2021
Sex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis
Chen J, Li H, Hird S, Chen M, Xu W, Maas K, Cong X. Sex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis. Frontiers In Cellular And Infection Microbiology 2021, 11: 671074. PMID: 34458157, PMCID: PMC8387566, DOI: 10.3389/fcimb.2021.671074.Peer-Reviewed Original ResearchConceptsStatistical Analysis of Metagenomic ProfilesNeonatal intensive care unitGut microbiotaGut microbiomeFunction of gut microbiotaCharacteristics of gut microbiotaReconstruction of Unobserved StatesPhylogenetic Investigation of CommunitiesGut microbial developmentGut microbiota patternInfant gut microbiotaGut microbiota compositionGut microbiome diversityInvestigation of CommunitiesInfant gut microbiomePostnatal ageNeurobehavioral developmentMetagenomic functionsMixed-sex groupsPhylogenetic investigationMetagenomic profilesEnvironmental factorsMicrobiota compositionKEGG pathwaysMicrobiome diversityClinical and vital sign changes associated with late-onset sepsis in very low birth weight infants at 3 NICUs
Sullivan BA, Nagraj VP, Berry KL, Fleiss N, Rambhia A, Kumar R, Wallman-Stokes A, Vesoulis ZA, Sahni R, Ratcliffe S, Lake DE, Moorman JR, Fairchild KD. Clinical and vital sign changes associated with late-onset sepsis in very low birth weight infants at 3 NICUs. Journal Of Neonatal-Perinatal Medicine 2021, 14: 553-561. PMID: 33523025, PMCID: PMC8316489, DOI: 10.3233/npm-200578.Peer-Reviewed Original ResearchConceptsLate-onset sepsisLow birth weight infantsBirth weight infantsClinical signsWeight infantsHeart rateBaseline risk factorsVital sign changesNon-infectious conditionsAbnormal CBCFirst sepsisAbdominal distensionVLBW infantsCentral cathetersMechanical ventilationPremature infantsPostnatal ageBaseline variablesClinician documentationRisk factorsClinical changesSepsisInfantsVital signsLogistic regression
2020
Log-contrast regression with functional compositional predictors: Linking preterm infants’ gut microbiome trajectories to neurobehavioral outcome
Sun Z, Xu W, Cong X, Li G, Chen K. Log-contrast regression with functional compositional predictors: Linking preterm infants’ gut microbiome trajectories to neurobehavioral outcome. The Annals Of Applied Statistics 2020, 14: 1535-1556. PMID: 34163544, PMCID: PMC8218926, DOI: 10.1214/20-aoas1357.Peer-Reviewed Original ResearchNeonatal intensive care unitPreterm infantsNeurobehavioral outcomesPreterm infant studyWeeks of post-menstrual ageVery preterm neonatesPost-menstrual ageIntensive care unitInfant studiesMicrobiome markersIdentified microbiome markersStressful early life experiencesBrain-gut axisPreterm neonatesPostnatal ageInfant fecal samplesPretermInfant neurodevelopmentInfant's first monthCare unitPostnatal stagesInfantsGut microbiome compositionEstimated time dynamicsFirst month
2017
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages
Song G, Sun X, Hines R, McCarver D, Lake B, Osimitz T, Creek M, Clewell H, Yoon M. Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. Drug Metabolism And Disposition 2017, 45: 468-475. PMID: 28228413, DOI: 10.1124/dmd.116.074583.Peer-Reviewed Original ResearchConceptsCYP2C8 expressionOntogeny dataMonths postnatal ageProtein levelsLiver microsomal samplesAge-dependent expressionMultiple cytochrome P450Weeks' gestationPostnatal agePostnatal dayYoung infantsPostnatal samplesFetal samplesMicrosomal samplesCYP1A2 expressionQuantitative Western blottingPyrethroid metabolismCYP2C8Western blottingHealth risk assessmentHuman health risk assessmentRisk assessmentAgeCarboxylesterase enzymesCytochrome P450Refractive and ocular biometric profile of children with a history of laser treatment for retinopathy of prematurity
Kaur S, Sukhija J, Katoch D, Sharma M, Samanta R, Dogra M. Refractive and ocular biometric profile of children with a history of laser treatment for retinopathy of prematurity. Indian Journal Of Ophthalmology 2017, 65: 835-840. PMID: 28905827, PMCID: PMC5621266, DOI: 10.4103/ijo.ijo_872_16.Peer-Reviewed Original ResearchConceptsRetinopathy of prematurityHistory of laser treatmentRefractive errorDevelopment of high myopiaDevelopment of myopiaDiverse socioeconomic strataLaser treatmentHigh birth weight babiesPrescribed glassesYear postnatal ageBirth weight babiesOcular biometryStructural outcomesSubnormal visionSocioeconomic strataHigh myopiaMyopiaAxial lengthHigh astigmatismWeight babiesTertiary centerPostnatal ageLens thicknessUnsatisfactory outcomeIndian children
2012
Retrospective Case‐Control Study of Apolipoprotein J/Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis
Kurian KM, McGuone D. Retrospective Case‐Control Study of Apolipoprotein J/Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis. Pathology Research International 2012, 2012: 479359. PMID: 22848862, PMCID: PMC3403500, DOI: 10.1155/2012/479359.Peer-Reviewed Original ResearchPontosubicular necrosisDuration of laborClinical asphyxiaNeonatal deathPostnatal ageProtein expressionRetrospective case-control studyCase-control studyClusterin protein expressionNeuronal protein expressionPerinatal StudyAsphyxiaControl groupGestationNecrosisPonsDeathAgeDurationGroupExpressionPatientsHippocampusCasesImmunohistochemistry
2009
Kangaroo Care modifies preterm infant heart rate variability in response to heel stick pain: Pilot study
Cong X, Ludington-Hoe S, McCain G, Fu P. Kangaroo Care modifies preterm infant heart rate variability in response to heel stick pain: Pilot study. Early Human Development 2009, 85: 561-567. PMID: 19505775, PMCID: PMC2742959, DOI: 10.1016/j.earlhumdev.2009.05.012.Peer-Reviewed Original ResearchConceptsHeel stick painKangaroo careHeel stickPreterm infantsIncubator careHeart rate variabilityPainful proceduresNeonatal intensive care unitMother-infant skin-to-skin contactSkin-to-skin contactWeeks gestational ageInfant heart rate variabilityDays postnatal ageLF/HF ratioInfant behavioral stateResponse to painIntensive care unitHeart rate variability differencesEffects of KCResponses to painful proceduresRate variabilityGestational ageInfant painPostnatal ageHeel warming
2006
Epirubicin Glucuronidation and UGT2B7 Developmental Expression
Zaya M, Hines R, Stevens J. Epirubicin Glucuronidation and UGT2B7 Developmental Expression. Drug Metabolism And Disposition 2006, 34: 2097-2101. PMID: 16985101, DOI: 10.1124/dmd.106.011387.Peer-Reviewed Original ResearchConceptsPediatric age categoriesPediatric age groupAge categoriesAge groupsLiver microsomesChildhood malignant diseaseMetabolism of epirubicinUse of epirubicinTreatment of adultsYears of ageMonths of ageAge-related changesPediatric patientsAdult age categoriesPostnatal ageCardiac toxicityMalignant diseaseUGT2B7 activityNeonatal samplesPreclinical evaluationUGT2B7 expressionGlucuronidation activityAdult groupGlucuronidationEquivalent doses
2005
Developmental Expression of Aryl, Estrogen, and Hydroxysteroid Sulfotransferases in Pre- and Postnatal Human Liver
Duanmu Z, Weckle A, Koukouritaki S, Hines R, Falany J, Falany C, Kocarek T, Runge-Morris M. Developmental Expression of Aryl, Estrogen, and Hydroxysteroid Sulfotransferases in Pre- and Postnatal Human Liver. Journal Of Pharmacology And Experimental Therapeutics 2005, 316: 1310-1317. PMID: 16339912, DOI: 10.1124/jpet.105.093633.Peer-Reviewed Original ResearchConceptsHuman liver cytosolImmunoreactive protein levelsHuman liverSULT2A1 expressionPostnatal liver samplesProtein levelsLiver cytosolPostnatal human developmentAdult human liverSemiquantitative Western blot analysisWestern blot analysisThird trimesterPostnatal ageEarly gestationEstrogen inactivationSulfotransferase expressionPostnatal lifeInterindividual variabilityPrenatal periodMale liverDifferent developmental profilesSULT1A1 expressionGestationLiverHydroxysteroid sulfotransferases
2003
Human Hepatic CYP2E1 Expression during Development
Johnsrud E, Koukouritaki S, Divakaran K, Brunengraber L, Hines R, McCarver D. Human Hepatic CYP2E1 Expression during Development. Journal Of Pharmacology And Experimental Therapeutics 2003, 307: 402-407. DOI: 10.1124/jpet.103.053124.Peer-Reviewed Original ResearchConceptsPostnatal ageDays of ageNeonatal samplesOlder infantsCYP2E1 contentHepatic CYP2E1 expressionDays postnatal ageHuman hepatic microsomesHuman fetal liverInfants 31CYP2E1 protein contentGestational ageThird trimesterPostnatal dataGreat intersubject variationCYP2E1 expressionCYP2E1 substratesAge groupsFetal samplesCYP2E1Hepatic microsomesFetal liverInfantsYoung adultsIntersubject variationDevelopmental Expression of the Major Human Hepatic CYP3A Enzymes
Stevens J, Hines R, Gu C, Koukouritaki S, Manro J, Tandler P, Zaya M. Developmental Expression of the Major Human Hepatic CYP3A Enzymes. Journal Of Pharmacology And Experimental Therapeutics 2003, 307: 573-582. PMID: 12975492, DOI: 10.1124/jpet.103.054841.Peer-Reviewed Original ResearchHuman hepatic CYP2E1 expression during development.
Johnsrud E, Koukouritaki S, Divakaran K, Brunengraber L, Hines R, McCarver D. Human hepatic CYP2E1 expression during development. Journal Of Pharmacology And Experimental Therapeutics 2003, 307: 402-7. PMID: 14500779, DOI: 10.1124/jpet.102.053124.Peer-Reviewed Original ResearchConceptsPostnatal ageNeonatal samplesThird trimesterOlder infantsIncreasing gestational ageDays postnatal ageHuman fetal liverCYP2E1 contentDays of ageImmunodetectable CYP2E1Gestational ageHuman hepatic microsomesSecond-trimesterPostnatal dataFetal liverFetal samplesHepatic CYP2E1 expressionDecreased clearanceInfantsCYP2E1 expressionIntersubject variationCYP2E1CYP2E1 protein contentAge groupsCYP2E1 substrates
1998
Complications of conjunctivitis caused by Pseudomonas aeruginosa in a newborn intensive care unit
SHAH S, GALLAGHER P. Complications of conjunctivitis caused by Pseudomonas aeruginosa in a newborn intensive care unit. The Pediatric Infectious Disease Journal 1998, 17: 97-102. PMID: 9493803, DOI: 10.1097/00006454-199802000-00004.Peer-Reviewed Original ResearchConceptsSystemic complicationsMean birth weightEye diseaseCare unitGestational ageBirth weightEye infectionsLower mean birth weightNewborn Special Care UnitNewborn intensive care unitYale-New Haven HospitalAverage postnatal ageMean gestational ageOutcomes of infantsIntensive care unitSpecial care unitsP. aeruginosa infectionBrain abscessesPostnatal ageAeruginosa infectionComplicationsConjunctivitisInfantsInfectionEarly detection
1995
Germinal matrix microvascular maturation correlates inversely with the risk period for neonatal intraventricular hemorrhage
Ment L, Stewart W, Ardito T, Madri J. Germinal matrix microvascular maturation correlates inversely with the risk period for neonatal intraventricular hemorrhage. Brain Research 1995, 84: 142-149. PMID: 7720213, DOI: 10.1016/0165-3806(94)00168-y.Peer-Reviewed Original ResearchConceptsNeonatal intraventricular hemorrhageIntraventricular hemorrhagePostnatal dayRisk periodDay 1Blood-brain barrierNewborn beagle pupsTenth postnatal dayEndothelial cell areaBasal lamina depositionPerinatal inductionPreterm neonatesBasement membrane areaWeeks' gestationGestational agePostnatal ageGerminal matrixBeagle pupsElectron microscopic examinationLuminal areaTight junction lengthWhite matterDay 10Time pointsBeagle model
1992
Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup.
Ment L, Stewart W, Ardito T, Huang E, Madri J. Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup. Stroke 1992, 23: 1132-1137. PMID: 1636188, DOI: 10.1161/01.str.23.8.1132.Peer-Reviewed Original ResearchConceptsNewborn beagle pupsPostnatal day 2Germinal matrixPostnatal ageBeagle pupsIntraventricular hemorrhageVessel densityDay 2Postnatal day 1Laminin depositionMechanism of actionMicrovessel maturationStudy medicationBeta 1 integrinImmunohistochemical studyPostnatal dayDose i.Animal studiesDay 1IndomethacinNewborn pupsHemorrhageBasement membrane depositionBuffered formalinCollagen staining
1987
Physiological properties of regenerated rat sciatic nerve following lesions at different postnatal ages
Bowe C, Kocsis J, Waxman S, Hildebrand C. Physiological properties of regenerated rat sciatic nerve following lesions at different postnatal ages. Brain Research 1987, 34: 123-131. DOI: 10.1016/0165-3806(87)90201-x.Peer-Reviewed Original ResearchControl nervesPostnatal ageSciatic nerveRegenerated nervesRegenerated rat sciatic nerveFrequency-following abilityOlder postnatal ageSciatic crush lesionRegenerated sciatic nerveAge 3 weeksCompound action potentialDifferent postnatal agesRat sciatic nerveWhole-nerve responseMonths of ageRelative refractory periodCrush lesionPharmacological blockadeNerve responsesSlight prolongationNerveElectrophysiological propertiesAction potentialsRefractory periodOlder ageNodal spacing along regenerated axons following a crush lesion of the developing rat sciatic nerve
Hildebrand C, Mustafa G, Bowe C, Kocsis J. Nodal spacing along regenerated axons following a crush lesion of the developing rat sciatic nerve. Brain Research 1987, 32: 147-154. DOI: 10.1016/0165-3806(87)90148-9.Peer-Reviewed Original ResearchNodal spacing along regenerated axons following a crush lesion of the developing rat sciatic nerve.
Hildebrand C, Mustafa G, Bowe C, Kocsis J. Nodal spacing along regenerated axons following a crush lesion of the developing rat sciatic nerve. Brain Research 1987, 429: 147-54. PMID: 3567658, DOI: 10.1016/0165-3806(87)90148-9.Peer-Reviewed Original ResearchConceptsRat sciatic nerveSciatic nerveRegenerated nervesCrush lesionRegenerated rat sciatic nerveNewborn rat pupsSciatic nerve axonsPostnatal ageRegenerated axonsPostnatal eventsRat pupsNerveNerve axonsMyelin sheathL increaseAxonsWeeksBirthAgeLesionsMyelinationSignsRemodellingSuch signsLength growth
1981
The total number, time of origin and kinetics of proliferation of neurons comprising the deep cerebellar nuclei in the rhesus monkey
Gould B, Rakic P. The total number, time of origin and kinetics of proliferation of neurons comprising the deep cerebellar nuclei in the rhesus monkey. Experimental Brain Research 1981, 44: 195-206. PMID: 7286107, DOI: 10.1007/bf00237341.Peer-Reviewed Original ResearchConceptsCerebellar nucleiPosterior interposed nucleusDeep nucleiSmall neuronsDentate nucleusFastigial nucleusRhesus monkeysInterposed nucleusCessation of neurogenesisGenesis of neuronsPostnatal rhesus monkeysIntermediate time courseDay gestation periodDeep cerebellar nucleiPostnatal ageCerebellar cortexAxonal connectionsOld monkeysNeuron populationsKinetics of proliferationNeuronsAutoradiographic methodTotal numberNeurogenesisPeak of proliferation
1976
Differentiation of Purkinje cells and their relationship to other components of developing cerebellar cortex in man
Zecevic N, Rakic P. Differentiation of Purkinje cells and their relationship to other components of developing cerebellar cortex in man. The Journal Of Comparative Neurology 1976, 167: 27-47. PMID: 818132, DOI: 10.1002/cne.901670103.Peer-Reviewed Original ResearchConceptsPurkinje cellsSomatic spinesCerebellar cortexPurkinje cell somatic spinesGolgi impregnation methodFirst postnatal yearTime of birthHuman Purkinje cellsNew dendritic branchesPurkinje cell maturationBipolar somataPostnatal ageDendritic shaftsIntrauterine lifeDendritic arborsFetal weekDendritic processesPostnatal yearFetal monthCell maturationPrimate cerebellumNeuronal differentiationHuman specimensDendritic branchesBasal cell pole
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