William Chang, MD, PhD
Assistant Professor of Medicine (Nephrology)DownloadHi-Res Photo
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Nephrology
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Titles
Assistant Professor of Medicine (Nephrology)
Appointments
Nephrology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Nephrology Fellow
- Yale University (2012)
- Resident
- Yale New Haven Hospital (2008)
- Intern
- Yale New Haven Hospital (2007)
- PhD
- New York University, Oncology and Immunology (2006)
- MD
- New York University School of Medicine (2006)
- AB
- Harvard, Biology (1998)
Research
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Overview
Medical Research Interests
Biotechnology; Cell Biology; Kidney; Organoids
ORCID
0000-0002-7707-9242
Research at a Glance
Yale Co-Authors
Frequent collaborators of William Chang's published research.
Publications Timeline
A big-picture view of William Chang's research output by year.
Research Interests
Research topics William Chang is interested in exploring.
Jordan Pober, MD, PhD
Maria Figetakis
Alfred Bothwell, PhD
Diane Krause, MD, PhD
Francesc Lopez-Giraldez, PhD
Lawrence Young, MD
24Publications
1,732Citations
Publications
2026
Design and Implementation of a Simple In Vitro Microfluidic Platform for Culturing Kidney Tubular Cells in the Presence of Flow.
Asghari F, Graham M, Chang W. Design and Implementation of a Simple In Vitro Microfluidic Platform for Culturing Kidney Tubular Cells in the Presence of Flow. ASAIO Journal 2026 PMID: 41975573, DOI: 10.1097/mat.0000000000002712.Peer-Reviewed Original ResearchAltmetric
2021
A therapeutic vascular conduit to support in vivo cell-secreted therapy
Han EX, Qian H, Jiang B, Figetakis M, Kosyakova N, Tellides G, Niklason LE, Chang WG. A therapeutic vascular conduit to support in vivo cell-secreted therapy. Npj Regenerative Medicine 2021, 6: 40. PMID: 34326344, PMCID: PMC8322381, DOI: 10.1038/s41536-021-00150-2.Peer-Reviewed Original ResearchCitationsAltmetricHuman Amniotic Membrane as a Novel Scaffold for Inducible Pluripotent Stem Cell-derived Kidney Organoids
Figetakis M, James KJ, Kosyakova N, Torres R, Chang WG. Human Amniotic Membrane as a Novel Scaffold for Inducible Pluripotent Stem Cell-derived Kidney Organoids. ASAIO Journal 2021, 68: e73-e76. PMID: 35503644, PMCID: PMC9065564, DOI: 10.1097/mat.0000000000001476.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro
Kosyakova N, Kao DD, Figetakis M, López-Giráldez F, Spindler S, Graham M, James KJ, Won Shin J, Liu X, Tietjen GT, Pober JS, Chang WG. Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro. Npj Regenerative Medicine 2020, 5: 1. PMID: 31934351, PMCID: PMC6944695, DOI: 10.1038/s41536-019-0086-3.Peer-Reviewed Original ResearchCitationsAltmetric
2019
NSAID associated bilateral renal infarctions: a case report
Jeon Y, Lis JB, Chang WG. NSAID associated bilateral renal infarctions: a case report. International Journal Of Nephrology And Renovascular Disease 2019, 12: 177-181. PMID: 31447577, PMCID: PMC6682756, DOI: 10.2147/ijnrd.s212010.Peer-Reviewed Original ResearchCitationsTools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell Sources
Chang WG. Tools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell Sources. In R. L. Reis, & M. E. Gomes (Eds.), Encyclopedia of Tissue Engineering and Regenerative Medicine, Vol. 1 (pp. 199–208). Academic Press: Elsevier. (2019).Books
2017
A short discourse on vascular tissue engineering
Chang WG, Niklason LE. A short discourse on vascular tissue engineering. Npj Regenerative Medicine 2017, 2: 7. PMID: 29057097, PMCID: PMC5649630, DOI: 10.1038/s41536-017-0011-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2016
ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight 2016, 1: e80920. PMID: 27525311, PMCID: PMC4982472, DOI: 10.1172/jci.insight.80920.Peer-Reviewed Original ResearchCitationsAltmetricBlocking MHC class II on human endothelium mitigates acute rejection
Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight 2016, 1: e85293. PMID: 26900601, PMCID: PMC4756651, DOI: 10.1172/jci.insight.85293.Peer-Reviewed Original ResearchCitationsAltmetric
2015
Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli
Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS. Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli. Tissue Engineering Part A 2015, 21: 2673-2679. PMID: 26414101, PMCID: PMC4652181, DOI: 10.1089/ten.tea.2015.0060.Peer-Reviewed Original ResearchCitations
Academic Achievements & Community Involvement
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Featured
honor Kidney X: Artificial Kidney Prize
06/12/2023National AwardASN and HHSDetailsUnited States
Activities
activity American Society of Nephrology
2008 - PresentProfessional OrganizationsMemberactivity Harvard College
01/26/2026 - PresentPublic ServiceInterviewerDetailsUndergraduate admission intervieweractivity Charles H. Hood Foundation
10/17/2025 - 08/03/2026Peer Review Groups and Grant Study SectionsGrant Revieweractivity Cell-based Tissue Engineering of Kidney: 8th Annual Global Summit on Kidney Disease Innovations
05/18/2026 - PresentLectureGlobal Summit on Kidney Disease InnovationsDetailsVirtual ConferenceSponsored by American Association of Kidney Patients (AAKP) and The George Washington Universityactivity Cell Transplantation
2026 - 2026Journal ServiceReviewer
Honors
honor Invited panelist
12/02/2021Regional AwardCharles H. Hood FoundationDetailsUnited Stateshonor Blavatnik Fund Semifinalist
11/06/2019Yale University AwardYale Blavatnik Fund for Innovation at YaleDetailsUnited Stateshonor Yale Center for Clinical Investigation, Junior Faculty Scholar
11/01/2012Yale University AwardYale UniversityDetailsUnited Stateshonor Scholar in Training Award for Special Conferences on Ubiquitination in Normal and Cancer Cells
11/01/2002National AwardAmerican Association of Cancer ResearchDetailsUnited Stateshonor Pathology Training Grant
11/01/2001Other AwardNew York UniversityDetailsUnited States
Teaching & Mentoring
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Teaching
Clinical Yale Affiliated Hospitals Program
LecturerLecture SettingDetails8/1/2023 - PresentForHouse Staff1 Average Instructional Hours Per YearFull-time faculty of the Department of Internal Medicine at Yale provide a series of lectures (including residency noon conferences, subspecialty presentations, ward rounds, and grand rounds) at the nine other affiliated hospitals. These lectures comprise a major proportion of the education of the residents at the affiliated institutions.
Mentoring
Maria Eugenia Gulino
Postdoc2025 - PresentJay Manish Pandya
Postgrad associate2025 - PresentNaysa Kalugdan
Undergraduate Student2025 - PresentFatemeh Asghari
Postdoc2023 - Present
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