2019
Prenatal Inflammation Dampens Neurogenesis and Enhances Serotonin Transporter Expression in the Hippocampus of Adult Female Rats
Mouihate A, Kalakh S, AlMutairi R, Alashqar A. Prenatal Inflammation Dampens Neurogenesis and Enhances Serotonin Transporter Expression in the Hippocampus of Adult Female Rats. Medical Principles And Practice 2019, 28: 352-360. PMID: 30884483, PMCID: PMC6639577, DOI: 10.1159/000499658.Peer-Reviewed Original ResearchConceptsAnxiety-like behaviorPrenatal LPSAdult female ratsFemale ratsHippocampal neurogenesisSERT expressionSerotonin transporterFemale offspringGestational day 15Serotonin transporter expressionOpen field testPrenatal inflammationPregnant ratsAdult neurogenesisPrenatal exposureHippocampal expressionBACKGROUND/Adult offspringDay 15LPSNeurogenesisWestern blotTransporter expressionRatsHippocampus
2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2017
H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses
Deng J, Mueller M, Geng T, Shen Y, Liu Y, Hou P, Ramillapalli R, Taylor HS, Paidas M, Huang Y. H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses. Cell Death & Disease 2017, 8: e3175-e3175. PMID: 29215608, PMCID: PMC5827203, DOI: 10.1038/cddis.2017.392.Peer-Reviewed Original ResearchMeSH KeywordsAdenosylhomocysteinaseAnimalsBase SequenceCell Line, TumorFemaleFetusGene Expression ProfilingGene Expression RegulationGluconeogenesisHepatocyte Nuclear Factor 4HepatocytesHumansHypoglycemic AgentsLiverMaleMaternal ExposureMetforminMethylationMicePregnancyPrenatal Exposure Delayed EffectsRNA, Long NoncodingSignal TransductionConceptsFetal liverPrenatal metformin exposureAnti-diabetic medicationsHuman liver cell lineHepatocyte nuclear factor 4αNuclear factor 4αMetabolic abnormalitiesMetformin exposureLiver cell lineH19 overexpressionMetabolic disordersAdult offspringFetal originAnimal studiesH19 expressionMouse fetusesMetforminElevated expressionLiverConcomitant activationCell linesFetusesGluconeogenic genesS-adenosylhomocysteine hydrolaseLiver development
2016
Can prenatal infection contribute to psychiatric disease in offspring?
Brennand K. Can prenatal infection contribute to psychiatric disease in offspring? Science Translational Medicine 2016, 8 DOI: 10.1126/scitranslmed.aaf3846.Commentaries, Editorials and Letters
2014
Altered Placental Tryptophan Metabolism: A Crucial Molecular Pathway for the Fetal Programming of Neurodevelopmental Disorders
Bonnin A, Goeden N, Lund B, Anderson G. Altered Placental Tryptophan Metabolism: A Crucial Molecular Pathway for the Fetal Programming of Neurodevelopmental Disorders. 2014 DOI: 10.21236/ada611000.Peer-Reviewed Original ResearchFetal brain developmentFetal programmingMaternal infectionFetal brainMolecular pathwaysMental disordersBrain developmentEssential amino acid tryptophanImpact of inflammationAutism spectrum disorderTrp metabolic pathwayAdult brain functionCrucial molecular pathwaysEarly pregnancyNew molecular pathwaysLong-term consequencesTrp metabolismTrophic factorsTryptophan metabolismAdult offspringPostnatal developmentBrain functionCritical mediatorAmino acid tryptophanNeurodevelopmental disorders
2013
Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System
Holloway T, Moreno JL, Umali A, Rayannavar V, Hodes GE, Russo SJ, González-Maeso J. Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System. Journal Of Neuroscience 2013, 33: 1088-1098. PMID: 23325246, PMCID: PMC3711555, DOI: 10.1523/jneurosci.2331-12.2013.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate 2 receptorPrenatal stressSevere adverse life eventsSchizophrenia-like alterationsMaternal immune systemHead-twitch responsePrenatal immune activationAntipsychotic-like effectsAntipsychotic drug developmentMGlu2/3 agonist LY379268Risk of schizophreniaAdverse life eventsCross-fostering studyEarly neurodevelopmental originHallucinogenic 5Serotonin 2AAgonist DOIImmune activationAgonist LY379268Pathophysiological hypothesesFrontal cortexPsychiatric disordersAdult offspringSerotonin 5Behavioral alterations
2011
Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring
Moreno JL, Kurita M, Holloway T, López J, Cadagan R, Martínez-Sobrido L, García-Sastre A, González-Maeso J. Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring. Journal Of Neuroscience 2011, 31: 1863-1872. PMID: 21289196, PMCID: PMC3037097, DOI: 10.1523/jneurosci.4230-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdult ChildrenAnimalsAntipsychotic AgentsCerebral CortexDisease Models, AnimalDown-RegulationEarly Growth Response Protein 1Early Growth Response Protein 2FemaleFrontal LobeGlutamic AcidHallucinogensInfluenza A Virus, H1N1 SubtypeMaternal-Fetal ExchangeMiceNeural PathwaysOrthomyxoviridae InfectionsPregnancyProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSchizophreniaUp-RegulationConceptsInfluenza viral infectionViral infectionMouse modelAdult offspringSchizophrenia-like alterationsPrenatal viral infectionHead-twitch responseSchizophrenia-like psychosisInfluenza A/WSN/33 virusMetabotropic glutamate receptorsAntipsychotic-like effectsPrevention of schizophreniaSpontaneous locomotor activityHigher c-fosEffects of hallucinogensBehavioral changesEgr-2 expressionEtiology of schizophreniaMechanism of actionMaternal infectionInfected mothersMaternal exposureGlutamate agonistsAntipsychotic drugsGlutamate system
2004
Gender effects of reported in utero tobacco exposure on smoking initiation, progression and nicotine dependence in adult offspring
Oncken C, McKee S, Krishnan-Sarin S, O'Malley S, Mazure C. Gender effects of reported in utero tobacco exposure on smoking initiation, progression and nicotine dependence in adult offspring. Nicotine & Tobacco Research 2004, 6: 829-833. PMID: 15700918, DOI: 10.1080/1462220042000282555.Peer-Reviewed Original ResearchConceptsUtero tobacco exposureTobacco exposureNicotine dependenceCigarette useUtero exposureAdult treatment-seeking smokersDaily cigarette useTreatment-seeking smokersCurrent cigarette useAdult smokersInteraction of exposureAdult offspringTobacco experimentationUnexposed malesCigarette experimentationProgressionSmokersExposureDaily useAgeGenderMalesOpposite effectFemalesGender effects
2001
Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress
Morrow B, Elsworth J, Roth R. Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress. Synapse 2001, 41: 337-344. PMID: 11494404, DOI: 10.1002/syn.1090.Peer-Reviewed Original ResearchConceptsA10 dopamine neuronsDopamine neuronsDopaminergic neuronsPrenatal exposurePrenatal saline controlsTyrosine hydroxylase immunoreactiveA10 dopaminergic neuronsCocaine-induced reductionRat dopaminergic neuronsCocaine-exposed ratsPoor cognitive performanceYoung adult offspringUnderlying biochemical changesDopaminergic functionA9 regionSaline controlsIntravenous modelPerinatal lossAdult offspringIntermittent footshockImmediate early genesCognitive deficitsNeuronal systemsBehavioral effectsCell groups
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