2024
Randomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation
Hungate J, Onders R, Diasty M, Abu-Omar Y, Arora R, Baeza C, Elgudin Y, Gray K, Markowitz A, Pelletier M, Ribeiro I, Vega P, Rushing G, Sabik J. Randomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation. JTCVS Open 2024, 22: 76-84. PMID: 39780786, PMCID: PMC11704535, DOI: 10.1016/j.xjon.2024.09.031.Peer-Reviewed Original ResearchProlonged mechanical ventilationStandard of care groupRisk of prolonged mechanical ventilationMechanical ventilationCardiac surgeryDiaphragmatic pacingDiaphragm pacingTreatment groupsRandomized trialsHistory of chronic obstructive pulmonary diseaseLeft ventricular ejection fractionIntra-aortic balloon pumpDecrease mechanical ventilationCardiac surgery patientsVentricular ejection fractionHigh-risk patientsMulticenter randomized trialCare groupEnhanced recoveryChronic obstructive pulmonary diseaseRelative risk reductionIntensive care unitStandard of carePredictive enrichment strategiesObstructive pulmonary diseaseShared Decision-Making Communication and Prognostic Misunderstanding in the ICU
Vick J, Berger B, Ubel P, Cox C, You H, E. J, Haverfield M, Hammill B, Carson S, Hough C, White D, Ashana D. Shared Decision-Making Communication and Prognostic Misunderstanding in the ICU. JAMA Network Open 2024, 7: e2439715. PMID: 39405057, PMCID: PMC11581528, DOI: 10.1001/jamanetworkopen.2024.39715.Peer-Reviewed Original ResearchConceptsShared decision-makingIntensive care unitFamily meetingsRetrospective cohort studyIntensive care unit family meetingsCohort studyIntensive care unit physiciansSurvival prognosisSurrogates' perceptionsAssociated with poor patientPhysicians' misunderstandingPhysicians' perceptionsWhite physiciansDecision-making communicationPhysician estimatesMain OutcomesBlack physiciansAbsolute differenceSurgical intensive care unitAsian physiciansPoor patientsSecondary outcomesPhysiciansPrimary outcomeProlonged mechanical ventilationGuillain-Barre in the long-term acute care hospital setting: Ventilation does not prolong stay
Weil K, Baumann V, Brown B, Nadeau R, Hrdlicka H, Gerstenhaber B, Rosenblum D, Manning E. Guillain-Barre in the long-term acute care hospital setting: Ventilation does not prolong stay. Journal Of Mechanical Ventilation 2024, 5: 13-19. DOI: 10.53097/jmv.10094.Peer-Reviewed Original ResearchGuillain-Barre syndrome patientsGuillain-Barre syndromeLong-term acute care hospitalProlonged mechanical ventilationGBS patientsMechanical ventilationLength of stayAcute inflammatory demyelinating polyneuropathyFunctional abilitySevere Guillain-Barre syndromeLong-term acute care hospital settingAcute care hospital settingInflammatory demyelinating polyneuropathyOutcomes of patientsAcute care hospitalsLoss of muscle functionRate of functional improvementTime of admissionMain outcome measuresPoor functional statusDemyelinating polyneuropathyProlonged ventilationRespiratory failureNo significant differenceRetrospective study
2023
Prognostic variables and decannulation of tracheostomy in the long-term acute care environment: a case for clinician-driven decision-making.
Weil K, Baumann V, Brown B, Nadeau R, Gerstenhaber B, Manning E. Prognostic variables and decannulation of tracheostomy in the long-term acute care environment: a case for clinician-driven decision-making. Journal Of Mechanical Ventilation 2023, 4: 1-8. PMID: 37426175, PMCID: PMC10328447, DOI: 10.53097/jmv.10069.Peer-Reviewed Original ResearchArterial blood gasLong-term acute care hospitalOvernight oximetryPrognostic variablesSingle prognostic variableDecannulation successSuccessful decannulationMechanical ventilationClinical judgmentPeak expiratory flow measurementsDecannulation of tracheostomyMechanical ventilation daysProlonged mechanical ventilationBlood gas analysisExpiratory flow measurementsAcute care hospitalsAcute care environmentExperienced medical professionalsOximetry testingVentilation daysCare hospitalTracheostomy removalDecannulation outcomesBlood gasRetrospective analysis
2022
Clinicopathologic characteristics of severe COVID-19 patients in Mexico City: A post-mortem analysis using a minimally invasive autopsy approach
Nava-Santana C, Rodríguez-Armida M, Jiménez J, Vargas-Parra N, León D, Campos-Murguia A, Macías-Rodriguez R, Arteaga-Garrido A, Hernández-Villegas A, Dominguez-Cherit G, Rivero-Sigarroa E, Gamboa-Dominguez A, Gullias-Herrero A, Sifuentes-Osornio J, Uribe-Uribe N, Morales-Buenrostro L. Clinicopathologic characteristics of severe COVID-19 patients in Mexico City: A post-mortem analysis using a minimally invasive autopsy approach. PLOS ONE 2022, 17: e0262783. PMID: 35239660, PMCID: PMC8893646, DOI: 10.1371/journal.pone.0262783.Peer-Reviewed Original ResearchConceptsClinicopathological characteristicsClinical findingsMicro-thrombosisDiagnosis of SARS-CoV-2 pneumoniaDeceased patientsSevere COVID-19 patientsSARS-CoV-2 pneumoniaAcute tubular injuryInvasive autopsyProlonged mechanical ventilationSevere SARS-CoV-2Liver function testsSARS-CoV-2Autopsy reportsLow lung complianceMinimally invasive autopsySARS-CoV-2 positivityCOVID-19 patientsDiagnostic yieldLung histologyTubular injuryMechanical ventilationNeutrophilic inflammationHistological featuresHistological findings
2021
PILOT STUDY OF PERCUTANEOUS TEMPORARY DIAPHRAGM PACING WIRES IN CARDIAC SURGERY PATIENTS AT RISK OF PROLONGED MECHANICAL VENTILATION DURING THE COVID-19 PANDEMIC
Jarrett C, Onders R, Pelletier M, Abu-Omar Y, Baeza C, Elgudin Y, Markowitz A, Vega P, Sabik J. PILOT STUDY OF PERCUTANEOUS TEMPORARY DIAPHRAGM PACING WIRES IN CARDIAC SURGERY PATIENTS AT RISK OF PROLONGED MECHANICAL VENTILATION DURING THE COVID-19 PANDEMIC. Canadian Journal Of Cardiology 2021, 37: s112-s113. PMCID: PMC8523110, DOI: 10.1016/j.cjca.2021.07.213.Peer-Reviewed Original ResearchProlonged mechanical ventilationCardiac surgery patientsCardiac surgeryDiaphragm pacingMechanical ventilationDiaphragm functionSurgery patientsHigh-risk cardiac surgery patientsVentilator induced diaphragm dysfunctionRisk of prolonged mechanical ventilationDecreased ventilation timeLikelihood of extubationPrevent diaphragm atrophyHistory of TIAOpen heart surgeryProlonged mechanical ventilation patientsRelated adverse eventsOutcomes of DPDevice related adverse eventsRandomized Controlled TrialsDiaphragm atrophyDiaphragm dysfunctionProspective trialsMedian timeVentilation timeThe association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality
Nandiwada S, Islam S, Jentzer JC, Miller PE, Fordyce CB, Lawler P, Alviar CL, Sun LY, Dover DC, Lopes RD, Kaul P, van Diepen S. The association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality. European Heart Journal Acute Cardiovascular Care 2021, 10: 797-805. PMID: 34318875, PMCID: PMC9067446, DOI: 10.1093/ehjacc/zuab055.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitMechanical ventilationHospital mortalityRespiratory failureCICU LOSNon-invasive mechanical ventilationNational population-based dataInvasive mechanical ventilationVolume-mortality relationshipProlonged mechanical ventilationProportion of patientsHigh-volume hospitalsPercutaneous coronary interventionLow-volume centersHigh-volume centersIntensive care unitPopulation-based dataOutcomes of interestCICU lengthCICU admissionCoronary interventionSurgical ICUCare unitVolume centersLower incidence
2020
Tracheostomy for Coronavirus Disease 2019 Patients: Maintaining the Standard of Care
Bassily-Marcus A, Leibner E, Kohli-Seth R. Tracheostomy for Coronavirus Disease 2019 Patients: Maintaining the Standard of Care. Critical Care Explorations 2020, 2: e0190. PMID: 32903998, PMCID: PMC7447361, DOI: 10.1097/cce.0000000000000190.Peer-Reviewed Original ResearchStandard of careTiming of tracheostomyMechanical ventilationProlonged ventilatory supportProlonged mechanical ventilationMechanically Ventilated PatientsDays follow-upLack of symptomsNegative antibody testProspective observational cohortCoronavirus diseaseTracheostomy teamViral clearanceVentilatory supportMedian timeDelayed tracheostomyBronchoscopic guidanceFollow-upAcademic medical centerObservational cohortTracheostomyPatientsPerforming tracheostomyMedical CenterPost-intubation
2005
Seventy-Five Years of Neonatal Sepsis at Yale: 1928–2003
Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG. Seventy-Five Years of Neonatal Sepsis at Yale: 1928–2003. 2005, 116: 595-602. PMID: 16140698, DOI: 10.1542/peds.2005-0552.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalEpisodes of sepsisLate-onset sepsisRecords of infantsPositive blood culturesNeonatal sepsisPreterm infantsBlood culturesSepsis-related mortality rateEarly-onset sepsisProlonged mechanical ventilationCentral vascular catheterNeonatal sepsis casesPopulation of infantsGroup B streptococciPercentage of casesDays of ageParenteral nutritionSepsis casesMechanical ventilationVascular cathetersIntensive careS pyogenesB streptococciSepsis
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