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Ruth R Montgomery, PhD

Professor of Medicine and Professor of Epidemiology (Microbial Diseases); Associate Dean for Scientific Affairs, Dept Clinical: Internal Medicine

Contact Information

Ruth R Montgomery, PhD

Mailing Address

  • Rheumatology

    300 Cedar St

    New Haven, CT 06520

    United States

Research Summary

My research focuses on translational studies of primary human cells in disease susceptibility and divergent clinical outcomes. The focus of our lab’s research is on use of novel emerging technology and high-dimensional OMICs platforms to define mechanisms of immune responses. The lab's projects include the effect of aging on immunity, divergent responses to infection with West Nile virus and SARS CoV2, and studies of inflammatory processes in asthma and sickle cell disease. We have published several methods using CyTOF, a mass-spec based cell analyzer which provides multi-dimensional (~50) single cell data in suspension or in tissue sections essentially without background signals or overlap between signals. We have used this expertise in collaborative studies of airway responses in asthma and COVID-19 infections.

Specialized Terms: Innate Immunity; Macrophage; Neutrophil; Aging; West Nile Virus

Extensive Research Description

Immune profiling; Single cell mass cytometry


Research Interests

Aging; Asthma; Immune System; Immunity, Innate; Immune System Diseases; Macrophages; Neutrophils; Pathology; Public Health; Rheumatology; Virus Diseases; West Nile virus; COVID-19

Public Health Interests


Research Images

Selected Publications

Clinical Trials

ConditionsStudy Title
Immune System; Men's Health; Women's HealthEffects of circadian regulation and sleep on immune responses
Addictive Behaviors; HIV/AIDS; Infectious DiseasesImpact of HIV Infection on Immunologic, Transcriptomic, and Metabolomic Signatures
Immune SystemImmune Response Analysis in Lymph Node Tissue