2025
1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity
DOYLE E, FOGELMAN N, JOSEPH K, HU P, JASTREBOFF A, SINHA R. 1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1771-p.Peer-Reviewed Original ResearchTraumatic life eventsCumulative Adversity InterviewLife eventsChronic stressSweet food intakeCue contextLife traumaAcute stressCumulative stressful life eventsScript-driven imageryFood ad libitumRecent life eventsStressful life eventsTotal life eventsSnack foods ad libitumSweet food consumptionFood intakeEffects of stressChronic stress scoresStress scoresFood cuesCommunity adultsNeutral contextsCue conditionTraumatic eventsThe prevalence, clinical impact, and therapeutic considerations of trauma in adults with bipolar disorder: A systematic review
Xiao K, Sayed H, Xing J, Zhang X, Ai J, Teopiz K, Ho R, Rhee T, Lo H, Guillen-Burgos H, Vinberg M, McIntyre R. The prevalence, clinical impact, and therapeutic considerations of trauma in adults with bipolar disorder: A systematic review. Journal Of Affective Disorders 2025, 119507. PMID: 40449746, DOI: 10.1016/j.jad.2025.119507.Peer-Reviewed Original ResearchBipolar disorderSevere stressful life eventsChildhood emotional maltreatmentChildhood physical maltreatmentStressful life eventsEffects of traumaImpact of traumaChildhood traumaClinical impactEmotional maltreatmentSymptom severityLife eventsPhysical maltreatmentTherapeutic considerationsIllness severityIntegrated model of careModerating effectTreatment responseTreatment outcomesSystematic reviewAssociated with poor prognosisMaltreatmentModality of treatmentNegative clinical impactHistory of traumaHigh rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention
Trujillo T, Mirzakhanian H, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. High rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention. Schizophrenia Research 2025, 281: 1-9. PMID: 40300257, DOI: 10.1016/j.schres.2025.04.030.Peer-Reviewed Original ResearchConceptsClinical high riskCalgary Depression Scale for SchizophreniaClinical high-risk youthSuicide risk assessmentParasuicidal behaviorSuicidal ideationLife eventsSelf-harmNorth American Prodrome Longitudinal StudyClinical high-risk participantsStructured Assessment of Violence RiskAssessment of Violence RiskClinical high-risk groupHealthy controlsRates of suicidal ideationHistory of self-harmHistory of SILevels of suicidalityStressful life eventsPredictors of SIRates of suicideAssociated with worse symptomsCHR participantsPsychotic conversionDSM diagnosesImpact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study
Ota V, Oliveira A, Bugiga A, Conceição H, Galante P, Asprino P, Schäfer J, Hoffmann M, Bressan R, Brietzke E, Manfro G, Grassi-Oliveira R, Gadelha A, Rohde L, Miguel E, Pan P, Santoro M, Salum G, Carvalho C, Belangero S. Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study. Frontiers In Psychiatry 2025, 16: 1505421. PMID: 40018685, PMCID: PMC11866055, DOI: 10.3389/fpsyt.2025.1505421.Peer-Reviewed Original ResearchBrazilian High-Risk Cohort StudyChild Behavior ChecklistHigh Risk Cohort StudyLife adversityPsychiatric symptomsExternalizing symptomsDevelopment of psychiatric symptomsAssociated with depressive symptomsEarly life adversityStressful life eventsAssociated with psychiatric phenotypesPsychiatric phenotypesBehavior ChecklistDepressive symptomsLife eventsMental disordersPsychopathologyNo mediationChild maltreatmentCohort studyLatent factorsAssociated with deprivationAdversityModerating effectMental conditionPersonal Narratives in Trauma-Related Disorders: Contributions from a Metacognitive Approach and Treatment Considerations
Wiesepape C, Smith E, Muth A, Faith L. Personal Narratives in Trauma-Related Disorders: Contributions from a Metacognitive Approach and Treatment Considerations. Behavioral Sciences 2025, 15: 150. PMID: 40001781, PMCID: PMC11851491, DOI: 10.3390/bs15020150.Peer-Reviewed Original ResearchTrauma-related disordersTrauma narrativesTraumatic experiencesTreatment of trauma-related disordersIntegrated model of metacognitionIntegration of traumatic experiencesStudy of metacognitionModel of metacognitionSignificant life eventsPersonal narrativesLife eventsNarrative cohesionMetacognitive approachMetacognitionClinical implicationsNarrative identityTreatment considerationsLife narrativesCompleted treatmentThe Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population
Dogan M, Prachason T, Lin B, Pries L, Arias-Magnasco A, Bortoletto R, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, van Os J, Rutten B, Brondino N, Colizzi M, Luykx J, Fusar-Poli L, Guloksuz S. The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population. Schizophrenia Bulletin Open 2025, 6: sgaf005. PMID: 40123716, PMCID: PMC11926675, DOI: 10.1093/schizbullopen/sgaf005.Peer-Reviewed Original ResearchPsychotic experiencesNegative life eventsAutistic traitsLife eventsCommunity Assessment of Psychic ExperiencesAssociated with psychotic experiencesAutism Spectrum QuotientModerating RolePsychosis expressionInteraction effectsPolygenic risk scoresRisk factorsEmotional neglectPsychic ExperiencesPhysical neglectModeration analysisCT subtypesAutism spectrumBonferroni correctionEmotional abuseGenetic overlapMultilevel linear regression modelsTrauma screeningSexual abusePhysical abuseHeterogeneity in Developmental Trajectories of Internalizing and Externalizing Symptomatology: Associations with Risk and Protective Factors
Brieant A, Cai T, Ip K, Holt-Gosselin B, Gee D. Heterogeneity in Developmental Trajectories of Internalizing and Externalizing Symptomatology: Associations with Risk and Protective Factors. Child Psychiatry & Human Development 2025, 1-12. PMID: 39786680, DOI: 10.1007/s10578-024-01804-0.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentHigh-decreasing classModerate-increasing classTrajectories of psychopathologyNegative life eventsLow-stable classSample of youthLow-decreasing classGrowth mixture modelingProtective factorsExternalizing symptomatologyPsychopathological trajectoriesExternalizing symptomsProportion of youthLife eventsDevelopmental trajectoriesPsychopathologyCognitive developmentExternalizing trajectoriesTrajectory classesParental acceptanceLatent classesDevelopmental patternsInternational trajectoriesCo-development
2024
Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons
Ku B, Yuan Q, Haardörfer R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Druss B, Walker E, Anglin D. Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons. Psychiatry Research 2024, 342: 116222. PMID: 39378539, PMCID: PMC11617269, DOI: 10.1016/j.psychres.2024.116222.Peer-Reviewed Original ResearchHealthy comparisonPositive symptomsCHR-PPeer victimizationNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsAttenuated positive symptomsPositive psychotic symptomsClinical high riskFewer life eventsAssociated with schizophreniaEthnoracial diversityPsychotic symptomsHigh riskPrevent psychosisDepressive symptomsStructural equation modelingLife eventsProdromal symptomsPsychosisDiscriminatory experiencesEthnoracial minoritiesSocial determinantsNeighborhood povertyEthnoracial groupsUsing latent transition analysis to evaluate the impact of perceived threats on emotional and behavioral development
Conley M, Dinc E, Xiang Z, Baskin‐Sommers A. Using latent transition analysis to evaluate the impact of perceived threats on emotional and behavioral development. Child Development 2024, 95: 2150-2165. PMID: 39113318, DOI: 10.1111/cdev.14138.Peer-Reviewed Original ResearchLatent transition analysisBehavior problemsPerceived threatAdolescent Brain Cognitive Development StudyImpact of perceived threatCognitive Development StudyStressful life eventsTransition analysisEthnically diverse youthSubgroups of youthThreat experienceLife eventsYouth’s neighborhoodsBehavioral developmentDiverse youthYouths' familiesYouthDevelopment studiesAdolescentsThreatAssociationChildhoodNeighborhoodInterventionEthnicityNegative Life Events and Emotional Symptoms From Ages 2 to 30 Years
Copeland W, Keen R, Tong G, Shanahan L. Negative Life Events and Emotional Symptoms From Ages 2 to 30 Years. JAMA Network Open 2024, 7: e2429448. PMID: 39207754, PMCID: PMC11362870, DOI: 10.1001/jamanetworkopen.2024.29448.Peer-Reviewed Original ResearchConceptsCross-sectional analysisEmotional symptomsNegative life eventsAssociated with emotional symptomsLife eventsYoung adulthoodAssociated with increased mental health symptomsCohort study analyzed dataStressful eventsTraumatic eventsMental health symptomsCross-sectional associationsLongitudinal analysisAged 2Years of follow-upStudy analyzed dataDevelopmental periodIndividuals aged 2Lifetime traumatic eventsHealth symptomsMain OutcomesLate adolescenceEmotional functioningCohort studyPrimary outcomeS18 Neural Correlates of Controllable Negative Life Events and Their Relationships With Cannabis and Alcohol Use Initiation
Zhao Y, Potenza M, Tapert S, Paulus M. S18 Neural Correlates of Controllable Negative Life Events and Their Relationships With Cannabis and Alcohol Use Initiation. Drug And Alcohol Dependence 2024, 260: 110129. DOI: 10.1016/j.drugalcdep.2023.110129.Peer-Reviewed Original ResearchSubstance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstanceThe Assessment and Treatment of Post-traumatic Stress Disorder in Autistic People: A Systematic Review
Quinton A, Ali D, Danese A, Happé F, Rumball F. The Assessment and Treatment of Post-traumatic Stress Disorder in Autistic People: A Systematic Review. Review Journal Of Autism And Developmental Disorders 2024, 1-35. DOI: 10.1007/s40489-024-00430-9.Peer-Reviewed Original ResearchPost-traumatic stress disorderStress disorderAutistic adultsAutistic individualsTreatment of post-traumatic stress disorderSevere PTSD symptomsTrauma-related symptomsAdverse life eventsNon-autistic peersMental health conditionsPTSD symptomsLife eventsAutistic populationAutistic peopleDisordersSymptom assessment toolsSystematic reviewSymptomsAdultsChildrenAssessment toolHealth conditionsAutisticIndividualsTreatment strategiesPsychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Gaffey A, Spatz E. Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan. Current Atherosclerosis Reports 2024, 26: 45-58. PMID: 38240928, PMCID: PMC11219074, DOI: 10.1007/s11883-023-01185-0.Peer-Reviewed Original ResearchConceptsIschemic heart disease riskPsychological healthIschemic heart diseasePsychosocial stressRisk of ischemic heart diseaseIschemic heart disease diagnosisPsychological factorsStudy of psychological factorsPositive psychological factorsOptimal psychological healthHeart diseaseSignificant life eventsIHD riskPsychosocial factorsSense of purposeWoman's riskPsychological screeningPsychological assessmentPsychological interventionsLife eventsSex-specific factorsSocial isolationHealthVulnerable groupsNarrative review
2023
Cumulative adversity and emotion dysregulation effects on suicidal ideation and attempts in a community sample
Tate M, Sinha R, Wemm S. Cumulative adversity and emotion dysregulation effects on suicidal ideation and attempts in a community sample. Journal Of Psychiatric Research 2023, 170: 277-282. PMID: 38183699, DOI: 10.1016/j.jpsychires.2023.12.029.Peer-Reviewed Original ResearchEmotion dysregulationCumulative adversityCommunity adultsLifetime traumaLife eventsSuicidal ideationNonacceptance of emotionsHigher emotion dysregulationSuicide attemptsHighest cumulative stressMajor life eventsConcurrent suicidal ideationRecent life eventsTraumatic eventsDifficult emotionsEmotional responsesLife traumaCommunity sampleTrauma historyAdversityChronic stressorsNonacceptanceSuicidal thoughtsCumulative stressEmotionsNeural correlates of negative life events and their relationships with alcohol and cannabis use initiation
Zhao Y, Potenza M, Tapert S, Paulus M. Neural correlates of negative life events and their relationships with alcohol and cannabis use initiation. Dialogues In Clinical Neuroscience 2023, 25: 112-121. PMID: 37916739, PMCID: PMC10623894, DOI: 10.1080/19585969.2023.2252437.Peer-Reviewed Original ResearchConceptsNegative life eventsCannabis initiationGreater cortical thicknessCaudate gray matter volumeGray matter volumeDose-response relationshipOdds of alcoholLife eventsInitiation of alcoholSubstance Use InitiationCortical thicknessSubstance-naïveSuperior temporal sulcusNeural pathwaysCannabis useBrain structuresAlcohol useUse initiationAlcohol initiationSubstance use trajectoriesPoor academic performanceTemporal sulcusNeural mechanismsCannabisLinear regression modelsGene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding
Klingenberg B, Guloksuz S, Pries L, Cinar O, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Lin B, Luykx J, van Os J, Rutten B. Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding. Personality Neuroscience 2023, 6: e5. PMID: 38107775, PMCID: PMC10725776, DOI: 10.1017/pen.2023.2.Peer-Reviewed Original ResearchChildhood adversityParental bondingLife eventsPositive life eventsNegative life eventsGene-environment correlationGenetic vulnerabilityEysenck Personality QuestionnaireParental bonding stylesExpression of neuroticismPaternal bondingNeuroticismPersonality QuestionnaireAdversityMultilevel mixed-effects modelsMaternal bondingGreater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample. Neurobiology Of Stress 2023, 26: 100557. PMID: 37501940, PMCID: PMC10369475, DOI: 10.1016/j.ynstr.2023.100557.Peer-Reviewed Original ResearchTraumatic eventsGrimAge accelerationMore traumatic eventsWhite participantsExploratory mediation analysisMajor life eventsImpact of stressAssaultive traumaPsychological dataCross-sectional sampleCommunity sampleLife eventsMediation analysisLifetime stressRace-related differencesChronic stressorsCumulative stressorsYoung adultsCumulative stressChronic illnessYoung adult populationStressorsGreater stressHealthy adultsParticipantsStressful Life Events, Unhealthy Eating Behaviors and Obesity among Chinese Government Employees: A Follow-Up Study
Qiu D, He J, Li Y, Ouyang F, Xiao S. Stressful Life Events, Unhealthy Eating Behaviors and Obesity among Chinese Government Employees: A Follow-Up Study. Nutrients 2023, 15: 2637. PMID: 37299600, PMCID: PMC10255864, DOI: 10.3390/nu15112637.Peer-Reviewed Original ResearchConceptsHigher risk of obesityUnhealthy eating behaviorsRisk of obesityFollow-upEating behaviorsStressful life eventsAssociated with obesityIrregular meal timesLife eventsFollow-up studyFollowed-upObesityMeal timesBaselineLife Events ScaleChinese government employeesGovernment employeesChinese workersEvent ScaleReportsVeteran Experiences With Suicide Ideation, Suicide Attempt, and Social Support in Safety Planning Within the Department of Veterans Affairs
Matthieu M, Morissette S, Clafferty S, Degutis L, Oliver C, Adkins D, DeBeer B. Veteran Experiences With Suicide Ideation, Suicide Attempt, and Social Support in Safety Planning Within the Department of Veterans Affairs. Military Medicine 2023, 188: e3289-e3294. PMID: 37201198, DOI: 10.1093/milmed/usad144.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationSuicide attemptsSuicidal ideationVeterans Affairs Health Care SystemSuicide prevention interventionsHealth care facilitiesWarning signsHealth care systemSafety planningSafety planPrevention interventionsRisk veteransCare facilitiesHealth AdministrationDrug useVeterans AffairsSuicide preventionCare systemNegative life eventsPersonal coping strategiesVeteransIdeationSuicide ideationLife eventsSocial support
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