2025
Associations among prenatal stress, socioeconomic status, and infant epigenetic aging
Sperber J, Hart E, Troller-Renfree S, Watts T, Miller M, Bellatin A, Meyer J, Dettmer A, Champagne F, Noble K. Associations among prenatal stress, socioeconomic status, and infant epigenetic aging. Psychoneuroendocrinology 2025, 107575. DOI: 10.1016/j.psyneuen.2025.107575.Peer-Reviewed Original ResearchRacially diverse sampleSocioeconomic disadvantagePrenatal stressFamily incomeEpigenetic ageMaternal perceived stressDiverse sample of mothersFamily socioeconomic disadvantagePre-registered studySample of mothersHair cortisol concentrationsMaternal physiological stressPerceived stressSocioeconomic statusEffect of family incomeEffect sizeGenome-wide DNA methylationOne-month-old infantsWeeks of pregnancyPhysiological stressEpigenetic clocksAssociationAgeDNA methylationCortisol concentrationsDepletion of Fkbp5 Protects Against the Rapid Decline in Ovarian Reserve Induced by Prenatal Stress in Female Offspring of Wild-Type Mice
Moore M, Cetinkaya-Un B, Sarkar P, Kayisli U, Semerci-Gunay N, Teng M, Lockwood C, Guzeloglu-Kayisli O. Depletion of Fkbp5 Protects Against the Rapid Decline in Ovarian Reserve Induced by Prenatal Stress in Female Offspring of Wild-Type Mice. International Journal Of Molecular Sciences 2025, 26: 2471. PMID: 40141115, PMCID: PMC11942629, DOI: 10.3390/ijms26062471.Peer-Reviewed Original ResearchConceptsOvarian reservePrenatal stressFKBP51 levelsPostnatal ovarian functionReduced ovarian reserveOvarian steroid synthesisWild-type miceMaternal restraint stressPrenatal stress groupPrenatally stressed offspringExpression of FKBP51Inhibit glucocorticoidProgesterone receptorTertiary folliclesEmbryonic day 8Granulosa cellsOvarian functionRestraint stressSteroidogenic enzymesMiddle-aged groupOvarian expressionFollicle atresiaPrenatal stress effectsDay 8Steroid synthesisPrenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways
Maurer S, Hing B, Lussier S, Radhakrishna S, Davis J, Abbott P, Michaelson J, Stevens H. Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways. Journal Of Psychiatric Research 2025, 182: 149-160. PMID: 39809011, PMCID: PMC11959308, DOI: 10.1016/j.jpsychires.2024.12.048.Peer-Reviewed Original ResearchConceptsPrenatal stressAutism spectrum disorderSex-specific wayDorsal striatumNeurodevelopmental disordersGABAergic populationEffects of prenatal stressStriatal GABAergic neuronsReversal learningVentral forebrain regionsBrain changesSpectrum disorderForebrain regionsStriatal developmentGABAergic neuronsBehavioral assaysBrain developmentPlacental transcriptomeStriatumCognitionDevelopmental originsDisordersPlacental differencesPlacental functionPlacenta function
2023
Amniotic fluid cortisol predicts neonatal and infant development in non-stressed rhesus monkeys: Implications for prenatal stress
Otridge J, Meyer J, Dettmer A. Amniotic fluid cortisol predicts neonatal and infant development in non-stressed rhesus monkeys: Implications for prenatal stress. Neurotoxicology And Teratology 2023, 100: 107308. PMID: 37890675, PMCID: PMC10872548, DOI: 10.1016/j.ntt.2023.107308.Peer-Reviewed Original ResearchConceptsHair cortisol concentrationsCORT exposureInfant developmentPrenatal stressMaternal hair cortisol concentrationsAmniotic fluid cortisolInfant hair cortisol concentrationsFetal cortisol exposurePostnatal day 30Healthy rhesus macaquesInfant growth rateHealthy primatesGestational ageClinical reasonsCortisol exposureDays gestationNeonatal assessmentSensorimotor scoresAmniotic fluidNeurological developmentCortisol concentrationsDay 30Rhesus monkeysRhesus macaquesCORT levelsMaternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic risk
2022
The effects of prenatal stress on neural responses to infant cries in expectant mothers and fathers
Peoples SG, Lowell AF, Bunderson M, Bartz C, Yip SW, Rutherford HJV. The effects of prenatal stress on neural responses to infant cries in expectant mothers and fathers. Developmental Psychobiology 2022, 64: e22280. PMID: 35603419, DOI: 10.1002/dev.22280.Peer-Reviewed Original ResearchConceptsInfant cryingAttentional processingNeural processingInfant cuesNeural responsesGreater LPP responsesMore attentional resourcesEvent-related potentialsLPP responsesAttentional resourcesAttentional processesPrenatal stress exposurePsychological changesNeural markersDistress levelsPerceptual responsesParental sex differencesStress exposurePrenatal stressSex differencesEarly riskCuesParentsCaregivingProcessingPerceived stress during the prenatal period: assessing measurement invariance of the Perceived Stress Scale (PSS-10) across cultures and birth parity
Katus L, Foley S, Murray A, Luong-Thanh B, Taut D, Baban A, Madrid B, Fernando A, Sikander S, Ward C, Osafo J, Marlow M, Du Toit S, Walker S, Van Vo T, Fearon P, Valdebenito S, Eisner M, Hughes C. Perceived stress during the prenatal period: assessing measurement invariance of the Perceived Stress Scale (PSS-10) across cultures and birth parity. Archives Of Women's Mental Health 2022, 25: 633-640. PMID: 35420323, PMCID: PMC9072510, DOI: 10.1007/s00737-022-01229-5.Peer-Reviewed Original Research
2020
Correction: Expectant Mothers Maximizing Opportunities: Maternal Characteristics Moderate Multifactorial Prenatal Stress in the Prediction of Birth Weight in a Sample of Children Adopted at Birth
Brotnow L, Reiss D, Stover CS, Ganiban J, Leve LD, Neiderhiser JM, Shaw DS, Stevens HE. Correction: Expectant Mothers Maximizing Opportunities: Maternal Characteristics Moderate Multifactorial Prenatal Stress in the Prediction of Birth Weight in a Sample of Children Adopted at Birth. PLOS ONE 2020, 15: e0230595. PMID: 32163515, PMCID: PMC7067406, DOI: 10.1371/journal.pone.0230595.Peer-Reviewed Original Research
2019
A Longitudinal Investigation of Military Sexual Trauma and Perinatal Depression
Gross GM, Kroll-Desrosiers A, Mattocks K. A Longitudinal Investigation of Military Sexual Trauma and Perinatal Depression. Journal Of Women's Health 2019, 29: 38-45. PMID: 31560602, DOI: 10.1089/jwh.2018.7628.Peer-Reviewed Original ResearchConceptsMilitary sexual traumaPerinatal mental healthPostnatal depressionSuicidal ideationPerinatal depressionPrenatal depressionWomen veteransEdinburgh Postnatal Depression ScalePostnatal Depression ScaleRisk of depressionVeterans Health AdministrationMental health careSexual traumaObstetrical carePostnatal symptomsDepression ScaleHigh riskPrenatal stressBivariate statistical testsHayes mediation modelHealth AdministrationImpact of MSTMental healthDepressionHealth care
2018
Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective
Glover V, O'Donnell KJ, O'Connor TG, Fisher J. Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective. Development And Psychopathology 2018, 30: 843-854. PMID: 30068411, DOI: 10.1017/s095457941800038x.BooksMeSH KeywordsAnxiety DisordersBrainChildCross-Cultural ComparisonDepressive DisorderDeveloping CountriesFemaleFetal DevelopmentHumansHypothalamo-Hypophyseal SystemInfantMental DisordersPituitary-Adrenal SystemPregnancyPrenatal Exposure Delayed EffectsPsychopathologyPsychosocial DeprivationRisk FactorsSocial EnvironmentStress, PsychologicalConceptsPrenatal stressLater psychopathologyPregnancy-specific anxietyPrenatal maternal stressPrenatal stress altersAdrenal axisChild neurodevelopmentHigh-income countriesFetal programmingInfant deathMaternal stressGene-environment interactionsNutritional deficienciesMothers' stressDifferent ethnic groupsStress altersPsychopathologyBiological differencesEthnic groupsInterpersonal violenceAnxietyCaucasian samplesHigh levelsPregnancyCytokinesPrenatal Exposure to Stressful Life Events and Infant Breastfeeding
Buck CO, Gjelsvik A, Vivier PM, Monteiro K, Amanullah S. Prenatal Exposure to Stressful Life Events and Infant Breastfeeding. Breastfeeding Medicine 2018, 13: 426-432. PMID: 29985635, DOI: 10.1089/bfm.2017.0200.Peer-Reviewed Original ResearchConceptsPrenatal exposurePregnancy Risk Assessment Monitoring System dataMultivariable logistic regressionStressful life event exposureLife event exposureLife eventsComplex survey designInfant breastfeedingStressful life eventsBreastfeeding ratesRisk womenPostpartum womenInfant characteristicsAnticipatory guidanceImpact of exposurePrenatal stressSLEEmotional stressorsLogistic regressionEvent exposureBreastfeedingTraumatic stressorsExposureMonitoring System dataWomen
2017
Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner
Braithwaite EC, Pickles A, Sharp H, Glover V, O'Donnell KJ, Tibu F, Hill J. Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner. Physiology & Behavior 2017, 175: 31-36. PMID: 28322912, PMCID: PMC5429387, DOI: 10.1016/j.physbeh.2017.03.017.Peer-Reviewed Original ResearchConceptsNeonatal Behavioral Assessment ScaleSex-dependent mannerPrenatal stressMaternal prenatal cortisolPrenatal cortisolFemale infantInfant negative emotionalityFetal developmental trajectoriesMaternal saliva samplesProspective longitudinal cohortDevelopment Study cohortGeneral population estimatesBehavioral Assessment ScaleWirral Child HealthPrenatal cortisol levelsInverse probability weightsStudy cohortMale infantLongitudinal cohortFetal programmingChild healthEvening cortisolSex-specific developmental trajectoriesGlucocorticoid mechanismsPrevention strategies
2016
Prenatal maternal bereavement and mortality in the first decades of life: a nationwide cohort study from Denmark and Sweden
Yu Y, Cnattingius S, Olsen J, Parner E, Vestergaard M, Liew Z, Zhao N, Li J. Prenatal maternal bereavement and mortality in the first decades of life: a nationwide cohort study from Denmark and Sweden. Psychological Medicine 2016, 47: 389-400. PMID: 27762181, DOI: 10.1017/s003329171600266x.Peer-Reviewed Original ResearchConceptsPrenatal maternal bereavementMaternal bereavementMortality riskCohort studyIncreased long-term mortality riskPopulation-based cohort studyLong-term mortality riskNationwide cohort studyLong-term mortalityCause mortality riskExcess mortality riskChildren of mothersFetal programming hypothesisYears of ageYears of lifeEndocrine/Stressful life eventsFetal deathSingleton birthsMedical conditionsProgramming hypothesisHigh riskUnnatural causesCongenital malformationsPrenatal stressDoes prenatal stress alter the developing connectome?
Scheinost D, Sinha R, Cross SN, Kwon SH, Sze G, Constable RT, Ment LR. Does prenatal stress alter the developing connectome? Pediatric Research 2016, 81: 214-226. PMID: 27673421, PMCID: PMC5313513, DOI: 10.1038/pr.2016.197.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderStress-related symptomsPrenatal exposureRisk factorsMajor depressionFetal brainMaternal stressPrenatal stressNeural elementsNeurobehavioral disordersFunctional connectivityHyperactivity disorderHuman neurodevelopmentDisordersAutism spectrum disorderFunctional networksConnectomeSpectrum disorderHuman connectomePregnancySymptomsNeurodevelopmentSchizophreniaBrainPrenatal stress alters amygdala functional connectivity in preterm neonates
Scheinost D, Kwon SH, Lacadie C, Sze G, Sinha R, Constable RT, Ment LR. Prenatal stress alters amygdala functional connectivity in preterm neonates. NeuroImage Clinical 2016, 12: 381-388. PMID: 27622134, PMCID: PMC5009231, DOI: 10.1016/j.nicl.2016.08.010.Peer-Reviewed Original ResearchConceptsPrenatal stress exposurePreterm neonatesPreterm birthPrenatal stressStress exposureTerm controlsFunctional connectivityAmygdala connectivityNeuropsychiatric disordersResting-state functional magnetic resonance imagingPrenatal stress altersEarly life stressFunctional magnetic resonance imagingMagnetic resonance imagingPeristriate cortexPrenatal exposureHigh riskMaternal stressIndependent cohortNeonatesLeft amygdalaSubcortical regionsResonance imagingAmygdalaCohortChapter 7 Maternal Prenatal Stress and the Developmental Origins of Mental Health The Role of Epigenetics
O’Donnell K, Glover V. Chapter 7 Maternal Prenatal Stress and the Developmental Origins of Mental Health The Role of Epigenetics. 2016, 103-126. DOI: 10.1016/b978-0-12-801383-0.00007-4.Chapters
2015
Expectant Mothers Maximizing Opportunities: Maternal Characteristics Moderate Multifactorial Prenatal Stress in the Prediction of Birth Weight in a Sample of Children Adopted at Birth
Brotnow L, Reiss D, Stover CS, Ganiban J, Leve LD, Neiderhiser JM, Shaw DS, Stevens HE. Expectant Mothers Maximizing Opportunities: Maternal Characteristics Moderate Multifactorial Prenatal Stress in the Prediction of Birth Weight in a Sample of Children Adopted at Birth. PLOS ONE 2015, 10: e0141881. PMID: 26544958, PMCID: PMC4636431, DOI: 10.1371/journal.pone.0141881.Peer-Reviewed Original ResearchConceptsPrenatal stressSample of childrenMultidimensional theoretical modelHierarchical regression modelingHierarchical regression modelsObjective stressorsDistress measuresChild developmentEffects of stressMaternal personal characteristicsSocial supportMothers' stressProtective factorsPersonal characteristicsDistressStressorsCross-sectional dataMaternal characteristicsRisk factorsAdoption studiesHigher SESBirth mothersEnvironmental risk factorsTheoretical modelPregnancy complications
2013
Prenatal maternal mood is associated with altered diurnal cortisol in adolescence
O’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAnxietyCircadian RhythmDepressionFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSalivaSampling StudiesSecretory RateSeverity of Illness IndexSocioeconomic FactorsWakefulnessConceptsPrenatal anxietyDiurnal cortisolMaternal postnatal anxietyMaternal prenatal anxietyPrenatal maternal moodMultilevel model analysisAdolescent cortisolCortisol awakening responsePostnatal covariatesProspective longitudinal studyFlatter diurnal slopeCommunity samplePrenatal moodPostnatal anxietyMaternal moodCortisol samplesMaternal depressionAnxietyAwakening responseLongitudinal studyDiurnal slopePersisting effectPrenatal stressAnimal workALSPAC cohortPrenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System
Holloway T, Moreno JL, Umali A, Rayannavar V, Hodes GE, Russo SJ, González-Maeso J. Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System. Journal Of Neuroscience 2013, 33: 1088-1098. PMID: 23325246, PMCID: PMC3711555, DOI: 10.1523/jneurosci.2331-12.2013.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate 2 receptorPrenatal stressSevere adverse life eventsSchizophrenia-like alterationsMaternal immune systemHead-twitch responsePrenatal immune activationAntipsychotic-like effectsAntipsychotic drug developmentMGlu2/3 agonist LY379268Risk of schizophreniaAdverse life eventsCross-fostering studyEarly neurodevelopmental originHallucinogenic 5Serotonin 2AAgonist DOIImmune activationAgonist LY379268Pathophysiological hypothesesFrontal cortexPsychiatric disordersAdult offspringSerotonin 5Behavioral alterations
2011
Maternal prenatal anxiety and downregulation of placental 11β-HSD2
O’Donnell K, Jensen A, Freeman L, Khalife N, O’Connor T, Glover V. Maternal prenatal anxiety and downregulation of placental 11β-HSD2. Psychoneuroendocrinology 2011, 37: 818-826. PMID: 22001010, DOI: 10.1016/j.psyneuen.2011.09.014.Peer-Reviewed Original ResearchConceptsPlacental 11β-HSD2Maternal prenatal anxietyMaternal anxietyPlacental 11β-hydroxysteroid dehydrogenase type 2Prenatal stressPrenatal anxietyDepression self-rating scalePrenatal maternal moodAdverse neurodevelopmental outcomesDehydrogenase type 2Subset of casesElective caesareanNeurodevelopmental outcomesFetal exposureMaternal moodMaternal cortisolFetal programmingState anxietyAnimal studiesSelf-rating scaleFemale fetusesType 2MRNA expressionDownregulationCortisol
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