2025
Exploring the Influence of Synaptic Density and Anxiety on Pain Perception: Evidence from a [11C]UCB-J PET Imaging Study
Moisieienko K, Asch R, Davis M, Pietrzak R, Esterlis I. Exploring the Influence of Synaptic Density and Anxiety on Pain Perception: Evidence from a [11C]UCB-J PET Imaging Study. The International Journal Of Neuropsychopharmacology 2025, pyaf040. PMID: 40511849, DOI: 10.1093/ijnp/pyaf040.Peer-Reviewed Original ResearchAnterior cingulate cortexDorsolateral prefrontal cortexFusiform gyrusAnxiety symptomsSV2A densitySynaptic densityState anxietyMediation analysisPain sensitivityAssociated with greater pain sensitivityAssociated with painState anxiety symptomsFunctional brain alterationsMedically healthy subjectsIndirect effectsPrefrontal cortexCingulate cortexPlasma input functionBrain alterationsOne-tissue compartment modelPET imaging studiesGyrusAnxietyRegional volumesHigher pain sensitivityAssessing and alleviating state anxiety in large language models
Ben-Zion Z, Witte K, Jagadish A, Duek O, Harpaz-Rotem I, Khorsandian M, Burrer A, Seifritz E, Homan P, Schulz E, Spiller T. Assessing and alleviating state anxiety in large language models. Npj Digital Medicine 2025, 8: 132. PMID: 40033130, PMCID: PMC11876565, DOI: 10.1038/s41746-025-01512-6.Peer-Reviewed Original ResearchSimulation-Based Education for Caregivers of Infants with Shunt-Dependent Cardiac Physiology: Decreasing Caregiver Anxiety
Dahlen B, Shafland H, Berbee J, Heil J, Vora S. Simulation-Based Education for Caregivers of Infants with Shunt-Dependent Cardiac Physiology: Decreasing Caregiver Anxiety. Journal Of Pediatric Health Care 2025 PMID: 39945709, DOI: 10.1016/j.pedhc.2025.01.003.Peer-Reviewed Original ResearchSimulation-based mastery learningCaregiver anxietySBML interventionState-Trait Anxiety IndexQuality improvement projectSimulation-based educationCaregivers of infantsTrait Anxiety IndexImprove patient outcomesCaregiver confidenceCaregiver educationImprovement projectCaregiversHome monitoring programForm YMonitoring skillsHospital dischargePatient outcomesState anxietyImprove confidenceDecreased confidenceAnxiety IndexAnxietyReduce mortalityIncreased confidence
2024
Using mobile eye-tracking to evaluate gaze behavior during a speech in pediatric anxiety disorders
Kitt E, Abend R, Amelio P, Galbraith J, Poe A, Gee D, Pine D, Harrewijn A. Using mobile eye-tracking to evaluate gaze behavior during a speech in pediatric anxiety disorders. Journal Of Affective Disorders 2024, 369: 462-466. PMID: 39389116, DOI: 10.1016/j.jad.2024.10.024.Peer-Reviewed Original ResearchSocial anxiety symptom severityAnxiety symptom severityAnxiety-related differencesAnxiety disordersState anxietyTask conditionsPediatric anxietySocial anxietyGaze behaviorSymptom severityNon-anxious controlsPediatric anxiety disordersSocial stress taskEye trackingAnxiety-provoking contextsPassive viewing conditionsAge-related differencesNaturalistic stressorElevated anxietyStress taskMobile eye-trackerDevelopmental sampleDiagnostic groupsEye-tracking technologyLonger gazeThe Role of Anxiety and Prosocial Behaviors on Adherence Behaviors to Prevent COVID-19 in University Students in the United States: Cross-Sectional Study
Corbera S, Marín-Chollom A. The Role of Anxiety and Prosocial Behaviors on Adherence Behaviors to Prevent COVID-19 in University Students in the United States: Cross-Sectional Study. JMIRx Med 2024, 5: e52970. PMID: 38832671, PMCID: PMC11149054, DOI: 10.2196/52970.Peer-Reviewed Original ResearchPublic prosocial behaviorsProsocial behaviorLevels of anxietyAdherence to COVID-19 preventive behaviorsCOVID-19 preventive behaviorsAnxiety typesModeration analysisInfluence of prosocial behaviorHigher levels of traitAdherence behaviorState anxiety symptomsLevels of traitSelf-oriented behaviorHigher prosocial behaviorAssociated with higher engagementAssociated with lower engagementAnxiety symptomsPsychology departmentsLower anxietyPredicting engagementHigher anxietyState anxietyAcute stressCreation of interventionsAnxietyPre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls
Díaz D, Tseng W, Michalska K. Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls. BMC Psychiatry 2024, 24: 1. PMID: 38167015, PMCID: PMC10759434, DOI: 10.1186/s12888-023-05403-6.Peer-Reviewed Original ResearchConceptsState anxietyTrait anxietyHappy facesEmotion processingLatina girlsImplicit emotion processingNon-anxious youthHigh trait anxietyFearful facial affectFearful facesEmotional valenceFacial affectNeural correlatesIndividual differencesBrain activationBrain responsesNeural activationReduced engagementCommunity sampleAnxietyInteractive effectsHigh levelsGirlsMethodsThe present studySystematic differences
2023
Seeing Red: Distraction Influences Visual Attention for Anger but Not for Other Negative Emotions
Rutherford A, Raila H, Blicher A, Vanderlind W, Joormann J. Seeing Red: Distraction Influences Visual Attention for Anger but Not for Other Negative Emotions. Emotion 2023, 23: 1224-1235. PMID: 36107655, DOI: 10.1037/emo0001136.Peer-Reviewed Original ResearchConceptsEmotion regulation strategiesRegulation strategiesFilm clipsState anxietyEmotion-eliciting film clipsEmotion-eliciting stimuliEmotional film clipsCurrent affective stateNegative emotional statesAttention allocation strategyCognitive reappraisalEmotion regulationEmotional informationVisual attentionNegative emotionsNegative affectDistraction conditionEmotional statesAffective statesNatural viewingEye trackingOverall functioningVital skillEffect of conditionCommunity participantsSerum BDNF levels and state anxiety are associated with somatic symptoms in patients with panic disorder
Li J, Li R, Li D, Zhang J, Luo X, Zhang Y. Serum BDNF levels and state anxiety are associated with somatic symptoms in patients with panic disorder. Frontiers In Psychiatry 2023, 14: 1168771. PMID: 37533888, PMCID: PMC10393281, DOI: 10.3389/fpsyt.2023.1168771.Peer-Reviewed Original ResearchPanic Disorder Severity Scale-Chinese VersionSerum BDNF levelsState-Trait Anxiety InventoryBDNF levelsSomatic symptomsPanic disorderPHQ-15State anxietyPD patientsSerum BDNFBaseline serum BDNF levelsHealthy controlsAssociated with somatic symptomsAnxiety-related symptomsAnxiety-related variablesMeasure somatic symptomsPHQ-15 scoresEscitalopram treatmentPanic severityAssess panicNinety PD patientsState-TraitAnxiety InventoryPanicPartial correlation analysis
2021
Emotion and Emotion Preferences in Daily Life: The Role of Anxiety
Vanderlind WM, Everaert J, Caballero C, Cohodes EM, Gee DG. Emotion and Emotion Preferences in Daily Life: The Role of Anxiety. Clinical Psychological Science 2021, 10: 109-126. PMID: 35174008, PMCID: PMC8845725, DOI: 10.1177/21677026211009500.Peer-Reviewed Original ResearchEmotion preferencesEcological momentary assessmentTrait anxietyLow-anxiety counterpartsSymptom severityAnxiety symptom severityMeasures of anxietyRole of anxietyState emotionsEmotion dysfunctionIndividual differencesSubsequent anxietySevere anxiety symptomsState anxietyAnxiety symptomsMomentary assessmentEmotionsAnxietyCurrent findingsNovel treatment targetsGreater preferenceCurrent studyTreatment targetsDifferent associationsDaily lifeSIMDiscovery: a simulation-based preparation program for adolescents undergoing spinal fusion surgery
Potthoff LM, Glotzbecker MP, O’Connell B, O’Neill N, Graber KM, Byrne CA, Tremmel JM, Weinstock P, Mednick L. SIMDiscovery: a simulation-based preparation program for adolescents undergoing spinal fusion surgery. Spine Deformity 2021, 9: 1363-1370. PMID: 33689156, PMCID: PMC7943935, DOI: 10.1007/s43390-021-00322-6.Peer-Reviewed Original ResearchConceptsSpinal fusion surgeryFusion surgeryPost-operative periodSurgical processProgram 30Medical appointmentsPatientsSurgeryIndependent sample t-testFeelings of preparednessFamily feedbackEvidenceLevel IIICaregiversSample t-testLower state anxietyMedical proceduresT-testAnxietySelf-report measuresState anxietyCurrent studyOverall experienceParticipantsHigh levels
2018
Preferences for in‐person disclosure: Patients declining telephone disclosure characteristics and outcomes in the multicenter Communication Of GENetic Test Results by Telephone study
Beri N, Patrick‐Miller L, Egleston B, Hall M, Domchek S, Daly M, Ganschow P, Grana G, Olopade O, Fetzer D, Brandt A, Chambers R, Clark D, Forman A, Gaber R, Gulden C, Horte J, Long J, Lucas T, Madaan S, Mattie K, McKenna D, Montgomery S, Nielsen S, Powers J, Rainey K, Rybak C, Savage M, Seelaus C, Stoll J, Stopfer J, Yao X, Bradbury A. Preferences for in‐person disclosure: Patients declining telephone disclosure characteristics and outcomes in the multicenter Communication Of GENetic Test Results by Telephone study. Clinical Genetics 2018, 95: 293-301. PMID: 30417332, PMCID: PMC6453119, DOI: 10.1111/cge.13474.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCommunicationFemaleGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHereditary Breast and Ovarian Cancer SyndromeHumansMaleMiddle AgedNeoplastic Syndromes, HereditaryOutcome Assessment, Health CarePatient CompliancePatient PreferenceTelephoneTruth DisclosureConceptsIn-person disclosureGenetic test resultsCancer-specific distressTelephone disclosureIn-personIn-person communicationCommunication of genetic test resultsDisclosure of genetic test resultsCancer genetic testingMultigene panel testingDisclosure of resultsGeneralized anxietyPretest counselingDelivery modelsCommunication of resultsTelephone studyDeclined randomizationGenetic medicineGenetic testingTelephoneState anxietyDistressPanel testingAnxietyDepressionUse and Patient-Reported Outcomes of Clinical Multigene Panel Testing for Cancer Susceptibility in the Multicenter Communication of Genetic Test Results by Telephone Study.
Hall M, Patrick-Miller L, Egleston B, Domchek S, Daly M, Ganschow P, Grana G, Olopade O, Fetzer D, Brandt A, Chambers R, Clark D, Forman A, Gaber R, Gulden C, Horte J, Long J, Lucas T, Madaan S, Mattie K, McKenna D, Montgomery S, Nielsen S, Powers J, Rainey K, Rybak C, Savage M, Seelaus C, Stoll J, Stopfer J, Yao X, Bradbury A. Use and Patient-Reported Outcomes of Clinical Multigene Panel Testing for Cancer Susceptibility in the Multicenter Communication of Genetic Test Results by Telephone Study. JCO Precision Oncology 2018, 2: 1-12. PMID: 31819920, PMCID: PMC6901130, DOI: 10.1200/po.18.00199.Peer-Reviewed Original ResearchMultigene panel testingCommunication of genetic test resultsGenetic test resultsPatient-reported outcomesCancer-specific distressMultigene panelsGenetics providersState anxietyDisclosure of genetic test resultsTelephone studyCancer genetic testingIn-person disclosureHistory of cancerTargeted testingAshkenazi Jewish ancestryIn-personDemographic adjustmentCancer susceptibilityPre-disclosureGenetic knowledgeGenetic testingGenetic counselingLower anxietyJewish ancestryTelephoneAnxiety in Adolescents with Type 1 Diabetes
RECHENBERG K, SADLER L, GREY M. Anxiety in Adolescents with Type 1 Diabetes. Diabetes 2018, 67 DOI: 10.2337/db18-815-p.Peer-Reviewed Original ResearchAnxiety symptomsState anxietyExperience of anxietyHigher state anxietyLower state anxietyState-Trait Anxiety InventoryHigh SES familiesSingle-parent familiesPoor quality sleepGeneral lifestyle factorsAnxiety InventorySES familiesAnxietyQuality sleepPoor sleepExploratory stratified analysisPoor glycemic controlSocioeconomic statusAdolescentsType 1 diabetesAge 13.6Low socioeconomic statusPsychosocial comorbiditiesSleep patternsParticipantsUsing Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change
Lebowitz ER, François B. Using Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change. Behavior Therapy 2018, 49: 853-865. PMID: 30316485, PMCID: PMC6394864, DOI: 10.1016/j.beth.2018.04.005.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral avoidanceThreat facesMotion-tracking technologyChild-rated anxiety symptomsChildhood anxiety disordersSelf-rated fearAnxiety symptom severitySpider stimuliAnxious childrenTest-retest correlationsAreas of psychopathologyState anxietyTest-retest reliabilityAnxiety symptomsAnxiety disordersTime-effective measurementsAvoidance behaviorPsychometric propertiesTreatment-related changesSymptom severityThird studySecond studyAvoidanceLarge sampleRandomized Noninferiority Trial of Telephone vs In-Person Disclosure of Germline Cancer Genetic Test Results
Bradbury A, Patrick-Miller L, Egleston B, Hall M, Domchek S, Daly M, Ganschow P, Grana G, Olopade O, Fetzer D, Brandt A, Chambers R, Clark D, Forman A, Gaber R, Gulden C, Horte J, Long J, Lucas T, Madaan S, Mattie K, McKenna D, Montgomery S, Nielsen S, Powers J, Rainey K, Rybak C, Savage M, Seelaus C, Stoll J, Stopfer J, Yao X. Randomized Noninferiority Trial of Telephone vs In-Person Disclosure of Germline Cancer Genetic Test Results. Journal Of The National Cancer Institute 2018, 110: 985-993. PMID: 29490071, PMCID: PMC6136932, DOI: 10.1093/jnci/djy015.Peer-Reviewed Original ResearchConceptsIn-person disclosureMultigene panel testingGenetic test resultsTelephone disclosureIn-personPretest counselingSurgery intentionsEra of multigene panel testingCancer-specific distressCancer genetic testingGenetic testingGermline genetic testingState anxietyMultiple imputation analysisGeneralized anxietyPanel testingSubgroup analysisStatistically significant differenceSecondary subgroup analysisUsual careGenetic counselorsImputation analysisSecondary analysisSecondary outcomesConfidence intervals
2011
Maternal prenatal anxiety and downregulation of placental 11β-HSD2
O’Donnell K, Jensen A, Freeman L, Khalife N, O’Connor T, Glover V. Maternal prenatal anxiety and downregulation of placental 11β-HSD2. Psychoneuroendocrinology 2011, 37: 818-826. PMID: 22001010, DOI: 10.1016/j.psyneuen.2011.09.014.Peer-Reviewed Original ResearchConceptsPlacental 11β-HSD2Maternal prenatal anxietyMaternal anxietyPlacental 11β-hydroxysteroid dehydrogenase type 2Prenatal stressPrenatal anxietyDepression self-rating scalePrenatal maternal moodAdverse neurodevelopmental outcomesDehydrogenase type 2Subset of casesElective caesareanNeurodevelopmental outcomesFetal exposureMaternal moodMaternal cortisolFetal programmingState anxietyAnimal studiesSelf-rating scaleFemale fetusesType 2MRNA expressionDownregulationCortisolChildren's State Anxiety in Reaction to Disaster Media Cues: A Preliminary Test of a Multivariate Model
Ortiz C, Silverman W, Jaccard J, La Greca A. Children's State Anxiety in Reaction to Disaster Media Cues: A Preliminary Test of a Multivariate Model. Psychological Trauma Theory Research Practice And Policy 2011, 3: 157-164. DOI: 10.1037/a0020098.Peer-Reviewed Original ResearchChildren's state anxietyState anxietySocial supportAnxiety symptomsLife eventsMedia cuesStructural equation modeling resultsElevated state anxietyChild anxiety symptomsAvailable social supportStudy's conceptual modelMultivariate conceptual modelConceptual modelNegative copingChildren's reactionsCuesElementary school studentsDepression symptomsAnxietyPreventive interventionsComparison groupSchool studentsCopingDepressive symptomsChildren
2000
Preoperative anxiety and postoperative pain in women undergoing hysterectomy A repeated-measures design
Kain Z, Sevarino F, Alexander G, Pincus S, Mayes L. Preoperative anxiety and postoperative pain in women undergoing hysterectomy A repeated-measures design. Journal Of Psychosomatic Research 2000, 49: 417-422. PMID: 11182434, DOI: 10.1016/s0022-3999(00)00189-6.Peer-Reviewed Original ResearchConceptsPostoperative pain responsePreoperative state anxietyPostoperative painPreoperative anxietyPain responseElective abdominal hysterectomyImmediate postoperative painPostoperative pain managementState anxietyAnalgesic consumptionAbdominal hysterectomyPositive predictorPerioperative periodPain managementSurgical managementMultiple time pointsPainRepeated-measures designTime pointsStudy sampleHysterectomySignificant positive predictorPerceived stressWardsAnxiety
1999
Preoperative Anxiety and Intraoperative Anesthetic Requirements
Maranets I, Kain Z. Preoperative Anxiety and Intraoperative Anesthetic Requirements. Anesthesia & Analgesia 1999, 89: 1346. DOI: 10.1213/00000539-199912000-00003.Peer-Reviewed Original ResearchConceptsIntraoperative anesthetic requirementsMaintenance of anesthesiaAnesthetic requirementsPropofol dosesPreoperative anxietyBaseline anxietyHypnotic componentAnesthetic stateIntraoperative propofol requirementsLaparoscopic tubal ligationCross-sectional studyHigh baseline anxietyAnxiety levelsBispectral index monitorMore propofolAnesthetic regimenIndependent predictorsPropofol requirementsInitial doseTubal ligationLarge dosesPatientsState anxietyAnxious patientsAnesthesiaPreoperative anxiety and intraoperative anesthetic requirements.
Maranets I, Kain Z. Preoperative anxiety and intraoperative anesthetic requirements. Anesthesia & Analgesia 1999, 89: 1346-51. PMID: 10589606, DOI: 10.1097/00000539-199912000-00003.Peer-Reviewed Original ResearchConceptsIntraoperative anesthetic requirementsTrait anxietyMaintenance of anesthesiaAnesthetic requirementsAnxiety levelsLow trait anxietyPropofol doseHigh trait anxietyLaparoscopic tubal ligationIntraoperative propofol requirementsAnesthetic stateDoses of anestheticsCross-sectional studyTubal ligationInitial doseBaseline anxietyAnxious patientsHypnotic componentState anxietyLarger dosesAnxietyInduction doseBispectral index monitoringPatientsDose
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