBrain correlatesBrain differencesCaudate volumeNeuroanatomical findingsModel of PDSubcortical differencesMega-AnalysisNeuroimaging databaseLate adulthoodHealthy controlsInconsistent effectsLateral ventricleDisordersAdulthoodIndividualsNeurocircuitryStructural brain correlates of childhood inhibited temperament: results from a pre-registered ENIGMA-Anxiety mega-analysis in 3,803 individuals
Bas-Hoogendam J, Bernstein R, Benson B, Frank S, Buss K, Gunther K, Pérez-Edgar K, Salum G, Jackowski A, Bressan R, Zugman A, Filippi C, Fox N, Henderson H, Tang A, Zeytinoglu S, Harrewijn A, Hillegers M, Muetzel R, White T, Schwartz C, Felicione J, DeYoung K, Shackman A, Smith J, Tillman R, van den Berg Y, Cillessen A, Roelofs K, Tyborowska A, Hill S, Battaglia M, Tettamanti M, Dougherty L, Jin J, Klein D, Leung H, Avery S, Blackford J, Clauss J, Bjork J, Hettema J, Moore A, Roberson-Nay R, Sawyers C, Hayden E, Liu P, Vandermeer M, Goldsmith H, Planalp E, Nichols T, Thompson P, Westenberg P, van der Wee N, Groenewold N, Stein D, Winkler A, Pine D. Structural brain correlates of childhood inhibited temperament: results from a pre-registered ENIGMA-Anxiety mega-analysis in 3,803 individuals. Neuroscience Applied 2026, 5: 105862. DOI: 10.1016/j.nsa.2025.105862.Peer-Reviewed Original Research
2025
Striatal compartment and white matter alterations in focal dystonia Subtypes: An MRI study
Marques Paulo A, Waugh J, Winkler A, Queiroz de Paiva J, de Faria D, Borges V, Silva S, de Ferraz H, Aguiar P. Striatal compartment and white matter alterations in focal dystonia Subtypes: An MRI study. Parkinsonism & Related Disorders 2025, 141: 108096. PMID: 41172714, DOI: 10.1016/j.parkreldis.2025.108096.Peer-Reviewed Original ResearchConceptsWhite matter alterationsHealthy controlsCervical dystoniaStriatal compartmentsUpper limb dystoniaCD patientsDystonia patientsStructural brain differencesDystonia subtypesAssociated with sensorimotorRight corona radiataT1-weighted imagesFocal dystonia patientsLeft caudateBrain differencesLimbic functionsLimb dystoniaSymptom severityLeft striatumNeuroanatomical patternsRight thalamusPutaminal volumeGlobus pallidusStriatumPathophysiological mechanismsReduced Threat-Related Neural Efficiency: A Possible Biomarker for Pediatric Anxiety Disorders
Linke J, Naim R, Haller S, Khosravi P, Scheinberg B, Byrne M, Harrewijn A, Leibenluft E, Brotman M, Winkler A, Pine D. Reduced Threat-Related Neural Efficiency: A Possible Biomarker for Pediatric Anxiety Disorders. American Journal Of Psychiatry 2025, 183: 48-57. PMID: 41058235, PMCID: PMC12614269, DOI: 10.1176/appi.ajp.20241043.Peer-Reviewed Original ResearchCognitive-behavioral therapyPediatric anxiety disordersNeural efficiencyTest-retest reliabilityAnxiety disordersExposure-based CBTCBT responseCBT's efficacyAssociated with poor treatment responseDot-probe taskAnxiety disorder diagnosisTreatment responsePoor treatment responseAnxious youthThreat-relatedAdult psychopathologySymptom dimensionsPediatric anxietyAnxiety diagnosesThreat taskPsychiatric diagnosisDisorder diagnosisFunctional MRIFunctional connectivityHealthy youthIntegrating Multimodal Neuroimaging of Error Monitoring to Estimate Future Anxiety in Adolescents
Valadez E, Conte S, Richards J, Feng Y, Liuzzi L, McSweeney M, Tan E, Buzzell G, Morales S, Winkler A, Cardinale E, White L, Pine D, Fox N. Integrating Multimodal Neuroimaging of Error Monitoring to Estimate Future Anxiety in Adolescents. JAMA Network Open 2025, 8: e2539133. PMID: 41129147, PMCID: PMC12550640, DOI: 10.1001/jamanetworkopen.2025.39133.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMultimodal neuroimaging measuresError monitoringEarly temperamentCingulate activityAnxiety trajectoriesMultimodal neuroimagingFuture anxietyFunctional magnetic resonance imaging sessionDorsal anterior cingulate activityAnterior cingulate activityPosterior cingulate activityAnxiety change scoresIntegration of electroencephalogramFollow-up analysisFlanker taskAnxiety disordersClinical InterviewCommunity sampleBrain regionsEEG sessionsBrain activityNeuroimaging dataTemperamentAnxietyShared and distinct alterations in brain structure of youth with internalizing or externalizing disorders: Findings from the ENIGMA Antisocial Behavior, ADHD, MDD, and Anxiety Working Groups
Sophie Townend, Staginnus M, Gao Y, Alexander N, Arolt V, Banaschewski T, Beesdo-Baum K, Bellgrove M, Benegal V, Blair R, Blanco-Hinojo L, Boeken O, Böhnlein J, Bölte S, Bonnekoh L, Brandeis D, Bressan R, Breuer F, Bruin W, Buitelaar J, Burkhouse K, Calkins M, Cano M, Cardoner N, Chen H, Chen X, Coghill D, Colins O, Connolly C, Craig M, Cullen K, Dannlowski U, Davey C, Dietrich A, Dong D, Freitag C, Frodl T, Goossens L, Grotegerd D, Gur R, Gur R, Haavik J, Hagan C, Hahn T, Hamm A, Harrison B, Hartman C, Herrmann M, Ho T, Hoekstra P, Holla B, Ibrahim K, Jackowski A, Jamalabadi H, Jiang Y, Kircher T, Konrad K, Kraus A, Kuntsi J, Langhammer T, Lazaro L, Leehr E, Lueken U, Ma R, MacMaster F, Manfro G, Martinelli A, Meinert H, Meinert S, Michałowski J, Ming Q, Moeck R, Muehlhan M, Mujica-Parodi L, Mwangi B, Neufeld J, Nigg J, O'Gorman Tuura R, Oh H, Oosterlaan J, Paloyelis Y, Pan P, Passamonti L, Peñate W, Phan K, Plessen K, Pujol J, Remnélius K, Rivero F, Rubia K, Salas R, Salum G, Satterthwaite T, Schienle A, Schrammen E, Schruers K, Schumann G, Sethi A, Silk T, Skokauskas N, Smoller J, Soares J, Sørensen L, Stadler C, Stevens M, Straube B, Straube T, Ströhle A, Sudre G, Sukhodolsky D, Sully K, Sun X, Sylvester C, Toschi N, van der Werff S, Vance A, Vermeiren R, Wabnegger A, Wang X, Wendt J, Whittle S, Wiemer J, Winkler A, Wittchen H, Wu M, Wu Q, Yang T, Yang Y, Yao S, Zhang J, Zhou J, Zugman A, Zunta-Soares G, Zwanzger P, Thomopoulos S, Jahanshad N, Thompson P, Hilbert K, Baskin-Sommers A, Cecil C, Aghajani M, Pine D, van der Wee N, Stein D, Groenewold N, Bas-Hoogendam J, Han L, Pozzi E, Schmaal L, Franke B, Hoogman M, Walton E, De Brito S, Fairchild G. Shared and distinct alterations in brain structure of youth with internalizing or externalizing disorders: Findings from the ENIGMA Antisocial Behavior, ADHD, MDD, and Anxiety Working Groups. Biological Psychiatry 2025 PMID: 40812743, DOI: 10.1016/j.biopsych.2025.08.003.Peer-Reviewed Original ResearchExternalizing disordersBrain structuresAnxiety disordersDisorder-specific alterationsSubcortical brain alterationsMiddle temporal gyrusYouth psychiatric disordersFronto-parietal regionsRegional cortical thicknessT1-weighted MRI dataTransdiagnostic associationsSalience attributionEmotional processingTemporal gyrusSubcortical volumesAntisocial behaviorInternalizing disordersPsychiatric disordersBrain alterationsENIGMA consortiumGroup differencesIndividual disordersMega-AnalysisIntracranial volumeEntorhinal cortexLongitudinal changes in infant attention-related brain networks and fearful temperament
Filippi C, Massera A, Xing J, Park H, Valadez E, Elison J, Kanel D, Pine D, Fox N, Winkler A. Longitudinal changes in infant attention-related brain networks and fearful temperament. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40684940, PMCID: PMC12340726, DOI: 10.1016/j.bpsc.2025.07.003.Peer-Reviewed Original ResearchResting-state functional connectivityDefault mode networkDorsal attentionFearful temperamentBrain networksResting-state functional connectivity changesAttention-related networksMarkers of anxietyFearful infantsAnxiety disordersMode networkAge-related changesAge-related decreaseFunctional connectivityNeonatal alterationsTemperamentAnxietyConnectome ProjectIndependent component analysisAged 2FearLongitudinal modelLongitudinal changesBaby Connectome ProjectFPNHuman development, inequality, and their associations with brain structure across 29 countries
Medel V, Alliende L, Bethlehem R, Seidlitz J, Ringlein G, Arango C, Arnatkevičiūtė A, Asmal L, Bellgrove M, Benegal V, Bernardo M, Billeke P, Bosch-Bayard J, Bressan R, Busatto G, Castro M, Chaim-Avancini T, Costanzi M, Czepielewski L, Dazzan P, de la Fuente-Sandoval C, Diaz-Caneja C, Di Forti M, Diaz-Zuluaga A, Du Plessis S, Duran F, Fittipaldi S, Fornito A, Freimer N, Gadelha A, Gama C, Garani R, Garcia-Rizo C, Campo C, Gonzalez-Valderrama A, Guinjoan S, Holla B, Ibañez A, Ivanovic D, Jackowski A, Leon-Ortiz P, Lochner C, Lopez-Jaramillo C, Luckhoff H, Massuda R, McGuire P, Miyata J, Mizrahi R, Murray R, Ozerdem A, Pan P, Parellada M, Phahladira L, Ramirez-Mahaluf J, Reckziegel R, Marques T, Reyes-Madrigal F, Roos A, Rosa P, Salum G, Scheffler F, Schumann G, Serpa M, Stein D, Tepper A, Tiego J, Ueno T, Undurraga J, Undurraga E, Valdes-Sosa P, Valli I, Villarreal M, Winton-Brown T, Yalin N, Zamorano F, Zanetti M, cVEDA, Winkler A, Evans-Lacko S, Crossley N. Human development, inequality, and their associations with brain structure across 29 countries. European Psychiatry 2025, 68: e100. PMID: 40665512, PMCID: PMC12344469, DOI: 10.1192/j.eurpsy.2025.10060.Peer-Reviewed Original ResearchConceptsBrain structuresAssociated with smaller hippocampal volumeGlobal cortical surface areaSmaller hippocampal volumeCortical surface areaMagnetic resonance imagingVariability of brain structureBrain-related disordersHealthy adultsThinner cortical thicknessCross-sectional studyHippocampal volumeFrontal areasMeta-regression approachBrain disordersCortical thicknessBrain imagingBrainHuman developmentDisordersLevel of developmentResonance imagingCountry levelAdultsCountry's level of development