Skip to Main Content
Yale School of Medicine
YSM Home

INFORMATION FOR

Michael H Nathanson, MD, PhD

Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology
DownloadHi-Res Photo

Are You a Patient?

View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

View Doctor Profile

Additional Titles

Co-Director, Yale Liver Center, Digestive Diseases

Director, Center for Cell and Molecular Imaging

Contact Info

michael.nathanson@yale.edu
203.785.5110

Yale School of Medicine

Department of Medicine (Digestive Diseases), PO Box 208019

New Haven, CT 06520-8019

United States

About

Titles

Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology

Co-Director, Yale Liver Center, Digestive Diseases; Director, Center for Cell and Molecular Imaging

Appointments

Other Departments & Organizations

  • Cancer Signaling Networks
  • Cell Biology
  • Confocal Microscopy
  • Diabetes Research Center
  • Digestive Diseases
  • Gastrointestinal Procedure Center
  • Hepatology
  • Internal Medicine
  • Liver Center
  • Membrane Traffic
  • Molecular Cell Biology, Genetics and Development
  • Molecular Medicine, Pharmacology, and Physiology
  • Obesity Research Working Group
  • Transplantation Center
  • Yale Cancer Center
  • Yale Combined Program in the Biological and Biomedical Sciences (BBS)
  • Yale Medicine
  • Yale Ventures

Education & Training

Postdoctoral Fellow
Yale University (1990)
Resident
Columbia-Presbyterian Medical Center (1988)
MD
Case Western Reserve Univ (1985)
PhD
Case Western Reserve Univ (1983)
MS
Massachusetts Institute of Technology (1977)
BS
University of California, Berkeley (1976)

Research

Overview

  • NIH P01 DK57751 (PI: M.H. Nathanson) 04/01/01-04/30/21 Title: Regulation of liver by nuclear calcium signaling Goals: The major goals of this project are to determine the mechanisms by which calcium is regulated in the nucleus of hepatocytes, and to determine the functional effects of nuclear calcium signals in liver. Dr. Nathanson directs Project 1 and the Administrative and Cell Imaging cores of this PPG.
  • NIH P30 DK34989 (PI: M.H. Nathanson) 09/01/84-08/31/20 (NCE pending) Title: Digestive Diseases Research Core Center (Yale Liver Center) Goals: Dr. Nathanson is Director of the Liver Center as well as of the Morphology and Administrative Core components of the Center. The major goals of the Morphology Core are to provide a multidisciplinary center where the research focus is liver structure, function and disease.
  • NIH R01 DK114041 (PI: M.H. Nathanson) 02/01/18-03/31/23 Title: Ca2+ waves in hepatocytes: Mechanisms and effects Goals: The major goals of this project are to determine the mechanisms by which the type 2 InsP3 receptor regulates calcium-mediated bile secretion by hepatocytes, and to determine the role that loss or mis-localization of this receptor plays in the pathogenesis of cholestatic liver disease.
  • NIH R01 DK112797 (PI: M.H. Nathanson) 09/01/17-08/31/22 Title: Molecular regulation of cholestasis in cholangiocytes. Goals: Major goals are to understand the role of type 3 inositol trisphosphate receptor function in cholestatic liver disease
  • NIH T32 DK007356 (PI: M.H. Nathanson) 7/1/84-6/30/24 Title: Investigative Training in Hepatology. Goals: This training grant provides 1) laboratory research training for physicians who have completed clinical training in Gastroenterology and are in preparation for careers as independent investigators in academic Hepatology and research training for recent Ph.D. graduates to prepare them for careers as independent investigators in basic liver-related research.

Medical Research Interests

Calcium Signaling; Cell Biology; Cell Nucleus; Digestive System Diseases; Hepatocytes; Liver

Research at a Glance

Yale Co-Authors

Frequent collaborators of Michael H Nathanson's published research.

Publications

2024

2023

2020

See All Publications

Clinical Trials

Current Trials

Academic Achievements & Community Involvement

  • activity

    VA

    CommitteesMember
  • activity

    NIH

    Peer Review Groups and Grant Study SectionsMember
  • activity

    NIH

    Peer Review Groups and Grant Study SectionsMember
  • activity

    AASLD

    CommitteesMember
  • honor

    Assoc of American Physicians (AAP)

    National Award
See All Achievements

Clinical Care

Overview

Michael H. Nathanson, MD, PhD, specializes in treating patients with liver disease.

He is a professor of medicine (digestive diseases) and of cell biology at Yale School of Medicine. In addition to his clinical work, he serves as co-director of the Yale Liver Center and director of the Center for Cellular and Molecular Imaging; he is also an active researcher.

Clinical Specialties

Internal Medicine; Hepatology

Fact Sheets

See All Fact Sheets On Yale Medicine

Board Certifications

  • Internal Medicine

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1988

Yale Medicine News

See All News On Yale Medicine

Are You a Patient?

View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

View Doctor Profile

Get In Touch

Contacts

Email
Academic Office Number
Appointment Number
Office Fax Number
Clinic Fax Number
Mailing Address

Yale School of Medicine

Department of Medicine (Digestive Diseases), PO Box 208019

New Haven, CT 06520-8019

United States

Administrative Support

Locations

  • Patient Care Locations

    Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

    See Patient Care Locations

Events

Jan 20253Friday