2025
Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways
Maurer S, Hing B, Lussier S, Radhakrishna S, Davis J, Abbott P, Michaelson J, Stevens H. Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways. Journal Of Psychiatric Research 2025, 182: 149-160. PMID: 39809011, PMCID: PMC11959308, DOI: 10.1016/j.jpsychires.2024.12.048.Peer-Reviewed Original ResearchConceptsPrenatal stressAutism spectrum disorderSex-specific wayDorsal striatumNeurodevelopmental disordersGABAergic populationEffects of prenatal stressStriatal GABAergic neuronsReversal learningVentral forebrain regionsBrain changesSpectrum disorderForebrain regionsStriatal developmentGABAergic neuronsBehavioral assaysBrain developmentPlacental transcriptomeStriatumCognitionDevelopmental originsDisordersPlacental differencesPlacental functionPlacenta function
2008
Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
Satta R, Maloku E, Zhubi A, Pibiri F, Hajos M, Costa E, Guidotti A. Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 16356-16361. PMID: 18852456, PMCID: PMC2570996, DOI: 10.1073/pnas.0808699105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationDown-Regulationgamma-Aminobutyric AcidGene Expression Regulation, EnzymologicGlutamate DecarboxylaseHippocampusMaleMiceNeuronsNicotinePromoter Regions, GeneticReceptors, CholinergicReelin ProteinRNA, MessengerTime FactorsUp-RegulationConceptsGABAergic neuronsFrontal cortexGABAergic interneuronsSchizophrenia patientsMedium spiny GABAergic neuronsDNMT1 expressionNicotinic receptor populationsStriatal GABAergic neuronsBlood-brain barrierHippocampal GABAergic interneuronsNicotine-induced decreasesDifferent cortical layersMouse frontal cortexDNA methyltransferase 1 expressionDNMT1 mRNA expressionSmoking habitsTobacco smokingReceptor dysfunctionMuscarinic receptorsSame dosesReceptor populationMethyltransferase 1 expressionCortical layersMRNA expressionHypermethylation of promoters
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