Makoto Mori, MD, PhD
Assistant ProfessorDownloadHi-Res Photo
About
Titles
Assistant Professor
Biography
Dr. Mori completed his medical education at Emory University School of Medicine and is currently an Integrated Cardiothoracic Surgery resident. He obtained his Ph.D. in clinical outcomes and health services research through the Investigative Medicine Program at Yale.
Last Updated on July 01, 2024.
Departments & Organizations
Education & Training
- PhD
- Yale Graduate School of Arts and Sciences, Investigative Medicine (2021)
- MD
- Emory University School of Medicine (2015)
- BS
- Emory University (2011)
Research
Overview
Medical Research Interests
Health Care Quality, Access, and Evaluation; Thoracic Surgery; Treatment Outcome
ORCID
0000-0002-2367-8354
Research at a Glance
Yale Co-Authors
Frequent collaborators of Makoto Mori's published research.
Publications Timeline
A big-picture view of Makoto Mori's research output by year.
Research Interests
Research topics Makoto Mori is interested in exploring.
Harlan Krumholz, MD, SM
Clancy Mullan, MD, PhD
Gabe Weininger
Roland Assi, MD, MMS, FACS
Andrea Amabile, MD
Tariq Ahmad, MD, MPH
161Publications
2,112Citations
Treatment Outcome
Thoracic Surgery
Publications
Featured Publications
Identifying quality of life outcome patterns to inform treatment choices in ischemic cardiomyopathy
Mori M, Mark DB, Khera R, Lin H, Jones P, Huang C, Lu Y, Geirsson A, Velazquez EJ, Spertus JA, Krumholz HM. Identifying quality of life outcome patterns to inform treatment choices in ischemic cardiomyopathy. American Heart Journal 2022, 254: 12-22. PMID: 35932911, DOI: 10.1016/j.ahj.2022.07.007.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCoronary artery bypass surgeryGuideline-directed medical therapyTreatment choiceBetter outcomesIschemic cardiomyopathyQOL outcomesQoL dataKansas City Cardiomyopathy Questionnaire overall summary scoreQOL trajectoriesOutcome patternsIschemic Heart Failure (STICH) trialHeart Failure TrialMain baseline predictorsArtery bypass surgeryOverall summary scoreDifferent treatment choicesLogistic regression modelsBypass surgeryMedical therapySurgical treatmentFailure TrialLife scoresQOL scoresPatient's probabilityBaseline predictorsTrends in Transcatheter and Surgical Aortic Valve Replacement Among Older Adults in the United States
Mori M, Gupta A, Wang Y, Vahl T, Nazif T, Kirtane AJ, George I, Yong CM, Onuma O, Kodali S, Geirsson A, Leon MB, Krumholz HM. Trends in Transcatheter and Surgical Aortic Valve Replacement Among Older Adults in the United States. Journal Of The American College Of Cardiology 2021, 78: 2161-2172. PMID: 34823659, DOI: 10.1016/j.jacc.2021.09.855.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsDevelopment and Validation of a Predictive Model to Identify Patients With an Ascending Thoracic Aortic Aneurysm
Mori M, Gan G, Deng Y, Yousef S, Weininger G, Daggula KR, Agarwal R, Shang M, Assi R, Geirsson A, Vallabhajosyula P. Development and Validation of a Predictive Model to Identify Patients With an Ascending Thoracic Aortic Aneurysm. Journal Of The American Heart Association 2021, 10: e022102. PMID: 34743563, PMCID: PMC8751931, DOI: 10.1161/jaha.121.022102.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsThoracic aortic aneurysmAortic aneurysmPatient riskTomography scanHigher body surface areaTertiary care centerAortic valve diseaseHistory of arrhythmiaAvailable clinical informationBody surface areaScreening of patientsCross-sectional studyRisk prediction algorithmAscending Thoracic Aortic AneurysmsLogistic regression modelsClinical characteristicsAortic dissectionUnique patientsValve diseaseC-statisticFemale sexThoracic aortaCare centerComorbidity variablesMultivariable modelToward Dynamic Risk Prediction of Outcomes After Coronary Artery Bypass Graft
Mori M, Durant TJS, Huang C, Mortazavi BJ, Coppi A, Jean RA, Geirsson A, Schulz WL, Krumholz HM. Toward Dynamic Risk Prediction of Outcomes After Coronary Artery Bypass Graft. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007363. PMID: 34078100, PMCID: PMC8635167, DOI: 10.1161/circoutcomes.120.007363.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCoronary artery bypass graftArtery bypass graftIntraoperative variablesBypass graftLogistic regression modelsOperative mortalityC-statisticCoronary artery bypass graft casesThoracic Surgeons Adult Cardiac Surgery DatabaseAdult Cardiac Surgery DatabaseMean patient ageGood c-statisticCardiac Surgery DatabaseBrier scoreRisk restratificationDynamic risk predictionIntraoperative deathsPostoperative complicationsPostoperative eventsAdverse eventsPatient agePreoperative variablesRegression modelsGraft casesSurgery DatabaseUsing Latent Class Analysis to Identify Hidden Clinical Phenotypes
Mori M, Krumholz HM, Allore HG. Using Latent Class Analysis to Identify Hidden Clinical Phenotypes. JAMA 2020, 324: 700-701. PMID: 32808993, DOI: 10.1001/jama.2020.2278.Peer-Reviewed Educational MaterialsCitationsAltmetricMeSH Keywords and Concepts
2025
Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice
Gao F, Chen Q, Mori M, Li S, Ferrari G, Krane M, Fan R, Tellides G, Liu Y, Geirsson A. Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice. Journal Of Clinical Investigation 2025 PMID: 40392604, DOI: 10.1172/jci183558.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMitral valve prolapseMyxomatous mitral valve degenerationValve prolapseMitral valve degenerationValve degenerationWeeks of ageTGF-bMgR miceMitral regurgitationAssociation of mitral valve prolapseProgression of mitral valve prolapseMTOR signalingMTOR inhibitionMitral valve diseaseMTOR activityTGF-b signalingLong-term inhibitionIncreased mTOR signalingMarfan syndromeMedical therapyLeukocyte infiltrationFBN1 variantsMacrophage recruitmentValve diseaseProlapseTranscatheter aortic valve replacement use in young patients before and after the first low-risk trial publication
Waldron C, Pirelli L, George I, Takayama H, Geirsson A, Assi R, Mori M. Transcatheter aortic valve replacement use in young patients before and after the first low-risk trial publication. JTCVS Structural And Endovascular 2025, 5: 100033. DOI: 10.1016/j.xjse.2024.100033.Peer-Reviewed Original ResearchAltmetricComparison of Outcomes Between Low-Risk Aortic Valve Replacement Trials and a Surgical Registry
Mori M, Shioda K, Waldron C, Huang C, Gaudino M, George I, Takayama H, Geirsson A. Comparison of Outcomes Between Low-Risk Aortic Valve Replacement Trials and a Surgical Registry. JAMA Network Open 2025, 8: e2453267. PMID: 39761046, PMCID: PMC11704974, DOI: 10.1001/jamanetworkopen.2024.53267.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSurgical aortic valve replacementLow-risk trialsSTS ACSDLow riskSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseSAVR armPARTNER 3Evolut Low Risk trialAdult Cardiac Surgery DatabaseCompare 30-day mortalityConcomitant cardiac operationsCardiac Surgery DatabaseLow surgical riskMortality rateAortic valve replacementSevere aortic stenosisStroke rateIncidence of patientsTrial exclusion criteriaRisk of mortalitySAVR cohortCross-sectional studyComparison of outcomesIncidence of strokeNontrial setting
2024
Concomitant Procedures in Robotic Mitral Valve Surgery
Waldron C, Mori M, LaLonde M, Geirsson A. Concomitant Procedures in Robotic Mitral Valve Surgery. Seminars In Thoracic And Cardiovascular Surgery 2024 PMID: 39672523, DOI: 10.1053/j.semtcvs.2024.11.007.Peer-Reviewed Original ResearchDiscussion to: Association between the proportionality of functional mitral regurgitation and survival after mitral valve operation
Mori M, Anyanwu A, Geirsson A. Discussion to: Association between the proportionality of functional mitral regurgitation and survival after mitral valve operation. JTCVS Open 2024 DOI: 10.1016/j.xjon.2024.07.005.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Honors
honor Emerging-Generation Awards
12/01/2023National AwardAmerican Society for Clinical Investigationhonor Clinical Excellence Award
06/01/2023Regional AwardYale Cardiothoracic Surgery Residencyhonor Surgeon Scientist Training Program
03/01/2023Regional AwardYale Department of Surgeryhonor Cardiothoracic Ethics Forum Scholarship
08/01/2019National AwardSociety of Thoracic Surgeons/American Association for Thoracic SurgeryDetailsUnited Stateshonor Adult Cardiac Surgery Best Poster Award
01/30/2018National AwardThe Society of Thoracic SurgeonsDetailsUnited States
Clinical Care
Overview
Clinical Specialties
Thoracic Surgery
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews
News
- April 26, 2024
Clancy Mullan Named 2024 Surgeon Scientist Training Program Scholar for Yale Department of Surgery
- February 01, 2024
Understanding Environmental Influences on Disease
- January 30, 2024
ASCI Recognizes Early-career Yale Faculty and Trainees
- February 16, 2023
Digital Platform Shows the Complexity of How Patients Recover After Surgery
Get In Touch
Contacts
Appointment Number
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.