2025
Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking
Wemm S, Holzhauer C, Harrison L, Milivojevic V, Fogelman N, Cao Z, Wulfert E. Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking. Psychoneuroendocrinology 2025, 177: 107469. PMID: 40250213, PMCID: PMC12131328, DOI: 10.1016/j.psyneuen.2025.107469.Peer-Reviewed Original ResearchConceptsTrier Social Stress TestHypothalamic-pituitary-adrenal axisAxis responseProblem gamblingPathophysiology of addictive disordersHPA axis responseSocial Stress TestHypothalamic-pituitary-gonadal axisHealthy control participantsLaboratory-induced stressStress-related changesStress hormone cortisolHypothalamic-pituitary-gonadal axis hormonesAddictive disordersAddiction mechanismsLaboratory stressorSubstance addictionControl participantsNeuroactive steroidsNeuroendocrine responsesAttenuated cortisolPsychological featuresProblem gamblersHormone cortisolGambling
2024
Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake
McGowan C, Krah M, Fogelman N, Seo D, Sinha R. Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake. Alcohol And Alcoholism 2024, 59: agae047. PMID: 39053499, DOI: 10.1093/alcalc/agae047.Peer-Reviewed Original ResearchConceptsMorning cortisol levelsCortisol levelsHigher morning cortisol levelsHypothalamic-pituitary-adrenal (HPA) axisSex differencesReports of alcohol consumptionProblematic drinking behaviorAlcohol consumptionAverage cortisol levelsBasal cortisol levelsAlcohol intakeHeavy alcohol useChronic alcohol consumptionHPA axisDrinking behaviorNeuroimaging scansPeripheral cortisolAlcohol useStress systemBinge drinkingMorning cortisolStress hormonesMorning plasma cortisolBingeNon-significant relationshipThe role of epigenetic mechanisms in the long‐term effects of early‐life adversity and mother–infant relationship on physiology and behavior of offspring in laboratory rats and mice
Burenkova O, Grigorenko E. The role of epigenetic mechanisms in the long‐term effects of early‐life adversity and mother–infant relationship on physiology and behavior of offspring in laboratory rats and mice. Developmental Psychobiology 2024, 66: e22479. PMID: 38470450, PMCID: PMC10959231, DOI: 10.1002/dev.22479.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Childhood ExperiencesAnimalsEpigenesis, GeneticFemaleHumansHypothalamo-Hypophyseal SystemInfantMammalsMiceMothersPituitary-Adrenal SystemRatsConceptsEarly-life adversityEffects of early-life adversityBehavior of offspringMother-infant relationshipRegulation of hypothalamic-pituitary-adrenal axisHypothalamic-pituitary-adrenal axisBrain-derived neurotrophic factorLaboratory ratsMaternity careBehavioral profileEpigenetic mechanismsNeurotrophic factorExperimental manipulationEarly postnatal periodPharmacological interventionsLong-term effectsAdversityLong-term influenceRatsAdaptation of offspringOffspringEpigenetic editingTranslational potentialNatural variationMiceGhrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis
Zhang C, Dong Y, Li S, Li M, Gao Y, Liu Y, Liu X, Zhou C, Li J. Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis. Asia-Pacific Psychiatry 2024, 16: e12552. PMID: 38348641, DOI: 10.1111/appy.12552.Peer-Reviewed Original ResearchMeSH KeywordsDepressionDepressive Disorder, MajorGhrelinHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemConceptsFirst-episode drug-naive MDD patientsMajor depressive disorderHAMD total scoreDrug-naive MDD patientsMDD patientsDepressive symptomsCorticotropin-releasing-hormoneTotal scoreDepressive disorderPathogenesis of major depressive disorderMeasures of depressive symptomsHealthy controlsHypothalamic-pituitary-adrenal axisHamilton Depression ScaleBody mass indexAdrenocorticotropic hormoneHAMD-17Plasma levels of ghrelinGhrelin levelsMediation analysisHAMDPartial correlation analysisDepression ScaleCortisol levelsLevels of ghrelin
2023
Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents
Picci G, Casagrande C, Ott L, Petro N, Christopher‐Hayes N, Johnson H, Willett M, Okelberry H, Wang Y, Stephen J, Calhoun V, Wilson T. Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents. Human Brain Mapping 2023, 44: 6388-6398. PMID: 37853842, PMCID: PMC10681633, DOI: 10.1002/hbm.26516.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxietyChildDehydroepiandrosteroneFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemConceptsTrauma-related symptomsAnxiety symptomsPituitary volumeAnterior pituitary volumeConsistent with adult findingsHigh-resolution T1-weighted MRI scansPG volumeEarly life stressLevels of dehydroepiandrosteroneT1-weighted MRI scansDehydroepiandrosterone levelsPituitary glandResponse to stressComorbid anxietyNeurobiological sequelaeSubclinical anxietyLife stressAnxiety/depression symptomsElevated anxietyAdult findingsAssociated with disruptionDevelopmental sampleHealthy youthTrained ratersPubertal windowAre hair cortisol levels dependent on hair growth rate? A pilot study in rhesus macaques
Dettmer A, Novak M, Meyer J. Are hair cortisol levels dependent on hair growth rate? A pilot study in rhesus macaques. General And Comparative Endocrinology 2023, 340: 114308. PMID: 37244411, PMCID: PMC10330586, DOI: 10.1016/j.ygcen.2023.114308.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleGlucocorticoidsHairHumansHydrocortisoneHypothalamo-Hypophyseal SystemMacaca mulattaMalePilot ProjectsPituitary-Adrenal SystemConceptsHair cortisol concentrationsHair growth rateHair growthMacaque monkeysCortisol accumulationPilot studyAccumulation of cortisolHPA axis regulationLower hair cortisol concentrationsHigher hair cortisol concentrationsGlucocorticoid-mediated inhibitionPresent pilot studyRhesus macaque monkeysAdult female macaquesHair cortisol levelsAge-related differencesAxis regulationHair samplesInfants 3Rodent studiesCortisol levelsCortisol concentrationsAge groupsCortisol studiesNonhuman primate speciesHypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology
Syed S, Sinha R, Milivojevic V, MacDougall A, LaValle H, Angarita G, Fox H. Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology. Human Psychopharmacology Clinical And Experimental 2023, 38: e2867. PMID: 37165544, DOI: 10.1002/hup.2867.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAlcohol DrinkingAlcoholismEthanolHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemRecurrenceStress, PsychologicalConceptsAlcohol use disorderRelapse riskDepressive symptomatologyDepressive symptomsAutonomic responsesIndividual relapse riskChronic alcohol useDepressive pathophysiologyAdrenocorticotropic hormoneInhibitory systemPlasma measuresUse disordersClinical practicePhasic changesConsecutive daysAlcohol usePsychological stressStroop performanceDisorder individualsDrinking controlsSymptomatologyImagery exposureCounterbalanced orderSymptomsDepression
2022
Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs
Wiley K, Camilo C, Gouveia G, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs. Developmental Psychobiology 2022, 65: e22352. PMID: 36567654, PMCID: PMC9792831, DOI: 10.1002/dev.22352.Peer-Reviewed Original ResearchConceptsPrenatal psychological distressLate pregnancyMaternal prenatal psychosocial stressMaternal hair cortisolMaternal prenatal psychological distressPrenatal psychosocial stressPsychological distressAdrenal axis functionInfants of mothersEvening salivary cortisolMother-infant pairsInfant DNA methylationMultivariable linear regressionHair cortisol concentrationsElevated anxiety symptomsAxis functionFetal programingEvening cortisolPregnant adolescentsMaternal distressPsychosocial stressCortisol concentrationsPregnancyHair cortisolSalivary cortisolPregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic V, Sullivan L, Tiber J, Fogelman N, Simpson C, Hermes G, Sinha R. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. Psychopharmacology 2022, 240: 101-114. PMID: 36445398, PMCID: PMC10630889, DOI: 10.1007/s00213-022-06278-3.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAlcoholismAnxietyArousalCravingCuesEthanolHumansHypothalamo-Hypophyseal SystemNeurosteroidsPituitary-Adrenal SystemPregnenoloneRecurrenceConceptsAlcohol use disorderDiastolic blood pressureHeart rateGABAergic transmissionNeuroactive steroidsHPA axisRelapse riskUse disordersAlcohol cravingTreatment of AUDAlcohol cue-induced cravingPilot clinical trialStress-induced anxietyCue-induced cravingAutonomic arousalNeurosteroid systemPreg groupStudy drugDBP responseBlood pressureDay groupClinical trialsPregnenolone levelsWeek 2Cue-provoked cravingAbnormal cortisol profile during psychosocial stress among patients with schizophrenia in a Chinese population
Zhu X, Zhu Y, Huang J, Zhou Y, Tong J, Zhang P, Luo X, Chen S, Tian B, Tan S, Wang Z, Han X, Tian L, Li CR, Hong LE, Tan Y. Abnormal cortisol profile during psychosocial stress among patients with schizophrenia in a Chinese population. Scientific Reports 2022, 12: 18591. PMID: 36329219, PMCID: PMC9633605, DOI: 10.1038/s41598-022-20808-1.Peer-Reviewed Original ResearchMeSH KeywordsChinaEndocrine System DiseasesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemSalivaSchizophreniaStress, PsychologicalConceptsNegative affect scoresAffect scoresPaced Auditory Serial Addition TaskAuditory Serial Addition TaskMirror-Tracing Persistence TaskSerial Addition TaskNegative Affect ScheduleChallenge taskNegative emotionsAddition taskPersistence taskCortisol responseSignificant interactionSalivary cortisol levelsNegative Syndrome ScaleCortisol profilesCortisol levelsSaliva cortisol levelsPsychological stressPsychosocial stressHealthy volunteersEmotionsSyndrome ScaleTaskAdrenal axis dysfunctionNon-linear associations between HPA axis activity during infancy and mental health difficulties during early childhood among children in rural Pakistan.
Frost A, Hagaman A, Baranov V, Chung EO, Bhalotra S, Sikander S, Maselko J. Non-linear associations between HPA axis activity during infancy and mental health difficulties during early childhood among children in rural Pakistan. Development And Psychopathology 2022, 35: 2086-2095. PMID: 35959681, PMCID: PMC9922341, DOI: 10.1017/s0954579422000773.Peer-Reviewed Original ResearchConceptsHPA axis activityMental health difficultiesAxis activityHealth difficultiesEarly childhoodHypothalamic pituitary adrenal axis activityPituitary-adrenal axis activitySDQ scoresAdrenal axis activityNon-linear associationLongitudinal cohortDepression trialsQuadratic associationHair cortisolDehydroepiandosteroneRural PakistanMental healthCortisolEarly adversitySignificant quadratic associationDifficulties QuestionnaireLow-resource contextsChildhoodChildrenAssociationPsychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes
Kalesnikava V, Clarke P, Mukherjee B, Sen S, Mezuk B. Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes. Biopsychosocial Science And Medicine 2022, 84: 813-821. PMID: 35980779, DOI: 10.1097/psy.0000000000001112.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiabetes Mellitus, Type 2HumansHydrocortisoneHypothalamo-Hypophyseal SystemMiddle AgedPituitary-Adrenal SystemSalivaSocial ClassStress, PsychologicalConceptsDomain-specific stressMeasures of psychosocial stressTrier Social Stress TestAssociated with cortisol recoveryHypothalamic-pituitary-adrenal axis reactivityPsychosocial stressPerceived stressEvidence of effect modificationCortisol responseHigh-SES neighborhoodsHigher perceived stressPsychosocial stress measuresSocioeconomically diverse cohortCortisol recoveryRisk of diabetesAssociated with cortisol responseNeighborhood SESHealth disparitiesEffect modificationNeurobiological stress responseSocioeconomic statusSocial Stress TestSelf-report measuresType 2 diabetesSalivary cortisol responseAmygdala reactivity during socioemotional processing and cortisol reactivity to a psychosocial stressor
Roberts A, Peckins M, Gard A, Hein T, Hardi F, Mitchell C, Monk C, Hyde L, Lopez-Duran N. Amygdala reactivity during socioemotional processing and cortisol reactivity to a psychosocial stressor. Psychoneuroendocrinology 2022, 144: 105855. PMID: 35835021, PMCID: PMC10485794, DOI: 10.1016/j.psyneuen.2022.105855.Peer-Reviewed Original Research
2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embeddingImaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer 11C-TASP699
Naganawa M, Nabulsi NB, Matuskey D, Henry S, Ropchan J, Lin SF, Gao H, Pracitto R, Labaree D, Zhang MR, Suhara T, Nishino I, Sabia H, Ozaki S, Huang Y, Carson RE. Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer 11C-TASP699. Journal Of Nuclear Medicine 2021, 63: 609-614. PMID: 34385336, DOI: 10.2967/jnumed.121.262430.Peer-Reviewed Original ResearchMeSH KeywordsHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPositron-Emission TomographyPyridinesPyrimidinonesReceptors, VasopressinReproducibility of ResultsConceptsMultilinear analysis 1Test-retest variabilityPlasma concentrationsHealthy subjectsR occupancyR antagonistBrain regionsMetabolite-corrected arterial input functionAbsolute test-retest variabilityAdrenal axis activityNovel PET radiotracersSubstantial specific bindingDose-dependent fashionVasopressin 1b receptorTest-retest reproducibilityHalf maximal inhibitory concentrationAdverse eventsAxis activityOutcome measuresReceptor occupancyTime-activity curvesArginine vasopressinPosterior pituitaryDistribution volumeNeuropsychiatric disorders
2020
PTSD symptoms and cortisol stress reactivity in adolescence: Findings from a high adversity cohort in South Africa
Zimmerman A, Halligan S, Skeen S, Morgan B, Fraser A, Fearon P, Tomlinson M. PTSD symptoms and cortisol stress reactivity in adolescence: Findings from a high adversity cohort in South Africa. Psychoneuroendocrinology 2020, 121: 104846. PMID: 32919210, DOI: 10.1016/j.psyneuen.2020.104846.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderCortisol stress reactivityTrier Social Stress TestPTSD symptomsTrauma exposureStress reactivityHPA axis stress reactivitySmall inverse associationHPA stress reactivitySex-specific associationsTotal cortisol outputElevated PTSD symptomsImpoverished South African communityMiddle-income countriesAdrenal axisInverse associationSocial Stress TestMiddle-income country contextCortisol responsePsychosocial stressCortisol outputCortisol increaseSalivary cortisolStress disorderSouth African communityAssociation of maternal depression and home adversities with infant hypothalamic-pituitary-adrenal (HPA) axis biomarkers in rural Pakistan
Hagaman AK, Baranov V, Chung E, LeMasters K, Andrabi N, Bates LM, Rahman A, Sikander S, Turner E, Maselko J. Association of maternal depression and home adversities with infant hypothalamic-pituitary-adrenal (HPA) axis biomarkers in rural Pakistan. Journal Of Affective Disorders 2020, 276: 592-599. PMID: 32871690, PMCID: PMC7792907, DOI: 10.1016/j.jad.2020.07.053.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersChildDepressionFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemInfantPakistanPituitary-Adrenal SystemPregnancyStress, PsychologicalConceptsHPA axis activityMaternal depressionSocio-economic statusYear postpartumDHEAS levelsAxis activityIntimate partner violenceInfant stress response systemsSignificant associationLow DHEAS levelsHPA axis dysregulationHPA axis hormonesOne-year-old infantsYears of ageConsistent significant associationsChildren's HPA-axis activityHigher socio-economic statusSignificant positive associationAxis dysregulationAxis hormonesAdrenal axisStress-related diseasesDHEA activityInfant cortisolDepression severityA new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks
Karin O, Raz M, Tendler A, Bar A, Korem Kohanim Y, Milo T, Alon U. A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks. Molecular Systems Biology 2020, 16: msb209510. PMID: 32672906, PMCID: PMC7364861, DOI: 10.15252/msb.20209510.Peer-Reviewed Original ResearchConceptsHPA axisPathophysiology of stress-related disordersHypothalamic-pituitary-adrenal (HPA) axisStress-related disordersImpaired glucocorticoid receptorDysregulation of cortisolGlucocorticoid receptorHPA hormonesMood disordersPsychiatric disordersChronic stressStress hormonesMass changesDisordersACTH dynamicsComplex network of hormonesTimescales of weeksDysregulationGland massGrowth factorNetwork of hormonesHormoneGlandtrans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder
Yuan Y, Zhen L, Li Z, Xu W, Leng H, Xu W, Zheng V, Luria V, Pan J, Tao Y, Zhang H, Cao S, Xu Y. trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder. Journal Of Psychopharmacology 2020, 34: 726-736. PMID: 32308103, DOI: 10.1177/0269881120914221.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) expressionPhosphorylated cAMP response elementAnxiety-like behaviorNeurotrophic factor expressionNeuropathic painCAMP response elementBrain-derived neurotrophic factor levelsGlucocorticoid receptorFactor expressionProlonged stressStress-induced anxiety-like behaviorStress disorderCold allodynia testsNeurotrophic factor levelsAdrenal axis functionPain-related regionsLocomotor activity testSerum corticosterone levelsMarble burying testNumber of marblesProtein kinase APost-traumatic stress disorderEnzyme-linked immunosorbentClassical animal modelsResponse element
2019
Systematic Review of Chronic Discrimination and Changes in Biology During Pregnancy Among African American Women
Chaney C, Lopez M, Wiley KS, Meyer C, Valeggia C. Systematic Review of Chronic Discrimination and Changes in Biology During Pregnancy Among African American Women. Journal Of Racial And Ethnic Health Disparities 2019, 6: 1208-1217. PMID: 31385262, DOI: 10.1007/s40615-019-00622-8.Peer-Reviewed Original ResearchConceptsChronic racial discriminationAfrican American womenSystematic reviewAmerican womenRacial health disparitiesInclusion criteriaMaternal biologyLarger sample sizeCardiovascular systemChronic discriminationHealth disparitiesHealth existLiterature searchPregnancyPsycINFO databasesRelevant biomarkersStudy designSmall sample sizeSample sizeEffective study designPreliminary evidenceCurrent literatureWomenIndirect evidenceInformative method
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