2021
Relation of glomerular filtration to insulin resistance and related risk factors in obese children
Magen D, Halloun R, Galderisi A, Caprio S, Weiss R. Relation of glomerular filtration to insulin resistance and related risk factors in obese children. International Journal Of Obesity 2021, 46: 374-380. PMID: 34725443, DOI: 10.1038/s41366-021-01001-2.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateInsulin sensitivityObese childrenInsulin resistanceBlood pressureFiltration rateRisk factorsWhole-body insulin sensitivityChildhood insulin resistanceFuture kidney diseaseRelation of eGFRSignificant renal morbiditySpectrum of obesityCardiovascular risk factorsPresence of microalbuminuriaSystolic blood pressureRelated risk factorsHepatic insulin sensitivityBody insulin sensitivityObjectiveChildhood obesityRenal morbidityClinical outcomesGlucose toleranceMale sexKidney diseaseThe Yale Bright Bodies Lifestyle Intervention Program: An Intensive Lifestyle Intervention for Obese Children and Adolescents With and Without T2D
Savoye M, Rose P, Samuels S, Tamborlane W, Caprio S, Van Name M. The Yale Bright Bodies Lifestyle Intervention Program: An Intensive Lifestyle Intervention for Obese Children and Adolescents With and Without T2D. Contemporary Endocrinology 2021, 203-216. DOI: 10.1007/978-3-030-64133-7_19.ChaptersLifestyle intervention programLifestyle interventionObese childrenIntensive lifestyle intervention programPediatric lifestyle interventionCornerstone of treatmentIntensive lifestyle interventionPrevalence of obesityType 2 diabetesIntervention programsOverproduction of insulinInsulin sensitivityClinical studiesBody weightCaregiver supportT2DChildrenInterventionPrevalenceAdolescentsGlycemiaObesityDiabetesT2D.Dietitians
2020
Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity
Tas E, Bai S, Ou X, Mercer K, Lin H, Mansfield K, Buchmann R, Diaz EC, Oden J, Børsheim E, Adams SH, Dranoff J. Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity. Frontiers In Endocrinology 2020, 11: 654. PMID: 33071964, PMCID: PMC7533567, DOI: 10.3389/fendo.2020.00654.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseMagnetic resonance imagingIntrahepatic triglyceridesPercent changePotential biomarkersClinical weight loss programSerum fibroblast growth factorFibroblast growth factor 21Liver fat percentFatty liver diseaseWeight loss programGrowth factor 21Non-invasive biomarkersFibroblast growth factorCourse diseaseSerum FGF21Adiponectin ratioFinal visitAdiponectin levelsLiver biopsyLiver diseaseObese childrenLoss programLiver fatFactor 21
2018
The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth
Umano GR, Caprio S, Di Sessa A, Chalasani N, Dykas DJ, Pierpont B, Bale AE, Santoro N. The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth. The American Journal Of Gastroenterology 2018, 113: 376. PMID: 29485130, PMCID: PMC12136689, DOI: 10.1038/ajg.2018.1.Peer-Reviewed Original ResearchMeSH KeywordsAcyltransferasesAdolescentAllelesBlack or African AmericanChildFemaleGenetic Predisposition to DiseaseGenotypeGlucose Tolerance TestHispanic or LatinoHumansInsulin ResistanceLiverMagnetic Resonance ImagingMaleMembrane ProteinsNon-alcoholic Fatty Liver DiseasePediatric ObesityPolymorphism, Single NucleotideWhite PeopleConceptsCaucasian obese childrenMBOAT7 geneObese childrenLiver diseaseHepatic steatosisInsulin resistanceInsulin sensitivityAlcoholic fatty liver diseaseBody mass index z-scoreOral glucose tolerance testWhole-body insulin sensitivityAlcoholic liver diseaseFatty liver diseaseCurve of glucoseGlucose tolerance testIndex z-scoreMagnetic resonance imagingFatty liverPNPLA3 rs738409Liver damageTolerance testLeading causeMultiethnic cohortObese youthGlucose metabolismChapter 4 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome
Santoro N, Giannini C, Caprio S. Chapter 4 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome. 2018, 43-52. DOI: 10.1016/b978-0-12-812019-4.00004-0.ChaptersInsulin resistanceAge groupsΒ-cellsChapter 4 ObesityPediatric age groupEctopic fat depositionProgression of obesityType 2 diabetesOvert diabetesObesity complicationsObese childrenChildhood obesityMore insulinSerum glucoseInsulin secretionPediatric diseasesNormal rangeType 2Progressive deteriorationObesityFat depositionDiabetesDiseaseComplicationsGroup
2017
Traffic‐related air pollution associations with cytokeratin‐18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population
Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. Traffic‐related air pollution associations with cytokeratin‐18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatric Obesity 2017, 13: 342-347. PMID: 28730729, PMCID: PMC5775922, DOI: 10.1111/ijpo.12228.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseTraffic-related air pollutionNon-alcoholic steatohepatitisHepatic fat fractionCK-18Pre-existing non-alcoholic fatty liver diseaseCytokeratin 18Fatty liver diseaseObese pediatric populationPediatric obesity clinicNitrogen dioxide exposureMagnetic resonance imagingObesity clinicStudy entryFatty liverLiver diseaseObese childrenPediatric populationLiver enzymesLiver susceptibilityHepatocellular apoptosisAnimal modelsResidential buffersResonance imagingAir pollution associationsChild, maternal and household-level correlates of nutritional status: a cross-sectional study among young Samoan children
Choy CC, Desai MM, Park JJ, Frame EA, Thompson AA, Naseri T, Reupena MS, Duckham RL, Deziel NC, Hawley NL. Child, maternal and household-level correlates of nutritional status: a cross-sectional study among young Samoan children. Public Health Nutrition 2017, 20: 1235-1247. PMID: 28162141, PMCID: PMC10261405, DOI: 10.1017/s1368980016003499.Peer-Reviewed Original ResearchConceptsOverweight/obesityCross-sectional community-based surveyNutritional statusOdds of anemiaOverweight/obeseCross-sectional studyPrevalence of stuntingCommunity-based surveyCondition-specific interventionsMother-child pairsNutritional status outcomesEarly childhood growthHigher family socio-economic statusAnemic mothersObese childrenSugar intakeSamoan childrenChildhood growthStatus outcomesSocio-economic statusDual burdenAge groupsAnemiaHealth programsGrowth standards
2016
Obesity and Gastrointestinal Disorders in Children
Phatak U, Phadke M, Pashankar D. Obesity and Gastrointestinal Disorders in Children. 2016, 149-157. DOI: 10.1007/978-3-319-19821-7_12.Peer-Reviewed Original ResearchGastrointestinal disordersAssociation of obesityFunctional gastrointestinal disordersOrganic gastrointestinal diseasesCommon gastrointestinal disorderInflammatory bowel diseaseBowel diseaseObese childrenCeliac diseasePossible complicationsComprehensive careClinical significanceGastrointestinal diseasesObesityDiseaseDisordersChildrenGlobal pandemicAssociationCurrent dataRecent studiesPossible mechanismComplicationsPhysiciansDiagnosisRole of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study
Goffredo M, Caprio S, Feldstein AE, D'Adamo E, Shaw MM, Pierpont B, Savoye M, Zhao H, Bale AE, Santoro N. Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study. Hepatology 2016, 63: 117-125. PMID: 26457389, PMCID: PMC4688225, DOI: 10.1002/hep.28283.Peer-Reviewed Original ResearchConceptsFatty liver diseaseHepatic fat contentLiver diseaseLiver biopsyTM6SF2 rs58542926Nonalcoholic fatty liver disease activity scorePediatric nonalcoholic fatty liver diseaseHigh hepatic fat contentPediatric fatty liver diseaseHigher alanine aminotransferase levelsNonalcoholic fatty liver diseaseOral glucose tolerance testMinor alleleDisease Activity ScoreIntrahepatic fat accumulationUnderwent liver biopsyAlanine aminotransferase levelsFavorable lipoprotein profileGlucose tolerance testLiver panelAminotransferase levelsCardiovascular riskActivity scoreObese childrenLipoprotein profile
2015
Obesity and Gastrointestinal Disorders in Children
Phatak UP, Pashankar DS. Obesity and Gastrointestinal Disorders in Children. Journal Of Pediatric Gastroenterology And Nutrition 2015, 60: 441-445. PMID: 25493349, DOI: 10.1097/mpg.0000000000000670.Peer-Reviewed Original ResearchConceptsGastrointestinal disordersCommon GI disordersOrganic GI diseaseAssociation of obesityFunctional gastrointestinal disordersInflammatory bowel diseaseGI disordersBowel diseaseObese childrenGI diseaseCeliac diseasePossible complicationsComprehensive careClinical significanceObesityDiseaseDisordersChildrenGlobal pandemicAssociationPresent dataRecent studiesPossible mechanismComplicationsPhysicians
2014
Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes
Giannini C, Man C, Groop L, Cobelli C, Zhao H, Shaw MM, Duran E, Pierpont B, Bale AE, Caprio S, Santoro N. Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes. Diabetes Care 2014, 37: 475-482. PMID: 24062323, PMCID: PMC3898754, DOI: 10.2337/dc13-1458.Peer-Reviewed Original ResearchConceptsIGT/T2DImpaired glucose toleranceNormal glucose toleranceInsulin secretionRisk allelesGlucose toleranceObese childrenChance of progressionType 2 diabetesHigh genetic predispositionHigh-risk scoreOral minimal modelObese subjectsPediatric obesityProgressive worseningHyperglycemic clampObese youthHigh riskLower oddsRisk scoreGenetic predispositionT2DSecretionGene variantsEarly phase
2013
Leveraging Text Messaging and Mobile Technology to Support Pediatric Obesity-Related Behavior Change: A Qualitative Study Using Parent Focus Groups and Interviews
Sharifi M, Dryden EM, Horan CM, Price S, Marshall R, Hacker K, Finkelstein JA, Taveras EM. Leveraging Text Messaging and Mobile Technology to Support Pediatric Obesity-Related Behavior Change: A Qualitative Study Using Parent Focus Groups and Interviews. Journal Of Medical Internet Research 2013, 15: e272. PMID: 24317406, PMCID: PMC3869083, DOI: 10.2196/jmir.2780.Peer-Reviewed Original ResearchConceptsText messagingBehavior changeParents of overweightChildren's health behaviorsTimes/weekDiverse race/ethnicityText-based interventionsFocus groupsSample text messagesSemistructured discussion guideRace/ethnicityObese childrenParental acceptabilityPediatric obesityFramework analysis approachText messagesChild's doctorHealth behaviorsHealthy behaviorsTelephone interviewsThematic saturationParent focus groupsParental perceptionsChildhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies
Egan KB, Ettinger AS, Bracken MB. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatrics 2013, 13: 121. PMID: 23941287, PMCID: PMC3751452, DOI: 10.1186/1471-2431-13-121.Peer-Reviewed Original ResearchConceptsBody mass indexCombined risk ratioProspective cohort studyRisk ratioYears of ageCohort studyMass indexChildhood body mass indexDescription of cohortPhysician-diagnosed asthmaNormal-weight childrenOverweight/obesityPotential effect modificationPotential effect modifiersIncident asthmaObesity definitionObserved sex effectsAsthma definitionsBMI assessmentObese childrenWeight childrenLanguage restrictionsSubgroup analysisObesity prevalenceEffect modificationPediatric Obesity and the Liver
Hardee S, Morotti R. Pediatric Obesity and the Liver. Academic Forensic Pathology 2013, 3: 28-33. DOI: 10.23907/2013.005.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseasePediatric nonalcoholic steatohepatitisFatty liver diseaseNonalcoholic steatohepatitisLiver diseaseAdult nonalcoholic steatohepatitisVariable fibrosisPediatric obesityPediatric populationMacrovesicular steatosisBallooning degenerationPediatric nonalcoholic fatty liver diseaseDifficult diagnostic entityPortal tract inflammationPediatric liver diseaseNoninvasive screening toolLobular inflammationSimple steatosisObese childrenPerisinusoidal fibrosisCardiovascular diseaseCommon causePrevalence ratesObesity epidemicObesity rates
2012
Year in Diabetes 2012: The Diabetes Tsunami
Sherwin R, Jastreboff AM. Year in Diabetes 2012: The Diabetes Tsunami. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 4293-4301. PMID: 23185035, PMCID: PMC3513534, DOI: 10.1210/jc.2012-3487.BooksConceptsClinical trialsAmerican Diabetes Association/European AssociationNew-onset type 1 diabetesPrevalence of diabetesCurrent treatment optionsLarge clinical trialsRecent clinical trialsBenefits of exerciseDevelopment of obesityNormal glucose metabolismType 1 diabetesStudy of DiabetesΒ-cell functionNovel therapeutic targetCentral nervous systemObese childrenSignificant morbidityTreatment optionsEndocrine SocietyInpatient settingTreatment strategiesIndividualized careOptimal preventionGlucose metabolismOptimization of interventionsMetabolic Syndrome in Childhood as a Risk Factor for Type 2 Diabetes
Santoro N, Giannini C, Caprio S. Metabolic Syndrome in Childhood as a Risk Factor for Type 2 Diabetes. 2012, 83-91. DOI: 10.1007/978-1-4471-2366-8_4.ChaptersType 2 diabetesMetabolic syndromeInsulin resistanceObese childrenInsulin-resistant statesObese subjectsGlucose dysregulationChildhood obesityRisk factorsWorldwide epidemicFrequent causeSex steroidsType 2DiabetesGrowth hormoneSyndromeObesityInsulin effectPutative defectPrevalenceChildrenCarbohydrate metabolismProgressionPathogenesisPediatricsChapter 6 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome
Santoro N, Giannini C, Caprio S. Chapter 6 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome. 2012, 77-87. DOI: 10.1016/b978-0-12-385083-6.00006-1.ChaptersInsulin resistanceΒ-cellsChapter 6 ObesityEctopic fat depositionProgression of obesityType 2 diabetesObesity complicationsObese childrenPediatric ageChildhood obesityMore insulinSerum glucoseInsulin secretionPediatric diseasesNormal rangeType 2Progressive deteriorationObesityFat depositionDiseaseInsulinComplicationsDiabetesPediatriciansPrevalence
2011
Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
Santoro N, Zhang CK, Zhao H, Pakstis AJ, Kim G, Kursawe R, Dykas DJ, Bale AE, Giannini C, Pierpont B, Shaw MM, Groop L, Caprio S. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. Hepatology 2011, 55: 781-789. PMID: 22105854, PMCID: PMC3288435, DOI: 10.1002/hep.24806.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentApolipoprotein C-IIIBlack or African AmericanChildFatty LiverFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHispanic or LatinoHumansLipaseLipoproteins, VLDLMaleMembrane ProteinsObesityPolymorphism, Single NucleotideRisk FactorsTriglyceridesWhite PeopleConceptsFatty liverObese childrenSingle nucleotide polymorphismsTriglyceride levelsOral glucose tolerance testGlucokinase regulatory proteinGlucose tolerance testHepatic fat accumulationAccumulation of triglyceridesLow-density lipoproteinElevated triglyceridesLarge VLDLTolerance testFat accumulationObese youthGlucokinase regulatory protein geneMagnetic resonancePNPLA3LiverRs1260326African AmericansTriglyceridesLipoproteinChildrenNucleotide polymorphismsHalo Effect for Bariatric Surgery: Collateral Weight Loss in Patients' Family Members
Woodard GA, Encarnacion B, Peraza J, Hernandez-Boussard T, Morton J. Halo Effect for Bariatric Surgery: Collateral Weight Loss in Patients' Family Members. JAMA Surgery 2011, 146: 1185-1190. PMID: 22006878, DOI: 10.1001/archsurg.2011.244.Peer-Reviewed Original ResearchConceptsGastric bypass surgeryBypass surgeryBody mass indexPatients' family membersAdult family membersHealthy behaviorsBariatric surgeryMass indexWeight lossLower body mass indexFamily membersMultidimensional health assessmentActivity levelsChildren of patientsSignificant weight lossDaily activity levelsQuality of lifeBariatric centerLifestyle counselingMorbid obesitySecondary outcomesWaist circumferenceObese childrenEffective treatmentUncontrollable eatingRelationship between sleep apnea, fat distribution, and insulin resistance in obese children.
Canapari CA, Hoppin AG, Kinane TB, Thomas BJ, Torriani M, Katz ES. Relationship between sleep apnea, fat distribution, and insulin resistance in obese children. Journal Of Clinical Sleep Medicine 2011, 7: 268-73. PMID: 21677896, PMCID: PMC3113965, DOI: 10.5664/jcsm.1068.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHomeostasis model assessmentBody mass indexLog homeostasis model assessmentBMI z-scoreObese childrenInsulin resistanceFat distributionSleep apneaMean body mass indexSubcutaneous adipose tissue areaZ-scoreVisceral fat areaVisceral fat distributionSubset of patientsAdipose tissue areaPediatric obesity clinicSubset of subjectsMagnetic resonance imagingOSA pathogenesisObesity clinicOSA severityObese subjectsMass indexFat area
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