2025
Machine learning for identifying caregiving adversities associated with greatest risk for mental health problems in children
Vannucci A, Fields A, Heleniak C, Bloom P, Harmon C, Nikolaidis A, Douglas I, Gibson L, Camacho N, Choy T, Hadis S, VanTieghem M, Dozier M, Milham M, Tottenham N. Machine learning for identifying caregiving adversities associated with greatest risk for mental health problems in children. Nature Mental Health 2025, 3: 71-82. DOI: 10.1038/s44220-024-00355-6.Peer-Reviewed Original Research
2024
Drug overdose deaths among homeless veterans in the United States Department of Veterans Affairs healthcare system
Tsai J, Szymkowiak D, Beydoun H. Drug overdose deaths among homeless veterans in the United States Department of Veterans Affairs healthcare system. Addiction 2024, 120: 306-315. PMID: 39415621, DOI: 10.1111/add.16689.Peer-Reviewed Original ResearchNon-homeless veteransDrug overdose deathsOverdose deathsDepartment of Veterans Affairs (VA) healthcare systemVeterans Affairs (VA) healthcare systemHealthcare systemDepartment of Veterans Affairs healthcare systemNational Death Index dataHazard ratioVeterans Affairs Healthcare SystemConfidence intervalsDeath Index dataEstimate hazard ratiosMental health characteristicsAssociated with greater riskEpidemic of drug overdoseHealth characteristicsHomeless veteransUS veteransCox regression modelsVeteransGreater riskHomeless populationSubstance useMultivariate Cox regression modelImpact of HIV Infection on Liver and Cardiovascular Outcomes in Veterans With Metabolic Dysfunction-Associated Steatotic Liver Disease
Wong R, Yang Z, Yeoh A, Do A, Ahmed A, Cheung R. Impact of HIV Infection on Liver and Cardiovascular Outcomes in Veterans With Metabolic Dysfunction-Associated Steatotic Liver Disease. The American Journal Of Gastroenterology 2024, 119: 1841-1848. PMID: 38477465, DOI: 10.14309/ajg.0000000000002760.Peer-Reviewed Original ResearchConceptsImpact of HIV infectionAntiretroviral therapyIncidence of cirrhosisAdverse cardiovascular eventsHIV infectionHepatocellular carcinomaAssociated with greater riskCardiovascular diseaseOverall survivalCardiovascular eventsLiver diseaseSteatotic liver diseaseConcurrent HIV infectionDecreased overall survivalRisk of cirrhosisRisk of liverGreater riskLiver disease progressionPropensity-matched cohortScore-matched cohortCardiovascular disease outcomesUS veteransCardiovascular outcomesDisease progressionPrimary outcomeAdverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery
Venkatesh K, Khan S, Yee L, Wu J, McNeil R, Greenland P, Chung J, Levine L, Simhan H, Catov J, Scifres C, Reddy U, Pemberton V, Saade G, Merz C, Grobman W, Mothers-to-Be A. Adverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery. Obstetrics And Gynecology 2024, 143: 775-784. PMID: 38574364, PMCID: PMC11098696, DOI: 10.1097/aog.0000000000005569.Peer-Reviewed Original ResearchConceptsRisk of atherosclerotic CVDAtherosclerotic CVD riskAdverse pregnancy outcomesHypertensive disorders of pregnancyAtherosclerotic CVDCVD riskDisorders of pregnancyPregnancy outcomesHypertensive disordersPreterm birthModified Poisson modelsFramingham risk scoreRisk of CVDRisk of atherosclerotic cardiovascular diseaseMagnitude of riskAbsolute riskAtherosclerotic cardiovascular diseaseSecondary analysisLongitudinal cohortRisk scoreGestational ageGreater riskBaseline covariatesCardiovascular diseaseDisease 2Risk of Intracranial Hemorrhage in Persons with Hemophilia A in the United States: Real-World Retrospective Cohort Study Using the ATHNdataset
Hu J, Chandler M, Manuel C, Caicedo J, Denne M, Ewenstein B, Mokdad A, Xing S, Recht M. Risk of Intracranial Hemorrhage in Persons with Hemophilia A in the United States: Real-World Retrospective Cohort Study Using the ATHNdataset. Journal Of Blood Medicine 2024, 15: 191-205. PMID: 38699197, PMCID: PMC11063465, DOI: 10.2147/jbm.s443380.Peer-Reviewed Original ResearchIntracranial hemorrhageIncidence rateInhibitor statusHemophilia AEstimate hazard ratiosAssociated with intracranial hemorrhageIncidence of intracranial hemorrhageMedian follow-up timeRisk of intracranial hemorrhageCurrent treatment landscapeIntracranial hemorrhage riskFollow-up timeTime-to-event analysisYears of ageProphylaxis statusHazard ratioTreatment landscapeGreater riskHepatitis CProphylactic treatmentPWHARate of mortalityIncreased riskRisk factorsATHNdataset
2023
Incidence and psychiatric predictors of Long COVID beyond 3 months in a city-wide community sample in Texas
Tsai J, Grace A, Kurian A. Incidence and psychiatric predictors of Long COVID beyond 3 months in a city-wide community sample in Texas. Journal Of Public Health 2023, 46: e51-e59. PMID: 38141051, DOI: 10.1093/pubmed/fdad276.Peer-Reviewed Original ResearchLong COVID symptomsLong COVIDCOVID symptomsDuration of illnessLaboratory-confirmed casesLongitudinal cohort studyLoss of tasteCOVID-19 symptomsBaseline depression symptomsPopulation-based sampleCOVID-19Persistent symptomsCohort studyInverse probability weightingDepression symptomsPsychiatric predictorsWhite adultsSymptomsCoronavirus diseaseGreater riskMonthsAdultsCommunity sampleCOVIDGreater anxietyRisk of dementia among veterans experiencing homelessness and housing instability
Roncarati J, DeVone F, Halladay C, Tsai J, Jutkowitz E. Risk of dementia among veterans experiencing homelessness and housing instability. Journal Of The American Geriatrics Society 2023, 72: 382-389. PMID: 38053404, PMCID: PMC10922215, DOI: 10.1111/jgs.18680.Peer-Reviewed Original ResearchADRD diagnosisCox proportional hazards modelHousing instabilityRisk of dementiaProportional hazards modelSubstance use disordersAge-related disordersHigh riskHazards modelUse disordersAlzheimer's diseaseGreater riskOlder ageHealth systemCohortSupportive housing programPermanent supportive housing programNine-year periodVeteransWraparound servicesHigher hazardDementiaSignificant proportionDiseaseDiagnosisUltra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis
Morales-Berstein F, Biessy C, Viallon V, Goncalves-Soares A, Casagrande C, Hémon B, Kliemann N, Cairat M, Blanco Lopez J, Al Nahas A, Chang K, Vamos E, Rauber F, Bertazzi Levy R, Barbosa Cunha D, Jakszyn P, Ferrari P, Vineis P, Masala G, Catalano A, Sonestedt E, Borné Y, Katzke V, Bajracharya R, Agnoli C, Guevara M, Heath A, Radoï L, Mancini F, Weiderpass E, Huerta J, Sánchez M, Tjønneland A, Kyrø C, Schulze M, Skeie G, Lukic M, Braaten T, Gunter M, Millett C, Agudo A, Brennan P, Borges M, Richmond R, Richardson T, Davey Smith G, Relton C, Huybrechts I. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. European Journal Of Nutrition 2023, 63: 377-396. PMID: 37989797, PMCID: PMC10899298, DOI: 10.1007/s00394-023-03270-1.Peer-Reviewed Original ResearchConceptsConsumption of ultra-processed foodsUltra-processed foodsWaist-to-hip ratioRisk of head and neck cancerUltra-processed food consumptionOesophageal adenocarcinoma riskEuropean Prospective InvestigationBody mass indexHead and neck cancerIncreased risk of HNCHigher consumption of ultra-processed foodsHead and neck cancer riskProspective InvestigationCancer and NutritionNegative control analysesOesophageal adenocarcinomaWaist-to-hipNegative control outcomesAssociated with greater riskMediation analysisNeck cancerAccidental deathEPIC participantsMass indexGreater riskThe interaction between geriatric and neighborhood vulnerability: Delineating prehospital risk among older adult emergency general surgery patients
Zogg C, Falvey J, Kodadek L, Staudenmayer K, Davis K. The interaction between geriatric and neighborhood vulnerability: Delineating prehospital risk among older adult emergency general surgery patients. Journal Of Trauma And Acute Care Surgery 2023, 96: 400-408. PMID: 37962136, PMCID: PMC10922165, DOI: 10.1097/ta.0000000000004191.Peer-Reviewed Original ResearchGeriatric vulnerabilitiesOlder adultsEGS careAdverse outcomesHospital Frailty Risk ScoreEmergency general surgery patientsGreater riskFlorida State Inpatient DatabaseFrailty Risk ScoreGeneral surgery patientsState Inpatient DatabasesArea Deprivation IndexEthnic minority patientsNeighborhood vulnerabilityEGS outcomesHazard ratioOlder patientsSurgery patientsPatient ageEGS conditionsInpatient DatabaseVulnerable patientsPatient residesMinority patientsRisk scoreCirculating Levels of Leptin and Lipocalin-2 in Patients With X-Linked Hypophosphatemia
Simpson C, Santoro A, Carpenter T, Deng Y, Parziale S, Insogna K. Circulating Levels of Leptin and Lipocalin-2 in Patients With X-Linked Hypophosphatemia. Journal Of The Endocrine Society 2023, 7: bvad116. PMID: 37860221, PMCID: PMC10583534, DOI: 10.1210/jendso/bvad116.Peer-Reviewed Original ResearchLipocalin-2Control subjectsGreater riskLevels of LCN2Excessive weight gainLevels of leptinSerum leptin levelsCirculating LevelsLCN2 levelsSerum levelsYear age cohortLeptin levelsMetabolic abnormalitiesRetrospective studyAge cohortsInsulin sensitivityHigh prevalencePatientsWeight gainXLHLeptinAge 2HypophosphatemiaObesityChildrenA digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial
Boomer T, Hoerner L, Fernandes C, Maslar A, Aiudi S, Kyriakides T, Fiellin L. A digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial. PLOS ONE 2023, 18: e0291298. PMID: 37683047, PMCID: PMC10490848, DOI: 10.1371/journal.pone.0291298.Peer-Reviewed Original ResearchConceptsMental health outcomesOpioid misuseMental healthHealth gamesHealth outcomesMeasures of depressionMental health symptomsGreater riskHelp-seeking behaviorSecondary outcome measuresCritical developmental periodOpioid use disorderPerception of riskRisk of initiationHealth symptomsSchool gradesProfessional helpMisusing opioidsPrimary outcomeDevelopmental periodAdolescentsOutcome measuresSubstance misuseUse disordersHealth settingsUnfilled in emergency medicine: An analysis of the 2022 and 2023 Match by program accreditation, ownership, and geography
Gettel C, Bennett C, Rothenberg C, Smith J, Goldflam K, Sun W, Venkatesh A. Unfilled in emergency medicine: An analysis of the 2022 and 2023 Match by program accreditation, ownership, and geography. AEM Education And Training 2023, 7: e10902. PMID: 37600854, PMCID: PMC10436034, DOI: 10.1002/aet2.10902.Peer-Reviewed Original ResearchEM residency programsClinical sitesResidency programsGreater riskCross-sectional observational studyPrimary outcomeObservational studyProfit ownershipResidency program characteristicsMedicaid ServicesEmergency medicineCore-based statistical areasGraduate Medical EducationHigher numberRiskAccreditation CouncilDurationMatch cycleProgram characteristicsYearsStatusAvailable dataResidency positionsUrinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus
Vasquez-Rios G, Katz R, Levitan E, Cushman M, Parikh C, Kimmel P, Bonventre J, Waikar S, Schrauben S, Greenberg J, Sarnak M, Ix J, Shlipak M, Gutierrez O. Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus. Kidney360 2023, 4: e1257-e1264. PMID: 37533144, PMCID: PMC10547219, DOI: 10.34067/kid.0000000000000226.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Monocyte chemoattractant protein-1Kidney tubule healthCause-specific mortalityUrine biomarkersYKL-40Risk factorsCardiovascular deathCause mortalityHigh riskChitinase-3-like protein 1Greater riskHigher MCP-1Higher urine levelsUrine KIM-1Injury molecule-1Cause-specific deathMortality risk factorsProportional hazards regressionRisk of deathAdditional risk factorsProtein 1Cancer-related deathChemoattractant protein-1Alpha-1-microglobulinInadvertent Perioperative Hypothermia.
Garceau C, Cosgrove M, Gonzalez K. Inadvertent Perioperative Hypothermia. AANA Journal 2023, 91: 303-309. PMID: 37527171.Peer-Reviewed Educational MaterialsConceptsInadvertent perioperative hypothermiaPerioperative periodAmbient operating room temperaturePreoperative risk factorsSurgical site infectionOperating room temperatureCore body temperatureWorld Health OrganizationHospital stayReadmission ratesSite infectionPerioperative hypothermiaPreoperative exposureRisk factorsRegional anesthesiaSkin exposurePhysiologic responsesGreater riskWashout solutionSkin preparationHealth OrganizationBody temperatureLonger lengthPatientsHypothermiaThe association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment
Zhang Z, Moeckel C, Mustafa M, Pham H, Olson A, Mehta D, Dorn L, Engeland C, Shenk C. The association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment. Journal Of Psychiatric Research 2023, 165: 7-13. PMID: 37441927, PMCID: PMC10529086, DOI: 10.1016/j.jpsychires.2023.07.007.Peer-Reviewed Original ResearchConceptsEpigenetic age accelerationSymptom severityAnxiety symptom severitySevere depressiveGreater riskAnxiety disordersStress-sensitive biomarkersAnxiety symptomsMajor risk factorAge accelerationYears of ageMultiple psychiatric disordersChild maltreatmentHorvath clockPediatric populationRisk factorsSubstantiated child maltreatmentPsychiatric disordersPromising biomarkerPredictive valueDiagnostic thresholdDepressiveChildren 8Transitory symptomsSymptomsMaternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic riskProbable PTSD, PTSD symptom severity, and comorbid PTSD and hazardous drinking among sexual minority women compared to heterosexual women: A meta-analysis
Scheer J, Helminen E, Cascalheira C, Jaipuriyar V, Shaw T, Zabelski S, Behari K, Pirog S, Batchelder A, Possemato K, Hughes T, Sullivan T. Probable PTSD, PTSD symptom severity, and comorbid PTSD and hazardous drinking among sexual minority women compared to heterosexual women: A meta-analysis. Clinical Psychology Review 2023, 102: 102283. PMID: 37150043, PMCID: PMC10205673, DOI: 10.1016/j.cpr.2023.102283.Peer-Reviewed Original ResearchConceptsProbable posttraumatic stress disorderPosttraumatic stress disorderHazardous drinkingSexual minority womenPTSD symptom severitySymptom severityPTSD riskComorbid posttraumatic stress disorderMinority womenHeterosexual womenEligible publicationsReference listsPeer-reviewed publicationsElectronic databasesPronounced riskGreater riskTrauma-related sequelaeStress disorderSystematic searchWomenDemographic characteristicsRiskGender diverse peopleRelevant papersSeverityObesity Risk Among West Point Graduates Later in Life
Szivak TK, Thomas MM, Pietrzak RH, Nguyen DR, Ryan DM, Mazure CM. Obesity Risk Among West Point Graduates Later in Life. The Journal Of Strength And Conditioning Research 2023, 37: 1284-1291. PMID: 33278268, DOI: 10.1519/jsc.0000000000003824.Peer-Reviewed Original ResearchConceptsBody mass indexPhysical activityObesity ratesMetabolic equivalentsObesity riskHigher self-reported physical activityInternational Physical Activity Questionnaire-Short FormSelf-reported physical activityWeekly metabolic equivalentLean body massU.S. adult populationQuestionnaire-Short FormLifetime obesityMass indexObesity statusBMI valuesJ Strength Cond ResHealth initiativesAdult populationGreater riskWomenMenObesityShort formResiliency factorsBrain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort
Zhao Y, Paulus M, Potenza M. Brain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort. Journal Of Behavioral Addictions 2023, 12: 80-93. PMID: 36940096, PMCID: PMC10260217, DOI: 10.1556/2006.2023.00006.Peer-Reviewed Original ResearchConceptsScreen media activitiesGray matter volumeInternalizing problemsTwo yearsSymptoms two yearsTwo-year followInferior temporal regionsCortical thickness measuresHours/dayLongitudinal brain imagingInternalizing psychopathologyABCD cohortSmall effect sizesFuture internalizing problemsInternalizing behaviorsExternalizing psychopathologyInferior parietalMediation analysisBrain patternsBrain featuresGreater riskLinear mixed-effects modelsTemporal regionsAge 9Thickness measuresThrombo-Inflammation in COVID-19 and Sickle Cell Disease: Two Faces of the Same Coin
Chiang K, Gupta A, Sundd P, Krishnamurti L. Thrombo-Inflammation in COVID-19 and Sickle Cell Disease: Two Faces of the Same Coin. Biomedicines 2023, 11: 338. PMID: 36830874, PMCID: PMC9953430, DOI: 10.3390/biomedicines11020338.Peer-Reviewed Original ResearchSickle cell diseaseVaso-occlusive crisisCell diseaseLipid mediatorsCOVID-19Severe SARS-CoV-2 infectionSARS-CoV-2 infectionSevere COVID-19Platelet-leukocyte adhesionAnti-thrombotic agentsThrombo-InflammationEndothelial injuryRespiratory infectionsSevere illnessClinical trialsThromboxane ATherapeutic strategiesTherapeutic targetPotential treatmentPlatelet activationComplement activationGreater riskClinical researchDiseaseEndothelial cells
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