Yuan Lu, ScD
Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)DownloadHi-Res Photo
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Cardiovascular Medicine
Primary
Chronic Disease Epidemiology
Secondary
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About
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Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)
Biography
Dr. Lu was trained in epidemiology and global health, with a particular focus on cardiovascular diseases. She obtained both of her ScD and MSc Degrees in Global Health and Population at the Harvard School of Public Health. She works in the intersection of cardiovascular disease prevention, clinical informatics, and digital health, using implementation science methods to resolve real-world issues. Her long-term goal is to improve care and outcomes of cardiovascular diseases by designing and implementing technology-based interventions.
She successfully completed an NHLBI K12 career development award in implementation science. During this award, she harnessed electronic health records from the Yale New Haven Health System to identify patients with persistent hypertension and designing decision support systems to improve their care. Currently, Dr. Lu serves as the Principal Investigator for an NIH R01 grant, where she leverages real-world data from five electronic health record databases encompassing over 100 million US adults. The goal of this endeavor is to generate real-world evidence that informs decisions regarding hypertension treatment escalation.
In addition to her domestic contributions, Dr. Lu has engaged in groundbreaking collaborative projects between Yale University and the Chinese National Center for Cardiovascular Diseases in Beijing. These include the Millions Persons Project that assembles remarkable population health and biomedical resources from 5 million individuals across China. Moreover, she has collaborated with the NCD Risk Factor Collaboration (NCD-RisC) on global analyses examining the impact of risk factors on the worldwide burden of cardiovascular diseases.
She has authored over 150 peer-reviewed publications, including first author articles in leading journals such as The Lancet, JAMA, BMJ, Circulation, and JACC, and her work has been cited more than 50,000 times. Dr. Lu is the recipient of the 2022 John H. Laragh Research Award of the American Journal of Hypertension for her contribution to the field of hypertension. She is a Fellow of the American Heart Association and the American College of Cardiology, and currently serves as an Executive Associate Editor at JACC.
Last Updated on August 20, 2025.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimaryBiomedical Informatics & Data Science
Assistant ProfessorSecondaryChronic Disease Epidemiology
Assistant ProfessorSecondary
Other Departments & Organizations
- Biomedical Informatics & Data Science
- Cardiovascular Medicine
- Center for Outcomes Research & Evaluation (CORE)
- Chronic Disease Epidemiology
- Internal Medicine
- Janeway Society
- Preventive Cardiovascular Health Program at Yale
- Yale Obesity Research Center (Y-Weight)
- Yale UNRAVEL Study
Education & Training
- ScD
- Harvard School of Public Health, Global Health and Population (2015)
Research
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Overview
Medical Research Interests
Cardiovascular Diseases; Chronic Disease
Public Health Interests
Implementation Science; Obesity; Epidemiology Methods; Global Health
ORCID
0000-0001-5264-2169- View Lab Website
Yale/YNHH Center for Outcomes Research and Evaluation (CORE)
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yuan Lu's published research.
Publications Timeline
A big-picture view of Yuan Lu's research output by year.
Research Interests
Research topics Yuan Lu is interested in exploring.
Harlan Krumholz, MD, SM
Erica Spatz, MD, MHS
Cesar Caraballo-Cordovez, MD
Mitsuaki Sawano, MD, PhD
Rohan Khera, MD, MS
Jeph Herrin, PhD
125Publications
40,330Citations
Cardiovascular Diseases
Chronic Disease
Publications
2025
Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study
AL Mouslmani M, Sawano M, Arun A, Wu Y, Shah R, Kaleem S, Zhou T, Murugiah K, Lu Y, Herrin J, Bishop P, Taub P, Peixoto A, Bhattacharjee B, Iwasaki A, Krumholz H. Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study. JACC Advances 2025, 4: 101873. PMID: 40883051, PMCID: PMC12399260, DOI: 10.1016/j.jacadv.2025.101873.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSelf-reported diagnosisPostural orthostatic tachycardia syndromeHealth statusSelf-reported long COVIDOrthostatic tachycardia syndromeHealth status of peopleEuroQol visual analog scaleDiagnosis of postural orthostatic tachycardia syndromeOnline observational studyExperiences of peopleStatus of peoplePostacute COVID-19 syndromeChest painVisual analog scaleHigher RatesExcessive fatigueHealth burdenMyalgic encephalomyelitis/chronic fatigue syndromeSocial isolationInternal tremorExercise intoleranceObservational studyFinancial difficultiesAnalog scaleSuicidal thoughtsEvaluating Blood Pressure Response Patterns to Exercise Stress Testing
Nene A, Lee D, Agboola O, Herrin J, Onuma O, Feher A, Miller E, Lu Y, Meadows J, Spatz E. Evaluating Blood Pressure Response Patterns to Exercise Stress Testing. Hypertension 2025, 82: 1663-1674. PMID: 40859827, DOI: 10.1161/hypertensionaha.124.23717.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHypertensive response to exerciseBlood pressureComposite outcomeResponse to exerciseCardiovascular eventsBlood pressure trajectoriesClass IIComposite outcome of myocardial infarctionBlood pressure response patternsAssociated with future cardiovascular eventsPeak blood pressureAssociated with cardiovascular outcomesOutcome of myocardial infarctionPressure trajectoriesExercise stress testDiastolic blood pressureSystolic blood pressureExercise tolerance testClass II and IIITrajectories of blood pressureSystolic blood pressure trajectoriesStages 1 to 3Heart failureCardiovascular outcomesTolerance testWhy Can’t We Get There? Understanding Persistent Hypertension in Real-World Care
Lu Y. Why Can’t We Get There? Understanding Persistent Hypertension in Real-World Care. Journal Of The American College Of Cardiology 2025 PMID: 40900054, DOI: 10.1016/j.jacc.2025.08.009.Peer-Reviewed Original ResearchAltmetricChanges in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
Lu Y, Liu Y, Totojani T, Kim C, Khera R, Xu H, Brush J, Krumholz H, Abaluck J. Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide. JAMA Network Open 2025, 8: e2526013. PMID: 40779264, PMCID: PMC12334959, DOI: 10.1001/jamanetworkopen.2025.26013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHealth care expendituresCardiovascular risk factorsCare expendituresCohort studyRisk factorsYale New Haven Health SystemCohort study of adultsType 2 diabetes statusLong-term impactStudy of adultsHealth systemRetrospective cohort studyBlood pressureHemoglobin A1c reductionMain OutcomesTotal cholesterolSentara HealthcareInpatient staySecondary outcomesGlucagon-like peptide-1 receptor agonistsPrimary outcomeHealthPeptide-1 receptor agonistsAssociated with clinical outcomesAssociated with reductionsReply Systolic Blood Pressure and All-Cause Mortality in Treated Hypertensive Adults Aged 80+ Years
Yang H, Lu Y. Reply Systolic Blood Pressure and All-Cause Mortality in Treated Hypertensive Adults Aged 80+ Years. Journal Of The American College Of Cardiology 2025, 86: e67-e68. PMID: 40803787, DOI: 10.1016/j.jacc.2025.05.050.Peer-Reviewed Original ResearchCoronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes
Dong W, Lu Y, Li S, Sawano M, Caraballo C, Liu Y, Khera A, Philippakis A, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Herrington D, Post W, Rich S, Rotter J, Krumholz H. Coronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes. JACC Advances 2025, 4: 101994. PMID: 40712269, PMCID: PMC12311502, DOI: 10.1016/j.jacadv.2025.101994.Peer-Reviewed Original ResearchConceptsAcute myocardial infarction subtypePolygenic risk scoresAcute myocardial infarctionRisk of acute myocardial infarctionRisk scoreCoronary artery diseaseAssociated with acute myocardial infarctionEstimated riskAssociated with higher riskAssociated with MIAcute myocardial infarction patientsMultinomial logistic regressionArtery diseaseNonobstructive coronary artery diseaseLogistic regressionFemale-to-male ratioYoung adultsCox regressionHigh riskInfarction subtypesYoung individualsMyocardial infarctionEarly-onsetScoresSexHypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic
Essa M, Malik D, Lu Y, Yang H, Spatz E, Krumholz H, Faridi K. Hypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic. Journal Of Clinical Hypertension 2025, 27: e70093. PMID: 40685707, PMCID: PMC12277530, DOI: 10.1111/jch.70093.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHypertension prevalencePrevalence ratiosUS adultsAge-standardized prevalence estimatesAggressive public health effortsPublic health effortsPre-pandemicControl of hypertensionCOVID-19 pandemicHypertension awarenessHealth effortsPoisson regressionImpact of hypertensionPost-pandemicPrevalence estimatesNHANES dataNationwide prevalenceCause of deathUnited StatesBlood pressure controlNational trendsPrevalenceCOVID-19AdultsHypertensionAssociation Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes
Brush J, Kim C, Liu Y, Xin X, Huang C, Lundy I, Asher J, Sawano M, Young P, McPadden J, Anderson M, Burrows J, Krumholz H, Lu Y. Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes. JACC Advances 2025, 4: 101912. PMID: 40627892, PMCID: PMC12272890, DOI: 10.1016/j.jacadv.2025.101912.Peer-Reviewed Original ResearchCitationsConceptsNeighborhood-level social vulnerabilitySocial Vulnerability IndexAssociated with hypertension prevalenceDiverse cohortSocial Vulnerability Index quartilesElectronic health dataIncident myocardial infarctionBaseline body mass indexDiverse cohort of patientsSocial vulnerabilityBody mass indexPoor BP controlCardiovascular outcomesHypertension prevalenceBlood pressureHypertension outcomesRacial disparitiesHealth dataHypertension managementAssociated with adverse cardiovascular outcomesLongitudinal cohortMass indexWhite raceBlack raceComposite endpointJACC Data Report Cardiovascular Disease Mortality Trends in the United States (1999-2023)
Yan B, Arun A, Curtis L, Kadakia K, Lin Z, Lu Y, Wadhera R, Krumholz H, Dhruva S. JACC Data Report Cardiovascular Disease Mortality Trends in the United States (1999-2023). Journal Of The American College Of Cardiology 2025, 85: 2495-2498. PMID: 40562514, DOI: 10.1016/j.jacc.2025.05.018.Peer-Reviewed Original ResearchCitationsAltmetricDelayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes
Lu Y, Brush J, Kim C, Liu Y, Xin X, Huang C, Sawano M, Young P, McPadden J, Anderson M, Burrows J, Asher J, Krumholz H. Delayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes. JAMA Network Open 2025, 8: e2520498. PMID: 40658418, PMCID: PMC12261005, DOI: 10.1001/jamanetworkopen.2025.20498.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsElectronic health recordsHypertension diagnosisIntegrated health care systemHazard ratioNon-Hispanic black raceAntihypertensive medication prescribingMedication prescription ratesClinical diagnosis of hypertensionHealth care systemCardiovascular outcomesRisk of myocardial infarctionCox proportional hazards regression modelsAssociated with younger ageOutpatient blood pressureBlood pressureCardiovascular riskProportional hazards regression modelsAntihypertensive medication prescriptionsDiagnosis of hypertensionMultivariate Cox proportional hazards regression modelsAssociated with delayHazards regression modelsMedication prescribingHealth recordsNon-Hispanic
Academic Achievements & Community Involvement
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Activities
activity National Institutes of Health (NIH)
06/01/2023 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity JACC
02/01/2024 - PresentJournal ServiceAssociate Editoractivity American Heart Association
07/01/2021 - PresentProfessional OrganizationsFellowactivity JACC
07/01/2024 - PresentJournal ServiceAssociate Editoractivity American College of Cardiology
03/01/2025 - PresentProfessional OrganizationsFellow
Honors
honor Fellow
03/01/2025National AwardAmerican College of CardiologyDetailsUnited Stateshonor Office of Health Equity Research Award for Yale Research Excellence, Finalist
02/23/2024Yale School of Medicine AwardOffice of Health Equity Research, Yale School of MedicineDetailsUnited Stateshonor Office of Health Equity Research Award for Yale Research Excellence
02/01/2023Yale University AwardOffice of Health Equity Research, Yale School of MedicineDetailsUnited Stateshonor The John Laragh Research Award
07/29/2022National AwardAmerican Journal of HypertensionDetailsUnited Stateshonor Batten Fellowship Award
07/01/2022Regional AwardSentara FoundationDetailsUnited States
Teaching & Mentoring
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Mentoring
Chungsoo Kim, PharmD/PhD
Postdoc2024 - PresentIvan Wu
Postgrad associate2024 - PresentAdith Arun
Medical student2024 - PresentXin Xin
Graduate student2023 - 2024
News
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News
- July 14, 2025Source: Cardiologytoday
Delays in Hypertension Diagnosis May Hold Up Treatment, Increase CVD Risk
- June 03, 2025Source: Yale News
Insights & Outcomes: Star Music, Kavli Kudos, and Summertime Heart Risks
- May 05, 2025
Why Aren’t People Who Need Weight Loss Drugs Getting Them?
- April 17, 2025
Lower Blood Pressure May Offer Benefits Even for the Very Elderly
Get In Touch
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Locations
Yale Center for Outcomes Research and Evaluation
Academic Office
195 Church Street, Fl 5th
New Haven, CT 06510