2025
Efficacy of anal botulinum toxin injection in children with functional constipation
Patel D, Saikumar P, Jayaraman M, Desai C, Rosen J, Rodriguez L. Efficacy of anal botulinum toxin injection in children with functional constipation. Journal Of Pediatric Gastroenterology And Nutrition 2025, 80: 956-962. PMID: 40123476, DOI: 10.1002/jpn3.70040.Peer-Reviewed Original ResearchConceptsResponse to therapyBotulinum toxin injectionFunctional constipationMedical therapyBotulinum toxinGroup 2Group 1No factorsGroup 3Side effectsRefractory to medical therapyResults of anorectal manometryDevelopmental delayDevelopment of side effectsPediatric age groupFrequency of BMPresence of developmental delayDose of botulinum toxinMedian doseMedian followAnorectal manometryMedian ageMulticenter studyBM frequencyLaxative regimensClinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension
Park J, An H, Kim S, Kim S, Cho H, Kim J, Cho A, Kwak J, Shin J, Lee K, Oh J, Lee J, Kim H, Shin H, Han M, Hyun M, Ha T, Song Y, Hypertension O. Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension. Kidney Research And Clinical Practice 2025, 44: 20-48. PMID: 39923806, PMCID: PMC11864819, DOI: 10.23876/j.krcp.24.096.Peer-Reviewed Original ResearchAmerican Academy of PediatricsEuropean Society of HypertensionPediatric hypertensionManagement of hypertensionKorean childrenKorean Working GroupEuropean Society of Hypertension guidelinesClinical guidelinesPediatric age groupManagement of childhood hypertensionTreatment of hypertensionBlood pressure valuesDiagnosis of hypertensionBurden of cardiovascular diseaseAcademy of PediatricsChildhood hypertensionClinical evidenceHypertension guidelinesHypertensionCardiovascular diseaseInternational guidelinesReference blood pressure valuesAmerican AcademyDiagnosisAge groups
2022
Cryptogenic acute lower extremities and multiorgan ischemia in an 8-year-old girl
Setia O, Chan SM, Ullrich S, Hornick MA, Chaar C. Cryptogenic acute lower extremities and multiorgan ischemia in an 8-year-old girl. Journal Of Vascular Surgery Cases And Innovative Techniques 2022, 8: 565-568. PMID: 36248384, PMCID: PMC9556621, DOI: 10.1016/j.jvscit.2022.08.020.Peer-Reviewed Original ResearchAcute limb ischemiaLimb ischemiaBilateral lower extremity ischemiaAcute lower extremityTraumatic vessel injuryLower extremity ischemiaPediatric age groupMultiple visceral organsInterdisciplinary workupMultiorgan ischemiaExtremity ischemiaCardiac catheterizationEmbolic eventsIatrogenic injuryLower extremitiesVessel injuryCommon causeVisceral organsIschemiaTimely interventionAge groupsInjuryGirlsDevastating effectsRevascularization
2021
COVID-19 Vaccination–Associated Myocarditis in Adolescents
Jain SS, Steele JM, Fonseca B, Huang S, Shah S, Maskatia SA, Buddhe S, Misra N, Ramachandran P, Gaur L, Eshtehardi P, Anwar S, Kaushik N, Han F, Chaudhuri NR, Grosse-Wortmann L. COVID-19 Vaccination–Associated Myocarditis in Adolescents. 2021, 148: e2021053427. PMID: 34389692, DOI: 10.1542/peds.2021-053427.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceMultisystem inflammatory syndromeMyocardial tissue changesInflammatory syndromeVentricular dysfunctionMyocardial injuryTissue changesExcellent short-term outcomesMild left ventricular dysfunctionDifferent pediatric age groupsQuick clinical recoveryLeft ventricular dysfunctionResolution of symptomsRetrospective multicenter studyPediatric age groupShort-term outcomesShort-term prognosisMessenger RNA vaccinesLate gadolinium enhancementYears of ageLake Louise criteriaSignificant dysrhythmiasHospital courseClinical characteristicsClinical recovery
2020
Pearls and Pitfalls in Pediatric Thyroid Imaging
Silva CT, Navarro OM. Pearls and Pitfalls in Pediatric Thyroid Imaging. Seminars In Ultrasound CT And MRI 2020, 41: 421-432. PMID: 32980089, DOI: 10.1053/j.sult.2020.05.007.Peer-Reviewed Original ResearchConceptsDiffuse thyroid enlargementThyroid enlargementCongenital hypothyroidismThyroid nodulesThyroid imagingPediatric age groupRole of imagingRisk of malignancyPermanent congenital hypothyroidismGraves' diseasePediatric populationHashimoto's diseaseNodular hyperplasiaPapillary carcinomaThyroid glandAccurate diagnosisAge groupsThyroid dysgenesisHypothyroidismDiseaseChildrenTeenage girlsImagingManagement recommendationsEnlargement
2018
Pediatric Congenital Cerebrovascular Anomalies
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B. Pediatric Congenital Cerebrovascular Anomalies. Journal Of Neuroimaging 2018, 29: 165-181. PMID: 30378722, DOI: 10.1111/jon.12575.Peer-Reviewed Original ResearchConceptsVascular malformationsCerebrovascular anomaliesCentral nervous system vascular malformationsMultiple developmental venous anomaliesPersistent carotid-vertebrobasilar anastomosesFamilial associationAssociated vascular malformationCarotid-vertebrobasilar anastomosesDevelopmental venous anomaliesPediatric age groupMultiple cavernous malformationsSturge-Weber syndromeCongenital vascular malformationsHereditary hemorrhagic telangiectasiaArterial anomaliesSinus thrombosisVenous anomaliesVenous malformationsVascular abnormalitiesVascular tumorsVascular lesionsDiverse etiologiesArteriovenous malformationsSystemic conditionsFurther managementProtocol for the P3BEP trial (ANZUP 1302): an international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours
Lawrence NJ, Chan H, Toner G, Stockler MR, Martin A, Yip S, Wong N, Yeung A, Mazhar D, Pashankar F, Frazier L, McDermott R, Walker R, Tan H, Davis ID, Grimison P, on behalf of ANZUP. Protocol for the P3BEP trial (ANZUP 1302): an international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours. BMC Cancer 2018, 18: 854. PMID: 30157803, PMCID: PMC6114870, DOI: 10.1186/s12885-018-4745-3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsBleomycinChildChild, PreschoolCisplatinClinical ProtocolsClinical Trials, Phase III as TopicEtoposideFemaleHumansInfantInfant, NewbornMaleMulticenter Studies as TopicNeoplasms, Germ Cell and EmbryonalRandomized Controlled Trials as TopicResearch DesignYoung AdultConceptsPoor-risk metastatic germ cell tumoursMetastatic germ cell tumorsGerm cell tumorsStandard BEP chemotherapyFirst-line chemotherapyCell tumorsLine chemotherapyBEP chemotherapyCure rateClinical trialsPoor-risk germ cell tumorsMulticentre phase 2 trialRandomised phase 3 trialStandard first-line treatmentPhase 3 clinical trialsComplete response rateFirst-line treatmentPhase 2 trialPhase 3 trialProgression-free survivalHealth-related qualityPediatric age groupFemale participantsInternational multicentreStandard BEPChapter 4 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome
Santoro N, Giannini C, Caprio S. Chapter 4 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome. 2018, 43-52. DOI: 10.1016/b978-0-12-812019-4.00004-0.ChaptersInsulin resistanceAge groupsΒ-cellsChapter 4 ObesityPediatric age groupEctopic fat depositionProgression of obesityType 2 diabetesOvert diabetesObesity complicationsObese childrenChildhood obesityMore insulinSerum glucoseInsulin secretionPediatric diseasesNormal rangeType 2Progressive deteriorationObesityFat depositionDiabetesDiseaseComplicationsGroup
2017
P3BEP (ANZUP 1302): An international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours (GCTs).
Grimison P, Lawrence N, Stockler M, Martin A, Yip S, Wong N, Yeung A, Friedlander M, Mazhar D, Pashankar F, Quinn D, Walker R, Winstanley M, Hanning F, Weickhardt A, Stevanovic A, Davis I, Toner G. P3BEP (ANZUP 1302): An international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours (GCTs). Journal Of Clinical Oncology 2017, 35: tps4592-tps4592. DOI: 10.1200/jco.2017.35.15_suppl.tps4592.Peer-Reviewed Original ResearchMetastatic germ cell tumorsGerm cell tumorsProgression-free survivalPoor-risk metastatic germ cell tumoursPhase 3 trialResponse rateStandard BEPLine chemotherapyCancer AustraliaDay 1Randomised phase 3 trialStandard BEP chemotherapyComplete response ratePediatric age groupArchival tumor tissueCancer Council AustraliaTranslational substudyBaseline bloodBEP chemotherapyFree survivalPrimary endpointWeekly dosesFemale patientsCure rateCell tumors
2016
Pediatric multiple sclerosis
Ghezzi A, Amato MP, Makhani N, Shreiner T, Gärtner J, Tenembaum S. Pediatric multiple sclerosis. Neurology 2016, 87: s97-s102. PMID: 27572869, DOI: 10.1212/wnl.0000000000002823.Peer-Reviewed Original ResearchConceptsFirst-line treatmentPediatric multiple sclerosisMultiple sclerosisObservational studyRandomized placebo-controlled trialStandard first-line treatmentFirst-line treatment optionRelapsing-remitting multiple sclerosisPlacebo-controlled trialAcceptable safety profilePediatric age groupDisease-modifying therapiesPediatric MSGlatiramer acetateRelapse rateUnblinded trialSafety profileTreatment optionsDisease progressionExpert guidelinesAge groupsSclerosisTrialsCurrent knowledgeTreatmentAcinar neoplasms of the pancreas—A summary of 25 years of research
Klimstra D, Adsay V. Acinar neoplasms of the pancreas—A summary of 25 years of research. Seminars In Diagnostic Pathology 2016, 33: 307-318. PMID: 27320062, DOI: 10.1053/j.semdp.2016.05.009.Peer-Reviewed Original ResearchConceptsAcinar neoplasmsAcinar-neuroendocrine carcinomaAcinar cell carcinomaPediatric age groupPancreatic exocrine enzymesNeuroendocrine carcinomaDuctal carcinomaNeuroendocrine neoplasmsCell carcinomaPancreatic carcinomaPotential therapeutic targetPancreatic neoplasmsDifferential diagnosisHistological featuresMolecular alterationsAcinar carcinomaCarcinomaNeoplasmsPathological featuresGenetic findingsExocrine enzymesTherapeutic targetAge groupsMolecular phenotypesPancreasTackling causes and costs of ED presentation for American football injuries: a population-level study
Smart BJ, Haring RS, Asemota AO, Scott JW, Canner JK, Nejim BJ, George BP, Alsulaim H, Kirsch TD, Schneider EB. Tackling causes and costs of ED presentation for American football injuries: a population-level study. The American Journal Of Emergency Medicine 2016, 34: 1198-1204. PMID: 27185745, DOI: 10.1016/j.ajem.2016.02.057.Peer-Reviewed Original ResearchConceptsFootball-related injuriesAmerican tackle footballAge groupsED presentationsED treatmentNationwide Emergency Department SampleClinical Modification diagnosis codesTackle footballAmerican football injuriesPrimary International ClassificationEmergency department treatmentMean hospital lengthPediatric age groupSprains/strainsLong-term outcomesMean total chargesEmergency Department SamplePatterns of injuryMajor therapeutic interventionPrevious epidemiologic studiesStandard descriptive methodsCross-sectional overviewFootball playersED dischargeHospital length
2012
The hot orbit: Orbital cellulitis
Chaudhry I, Al-Rashed W, Arat Y. The hot orbit: Orbital cellulitis. Middle East African Journal Of Ophthalmology 2012, 19: 34-42. PMID: 22346113, PMCID: PMC3277022, DOI: 10.4103/0974-9233.92114.Peer-Reviewed Original ResearchOrbital cellulitisHistory of upper respiratory tract infectionTreatment of orbital cellulitisAssociated with severe complicationsUpper respiratory tract infectionPediatric age groupRespiratory tract infectionsVisual morbidityEyelid edemaBlurred visionHematogenous spreadTract infectionsVision lossSevere complicationsDouble visionEarly drainageCellulitisImaging studiesLate interventionComplicationsForeign bodyAge groupsEyelidInfectionAntibiotics
2009
Novel Biomarkers for the Diagnosis of Urinary Tract Infection–-A systematic Review
Nanda N, Juthani-Mehta M. Novel Biomarkers for the Diagnosis of Urinary Tract Infection–-A systematic Review. Biomarker Insights 2009, 4: bmi.s3155. PMID: 19707519, PMCID: PMC2729697, DOI: 10.4137/bmi.s3155.Peer-Reviewed Original ResearchLower urinary tract infectionsUrinary tract infectionClinical presentationNovel biomarkersTract infectionsElevated serum procalcitonin levelsKidney transplant recipientsSerum procalcitonin levelsPediatric age groupExtremes of ageTime of presentationSpinal cord injuryClinical management decisionsPaucity of dataAsymptomatic bacteriuriaProcalcitonin levelsTransplant recipientsAggressive treatmentSignificant morbidityUrine cultureCord injuryInterleukin-6High prevalenceImmunocompromised individualsDiagnostic criteria
2006
Epirubicin Glucuronidation and UGT2B7 Developmental Expression
Zaya M, Hines R, Stevens J. Epirubicin Glucuronidation and UGT2B7 Developmental Expression. Drug Metabolism And Disposition 2006, 34: 2097-2101. PMID: 16985101, DOI: 10.1124/dmd.106.011387.Peer-Reviewed Original ResearchConceptsPediatric age categoriesPediatric age groupAge categoriesAge groupsLiver microsomesChildhood malignant diseaseMetabolism of epirubicinUse of epirubicinTreatment of adultsYears of ageMonths of ageAge-related changesPediatric patientsAdult age categoriesPostnatal ageCardiac toxicityMalignant diseaseUGT2B7 activityNeonatal samplesPreclinical evaluationUGT2B7 expressionGlucuronidation activityAdult groupGlucuronidationEquivalent dosesEvaluation and Management of Intractable Constipation in Children
Rodriguez L, Flores A, Doody D. Evaluation and Management of Intractable Constipation in Children. Seminars In Colon And Rectal Surgery 2006, 17: 29-37. DOI: 10.1053/j.scrs.2006.02.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIntractable constipationPediatric age groupAdditional surgical interventionUse of laxativesSevere intractable constipationRefractory constipationStool softenersYounger patientsPediatric gastroenterologistsPossible surgerySurgical interventionConstipationDaily livingSmall percentageSevere formDiet managementDays of schoolGastroenterologists' officesAge groupsNormal activityChildren's qualityBehavioral modificationFrequent visitsPatientsChildren
2005
Primary epithelial lung malignancies in the pediatric population
Lal D, Clark I, Shalkow J, Downey R, Shorter N, Klimstra D, La Quaglia M. Primary epithelial lung malignancies in the pediatric population. Pediatric Blood & Cancer 2005, 45: 683-686. PMID: 15714450, DOI: 10.1002/pbc.20279.Peer-Reviewed Original ResearchConceptsLung malignancyCarcinoid tumorsBasaloid carcinomaAdvanced diseaseMemorial Sloan-Kettering Cancer Center experienceTreated with multimodality therapyTreated with surgical resectionMemorial Sloan-Kettering Cancer CenterHistologic type of tumorDistant metastatic diseaseMedian Follow-UpFinal pathologic diagnosisPediatric age groupType of tumorProgression of diseaseYears of ageAdvanced locoregionalMetastatic diseaseMucoepidermoid carcinomaSurgical resectionLocalized diseaseMultimodal therapyBronchogenic carcinomaHistological typeMedian age
1998
Amiodarone Induced Pulmonary Fibrosis in Infancy
BOWERS P, FIELDS J, SCHWARTZ D, ROSENFELD L, NEHGME R. Amiodarone Induced Pulmonary Fibrosis in Infancy. Pacing And Clinical Electrophysiology 1998, 21: 1665-1667. PMID: 9725167, DOI: 10.1111/j.1540-8159.1998.tb00257.x.Peer-Reviewed Original ResearchConceptsInduced Pulmonary FibrosisPulmonary fibrosisDiffuse interstitial infiltratesPediatric age groupAtrioventricular reentrant tachycardiaPediatric arrhythmiasInterstitial infiltratesWolff-ParkinsonReentrant tachycardiaWhite syndromeChest radiographsFibrosisAge groupsAmiodaroneInfantsMonthsFirst reportInfiltratesComplicationsTachycardiaAntiarrhythmiaArrhythmiasSyndromeRadiographs
1994
Sudden Death in Childhood Due to Right Ventricular Dysplasia: Report of Two Cases
Pawel B, De Chadarévian J, Wolk J, Donner R, Vogel R, Braverman P. Sudden Death in Childhood Due to Right Ventricular Dysplasia: Report of Two Cases. Fetal And Pediatric Pathology 1994, 14: 987-995. PMID: 7855018, DOI: 10.3109/15513819409037695.Peer-Reviewed Case Reports and Technical Notes
1990
Malignant Rhabdoid Tumor of the Kidney in an Adult
Lowe W, Weiss R, Todd M, True L. Malignant Rhabdoid Tumor of the Kidney in an Adult. Journal Of Urology 1990, 143: 110-111. PMID: 2152948, DOI: 10.1016/s0022-5347(17)39882-8.Peer-Reviewed Original Research
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