Alice Braun, PhD
Postdoctoral FellowAbout
Research
Publications
Featured Publications
Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction
Braun A, Shekhar S, Levey D, Straub P, Kraft J, Panagiotaropoulou G, Heilbron K, Awasthi S, Meleka Hanna R, Hoffmann S, Stein M, Lehnerer S, Mergenthaler P, Elnahas A, Topaloudi A, Koromina M, Palviainen T, Asbjornsdottir B, Stefansson H, Skuladóttir A, Jónsdóttir I, Stefansson K, Reis K, Esko T, Palotie A, Leypoldt F, Stein M, Fontanillas P, Kaprio J, Gelernter J, Davis L, Paschou P, Tannemaat M, Verschuuren J, Kuhlenbäumer G, Gregersen P, Huijbers M, Stascheit F, Meisel A, Ripke S. Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction. Nature Communications 2024, 15: 9839. PMID: 39537604, PMCID: PMC11560923, DOI: 10.1038/s41467-024-53595-6.Peer-Reviewed Original ResearchConceptsPerformance of polygenic risk scoresGenome-wide significant hitsGenome-wide association studiesGenome-Wide Meta-AnalysisControls of European ancestryGenetic architecturePolygenic risk scoresSignificant hitsAssociation studiesPhenotypic variationPolygenic predictionEuropean ancestryAssociated with early-onsetHuman leukocyte antigen allelesLociEarly-onsetReplication studyNeuromuscular junctionMyasthenia gravisAutoantibody-mediated diseasesAntigen allelesAllelesAncestryDisease manifestationsLate-onset MGMapping genomic loci implicates genes and synaptic biology in schizophrenia
Trubetskoy V, Pardiñas A, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli T, Bryois J, Chen C, Dennison C, Hall L, Lam M, Watanabe K, Frei O, Ge T, Harwood J, Koopmans F, Magnusson S, Richards A, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson E, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh B, Alptekin K, Als T, Amin F, Arolt V, Arrojo M, Athanasiu L, Azevedo M, Bacanu S, Bass N, Begemann M, Belliveau R, Bene J, Benyamin B, Bergen S, Blasi G, Bobes J, Bonassi S, Braun A, Bressan R, Bromet E, Bruggeman R, Buckley P, Buckner R, Bybjerg-Grauholm J, Cahn W, Cairns M, Calkins M, Carr V, Castle D, Catts S, Chambert K, Chan R, Chaumette B, Cheng W, Cheung E, Chong S, Cohen D, Consoli A, Cordeiro Q, Costas J, Curtis C, Davidson M, Davis K, de Haan L, Degenhardt F, DeLisi L, Demontis D, Dickerson F, Dikeos D, Dinan T, Djurovic S, Duan J, Ducci G, Dudbridge F, Eriksson J, Fañanás L, Faraone S, Fiorentino A, Forstner A, Frank J, Freimer N, Fromer M, Frustaci A, Gadelha A, Genovese G, Gershon E, Giannitelli M, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein J, González Peñas J, González-Pinto A, Gopal S, Gratten J, Green M, Greenwood T, Guillin O, Gülöksüz S, Gur R, Gur R, Gutiérrez B, Hahn E, Hakonarson H, Haroutunian V, Hartmann A, Harvey C, Hayward C, Henskens F, Herms S, Hoffmann P, Howrigan D, Ikeda M, Iyegbe C, Joa I, Julià A, Kähler A, Kam-Thong T, Kamatani Y, Karachanak-Yankova S, Kebir O, Keller M, Kelly B, Khrunin A, Kim S, Klovins J, Kondratiev N, Konte B, Kraft J, Kubo M, Kučinskas V, Kučinskiene Z, Kusumawardhani A, Kuzelova-Ptackova H, Landi S, Lazzeroni L, Lee P, Legge S, Lehrer D, Lencer R, Lerer B, Li M, Lieberman J, Light G, Limborska S, Liu C, Lönnqvist J, Loughland C, Lubinski J, Luykx J, Lynham A, Macek M, Mackinnon A, Magnusson P, Maher B, Maier W, Malaspina D, Mallet J, Marder S, Marsal S, Martin A, Martorell L, Mattheisen M, McCarley R, McDonald C, McGrath J, Medeiros H, Meier S, Melegh B, Melle I, Mesholam-Gately R, Metspalu A, Michie P, Milani L, Milanova V, Mitjans M, Molden E, Molina E, Molto M, Mondelli V, Moreno C, Morley C, Muntané G, Murphy K, Myin-Germeys I, Nenadić I, Nestadt G, Nikitina-Zake L, Noto C, Nuechterlein K, O’Brien N, O’Neill F, Oh S, Olincy A, Ota V, Pantelis C, Papadimitriou G, Parellada M, Paunio T, Pellegrino R, Periyasamy S, Perkins D, Pfuhlmann B, Pietiläinen O, Pimm J, Porteous D, Powell J, Quattrone D, Quested D, Radant A, Rampino A, Rapaport M, Rautanen A, Reichenberg A, Roe C, Roffman J, Roth J, Rothermundt M, Rutten B, Saker-Delye S, Salomaa V, Sanjuan J, Santoro M, Savitz A, Schall U, Scott R, Seidman L, Sharp S, Shi J, Siever L, Sigurdsson E, Sim K, Skarabis N, Slominsky P, So H, Sobell J, Söderman E, Stain H, Steen N, Steixner-Kumar A, Stögmann E, Stone W, Straub R, Streit F, Strengman E, Stroup T, Subramaniam M, Sugar C, Suvisaari J, Svrakic D, Swerdlow N, Szatkiewicz J, Ta T, Takahashi A, Terao C, Thibaut F, Toncheva D, Tooney P, Torretta S, Tosato S, Tura G, Turetsky B, Üçok A, Vaaler A, van Amelsvoort T, van Winkel R, Veijola J, Waddington J, Walter H, Waterreus A, Webb B, Weiser M, Williams N, Witt S, Wormley B, Wu J, Xu Z, Yolken R, Zai C, Zhou W, Zhu F, Zimprich F, Atbaşoğlu E, Ayub M, Benner C, Bertolino A, Black D, Bray N, Breen G, Buccola N, Byerley W, Chen W, Cloninger C, Crespo-Facorro B, Donohoe G, Freedman R, Galletly C, Gandal M, Gennarelli M, Hougaard D, Hwu H, Jablensky A, McCarroll S, Moran J, Mors O, Mortensen P, Müller-Myhsok B, Neil A, Nordentoft M, Pato M, Petryshen T, Pirinen M, Pulver A, Schulze T, Silverman J, Smoller J, Stahl E, Tsuang D, Vilella E, Wang S, Xu S, Adolfsson R, Arango C, Baune B, Belangero S, Børglum A, Braff D, Bramon E, Buxbaum J, Campion D, Cervilla J, Cichon S, Collier D, Corvin A, Curtis D, Forti M, Domenici E, Ehrenreich H, Escott-Price V, Esko T, Fanous A, Gareeva A, Gawlik M, Gejman P, Gill M, Glatt S, Golimbet V, Hong K, Hultman C, Hyman S, Iwata N, Jönsson E, Kahn R, Kennedy J, Khusnutdinova E, Kirov G, Knowles J, Krebs M, Laurent-Levinson C, Lee J, Lencz T, Levinson D, Li Q, Liu J, Malhotra A, Malhotra D, McIntosh A, McQuillin A, Menezes P, Morgan V, Morris D, Mowry B, Murray R, Nimgaonkar V, Nöthen M, Ophoff R, Paciga S, Palotie A, Pato C, Qin S, Rietschel M, Riley B, Rivera M, Rujescu D, Saka M, Sanders A, Schwab S, Serretti A, Sham P, Shi Y, St Clair D, Stefánsson H, Stefansson K, Tsuang M, van Os J, Vawter M, Weinberger D, Werge T, Wildenauer D, Yu X, Yue W, Holmans P, Pocklington A, Roussos P, Vassos E, Verhage M, Visscher P, Yang J, Posthuma D, Andreassen O, Kendler K, Owen M, Wray N, Daly M, Huang H, Neale B, Sullivan P, Ripke S, Walters J, O’Donovan M. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 2022, 604: 502-508. PMID: 35396580, PMCID: PMC9392466, DOI: 10.1038/s41586-022-04434-5.Peer-Reviewed Original ResearchConceptsGenomic lociTwo-stage genome-wide association studyVariant associationsDistinct genomic lociGenome-wide association studiesTranscription factor Sp4Functional genomics dataCommon variant associationsRare variant associationsCommon risk allelesSynaptic biologyGenomic dataBiological processesAssociation studiesGenesCell typesNeurodevelopmental disordersRegion variationLociFundamental processesNeuronal functionSuch variantsRisk allelesMechanistic studiesVariants
2026
From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics
Davies H, Ryan N, Reed K, Berthold N, Maina J, McNulty R, ter Kuile A, Ubah O, Trujillo-ChiVacuan E, Schulte E, Yang J, de Wit M, Bruxel E, Deak J, Koromina M, Sollie T, Braun A, Bulik C, Lewis C, Dick D, Guintivano J, Edenberg H. From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics. Behavior Genetics 2026, 1-9. PMID: 41642423, DOI: 10.1007/s10519-025-10246-w.Peer-Reviewed Original ResearchPsychiatric Genomics ConsortiumPsychiatric genetic researchPsychiatric geneticsDirect-to-consumer genetic testingGenetic researchGenomics communityLack of skillsGenetic dataSocial media campaignsMedia campaignsGenetic testingGenomics ConsortiumEffective communicationOutreachGenetic findingsEngagement programsClinical practicePsychiatric disordersGeneticsSeminar seriesPsychiatricFamily engagement programAcademic missionCatalyze initiationInaccurate information
2025
Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies
Consortium M, Adams M, Streit F, Meng X, Awasthi S, Adey B, Choi K, Chundru V, Coleman J, Ferwerda B, Foo J, Gerring Z, Giannakopoulou O, Gupta P, Hall A, Harder A, Howard D, Hübel C, Kwong A, Levey D, Mitchell B, Ni G, Ota V, Pain O, Pathak G, Schulte E, Shen X, Thorp J, Walker A, Yao S, Zeng J, Zvrskovec J, Aarsland D, Actkins K, Adli M, Agerbo E, Aichholzer M, Aiello A, Air T, Als T, Andersson E, Andlauer T, Arolt V, Ask H, Bäckman J, Badola S, Ballard C, Banasik K, Bass N, Beekman A, Belangero S, Bigdeli T, Binder E, Bjerkeset O, Bjornsdottir G, Børte S, Bränn E, Braun A, Brodersen T, Brückl T, Brunak S, Bruun M, Burmeister M, Buspavanich P, Bybjerg-Grauholm J, Byrne E, Cai J, Campbell A, Campbell M, Campos A, Castelao E, Cervilla J, Chaumette B, Chen C, Chen H, Chen Z, Cichon S, Colodro-Conde L, Corbett A, Corfield E, Couvy-Duchesne B, Craddock N, Dannlowski U, Davies G, de Geus E, Deary I, Degenhardt F, Dehghan A, DePaulo J, Deuschle M, Didriksen M, Dinh K, Direk N, Djurovic S, Docherty A, Domschke K, Dowsett J, Drange O, Dunn E, Eaton W, Einarsson G, Eley T, Elsheikh S, Engelmann J, Benros M, Erikstrup C, Escott-Price V, Fabbri C, Fang Y, Finer S, Frank J, Free R, Gallo L, Gao H, Gill M, Gilles M, Goes F, Gordon S, Grove J, Gudbjartsson D, Gutierrez B, Hahn T, Hall L, Hansen T, Haraldsson M, Hartman C, Havdahl A, Hayward C, Heilmann-Heimbach S, Herms S, Hickie I, Hjalgrim H, Hjerling-Leffler J, Hoffmann P, Homuth G, Horn C, Hottenga J, Hougaard D, Hovatta I, Huang Q, Hucks D, Huider F, Hunt K, Ialongo N, Ising M, Isometsä E, Jansen R, Jiang Y, Jones I, Jones L, Jonsson L, Kanai M, Karlsson R, Kasper S, Kendler K, Kessler R, Kloiber S, Knowles J, Koen N, Kraft J, Kranzler H, Krebs K, Kallak T, Kutalik Z, Lahtela E, Lake M, Larsen M, Lenze E, Lewins M, Lewis G, Li L, Lin B, Lin K, Lind P, Liu Y, MacIntyre D, MacKinnon D, Maher B, Maier W, Marshe V, Martinez-Levy G, Matsuda K, Mbarek H, McGuffin P, Medland S, Meinert S, Mikkelsen C, Mikkelsen S, Milaneschi Y, Millwood I, Molina E, Mondimore F, Mortensen P, Mulsant B, Naamanka J, Najman J, Nauck M, Nenadić I, Nielsen K, Nolt I, Nordentoft M, Nöthen M, Nyegaard M, O'Donovan M, Oddsson A, Oliveira A, Olsen C, Oskarsson H, Ostrowski S, Owen M, Packer R, Palviainen T, Pan P, Pato C, Pato M, Pedersen N, Pedersen O, Peyrot W, Potash J, Preisig M, Preuss M, Quiroz J, Renteria M, Reynolds C, Rice J, Sakaue S, Santoro M, Schoevers R, Schork A, Schulze T, Send T, Shi J, Sigurdsson E, Singh K, Sinnamon G, Sirignano L, Smeland O, Smith D, Sofer T, Sørensen E, Srinivasan S, Stefansson H, Stefansson K, Straub P, Su M, Tadic A, Teismann H, Teumer A, Thapar A, Thomson P, Thørner L, Topaloudi A, Tsai S, Tzoulaki I, Uhl G, Uitterlinden A, Ullum H, Umbricht D, Ursano R, Van der Auwera S, van Hemert A, Veluchamy A, Viktorin A, Völzke H, Walters G, Wang X, Wani A, Weissman M, Wellmann J, Whiteman D, Wildman D, Willemsen G, Williams A, Winsvold B, Witt S, Xiong Y, Zillich L, Zwart J, Team T, Group C, Team E, Team G, Psychiatry H, Project T, Program V, Andreassen O, Baune B, Berger K, Boomsma D, Børglum A, Breen G, Cai N, Coon H, Copeland W, Creese B, Cruz-Fuentes C, Czamara D, Davis L, Derks E, Domenici E, Elliott P, Forstner A, Gawlik M, Gelernter J, Grabe H, Hamilton S, Hveem K, John C, Kaprio J, Kircher T, Krebs M, Kuo P, Landén M, Lehto K, Levinson D, Li Q, Lieb K, Loos R, Lu Y, Lucae S, Luykx J, Maes H, Magnusson P, Martin H, Martin N, McQuillin A, Middeldorp C, Milani L, Mors O, Müller D, Müller-Myhsok B, Okada Y, Oldehinkel A, Paciga S, Palmer C, Paschou P, Penninx B, Perlis R, Peterson R, Pistis G, Polimanti R, Porteous D, Posthuma D, Rabinowitz J, Reichborn-Kjennerud T, Reif A, Rice F, Ricken R, Rietschel M, Rivera M, Rück C, Salum G, Schaefer C, Sen S, Serretti A, Skalkidou A, Smoller J, Stein D, Stein F, Stein M, Sullivan P, Tesli M, Thorgeirsson T, Tiemeier H, Timpson N, Uddin M, Uher R, van Heel D, Verweij K, Walters R, Wassertheil-Smoller S, Wendland J, Werge T, Zwinderman A, Kuchenbaecker K, Wray N, Ripke S, Lewis C, McIntosh A. Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell 2025, 188: 640-652.e9. PMID: 39814019, PMCID: PMC11829167, DOI: 10.1016/j.cell.2024.12.002.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCell-type enrichment analysisSingle-cell dataTrans-ancestryAdmixed ancestrySingle-cell analysisFine-mappingPotential repurposing opportunitiesAssociation studiesGene associationsEnrichment analysisReceptor clusteringPolygenic scoresRepurposing opportunitiesPostsynaptic densityCell typesStudies of depressionMedium spiny neuronsAncestryAntidepressant targetSpiny neuronsAmygdala neuronsLociBiological targetsEffective treatment
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