2025
Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension
Park J, An H, Kim S, Kim S, Cho H, Kim J, Cho A, Kwak J, Shin J, Lee K, Oh J, Lee J, Kim H, Shin H, Han M, Hyun M, Ha T, Song Y, Hypertension O. Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension. Kidney Research And Clinical Practice 2025, 44: 20-48. PMID: 39923806, PMCID: PMC11864819, DOI: 10.23876/j.krcp.24.096.Peer-Reviewed Original ResearchAmerican Academy of PediatricsEuropean Society of HypertensionPediatric hypertensionManagement of hypertensionKorean childrenKorean Working GroupEuropean Society of Hypertension guidelinesClinical guidelinesPediatric age groupManagement of childhood hypertensionTreatment of hypertensionBlood pressure valuesDiagnosis of hypertensionBurden of cardiovascular diseaseAcademy of PediatricsChildhood hypertensionClinical evidenceHypertension guidelinesHypertensionCardiovascular diseaseInternational guidelinesReference blood pressure valuesAmerican AcademyDiagnosisAge groups
2024
Epidemiology, treatment and outcomes of gastroenteropancreatic neuroendocrine neoplasms
Uhlig J, Nie J, Gibson J, Cecchini M, Stein S, Lacy J, Kunz P, Kim H. Epidemiology, treatment and outcomes of gastroenteropancreatic neuroendocrine neoplasms. Scientific Reports 2024, 14: 30536. PMID: 39690170, PMCID: PMC11652651, DOI: 10.1038/s41598-024-81518-4.Peer-Reviewed Original ResearchConceptsGEP-NEN patientsGastroenteropancreatic neuroendocrine neoplasmsOverall survivalGEP-NENsTreatment patternsSystemic therapyNeuroendocrine neoplasmsAssociated with improved survivalLow-grade diseaseNational Cancer DatabaseLonger overall survivalSite-specific incidenceDisease specific factorsG3 NENSurgical resectionCancer DatabaseImproved survivalLow-stageCox regressionImprove outcomesPatientsIncidence increasesInternational guidelinesInvestigate incidenceSurvivalTuberculosis Preventive Treatment for Pregnant People With Human Immunodeficiency Virus in South Africa: A Modeling Analysis of Clinical Benefits and Risks
Rosen L, Thielking A, Dugdale C, Montepiedra G, Kalk E, Kim S, LaCourse S, Mathad J, Freedberg K, Horsburgh C, Paltiel A, Wood R, Ciaranello A, Reddy K. Tuberculosis Preventive Treatment for Pregnant People With Human Immunodeficiency Virus in South Africa: A Modeling Analysis of Clinical Benefits and Risks. Clinical Infectious Diseases 2024, ciae508. PMID: 39544107, DOI: 10.1093/cid/ciae508.Peer-Reviewed Original ResearchAdverse pregnancy outcomesHuman immunodeficiency virusRisk of stillbirthFetal/infant deathImmunodeficiency virusHigher risk of LBWMaternal CD4 cell countCD4 cell countMonths of isoniazidRisk of LBWPregnant peopleHigher-risk scenarioTuberculosis preventive treatmentIsoniazid-rifapentineAntiretroviral therapyPregnancy outcomesClinical benefitPrimary outcomeCombined deathPreventive treatmentCell countHigh riskStillbirthPregnancyInternational guidelinesDevelopment of PD in lower-income countries: a rational solution for the management of AKI and ESKD
Cullis B, McCulloch M, Finkelstein F. Development of PD in lower-income countries: a rational solution for the management of AKI and ESKD. Kidney International 2024, 105: 953-959. PMID: 38431214, DOI: 10.1016/j.kint.2023.11.036.Peer-Reviewed Original ResearchEnd-stage kidney diseasePeritoneal dialysisResource-poor countriesAcute kidney injuryManagement of AKIEnd-stage kidney disease careLow-resource countriesOut-of-pocket expenditureKidney disease careLower-resource countriesKidney injuryBenefits of PDDialysis accessKidney diseaseDevelopment of PDAccess dialysisDisease careLower-income countriesInternational guidelinesPD servicesDisease programsIncome countriesVulnerable populationsHemodialysisLiving ProgramTherapie der Sarkoidose. Ein Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DGP)
Skowasch D, Bonella F, Buschulte K, Kneidinger N, Korsten P, Kreuter M, Müller-Quernheim J, Pfeifer M, Prasse A, Quadder B, Sander O, Schupp J, Sitter H, Stachetzki B, Grohé C. Therapie der Sarkoidose. Ein Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DGP). Pneumologie 2024, 78: 151-166. PMID: 38408486, DOI: 10.1055/a-2259-1046.Peer-Reviewed Original ResearchDiagnosis and management of pyruvate kinase deficiency: international expert guidelines
Al-Samkari H, Shehata N, Lang-Robertson K, Bianchi P, Glenthøj A, Sheth S, Neufeld E, Rees D, Chonat S, Kuo K, Rothman J, Barcellini W, van Beers E, Pospíšilová D, Shah A, van Wijk R, Glader B, Mañú Pereira M, Andres O, Kalfa T, Eber S, Gallagher P, Kwiatkowski J, Galacteros F, Lander C, Watson A, Elbard R, Peereboom D, Grace R. Diagnosis and management of pyruvate kinase deficiency: international expert guidelines. The Lancet Haematology 2024, 11: e228-e239. PMID: 38330977, DOI: 10.1016/s2352-3026(23)00377-0.Peer-Reviewed Original ResearchExpert panelCountry of practiceCare of patientsEvidence-based guidelinesQuality of lifeClinical care of patientsPyruvate kinase deficiencySystematic literature searchDeficient careGuideline methodologistsPK deficiencyClinical careClinical guidelinesInternational expert guidelinesEstimated prevalenceHaemolytic anaemiaConsensus procedureManagement of chronic complicationsDraft recommendationsGRADE methodologyAGREE II frameworkExpert guidelinesLiterature searchClinical practiceInternational guidelines
2023
An international, multispecialty, expert-based Delphi Consensus document on controversial issues in the management of patients with asymptomatic and symptomatic carotid stenosis
Paraskevas K, Mikhailidis D, Ringleb P, Brown M, Dardik A, Poredos P, Gray W, Nicolaides A, Lal B, Mansilha A, Antignani P, de Borst G, Cambria R, Loftus I, Lavie C, Blinc A, Lyden S, Matsumura J, Jezovnik M, Bacharach J, Meschia J, Clair D, Zeebregts C, Lanza G, Capoccia L, Spinelli F, Liapis C, Jawien A, Parikh S, Svetlikov A, Menyhei G, Davies A, Musialek P, Roubin G, Stilo F, Sultan S, Proczka R, Faggioli G, Geroulakos G, Fernandes E Fernandes J, Ricco J, Saba L, Secemsky E, Pini R, Myrcha P, Rundek T, Martinelli O, Kakkos S, Sachar R, Goudot G, Schlachetzki F, Lavenson G, Ricci S, Topakian R, Millon A, Di Lazzaro V, Silvestrini M, Chaturvedi S, Eckstein H, Gloviczki P, White C. An international, multispecialty, expert-based Delphi Consensus document on controversial issues in the management of patients with asymptomatic and symptomatic carotid stenosis. Journal Of Vascular Surgery 2023, 79: 420-435.e1. PMID: 37944771, DOI: 10.1016/j.jvs.2023.09.031.Peer-Reviewed Original ResearchSymptomatic carotid stenosisManagement of patientsConsensus documentCarotid stenosisHospital stroke/deathStroke/deathThree-round Delphi consensus processDelphi consensus processGrade of stenosisCarotid interventionHigh riskPatientsInternational guidelinesStenosisControversial evidenceRound 2Round 1Round 3Consensus processMonthsMost expertsCurrent definitionSpecific responsesGuidelinesParticipants
2022
Prediction of pathologic complete response to neoadjuvant chemotherapy in breast cancer (SWOG S0800) using image analysis-based tumor infiltrating lymphocyte measurements.
Blenman K, Fanucci K, Bai Y, Pelekanou V, Nahleh Z, Shafi S, Burela S, Barlow W, Sharma P, Thompson A, Godwin A, Rimm D, Hortobagyi G, Pusztai L. Prediction of pathologic complete response to neoadjuvant chemotherapy in breast cancer (SWOG S0800) using image analysis-based tumor infiltrating lymphocyte measurements. Journal Of Clinical Oncology 2022, 40: 594-594. DOI: 10.1200/jco.2022.40.16_suppl.594.Peer-Reviewed Original ResearchPathologic complete responseBreast cancerNeoadjuvant chemotherapyComplete responseTIL scoreResidual diseaseResponse predictive markersBetter EFSBevacizumab benefitLymphocyte measurementsTIL assessmentFree survivalPredictive markerTIL quantificationInternational guidelinesPretreatment samplesLogistic regressionCancerOutcome discriminationChemotherapyScoresContinuous scoresTumorsClinical adoptionStrong positive correlationInternational guidelines regarding the role of IVIG in the management of Rh‐ and ABO‐mediated haemolytic disease of the newborn
Lieberman L, Lopriore E, Baker JM, Bercovitz RS, Christensen RD, Crighton G, Delaney M, Goel R, Hendrickson JE, Keir A, Landry D, La Rocca U, Lemyre B, Maier RF, Muniz‐Diaz E, Nahirniak S, New HV, Pavenski K, dos Santos M, Ramsey G, Shehata N, Guidelines F. International guidelines regarding the role of IVIG in the management of Rh‐ and ABO‐mediated haemolytic disease of the newborn. British Journal Of Haematology 2022, 198: 183-195. PMID: 35415922, PMCID: PMC9324942, DOI: 10.1111/bjh.18170.Peer-Reviewed Original ResearchConceptsRole of IVIGIntravenous immunoglobulinExchange transfusionHaemolytic diseaseSafety of IVIGRed blood cell transfusionBlood cell transfusionDuration of hospitalizationSeverity of anemiaEvidence-based recommendationsHigh-quality studiesCell transfusionPrompt treatmentBilirubin levelsSignificant morbidityAlternative therapiesIntensive phototherapyNeurocognitive outcomesManagement of RhInternational guidelinesTransfusionNewbornsDiseasePhototherapyInternational panel
2021
Determinants of Influenza Vaccine Uptake in Patients With Cardiovascular Disease and Strategies for Improvement
Bhugra P, Grandhi G, Mszar R, Satish P, Singh R, Blaha M, Blankstein R, Virani S, Cainzos‐Achirica M, Nasir K. Determinants of Influenza Vaccine Uptake in Patients With Cardiovascular Disease and Strategies for Improvement. Journal Of The American Heart Association 2021, 10: e019671. PMID: 34315229, PMCID: PMC8475658, DOI: 10.1161/jaha.120.019671.Peer-Reviewed Original ResearchConceptsInfluenza vaccine uptakeInfluenza vaccineCardiovascular diseaseProspective studyDeterminants of influenza vaccination uptakeUptake of influenza vaccinationVaccine uptakeRisk of cardiovascular eventsInfluenza vaccination coveragePatients aged <Studies of at-risk populationsHigh-risk conditionsAssociated with vaccinationInfluenza infectionCause of deathNon-Hispanic Black individualsDestabilization of atherosclerotic plaquesCardiovascular eventsCerebrovascular eventsAt-risk populationsInfluenzaVaccine efficacyPatientsInternational guidelinesConcurrent epidemicsTowards personalised management for non-variceal upper gastrointestinal bleeding
Sung JJY, Laine L, Kuipers EJ, Barkun AN. Towards personalised management for non-variceal upper gastrointestinal bleeding. Gut 2021, 70: 818-824. PMID: 33649044, DOI: 10.1136/gutjnl-2020-323846.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIndividual patientsNon-variceal upper gastrointestinal bleedingPre-endoscopic assessmentUpper gastrointestinal bleedingImportant clinical issuePostendoscopic managementGastrointestinal bleedingPatient characteristicsEndoscopic evaluationPoint of careOptimal treatmentInternational guidelinesClinical issuesInternational professional societiesClinical settingSpecific management strategiesStages of managementPatientsTreatmentProfessional societiesManagement strategiesGuidelinesBleedingHaemostasisLesions
2020
Quality indicators for the diagnosis and management of pediatric tonsillitis
Cottrell J, Yip J, Campisi P, Chadha N, Damji A, Hong P, Lachance S, Leitao D, Nguyen L, Saunders N, Strychowsky J, Yunker W, Vaccani J, Chan Y, de Almeida J, Eskander A, Witterick I, Monteiro E. Quality indicators for the diagnosis and management of pediatric tonsillitis. International Journal Of Pediatric Otorhinolaryngology 2020, 139: 110441. PMID: 33120099, DOI: 10.1016/j.ijporl.2020.110441.Peer-Reviewed Original ResearchConceptsCandidate indicatorsQuality indicatorsMeasures of high-quality carePediatric tonsillitisExpert panelHigh quality guidelinesHigh-quality careQuality of careQuality improvement initiativesHead & Neck SurgeonsRAND/UCLA appropriateness methodologyExpert panel meetingQI developmentFamily physiciansImprovement initiativesSpectrum of management optionsAntibiotic overprescribingGuideline-based approachPanel meetingPractice variabilityPatient outcomesInternational guidelinesAppropriate methodologiesCareObjective dataExecutive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 1-9. PMID: 32030528, DOI: 10.1007/s00134-019-05877-7.Peer-Reviewed Original ResearchSurviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 10-67. PMID: 32030529, PMCID: PMC7095013, DOI: 10.1007/s00134-019-05878-6.Peer-Reviewed Original ResearchConceptsSepsis-associated organ dysfunctionOrgan dysfunctionSeptic shockBest practice statementsWeak recommendationKey international meetingsStand-alone meetingManagement of childrenManagement of infectionsQuality of evidenceEvidence-based recommendationsResuscitation of childrenGuideline development processMethodsThe panelInternational expertsRecommendations AssessmentAdjunctive therapyPractice patternsMetabolic therapyConsistent careLarge cohortPanel membersResearch prioritiesInternational guidelinesSystematic reviewExecutive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: 186-195. PMID: 32032264, DOI: 10.1097/pcc.0000000000002197.Peer-Reviewed Original ResearchSurviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: e52-e106. PMID: 32032273, DOI: 10.1097/pcc.0000000000002198.Peer-Reviewed Original ResearchConceptsSepsis-associated organ dysfunctionOrgan dysfunctionSeptic shockBest practice statementsWeak recommendationKey international meetingsStand-alone meetingManagement of childrenQuality of evidenceManagement of infectionsEvidence-based recommendationsGuideline development processResuscitation of childrenInternational expertsRecommendations AssessmentAdjunctive therapyMetabolic therapyPractice patternsConsistent careLarge cohortPanel membersResearch prioritiesSystematic reviewInternational guidelinesDysfunction
2019
Clinical outcome indicators in chronic hepatitis B and C: A primer for value‐based medicine in hepatology
Strazzabosco M, Cortesi P, Conti S, Okolicsanyi S, Rota M, Ciaccio A, Cozzolino P, Fornari C, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Zavaglia C, Perricone G, Munari L, Mantovani L, Belli L. Clinical outcome indicators in chronic hepatitis B and C: A primer for value‐based medicine in hepatology. Liver International 2019, 40: 60-73. PMID: 31654608, PMCID: PMC10916792, DOI: 10.1111/liv.14285.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntiviral AgentsCarcinoma, HepatocellularFemaleGastroenterologyHepatitis B, ChronicHepatitis C, ChronicHumansItalyLiver CirrhosisLiver NeoplasmsLongitudinal StudiesMaleMiddle AgedProspective StudiesQuality Indicators, Health CareSurvival AnalysisTreatment OutcomeValue-Based Health InsuranceConceptsClinical outcome indicatorsClinical practiceOutcome indicatorsChronic hepatitis BClinical practice settingMajor health problemCurrent international guidelinesNew effective treatmentsValue of careMETHODS/RESULTSHCV patientsHCV infectionHepatitis BClinical outcomesLiver diseaseMulticentre studyEffective treatmentHealth problemsInternational guidelinesCare deliveryValue-based medicineCostly treatmentPractice settingsHBVPatientsWhat electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons
Babiloni C, Blinowska K, Bonanni L, Cichocki A, De Haan W, Del Percio C, Dubois B, Escudero J, Fernández A, Frisoni G, Guntekin B, Hajos M, Hampel H, Ifeachor E, Kilborn K, Kumar S, Johnsen K, Johannsson M, Jeong J, LeBeau F, Lizio R, Lopes da Silva F, Maestú F, McGeown W, McKeith I, Moretti D, Nobili F, Olichney J, Onofrj M, Palop J, Rowan M, Stocchi F, Struzik Z, Tanila H, Teipel S, Taylor J, Weiergräber M, Yener G, Young-Pearse T, Drinkenburg W, Randall F. What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons. Neurobiology Of Aging 2019, 85: 58-73. PMID: 31739167, DOI: 10.1016/j.neurobiolaging.2019.09.008.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD patientsAD clinical researchExperimental animal modelsCurrent international guidelinesDifferent disease stagesExcitation/inhibitionAD neuropathologyDisease stageClinical trialsBrain neuronsAnimal modelsApplication of electrophysiologyPatientsInternational guidelinesCognitive deficitsElectrophysiological techniquesClinical researchFunctional connectivityNeural functionAD studiesResidual capacityMulticentric projectDiseaseBrain network dynamics
2017
Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm
Zafar MA, Li Y, Rizzo JA, Charilaou P, Saeyeldin A, Velasquez CA, Mansour AM, Bin Mahmood SU, Ma WG, Brownstein AJ, Tranquilli M, Dumfarth J, Theodoropoulos P, Thombre K, Tanweer M, Erben Y, Peterss S, Ziganshin BA, Elefteriades JA. Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm. Journal Of Thoracic And Cardiovascular Surgery 2017, 155: 1938-1950. PMID: 29395211, DOI: 10.1016/j.jtcvs.2017.10.140.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAortic Aneurysm, ThoracicBody HeightBody Surface AreaDatabases, FactualDecision Support TechniquesDisease ProgressionFemaleHumansMaleMiddle AgedPredictive Value of TestsProgression-Free SurvivalRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsYoung AdultConceptsAortic size indexBody surface areaAortic height indexAortic diameterAortic aneurysmYearly riskComplication-free survivalLong-term complicationsRisk of complicationsRisk estimationAortic dissectionComplication rateAortic sizeRisk stratificationComplicationsPredictive valueConcordance statisticInternational guidelinesNatural complicationsPatientsHeight indexSignificant predictorsAneurysmsTAAARiskUpdate on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer
Dieci MV, Radosevic-Robin N, Fineberg S, van den Eynden G, Ternes N, Penault-Llorca F, Pruneri G, D’Alfonso T, Demaria S, Castaneda C, Sanchez J, Badve S, Michiels S, Bossuyt V, Rojo F, Singh B, Nielsen T, Viale G, Kim SR, Hewitt S, Wienert S, Loibl S, Rimm D, Symmans F, Denkert C, Adams S, Loi S, Salgado R, Cancer O. Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Seminars In Cancer Biology 2017, 52: 16-25. PMID: 29024776, DOI: 10.1016/j.semcancer.2017.10.003.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesBreast cancerResidual diseaseTIL assessmentDuctal carcinomaInternational Immuno-Oncology Biomarker Working GroupBiomarker Working GroupClinical breast cancer researchBreast cancer researchNeoadjuvant chemotherapyNeoadjuvant therapyImmunotherapeutic strategiesImmunological biomarkersInvasive carcinomaClinical trialsClinical relevanceConsensus guidanceInternational guidelinesCarcinomaWorking GroupCancerDiseaseMorphological evaluationLymphocytesCancer research
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