2020
Outpatient Opioid Use After Cesarean Delivery.
Emerson J, Danilack V, Kulkarni A, Kesselring C, Brousseau E, Matteson K. Outpatient Opioid Use After Cesarean Delivery. Rhode Island Medical Journal 2020, 103: 68-74. PMID: 32752572.Peer-Reviewed Original ResearchConceptsMorphine equivalent dosesCesarean deliveryOpioid needsOpioid useOpioid prescribingOutpatient opioid prescribingOutpatient opioid useAvailability of opioidsPatient-specific factorsOpioid patientsPrescribe opioidsClinical characteristicsPatient characteristicsPsychiatric comorbidityMedical recordsOpioid abuseOpiate useInpatient needsOpioidsEquivalent dosesLimited dataPearson correlation coefficientPrescribingPatientsT-testOpioid Prescription Consumption Patterns After Total Joint Arthroplasty in Chronic Opioid Users Versus Opioid Naive Patients
Kaidi A, Lakra A, Jennings E, Neuwirth A, Geller J, Shah R, Cooper H, Hickernell T. Opioid Prescription Consumption Patterns After Total Joint Arthroplasty in Chronic Opioid Users Versus Opioid Naive Patients. JAAOS Global Research And Reviews 2020, 4: e20.00066. PMID: 32656479, PMCID: PMC7322780, DOI: 10.5435/jaaosglobal-d-20-00066.Peer-Reviewed Original ResearchConceptsChronic opioid usersOpioid-naive patientsMorphine equivalent dosesOpioid prescriptionsOpioid useChronic usersOpioid usersOrthopaedic departmentChronic preoperative opioid useTotal joint arthroplasty outcomesEquivalent dosesElective total hipJoint arthroplasty outcomesMore opioid prescriptionsPreoperative opioid useTotal joint arthroplastyUrban medical centerCurrent opioid epidemicNaive patientsOpioid prescribingPostoperative periodPrescribing patternsPostoperative intervalsTotal hipArthroplasty outcomes
2006
Epirubicin Glucuronidation and UGT2B7 Developmental Expression
Zaya M, Hines R, Stevens J. Epirubicin Glucuronidation and UGT2B7 Developmental Expression. Drug Metabolism And Disposition 2006, 34: 2097-2101. PMID: 16985101, DOI: 10.1124/dmd.106.011387.Peer-Reviewed Original ResearchConceptsPediatric age categoriesPediatric age groupAge categoriesAge groupsLiver microsomesChildhood malignant diseaseMetabolism of epirubicinUse of epirubicinTreatment of adultsYears of ageMonths of ageAge-related changesPediatric patientsAdult age categoriesPostnatal ageCardiac toxicityMalignant diseaseUGT2B7 activityNeonatal samplesPreclinical evaluationUGT2B7 expressionGlucuronidation activityAdult groupGlucuronidationEquivalent doses
2000
Comparison of intravenous cocaethylene and cocaine in humans
Hart C, Jatlow P, Sevarino K, McCance-Katz E. Comparison of intravenous cocaethylene and cocaine in humans. Psychopharmacology 2000, 149: 153-162. PMID: 10805610, DOI: 10.1007/s002139900363.Peer-Reviewed Original ResearchConceptsBlood pressureActive drug conditionsDouble-blind studyDiastolic blood pressureSystolic blood pressureTransesterification of cocaineCocaine-dependent participantsStudy drugMetabolite of cocaineHeart rateSlow clearanceDrug conditionsSeparate daysHuman volunteersSubjective effectsPharmacological propertiesEquivalent dosesCocainePlaceboSignificant increaseSimilar differencesCocaethyleneExperimental sessionsSubjective measuresPrevious studies
1974
A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons
Bunney B, Aghajanian G. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sciences 1974, 15: 309-318. PMID: 4549921, DOI: 10.1016/0024-3205(74)90221-5.Peer-Reviewed Original ResearchConceptsChlorpromazine sulfoxideSingle-unit recording techniquesAnti-psychotic propertyCentral dopaminergic neuronsVentral tegmental neuronsPossible clinical importanceEffect of chlorpromazineA10 neuronsDopaminergic neuronsAntipsychotic efficacyPlasma levelsTegmental neuronsAntipsychotic agentsTherapeutic effectAntipsychotic propertiesClinical importanceEquivalent dosesRecording techniquesChlorpromazineNeuronsDepressionPreliminary studyPrevious findingsSulfoxide levelsChlorpromazine metabolites
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