2025
Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma
Yang J, Wang C, Fu D, Ho L, Galani K, Chen L, Gonzalez J, Fu J, Huang A, Frederick D, He L, Asnani M, Tacke R, Robitschek E, Yadav S, Deng W, Burke K, Sharova T, Sullivan R, Weiss S, Rai K, Liu D, Boland G, Kellis M. Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma. Nature Communications 2025, 16: 8151. PMID: 40890106, PMCID: PMC12402436, DOI: 10.1038/s41467-025-62878-5.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsProgression-free survivalDendritic cellsTumor microenvironmentAnti-PD-1 checkpoint blockadeTranscriptional hallmarksCD8 T-cell ratiosT-and B-cellsAnti-PD-1 therapyDendritic cell subtypesT cell ratioConventional dendritic cellsMigratory dendritic cellsMetastatic melanoma samplesCheckpoint blockadeCheckpoint inhibitorsMetastatic melanomaImmunotherapy responsePredictive biomarkersImmune infiltrationMalignant cellsB cellsImmunoregulatory moleculesIndependent cohortMelanoma samplesPredicting tumor recurrence site after reirradiation in head and neck cancer: a retrospective external validation of a published [18F]-FDG PET radiomic signature
Beddok A, Grogg K, Nioche C, Rozenblum L, Orlhac F, Calugaru V, Crehange G, Shih H, Marin T, Buvat I, El Fakhri G. Predicting tumor recurrence site after reirradiation in head and neck cancer: a retrospective external validation of a published [18F]-FDG PET radiomic signature. La Radiologia Medica 2025, 1-10. PMID: 40833475, DOI: 10.1007/s11547-025-02072-1.Peer-Reviewed Original ResearchHead and neck cancerPET radiomics signaturePositive predictive valueNeck cancerRadiomics signatureRecurrent head and neck cancerExternal cohortTumor recurrence siteDose escalationLocoregional failurePET radiomicsRecurrence siteMassachusetts General HospitalLIFEx softwareIndependent cohortRadiomic featuresOriginal cutoffPatientsPredictive valuePublished cutoffsPurposeThis studyCohortGeneral HospitalRecurrenceConclusionThe studyIntegrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma
Nassar A, Kim C, Adeyelu T, Bou Farhat E, Abushukair H, Rakaee M, Matteson K, Lau S, Takabe Y, Ocejo A, Ardeshir-Larijani F, Leal T, Ramalingam S, Alam S, Gray J, Hicks J, Kaldas D, Baena J, Berjaga M, Nana F, Grohe C, Leuders H, Citarella F, Cortellini A, Mingo E, Pancirer D, Das M, Ellis-Caleo T, Cheung J, Lin J, Watson A, Camidge D, Sridhar A, Parikh K, Crowley F, Marron T, Aggarwal V, Ahmed M, Sankar K, Kawtharany H, Zhang J, Owen D, Li M, Nagasaka M, Pinato D, Awosika N, Alhamad K, Puri S, Zaman U, Gupta D, Lau C, Khan H, Liauw J, Velazquez A, Brown T, Moliner L, Mosteiro M, Rocha P, Evans M, Vanderwalde A, Elliott A, Nieva J, Lopes G, Ma P, Borghaei H, Lee M, Young L, Aljumaily R, Mirza H, Kwiatkowski D, Herbst R, Flavell R, Naqash A, Chiang A. Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma. Nature Communications 2025, 16: 7717. PMID: 40830141, PMCID: PMC12365225, DOI: 10.1038/s41467-025-63091-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorCarcinoma, Large CellCarcinoma, NeuroendocrineCarcinoma, Non-Small-Cell LungFemaleGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsKelch-Like ECH-Associated Protein 1Lung NeoplasmsLymphocytes, Tumor-InfiltratingMaleMembrane ProteinsMiddle AgedMutationTrypsin Inhibitor, Kazal PancreaticConceptsLarge cell neuroendocrine carcinomaPulmonary large cell neuroendocrine carcinomaCell neuroendocrine carcinomaNeuroendocrine carcinomaClinical characterizationFGL-1DLL3-targeting therapiesTumor-infiltrating lymphocytesAggressive lung tumorsImmunogenomic profilingSCLC-likeOverall survivalLAG-3SPINK1 expressionLung tumorsTreatment regimensAdverse eventsLung cancerIndependent cohortCancer-likeSerial samplesMolecular heterogeneitySPINK1CarcinomaTranscriptional profilesUrine Proteomic Signatures of Kidney Function Decline after Hospitalization
Wen Y, Menez S, Philbrook H, Moledina D, Coca S, Xue J, Kaufman J, Chinchillil V, Kimmel P, Ikizler T, Hsu C, Kelly T, Ricardo A, Himmelfarb J, Parikh C. Urine Proteomic Signatures of Kidney Function Decline after Hospitalization. JCI Insight 2025, 10 PMID: 40794429, DOI: 10.1172/jci.insight.195577.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUrine proteomic signatureKidney Precision Medicine ProjectEGFR declineHistopathological featuresTubular injuryUrinary proteinFeatures of acute kidney injuryHigh riskAssociated with eGFR declineSlower eGFR declineAssociated with eGFRGlomerular filtration rateKidney function declineResearch kidney biopsiesYear Follow-UpKidney biopsyInterstitial inflammationMyeloid cellsKidney injuryProximal tubulesFiltration rateFollow-upKidney functionIndependent cohortDecomposition of phenotypic heterogeneity in autism reveals underlying genetic programs
Litman A, Sauerwald N, Green Snyder L, Foss-Feig J, Park C, Hao Y, Dinstein I, Theesfeld C, Troyanskaya O. Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs. Nature Genetics 2025, 57: 1611-1619. PMID: 40634707, PMCID: PMC12283356, DOI: 10.1038/s41588-025-02224-z.Peer-Reviewed Original ResearchConceptsGenetic complexityPhenotypic complexityClinically relevant classesPhenotypic dataPhenotypic heterogeneityDe novoMolecular programsClass-specific differencesMechanistic hypothesesDysregulation patternsDevelopmental timeGenetic programmingComplexity of autismIndependent cohortClinical outcome differencesGenesMutationsGeneticsTraitsClinical outcomesClinical manifestationsPathwayMixture model approachInheritanceBiologyPosterior parasagittal meningiomas display aggressive features independent of size: a multicenter analysis
Koçyiğit S, Chavez M, Orhun Ö, O’Brien J, Inan A, Yaşar A, Dinçer A, Moliterno J, Günel M, Pamir M, Özduman K, Erşen-Danyeli A. Posterior parasagittal meningiomas display aggressive features independent of size: a multicenter analysis. Journal Of Neuro-Oncology 2025, 175: 101-110. PMID: 40569492, PMCID: PMC12367906, DOI: 10.1007/s11060-025-05103-z.Peer-Reviewed Original ResearchConceptsParasagittal meningiomaAnatomical locationKi67 indexWHO-gradeAggressive featuresTumor volume ratioChromosome 1p lossGrading criteriaResultsTumor volumeLarge meningiomasHistological subtypesAggressive biologyHistological gradeMolecular subsetsMulticenter analysisCohort BMeningioma sizeMitotic countRadiological featuresTumor behaviorRisk stratificationBrain invasionRetrospective analysisHistopathological markersIndependent cohortIntegrating TSPO-PET imaging with metabolomics for enhanced prognostic accuracy in multiple sclerosis
Radford-Smith D, Yates A, Kacerova T, Nylund M, Sucksdorff M, Matilainen M, Willemse E, Oechtering J, Maceski A, Leppert D, Kuhle J, Probert F, Anthony D, Airas L. Integrating TSPO-PET imaging with metabolomics for enhanced prognostic accuracy in multiple sclerosis. BMJ Neurology Open 2025, 7: e001026. PMID: 40248672, PMCID: PMC12004482, DOI: 10.1136/bmjno-2025-001026.Peer-Reviewed Original ResearchSecondary progressive MSDisease progressionPET imagingMultiple sclerosisNuclear magnetic resonance (NMR)-based metabolomicsTSPO PET imagingTSPO-PETTSPO imagingMRI-visible lesionsNormal-appearing white matterPrediction of disease progressionPredicting disease progressionClinical trial stratificationSerum metabolite analysisTSPO availabilitySerum metabolomeNMR analysisPrognostic accuracyC-PK11195Progressive MSRelapsing-remittingTreatment strategiesIndependent cohortMetabolites glutamateMS patients
2023
Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores
Chen L, Pokhvisneva I, Lahti-Pulkkinen M, Kvist T, Baldwin J, Parent C, Silveira P, Lahti J, Räikkönen K, Glover V, O'Connor T, Meaney M, O'Donnell K. Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 640-651. PMID: 37977417, PMCID: PMC11105503, DOI: 10.1016/j.jaac.2023.08.018.Peer-Reviewed Original ResearchPrenatal maternal depressionMaternal mental healthMaternal depressionAttention-deficit/hyperactivity disorderChild psychiatric symptomsPolygenic risk scoresPsychiatric symptomsRisk scoreMental healthFetal originGenomic riskAvon Longitudinal StudySimilar independent effectsAdolescent psychiatric symptomsHealth hypothesisMaternal symptomsChild CohortIndependent cohortBehavioral symptomsALSPAC cohortMental disordersSymptom dataSymptomsCohortChildren's symptomsmiR-122 and miR-21 are Stable Components of miRNA Signatures of Early Lung Cancer after Validation in Three Independent Cohorts
Zyla J, Dziadziuszko R, Marczyk M, Sitkiewicz M, Szczepanowska M, Bottoni E, Veronesi G, Rzyman W, Polanska J, Widlak P. miR-122 and miR-21 are Stable Components of miRNA Signatures of Early Lung Cancer after Validation in Three Independent Cohorts. Journal Of Molecular Diagnostics 2023, 26: 37-48. PMID: 37865291, DOI: 10.1016/j.jmoldx.2023.09.010.Peer-Reviewed Original ResearchConceptsEarly lung cancerLung cancerLung cancer screening studyMiR-122MiR-21MiRNA signatureCancer screening studyLung cancer developmentPlasma miRNA signatureScreening studyIndependent cohortDiagnostic biomarkersPotential biomarkersCancer typesCohortCancer developmentCancerHealthy participantsMiR-144MiRNA panelDiagnostic potentialBiomarkersAdenocarcinomaDifferent cohortsMiRNAsEpigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders
Felt J, Yusupov N, Harrington K, Fietz J, Zhang Z, Sliwinski M, Ram N, O'Donnell K, Group B, Meaney M, Putnam F, Noll J, Binder E, Shenk C. Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders. Neurobiology Of Stress 2023, 27: 100577. PMID: 37885906, PMCID: PMC10597797, DOI: 10.1016/j.ynstr.2023.100577.Peer-Reviewed Original ResearchEarly life adversityPsychiatric disordersEpigenetic age accelerationLife adversityAge accelerationProspective cohort studyBiological agingNon-abused controlsCohort studyNeurocognitive screeningPeripheral bloodCommunity cohortNeurocognitive declineIndependent cohortCognitive declineEarly screeningMental disordersCohortGrimAge clockDisordersBiomarkersLower general cognitive abilityEarly declineNeurocognitive abilitiesCognitive abilitiesMapping Lesion-Related Epilepsy to a Human Brain Network
Schaper F, Nordberg J, Cohen A, Lin C, Hsu J, Horn A, Ferguson M, Siddiqi S, Drew W, Soussand L, Winkler A, Simó M, Bruna J, Rheims S, Guenot M, Bucci M, Nummenmaa L, Staals J, Colon A, Ackermans L, Bubrick E, Peters J, Wu O, Rost N, Grafman J, Blumenfeld H, Temel Y, Rouhl R, Joutsa J, Fox M. Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurology 2023, 80: 891-902. PMID: 37399040, PMCID: PMC10318550, DOI: 10.1001/jamaneurol.2023.1988.Peer-Reviewed Original ResearchConceptsRisk of epilepsyLesion locationBrain regionsPoststroke epilepsyControl patientsSeizure controlBrain lesionsIndependent cohortBrain networksLesion typeBrain stimulation sitesLesion network mappingLesion-related epilepsyImproved seizure controlDrug-resistant epilepsyCase-control studyBrain stimulation therapyHuman brain networksSpecific brain regionsDifferent lesion typesSpecific brain networksBasal gangliaVascular territoriesStimulation therapyMAIN OUTCOMENoncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors
Schrank T, Kothari A, Weir W, Stepp W, Rehmani H, Liu X, Wang X, Sewell A, Li X, Tasoulas J, Kim S, Yarbrough G, Xie Y, Flamand Y, Marur S, Hayward M, Wu D, Burtness B, Anderson K, Baldwin A, Yarbrough W, Issaeva N. Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2216532120. PMID: 37523561, PMCID: PMC10410762, DOI: 10.1073/pnas.2216532120.Peer-Reviewed Original ResearchConceptsNF-κB-related genesEstrogen receptor alpha expressionDeintensification of therapyTreatment-related morbidityTumor-infiltrating CD4Receptor alpha expressionHPV carcinogenesisRadiosensitization of headOncogenic subtypesPIK3CA alterationsHNSCC tumorsPatient outcomesNeck tumorsT cellsTreatment responseHNSCC cellsTherapeutic intensityAtypical featuresIndependent cohortAlpha expressionNF-κBActive tumorTNF receptorTumorsPatient dataPleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersIntracranial volumeSingle nucleotide polymorphismsParkinson's diseaseCACNA1C variantsCACNA1C mRNARisk allelesAlcohol use disorderAverage cortical thicknessTotal intracranial volumeMultiple psychiatric disordersFalse discovery rate correctionDifferent neuropsychiatric disordersCortical surface areaBrain cohortCortical thicknessIndependent cohortPsychiatric disordersUse disordersMatter volumeSubcortical structuresSubstance dependenceDiseaseMultiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2–, PIK3CA-mutated breast cancers
Hutchinson K, Chen J, Savage H, Stout T, Schimmoller F, Cortés J, Dent S, Harbeck N, Jacot W, Krop I, Trabucco S, Sivakumar S, Sokol E, Wilson T. Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2–, PIK3CA-mutated breast cancers. Genome Medicine 2023, 15: 28. PMID: 37101291, PMCID: PMC10131374, DOI: 10.1186/s13073-023-01181-8.Peer-Reviewed Original ResearchConceptsPI3K pathwayBreast cancerK pathwayP110α inhibitionLonger progression-free survivalReceptor tyrosine kinasesProgression-free survivalMetastatic breast cancerComprehensive genomic profilingPI3K pathway genesFurther clinical investigationP110α inhibitorsHigh response rateSolid tumor typesBreast cancer tumorsP110α catalytic subunitClinical trialsClinical investigationIndependent cohortImportant molecular determinantResponse rateTumor typesPIK3CA geneConclusionsOur studyTumor DNATRPA1 rare variants in chronic neuropathic and nociplastic pain patients
Marchi M, Salvi E, Andelic M, Mehmeti E, D'Amato I, Cazzato D, Chiappori F, Lombardi R, Cartelli D, Devigili G, Bella E, Gerrits M, Almomani R, Malik R, Ślęczkowska M, Mazzeo A, Gentile L, Dib-Hajj S, Waxman S, Faber C, Vecchio E, de Tommaso M, Lauria G. TRPA1 rare variants in chronic neuropathic and nociplastic pain patients. Pain 2023, 164: 2048-2059. PMID: 37079850, PMCID: PMC10443199, DOI: 10.1097/j.pain.0000000000002905.Peer-Reviewed Original ResearchConceptsNociplastic painPainful neuropathyPain patientsHealthy controlsRare variantsChronic neuropathic painChronic pain disordersChronic widespread painChronic pain patientsMolecular profilePainless neuropathyNeuropathic painPain disordersWidespread painChronic painPatient's molecular profileIndependent cohortPainPatientsClinical diagnosisDisease riskNeuropathyTRPA1 variantsNew risk genesPain genesCirculating levels of micronutrients and risk of infections: a Mendelian randomization study
Flatby H, Ravi A, Damås J, Solligård E, Rogne T. Circulating levels of micronutrients and risk of infections: a Mendelian randomization study. BMC Medicine 2023, 21: 84. PMID: 36882828, PMCID: PMC9993583, DOI: 10.1186/s12916-023-02780-3.Peer-Reviewed Original ResearchConceptsRisk of infectionGastrointestinal infectionsBlood levelsMendelian randomizationMendelian randomization studyOdds ratioObservational studyImmune responseIndependent cohortRandomization studySignificant associationInfectionClear associationMR analysisLevels of micronutrientsStatistical significanceConclusionsOur resultsPrevious observational studiesStandard deviation increaseUK BiobankRiskLevels of copperEuropean ancestryAvailable summary statisticsAssociationTowards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
Roseberry K, Le-Niculescu H, Levey D, Bhagar R, Soe K, Rogers J, Palkowitz S, Pina N, Anastasiadis W, Gill S, Kurian S, Shekhar A, Niculescu A. Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Molecular Psychiatry 2023, 28: 2894-2912. PMID: 36878964, PMCID: PMC10615756, DOI: 10.1038/s41380-023-01998-0.Peer-Reviewed Original ResearchConceptsIndependent cohortCandidate biomarkersPsychiatric subjectsPersonalized approachConvergent functional genomics approachAnxiety disordersBest overall evidenceAdverse life eventsClinical worseningGene expression signaturesBlood biomarkersAnxiety medicationClinical utilityPsychiatric disordersHigh anxiety stateSevere anxietyUntreated anxietyDecrease qualityIndividual biomarkersAddiction potentialBiomarkersTop biomarkersAnxiety statesRisk predictionExpression signaturesDevelopment and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers
Hawken S, Ducharme R, Murphy M, Olibris B, Bota A, Wilson L, Cheng W, Little J, Potter B, Denize K, Lamoureux M, Henderson M, Rittenhouse K, Price J, Mwape H, Vwalika B, Musonda P, Pervin J, Chowdhury A, Rahman A, Chakraborty P, Stringer J, Wilson K. Development and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers. PLOS ONE 2023, 18: e0281074. PMID: 36877673, PMCID: PMC9987787, DOI: 10.1371/journal.pone.0281074.Peer-Reviewed Original ResearchConceptsGestational ageCord blood dataClinical dataBlood dataMetabolomic markersEarly pregnancy ultrasoundHeel-prick blood sampleProspective birth cohortMultivariable linear regressionBlood sample dataExternal validationGestational age estimationRetrospective cohortPregnancy ultrasoundHeel prickExternal cohortIndependent cohortBlood samplesBirth cohortNewbornsPostnatal gestational age estimationCohortUltrasound estimatesInternal model validationLow-income countriesAssociation of SNPs in the PAI1 Gene with Disease Recurrence and Clinical Outcome in Bladder Cancer
Murakami K, Furuya H, Hokutan K, Goodison S, Pagano I, Chen R, Shen C, Chan M, Ng C, Kobayashi T, Ogawa O, Miyake M, Thornquist M, Shimizu Y, Hayashi K, Wang Z, Yu H, Rosser C. Association of SNPs in the PAI1 Gene with Disease Recurrence and Clinical Outcome in Bladder Cancer. International Journal Of Molecular Sciences 2023, 24: 4943. PMID: 36902377, PMCID: PMC10003630, DOI: 10.3390/ijms24054943.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Bladder cancerSingle nucleotide polymorphismsMutational statusWorse recurrence-free survivalUntranslated region (UTR) single nucleotide polymorphismRecurrence-free survivalBladder cancer developmentHuman bladder tumorsAssociation of SNPsCommon cancer typesActivator inhibitor-1Anti-apoptotic effectsOverall survivalDisease recurrenceClinical outcomesOverall incidenceBladder tumorsCaucasian patientsIndependent cohortCancer typesCancer developmentCancerInhibitor-1Cellular proliferationA data‐driven examination of apathy and depressive symptoms in dementia with independent replication
Da Silva M, Melendez‐Torres G, Ismail Z, Testad I, Ballard C, Creese B, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Donohue M, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Van der Swag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geldmacher D, Brockington J, Roberson E, Grossman H, Mitsis E, deToledoMorrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D'Agostino D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc Adams Ortiz C, Womack K, Mathews D, Quiceno M, Arrastia R, King R, Weiner M, Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. A data‐driven examination of apathy and depressive symptoms in dementia with independent replication. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2023, 15: e12398. PMID: 36777092, PMCID: PMC9899765, DOI: 10.1002/dad2.12398.Peer-Reviewed Original ResearchNeuropsychiatric symptomsDepressive symptomsLatent class analysisDifferent clinical associationsPoor clinical outcomeCommon neuropsychiatric symptomsApathy/depressionClinical outcomesClinical associationsIndependent cohortDepression syndromeDiagnostic criteriaClinical practiceApathy syndromeDepression symptomsSymptomsDiagnostic categoriesBiomarker studiesDepressionSyndromeLatent class membershipCohortFour-class solutionApathyData-driven examination
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