2021
Predictors of Time-in-Range (70–180 mg/dL) Achieved Using a Closed-Loop Control System
Schoelwer MJ, Kanapka LG, Wadwa RP, Breton MD, Ruedy KJ, Ekhlaspour L, Forlenza GP, Cobry EC, Messer LH, Cengiz E, Jost E, Carria L, Emory E, Hsu LJ, Weinzimer SA, Buckingham BA, Lal RA, Oliveri MC, Kollman CC, Dokken BB, Cherñavvsky DR, Beck RW, DeBoer MD, Gonder-Frederick L, Robic J, Voelmle M, Conschafter K, Morris K, Barnett C, Carr K, Hellmann J, Kime M, Todd Alonso G, Slover R, Berget C, Towers L, Lange S, Buckingham B, Maahs D, Lal R, Ekhlaspour L, Norlander L, Hood K, Town M, Weir C, Smith K, Hsu L, Shinksy D, Viana J, Cengiz E, Weinzimer S, Weyman K, Carria L, Zgorski M, Ruedy K, Beck R, Borgman S, Rusnak J, Kanapka L, Kollman C, Murphy C, Arreza-Rubin G, Green N, Kovatchev B, Brown S, Anderson S, Breton M, Laffel L, Pinsker J, Levy C, Kudva Y, Wadwa R, Buckingham B, Doyle III F, Renard E, Cobelli C, Reznik Y, Arreza-Rubin G, Lum J, Beck R, Ruedy K, Janicek R, Gabrielson D. Predictors of Time-in-Range (70–180 mg/dL) Achieved Using a Closed-Loop Control System. Diabetes Technology & Therapeutics 2021, 23: 475-481. PMID: 33689454, PMCID: PMC8252894, DOI: 10.1089/dia.2020.0646.Peer-Reviewed Original ResearchConceptsGlycemic controlLower TIROptimal glycemic controlType 1 diabetesPredictors of timeGreater improvementClinical characteristicsClinical predictorsFourth quartileMore insulinBody weightGlucose monitor dataExtension phaseMultivariate modelBolusStrongest predictorContinuous glucose monitor dataQuartileInsulinPredictorsChildrenParticipantsT1D.T1DDiabetes
2020
“Life or death”: Experiences of insulin insecurity among adults with type 1 diabetes in the United States
Willner S, Whittemore R, Keene D. “Life or death”: Experiences of insulin insecurity among adults with type 1 diabetes in the United States. SSM - Population Health 2020, 11: 100624. PMID: 32676533, PMCID: PMC7352063, DOI: 10.1016/j.ssmph.2020.100624.Peer-Reviewed Original ResearchType 1 diabetesInsulin accessInsulin needsU.S. healthcare systemHealthcare systemDiabetes support groupsPublic health concernSemi-structured phone interviewsMore insulinInsulin supplyParticipants' healthU.S. adultsT1D.DiabetesHealth concernUnaffordable health careAccess barriersSupport groupsPhone interviewsHealth careInsulinPsychosocial contextAdultsLives of adultsT1D
2018
Chapter 4 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome
Santoro N, Giannini C, Caprio S. Chapter 4 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome. 2018, 43-52. DOI: 10.1016/b978-0-12-812019-4.00004-0.ChaptersInsulin resistanceAge groupsΒ-cellsChapter 4 ObesityPediatric age groupEctopic fat depositionProgression of obesityType 2 diabetesOvert diabetesObesity complicationsObese childrenChildhood obesityMore insulinSerum glucoseInsulin secretionPediatric diseasesNormal rangeType 2Progressive deteriorationObesityFat depositionDiabetesDiseaseComplicationsGroup
2012
Chapter 6 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome
Santoro N, Giannini C, Caprio S. Chapter 6 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome. 2012, 77-87. DOI: 10.1016/b978-0-12-385083-6.00006-1.ChaptersInsulin resistanceΒ-cellsChapter 6 ObesityEctopic fat depositionProgression of obesityType 2 diabetesObesity complicationsObese childrenPediatric ageChildhood obesityMore insulinSerum glucoseInsulin secretionPediatric diseasesNormal rangeType 2Progressive deteriorationObesityFat depositionDiseaseInsulinComplicationsDiabetesPediatriciansPrevalence
2010
Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity
Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RT. Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity. Diabetes 2010, 59: 1424-1434. PMID: 20299477, PMCID: PMC2874703, DOI: 10.2337/db09-1212.Peer-Reviewed Original ResearchConceptsTxnip knockout miceInsulin resistanceInsulin sensitivityKnockout miceInsulin responsivenessTXNIP expressionSkeletal muscleWild-type littermate control miceStandard chow dietType 2 diabetes pathogenesisHigh-fat dietHigh-fat feedingLittermate control miceGene-deleted miceInhibits glucose uptakeControl miceChow dietAdipose massMore insulinCaloric excessFat massDiabetes pathogenesisMouse embryonic fibroblastsRegulator of adipogenesisPPARgamma expression
1980
Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats
Cech J, Freeman R, F. J, Amatruda J. Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats. Biochemical Journal 1980, 188: 839-845. PMID: 7008780, PMCID: PMC1161968, DOI: 10.1042/bj1880839.Peer-Reviewed Original ResearchConceptsObese ratsInsulin-stimulated uptakeDose-response curveDiabetic animalsInsulin resistanceAminoisobutyrate uptakeDecreased maximal responseStreptozotocin-diabetic ratsBasal rateYoung control animalsYoung control ratsInsulin receptorControl cellsOld obese ratsConcentrations of insulinDose-response relationshipEnhanced basal rateMaximal insulin responsivenessHalf-maximal responseNumber of receptorsIsolated hepatocytesStreptozotocin-diabeticMore insulinControl ratsInsulin response
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