2025
Induction of Immune Tolerance in Living Related HLA-Matched Kidney Transplantation: A Phase 3 Randomized Clinical Trial
Kaufman D, Akkina S, Stegall M, Piper J, Gaber A, Asch W, Busque S, Stites E, De Vera M, Srinivas T, Alonso D, Shah A, Patel A, L. M, Chavin K, DebRoy M, Jittirat A, Costa N, Cooper M, Vranic G, Laftavi M, Saidi R, Collette S, Brennan D, Group M. Induction of Immune Tolerance in Living Related HLA-Matched Kidney Transplantation: A Phase 3 Randomized Clinical Trial. American Journal Of Transplantation 2025, 25: 1461-1470. PMID: 39922283, DOI: 10.1016/j.ajt.2025.01.044.Peer-Reviewed Original ResearchRecurrent immunoglobulin A nephropathyKidney transplant recipientsImmunoglobulin A nephropathyImmune toleranceStandard of careMixed chimerismHost diseaseTransplant recipientsKidney transplantationClinical trialsPhase 3 randomized clinical trialInduction of immune toleranceInstitutional standard of careDonor mixed chimerismFunctional immune toleranceHematopoietic mixed chimerismNonmyeloablative conditioning protocolTotal lymphoid irradiationRabbit antithymocyte globulinPrimary study endpointHLA-matched kidney transplantsRecipients of kidneysPhase 3 multicenterControlled clinical trialsLymphoid irradiationA Rare Case of Cyberlindnera jadinii Fungemia in a Kidney Transplant Recipient: A Case Report
Patil J, Sogawa H, Mulligan D. A Rare Case of Cyberlindnera jadinii Fungemia in a Kidney Transplant Recipient: A Case Report. Case Reports In Transplantation 2025, 2025 DOI: 10.1155/crit/3478928.Peer-Reviewed Original ResearchKidney transplant recipientsTransplant recipientsRare caseSolid organ transplant recipientsAspergillus speciesOrgan transplant recipientsAntifungal prophylaxisFungal infectionsCausative agentGraft rejectionPerioperative mortalityCase reportKidney transplantationCardiovascular eventsFungemiaEarly diagnosisQuality of lifeSpeciesKidneyImmunosuppressive pathologyMortalityRecipientsInfectionCandidaAspergillus
2024
Cognitive bias: Chromoblastomycosis misdiagnosed as a giant cell tumor of soft tissue in a kidney transplant recipient
Wang S, Cowper S, Ko C. Cognitive bias: Chromoblastomycosis misdiagnosed as a giant cell tumor of soft tissue in a kidney transplant recipient. Journal Of The American Academy Of Dermatology 2024, 92: 668-669. PMID: 39549847, DOI: 10.1016/j.jaad.2024.10.087.Peer-Reviewed Original ResearchTumors of soft tissueGiant cell tumor of soft tissueKidney transplant recipientsGiant cell tumorTransplant recipientsClinical features and outcomes in kidney transplant recipients with COVID-19 pneumonia: a single center retrospective cohort study
Xu L, Chen X, Yang X, Chen S, Yang M, Yuan Z, Chen R, Wang J, Jiang H, Xu J, Wang Y. Clinical features and outcomes in kidney transplant recipients with COVID-19 pneumonia: a single center retrospective cohort study. Frontiers In Cellular And Infection Microbiology 2024, 14: 1392491. PMID: 39211792, PMCID: PMC11358093, DOI: 10.3389/fcimb.2024.1392491.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsCOVID-19 pneumoniaViral shedding timeRetrospective cohort studyShort-term prognosisTransplant recipientsClinical featuresAntiviral drugsAntiviral medicationsCohort studyShort-term renal functionAdministration of antiviral drugsAssociated with better therapeutic outcomesSevere COVID-19 pneumoniaConcurrent coronavirus disease 2019Diagnosis of COVID-19 pneumoniaTransplanted kidney functionStatistically significant reductionShedding timeRenal functionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Clinical symptomsKidney functionInitial symptomsThe Role of Angiopoietins in Cardiovascular Outcomes of Kidney Transplant Recipients: An Ancillary Study from the FAVORIT
Gendy N, Brown L, Staunton M, Garg K, Hernandez Garcilazo N, Qian L, Yamamoto Y, Ugwuowo U, Obeid W, Al-Qusairi L, Bostom A, Mansour S. The Role of Angiopoietins in Cardiovascular Outcomes of Kidney Transplant Recipients: An Ancillary Study from the FAVORIT. American Journal Of Nephrology 2024, 55: 597-606. PMID: 38735283, PMCID: PMC11444892, DOI: 10.1159/000538878.Peer-Reviewed Original ResearchKidney transplant recipientsRisk of cardiovascular diseaseGraft failureCardiovascular disease developmentAngpt-2Cardiovascular diseaseIncreased risk of future CVDAncillary studiesClinical variablesCare of kidney transplant recipientsIncreased riskRisk of future CVDUrine albumin-to-creatinine ratioDonor kidney transplant recipientsAlbumin-to-creatinine ratioIncreased risk of cardiovascular diseaseFuture cardiovascular diseaseImproves prediction of cardiovascular diseaseTransplant-related variablesAssociated with outcomeParticipants' median ageMitigate CVD riskMedian ageTransplant recipientsMedian timeKidney Transplant Outcomes From Deceased Donors Who Received Dialysis
Wen Y, Mansour S, Srialluri N, Hu D, Philbrook H, Hall I, Doshi M, Mohan S, Reese P, Parikh C. Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis. JAMA 2024, 332: 215-225. PMID: 38780515, PMCID: PMC11117155, DOI: 10.1001/jama.2024.8469.Peer-Reviewed Original ResearchDeath-censored graft failureKidney transplant recipientsGraft failureDeceased kidney donorsKidney transplantationTransplant recipientsGraft functionDeceased donorsFollow-upHigher risk of delayed graft functionIncidence of delayed graft functionOutcomes of transplant recipientsRisk of delayed graft functionMedian Follow-UpKidney donorsDelayed graft functionUS organ procurement organizationsKidney transplant outcomesRetrospective cohort studyRecipients of kidneysKidney donationSuccessful combination therapy for recurrent refractory cytomegalovirus treatment in a kidney transplant recipient
Marvin J, Trubin P, Azar M. Successful combination therapy for recurrent refractory cytomegalovirus treatment in a kidney transplant recipient. Transplant Infectious Disease 2024, 26: e14329. PMID: 38971997, DOI: 10.1111/tid.14329.Peer-Reviewed Original ResearchBK polyomavirus DNAemia, allograft rejection, and de novo donor‐specific antibodies after lowering target tacrolimus levels in pediatric kidney transplant recipients
Huang H, Xiang Y, George R, Winterberg P, Serluco A, Liverman R, Yildirim I, Garro R. BK polyomavirus DNAemia, allograft rejection, and de novo donor‐specific antibodies after lowering target tacrolimus levels in pediatric kidney transplant recipients. Pediatric Transplantation 2024, 28: e14791. PMID: 38808701, DOI: 10.1111/petr.14791.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibodiesTarget tacrolimus levelsDevelopment of de novo donor-specific antibodiesBiopsy-proven rejectionDonor-specific antibodiesMonths post-KTTacrolimus levelsTime of transplantationPediatric KT recipientsBK polyomavirusBKV-DNAemiaPost-KTPost-intervention cohortAllograft rejectionRecipient ageKT recipientsKidney transplantationPediatric kidney transplant recipientsLow tacrolimus levelsReduction of immunosuppressionKaplan-Meier survival analysisYounger recipient ageIndividualized immunosuppressive regimensKidney transplant recipientsRetrospective chart reviewClinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series
Qu Y, Zhuang J, Duan Y, Baibutihan A, Maimaiti Z, Zhang C, Niu J, Teng W, Ailimu M, Wei X, Qi B, Li J, Du S, Wang D, Cao K, Wang J, Lu C, Tian X, Jiang H. Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series. Integrative Medicine In Nephrology And Andrology 2024, 11: e00019. DOI: 10.1097/imna-d-23-00019.Peer-Reviewed Original ResearchKidney transplant recipientsKT recipientsClinical characteristicsKidney transplantationTransplant recipientsElevated serum D-dimerIncidence of severe infectionsOmicron infectionSevere/critical illnessOutcomes of severe acute respiratory syndrome coronavirus 2Calcineurin inhibitor drugsSerum D-dimerSerum albumin levelSARS-CoV-2Acute kidney injuryFollow-up periodC-reactive proteinSARS-CoV-2 Omicron infectionSARS-CoV-2 Omicron variantReverse transcription polymerase chain reactionImmunocompromised statusFerritin levelsTranscription polymerase chain reactionSevere/critical groupAntiviral therapyUse of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians
Wiseman A, Alhamad T, Alloway R, Concepcion B, Cooper M, Formica R, Klein C, Kumar V, Leca N, Shihab F, Taber D, Mulnick S, Bushnell D, Hadi M, Bunnapradist S. Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians. Annals Of Transplantation 2024, 29: e943498-1-e943498-13. PMID: 38526543, PMCID: PMC10944009, DOI: 10.12659/aot.943498.Peer-Reviewed Original ResearchConceptsLCP-tacrolimusImmediate-release tacrolimusKidney transplantationFirst-line optionKidney transplant recipientsRandomized clinical trialsDe novo settingTacrolimus formulationReview available dataEvidence-based recommendationsTrough levelsOnce-DailyTransplant recipientsClinical decision-makingOptimal doseClinical trialsExpert cliniciansConsensus statementTransplant expertsStrength of evidenceClinical practiceKidneyTacrolimusDe novoDelphi consensus surveyClinical outcomes of SARS‐CoV‐2 infection in kidney transplant recipients on belatacept: a single‐center experience
Feller F, Azar M, Marvin J, Cohen E, Virmani S, Malinis M. Clinical outcomes of SARS‐CoV‐2 infection in kidney transplant recipients on belatacept: a single‐center experience. Transplant Infectious Disease 2024, 26: e14253. PMID: 38351494, DOI: 10.1111/tid.14253.Peer-Reviewed Original Research
2023
MDR-101-MLK Update: Operational Immune Tolerance Achieved in Living Related HLA-Matched Kidney Transplant Recipients
Kaufman D, Stegall M, Akkina S, Piper J, Asch W, Busque S, Gaber A, L. M, de Vera M, Collette S, Patel A, Shah A, Stites E, Micsa L, Brennan D. MDR-101-MLK Update: Operational Immune Tolerance Achieved in Living Related HLA-Matched Kidney Transplant Recipients. Journal Of The American Society Of Nephrology 2023, 34: b3-b3. DOI: 10.1681/asn.20233411b3a.Peer-Reviewed Original ResearchOnconephrology: Core Curriculum 2023
Yarandi N, Shirali A. Onconephrology: Core Curriculum 2023. American Journal Of Kidney Diseases 2023, 82: 743-761. PMID: 37855786, DOI: 10.1053/j.ajkd.2023.04.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsKidney diseaseChimeric antigen receptor T cellsAntigen receptor T cellsAJKD's Core CurriculumAcute kidney injuryKidney transplant recipientsChronic kidney diseaseReceptor T cellsKidney injuryTransplant recipientsElectrolyte disordersCell transplantClinical syndromeMonoclonal gammopathyGlomerular diseaseT cellsCancer riskClinical decisionCancer treatmentDiseaseOnconephrologySyndromeCancerSpecific considerationsHypertensionThe Role of Vascular Biomarkers in Outcomes of Patients with Kidney Disease
Shi A, Mansour S. The Role of Vascular Biomarkers in Outcomes of Patients with Kidney Disease. Nephron 2023, 147: 778-781. PMID: 37611550, PMCID: PMC10841333, DOI: 10.1159/000533415.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAngpt-2 levelsCardiovascular diseaseVascular biomarkersPoor outcomeChronic kidney disease patientsPoor long-term outcomesGrowth factorKidney transplant recipientsOutcomes of patientsKidney disease progressionKidney disease patientsLong-term outcomesPlacental growth factorVascular endothelial growth factorEndothelial growth factorAKI patientsAKI survivorsCardiac complicationsKidney injuryTransplant recipientsCardiac surgeryHeart failureHospitalized patientsEndothelial damageFirst case of rapidly fatal mpox from secondary (household) transmission in a kidney transplant recipient
Fuller R, Cederroth T, Patel G, Reidy J, Patiño L, Ramírez J, Bassily-Marcus A, Paniz-Mondolfi A. First case of rapidly fatal mpox from secondary (household) transmission in a kidney transplant recipient. American Journal Of Transplantation 2023, 23: 1995-1999. PMID: 37516244, DOI: 10.1016/j.ajt.2023.07.017.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsKidney transplant recipientsTransplant recipientsMale kidney transplant recipientsCases of mpoxGenomic analysisLaboratory findingsFatal courseProphylaxis effortsPublic health authoritiesPatient populationHousehold contactsRisk factorsAutopsy findingsHealth authoritiesRecipientsPatientsMPOXDiseaseMenGenomeSecondary transmission
2022
Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity
Sun Z, Zhang Z, Banu K, Al Azzi Y, Reghuvaran A, Fredericks S, Planoutene M, Hartzell S, Kim Y, Pell J, Tietjen G, Asch W, Kulkarni S, Formica R, Rana M, Maltzman JS, Zhang W, Akalin E, Heeger PS, Cravedi P, Menon MC. Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity. Journal Of The American Society Of Nephrology 2022, 33: 2108-2122. PMID: 36041788, PMCID: PMC9678030, DOI: 10.1681/asn.2022010125.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsImmune activation pathwaysImmunosuppressant useKTR cohortAcute illnessBlood transcriptomeAcute casesT cellsCOVID-19Most kidney transplant recipientsPost-acute COVID-19Adaptive immune system activationManagement of immunosuppressionReinstitution of immunosuppressionAcute COVID-19Serum inflammatory cytokinesCOVID-19 severity scoreCOVID-19 infectionImmune system activationUpregulation of neutrophilActivation pathwayTransplant recipientsChart reviewImmune signaturesLymphocyte countInfliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial
Hricik D, Armstrong B, Alhamad T, Brennan D, Bromberg J, Bunnapradist S, Chandran S, Fairchild R, Foley D, Formica R, Gibson I, Kesler K, Kim SJ, Mannon R, Menon M, Newell K, Nickerson P, Odim J, Poggio E, Sung R, Shapiro R, Tinckam K, Vincenti F, Heeger P. Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial. Journal Of The American Society Of Nephrology 2022, 34: 145-159. PMID: 36195441, PMCID: PMC10101585, DOI: 10.1681/asn.2022040454.Peer-Reviewed Original ResearchConceptsBiopsy-proven acute rejectionBK virus infectionIntravenous infliximabPrimary end pointTransplant recipientsKidney transplantVirus infectionDe novo donor-specific antibodiesDeceased donor kidney transplant recipientsRabbit anti-thymocyte globulin (rATG) inductionAnti-thymocyte globulin inductionCLINICAL TRIAL REGISTRY NAMEDonor kidney transplant recipientsNovo donor-specific antibodiesEnd pointPhase 2 clinical trialIFX induction therapyTRIAL REGISTRY NAMEDelayed graft functionDonor-specific antibodiesKidney transplant recipientsDeceased donor kidneysTNF-α productionPrimary transplant recipientsAcute rejectionDeceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort
Reese PP, Doshi MD, Hall IE, Besharatian B, Bromberg JS, Thiessen-Philbrook H, Jia Y, Kamoun M, Mansour SG, Akalin E, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort. American Journal Of Kidney Diseases 2022, 81: 222-231.e1. PMID: 36191727, PMCID: PMC9868058, DOI: 10.1053/j.ajkd.2022.08.011.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibodiesBiopsy-proven acute rejectionAcute kidney injuryNeutrophil Gelatinase-Associated LipocalinDe novo DSAGraft failurePrimary outcomeAcute rejectionKidney recipientsKidney injurySecondary outcomesAcute Kidney Injury Network criteriaClinical acute kidney injuryNovo donor-specific antibodiesSignificant associationKidney injury molecule-1Recipient alloimmune responsesUrinary IL-18Donor-specific antibodiesFirst posttransplant yearKidney transplant recipientsInjury molecule-1Gelatinase-Associated LipocalinDeceased donor kidneysFine-Gray modelOverall Infectious Complications Related to Belatacept Conversion in Comparison to Tacrolimus in Kidney Transplant Recipients
Marvin JE, Azar MM, Belfield KD, Do V, Formica R, Cohen EA. Overall Infectious Complications Related to Belatacept Conversion in Comparison to Tacrolimus in Kidney Transplant Recipients. Progress In Transplantation 2022, 32: 351-356. PMID: 36039533, DOI: 10.1177/15269248221122894.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsProportion of patientsBelatacept conversionInfectious complicationsTransplant recipientsExact testLong-term infectious complicationsFavorable side effect profileOverall infectious complicationsSide effect profileTime of transplantFisher's exact testT-testStudent's t-testMann-Whitney UInduction immunosuppressionTacrolimus patientsKidney transplantMore patientsPrimary outcomeEffect profileTacrolimusOutcome dataHigh incidenceRetrospective evaluationElevated tacrolimus levels after treatment with nirmatrelvir/ritonavir (Paxlovid) for COVID-19 infection in a child with a kidney transplant
Young C, Papiro T, Greenberg JH. Elevated tacrolimus levels after treatment with nirmatrelvir/ritonavir (Paxlovid) for COVID-19 infection in a child with a kidney transplant. Pediatric Nephrology 2022, 38: 1-2. PMID: 35982345, PMCID: PMC9388350, DOI: 10.1007/s00467-022-05712-0.Peer-Reviewed Original ResearchConceptsCOVID-19 infectionSupratherapeutic tacrolimus levelsTacrolimus levelsKidney transplantCase reportPediatric kidney transplant recipientsElevated tacrolimus levelsKidney transplant recipientsPotent CYP3A4 inhibitorEmergency use authorizationDrug-drug interactionsPaucity of dataCytochrome P450 systemImmunosuppressant medicationsTransplant recipientsSerum creatininePediatric patientsCalcineurin inhibitorsKidney functionCYP3A4 inhibitorsConcomitant useTacrolimusTherapeutic goalsRitonavirDrug Administration
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