2025
Associations among prenatal stress, socioeconomic status, and infant epigenetic aging
Sperber J, Hart E, Troller-Renfree S, Watts T, Miller M, Bellatin A, Meyer J, Dettmer A, Champagne F, Noble K. Associations among prenatal stress, socioeconomic status, and infant epigenetic aging. Psychoneuroendocrinology 2025, 107575. DOI: 10.1016/j.psyneuen.2025.107575.Peer-Reviewed Original ResearchRacially diverse sampleSocioeconomic disadvantagePrenatal stressFamily incomeEpigenetic ageMaternal perceived stressDiverse sample of mothersFamily socioeconomic disadvantagePre-registered studySample of mothersHair cortisol concentrationsMaternal physiological stressPerceived stressSocioeconomic statusEffect of family incomeEffect sizeGenome-wide DNA methylationOne-month-old infantsWeeks of pregnancyPhysiological stressEpigenetic clocksAssociationAgeDNA methylationCortisol concentrations
2020
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics
Blumental-Perry A, Jobava R, Bederman I, Degar A, Kenche H, Guan B, Pandit K, Perry N, Molyneaux N, Wu J, Prendergas E, Ye Z, Zhang J, Nelson C, Ahangari F, Krokowski D, Guttentag S, Linden P, Townsend D, Miron A, Kang M, Kaminski N, Perry Y, Hatzoglou M. Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics. Communications Biology 2020, 3: 626. PMID: 33127975, PMCID: PMC7603330, DOI: 10.1038/s42003-020-01322-4.Peer-Reviewed Original ResearchConceptsMitochondrial genomeNuclear-encoded genesCell type-specific mannerNon-coding RNASteady-state transcriptionMitochondrial energy metabolismControl regionPositive regulationMitochondrial bioenergeticsMitochondria stressMitochondrial functionSpecific mannerAlveolar epithelial type II cellsEnergy metabolismType II cellsEpithelial type II cellsGenomePhysiological stressRNAII cellsCellsMouse lungTranscriptionGenesMitochondria
2019
Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress
Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. Cell Stem Cell 2019, 25: 814-829.e6. PMID: 31809739, PMCID: PMC6925542, DOI: 10.1016/j.stem.2019.11.005.Peer-Reviewed Original ResearchConceptsStem cell populationJunctional zoneOral mucosaStem cellsImportant model systemCell populationsEpithelial stem cell populationSingle-progenitor modelAsymmetric divisionLabel-retention assaysCandidate nichesSymmetric divisionTissue stressOral cavityPalatal epitheliumPhysiological stressModel systemStratified epitheliumMucosaProliferative heterogeneityEpitheliumCity sicker? A meta‐analysis of wildlife health and urbanization
Murray M, Sánchez C, Becker D, Byers K, Worsley‐Tonks K, Craft M. City sicker? A meta‐analysis of wildlife health and urbanization. Frontiers In Ecology And The Environment 2019, 17: 575-583. DOI: 10.1002/fee.2126.Peer-Reviewed Original ResearchWildlife healthToxic loadHigher toxicant loadsNon-urban counterpartsWildlife populationsTaxonomic biasCommunity compositionLand useGeneralizable relationshipsParasite abundanceHealth risksPhylogenetic meta-analysisResource availabilityWildlifeParasite diversityBody conditionUrban areasUrban developmentResearch needsUrbanizationNegative relationshipSpeciesPhysiological stressParasitesUrban population
2010
Spouses’ Cardiovascular Reactivity to Their Partners’ Suffering
Monin JK, Schulz R, Martire LM, Jennings JR, Lingler JH, Greenberg MS. Spouses’ Cardiovascular Reactivity to Their Partners’ Suffering. The Journals Of Gerontology Series B 2010, 65B: 195-201. PMID: 20067977, PMCID: PMC2821945, DOI: 10.1093/geronb/gbp133.Peer-Reviewed Original ResearchConceptsPartners' sufferingOne's sufferingBlood pressureCaregiver riskUnique influencePain expressionHeart rateOlder adultsPhysical healthCardiovascular reactivityHeavy logsSpousesTaskSufferingCardiovascular diseasePartnersPhysiological stressCaregiversRiskExposureAdultsFindingsLaboratory studiesOsteoarthritisDisease
2004
Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy
McMullen J, Shioi T, Zhang L, Tarnavski O, Sherwood M, Dorfman A, Longnus S, Pende M, Martin K, Blenis J, Thomas G, Izumo S. Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy. Molecular And Cellular Biology 2004, 24: 6231-6240. PMID: 15226426, PMCID: PMC434247, DOI: 10.1128/mcb.24.14.6231-6240.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibiotics, AntineoplasticAortaCardiomegalyFemaleFetusGene Expression Regulation, DevelopmentalMiceMice, KnockoutMice, TransgenicOrgan SizePhosphatidylinositol 3-KinasesPhysical Conditioning, AnimalReceptor, IGF Type 1Ribosomal Protein S6 Kinases, 90-kDaSignal TransductionSirolimusStress, MechanicalSwimmingConceptsRibosomal S6 kinaseS6 kinaseOverexpression of S6K1PI3K mutantCritical downstream effectorRibosomal proteinsTransgenic miceCardiac hypertrophyDownstream effectorsK mutantS6KsGrowth factor pathwaysGenetic relationshipsPathological stressProtein synthesisCritical effectorS6K1K pathwayIGF1 receptorFactor 1Factor pathwayPhysiological stressInsulin-like growth factor-1Physiological stimuliKinase
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