Alexandra Bayer Wildberger
Postdoctoral AssociateDownloadHi-Res Photo
About
Copy Link
Titles
Postdoctoral Associate
Appointments
Neurology
Postdoctoral AssociatePrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Yale Univeristy School of Medicine (2026)
- PhD
- Sorbonne Université, Immunology & Cellular Therapy (2022)
- MSc
- Sorbonne Université, Molecular and Cellular Biology (2018)
- BSc (Hon)
- Universidad Católica “Nuestra Señora de la Asunción”, Medical Biochemistry (2014)
Research
Copy Link
Research at a Glance
Yale Co-Authors
Frequent collaborators of Alexandra Bayer Wildberger's published research.
Kevin C O'Connor, PhD
Richard Nowak, MD, MS
Gianvito Masi, MD
Akiko Iwasaki, PhD
Kenneth Hoehn
Former YSM
Publications
2025
IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology
Masi G, Chen K, Bayer A, Bayarri-Olmos R, Pham M, Wallace A, Falso S, Evoli A, Iorio R, Hoehn K, Iwasaki A, Nowak R, O’Connor K. IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology. Brain 2025, 149: awaf410. PMID: 41147199, PMCID: PMC13005154, DOI: 10.1093/brain/awaf410.Peer-Reviewed Original ResearchThis study investigates the role of IgA antibodies in MuSK myasthenia gravis, showing they coexist with IgG4 antibodies, exhibit unique pathogenic potential, and can resist B-cell depletion therapy.Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology
Bayer A, Sanmarco L, Pellerin A, Masi G, Plasencia A, Anderson J, Nowak R, Damato V, Massacesi L, Pham M, Khani-Habibabadi F, Vital H, Higginson-Scott N, Otipoby K, Xing Y, Mascanfroni I, O’Connor K. Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2505984122. PMID: 41118207, PMCID: PMC12582293, DOI: 10.1073/pnas.2505984122.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMyasthenia gravisComplement depositionLive cell-based assayComplement activationTherapeutic potentialAcetylcholine receptor autoantibodiesPathogenic effectsReceptor autoantibodiesAChR autoantibodiesAutoantibody-mediated pathologyAutoimmune disordersPatient cohortIgG autoantibodiesEffector functionsPatient stratificationMuscle weaknessPersonalized therapySerum IgGAutoantibodiesPatientsReceptor bindingAcetylcholine receptorsIgGSerum samplesCell-based assaysMesenchymal stromal cells conditioned by peripheral blood mononuclear cells exert enhanced immunomodulation capacities and alleviate a model of Myasthenia Gravis
Bayer AC, Pinzón N, You A, Bergman C, Dragin N, Corneau A, Truffault F, Noël D, Martinaud C, Le Panse R, Berrih-Aknin S, Vilquin JT. Mesenchymal stromal cells conditioned by peripheral blood mononuclear cells exert enhanced immunomodulation capacities and alleviate a model of Myasthenia Gravis. Stem Cell Research & Therapy 2025, 16: 437. DOI: 10.1186/s13287-025-04534-9.Peer-Reviewed Original ResearchContribution of cellular immune dysregulation to myasthenia gravis pathology
Bayer A, Nowak R, O'Connor K. Contribution of cellular immune dysregulation to myasthenia gravis pathology. International Review Of Neurobiology 2025, 182: 43-66. PMID: 40675740, DOI: 10.1016/bs.irn.2025.04.035.ChaptersCitationsConceptsMyasthenia gravisPersistence of autoimmunityB cell compartmentAbnormal immune responseDevelopment of TResponse to treatmentCellular compartmentsImpaired neuromuscular transmissionImmunopathology of MGTolerance checkpointsComplex immunopathologyImmune dysregulationPrevent autoimmunityT cellsAutoantibody productionPathological responseAutoimmune disordersB cellsDisease developmentAutoimmune diseasesDisease progressionImmune responseMultifactorial diseaseImmune systemNeuromuscular transmission
2020
The authors reply: Comment on: "Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients" by Etienne et al.
Etienne J, Joanne P, Catelain C, Riveron S, Bayer Wildberger A, Lafable J, Punzon I, Blot S, Agbulut O, Vilquin J. The authors reply: Comment on: "Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients" by Etienne et al. Journal Of Cachexia, Sarcopenia And Muscle 2020, 11 DOI: 10.1002/jcsm.12629.Peer-Reviewed Original ResearchAldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients
Etienne J, Joanne P, Catelain C, Riveron S, Bayer AC, Lafable J, Punzon I, Blot S, Agbulut O, Vilquin J. Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients. Journal Of Cachexia, Sarcopenia And Muscle 2020, 11 DOI: 10.1002/jcsm.12557.Peer-Reviewed Original Research
2019
The Muscle Is Not a Passive Target in Myasthenia Gravis
Vilquin JT, Bayer AC, Le Panse R, Berrih-Aknin S. The Muscle Is Not a Passive Target in Myasthenia Gravis. Frontiers In Neurology 2019, 10: 1343. DOI: 10.3389/fneur.2019.01343.Peer-Reviewed Original ResearchIl-23/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis
Villegas JA, Bayer AC, Ider K, Bismuth J, Truffault F, Roussin R, Santelmo N, Le Panse R, Berrih-Aknin S, Dragin N. Il-23/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis. Journal Of Autoimmunity 2019, 98 DOI: 10.1016/j.jaut.2018.11.005.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Copy Link
Honors
honor Next Generation Research Grant in Myasthenia Gravis
07/01/2026National AwardAmerican Brain Foundation & American Academy of Neurologyhonor The Myasthenia Gravis Rare Disease Network (MGNet) Scholar Award
01/01/2025National AwardThe Myasthenia Gravis Rare Disease Network (MGNet)
News
Copy Link
News
Get In Touch
Copy Link
Contacts
Locations
O'Connor Lab
Lab
300 George Street, Fl 3rd Floor, Rm 325B
New Haven, CT 06511